BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0248.0038.p (283 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC1578 [GER] COG0697 Permeases of the drug/metabolite transporte... 143 4e-34 AGc3419 [GER] COG0697 Permeases of the drug/metabolite transport... 110 3e-24 CC3090 [GER] COG0697 Permeases of the drug/metabolite transporte... 107 2e-23 ECs2140 [GER] COG0697 Permeases of the drug/metabolite transport... 100 3e-21 PA4779 [GER] COG0697 Permeases of the drug/metabolite transporte... 95 2e-19 >CC1578 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ccr Caulobacter vibrioides Length = 301 Score = 143 bits (361), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 97/277 (35%), Positives = 147/277 (53%), Gaps = 2/277 (0%) Query: 1 MSAIQIVCAVAVPLLWGYQFVVIKVGVTEFPPLFFLGLRFLAIALLLVPFVRRPTRQQLG 60 +S ++ + A+ + WG KV PP+ GLRFLA + L PF+R P + Sbjct: 8 LSVLEYLAIFAIIMTWGINNAAAKVATAYLPPMTVGGLRFLAALVFLFPFIRPPFPEP-K 66 Query: 61 PVAAISVFLGGLNFGLFYVGLGLGSG-SMSAVAYQLAPPFTVLLAWPLLAERPSLVTSAG 119 +AAI + G ++FGL YVG G+G S VA QL PFT L+AW LL E L G Sbjct: 67 KLAAIVLLTGPIHFGLVYVGFGMGQSLSPLVVASQLWIPFTALVAWKLLGETMRLPAVLG 126 Query: 120 VVLAFVGVVVLAAGPGLSANVLPLLLVVGAAFAFAVSTVLTKRYGPFDPLMLMGWSSLLT 179 +++AFVGV + P S ++ ++L+V A+ +AV+T+L + PL + ++L Sbjct: 127 LIVAFVGVAWMTLDPHTSGDLPAIVLIVLASACWAVATILVRMTPGAKPLKVQAVTALFA 186 Query: 180 VPQVMLMSLLLEYGQAASLVTADQRGWLALAYTIFIGGIVGFGLWFWLIARCSMGRVAPF 239 P ++ MS E ++TA W + + + I L FWL+ R GRV P+ Sbjct: 187 APSLLAMSFAFETQVVERVMTAPPIAWACVIFAGVVSTIGASALLFWLVQRREAGRVTPY 246 Query: 240 GLLLPVFALIFSVMFLGDSVTPKLIVGGLLAISGVAI 276 LL P+ + V FLGD +TP+L++GG + GVA+ Sbjct: 247 FLLTPLVSCTLGVAFLGDKLTPQLLIGGAATMVGVAL 283 >AGc3419 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 321 Score = 110 bits (276), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 95/283 (33%), Positives = 150/283 (53%), Gaps = 10/283 (3%) Query: 1 MSAIQIVCAVAVPLLWGYQFVVIKVGVTEFPPLFFLGLRFLAIALLLVPFVRRPT---RQ 57 M+ I A+ LWG+ FV IKVGV + PPLF G+R+L A+ LV F+ +P R Sbjct: 25 MALPHIFLALITVFLWGFNFVAIKVGVADMPPLFLTGVRYLFAAVPLVFFLPKPNVPWRH 84 Query: 58 QLGPVAAISVFLGGLNFGLFYVGLGLG-SGSMSAVAYQLAPPFTVLLAWPLLAERPSLVT 116 + + +G FGL Y + LG ++++ Q FT+ LA L ERP Sbjct: 85 MI----VYGMAMGFFQFGLLYPAIKLGLPAGLASLVMQSQAFFTLALAVVFLGERPLPSQ 140 Query: 117 SAGVVLAFVGVVVLAAGPGLSANVLPLLLVVGAAFAFAVSTVLTKRYGPFDPLMLMGWSS 176 AG ++AF G+ V+ +A ++PLL+ VG+A A+A ++ +R G + + + W+S Sbjct: 141 IAGAIVAFGGLAVIGMERMTAAALIPLLMGVGSAIAWACGNIVNRRIGQVNVVSFIAWTS 200 Query: 177 LLTVPQVMLMSLLLEYGQA--ASLVTADQRGWLALAYTIFIGGIVGFGLWFWLIARCSMG 234 L+ V ++L+SL++E A L A L + Y + IVG G+W +L+ R G Sbjct: 201 LVPVLPLVLLSLVVEGPDAIVEGLQNATPTMALVVIYMAYGATIVGAGIWSYLLLRYPAG 260 Query: 235 RVAPFGLLLPVFALIFSVMFLGDSVTPKLIVGGLLAISGVAIT 277 VAPF LL+P+ I + + + +T I+G L I G+A+ Sbjct: 261 TVAPFSLLVPIVGFISAYLAFAEHITIFEIIGAALVILGLALN 303 >CC3090 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ccr Caulobacter vibrioides Length = 300 Score = 107 bits (268), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/280 (30%), Positives = 146/280 (52%), Gaps = 4/280 (1%) Query: 5 QIVCAVAVPLLWGYQFVVIKVGVTEFPPLFFLGLRFLAIALLLVPFVRRPTRQQLGPVAA 64 + A+AV +WG FVVI++G+ PPL F LRF + L + FV+RP +AA Sbjct: 10 HFLLALAVVAVWGTNFVVIRIGLDHLPPLLFATLRFSMVLLPMAFFVKRPAVSWAN-LAA 68 Query: 65 ISVFLGGLNFGLFYVGL-GLGSGSMSAVAYQLAPPFTVLLAWPLLAERPSLVTSAGVVLA 123 V +G FGL +V + G S ++++ Q FT+ +A + ER ++LA Sbjct: 69 YGVAIGAGQFGLLFVAMKGHISPGLASLVVQTQVFFTIGMAMWISRERVQGFQVVALLLA 128 Query: 124 FVGVVVLAAGPGLSANVLPLLLVVGAAFAFAVSTVLTKRYGPFDPLMLMGWSSLLTVPQV 183 G+V++A G SA L + LV+ AA +++ +++++ G + L + W+SL ++P + Sbjct: 129 ASGIVLIAVHGGGSATPLGVTLVLLAAASWSAGNMISRQAGAVNMLGYVVWASLFSIPPL 188 Query: 184 MLMSLLLEYGQA--ASLVTADQRGWLALAYTIFIGGIVGFGLWFWLIARCSMGRVAPFGL 241 MSL LE A + A W A+A+ + G+ W WL+AR V P L Sbjct: 189 FAMSLWLEGWPAIVQGVTAATPWTWAAVAWQAVGNTMFGYAAWGWLLARHPAATVTPMAL 248 Query: 242 LLPVFALIFSVMFLGDSVTPKLIVGGLLAISGVAITQVRP 281 L+PVF + S + L +++ ++ L ++G+A+ + P Sbjct: 249 LVPVFGMGASALLLHEALPAWKLIAAALVLTGLAVNMLWP 288 >ECs2140 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ecs Escherichia coli O157:H7 Length = 299 Score = 100 bits (250), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/271 (31%), Positives = 134/271 (49%), Gaps = 10/271 (3%) Query: 16 WGYQFVVIKVGVTEFPPLFFLGLRFLAIALLLVPFVRRPTRQQLGPVAAISVFLGGLNFG 75 WG FVVIKVG+ PPL GLRF+ +A + FV RP + L + + + F Sbjct: 16 WGLNFVVIKVGLHNMPPLMLAGLRFMLVAFPAIFFVARP-KVPLNLLLGYGLTISFAQFA 74 Query: 76 LFYVGLGLGS-GSMSAVAYQLAPPFTVLLAWPLLAERPSLVTSAGVVLAFVGVVVLAAGP 134 + + G ++++ Q FT++L ER AG+ LA GV+VL Sbjct: 75 FLFCAINFGMPAGLASLVLQAQAFFTIVLGAFTFGERLHGKQLAGIALAISGVLVLIEDS 134 Query: 135 --GLSANVLPLLLVVGAAFAFAVSTVLTKRYGPFDP----LMLMGWSSLLTVPQVMLMSL 188 G +L +L + AAF++A + K+ + L+ WS+L+ + + SL Sbjct: 135 FNGQHVAMLGFMLTLAAAFSWASGNIFNKKIMSHSSRPAVMSLVVWSALIPIIPFFVASL 194 Query: 189 LLE-YGQA-ASLVTADQRGWLALAYTIFIGGIVGFGLWFWLIARCSMGRVAPFGLLLPVF 246 +L+ G+ SLVT D LAL Y F+ IVG+G+W L+ R RVAP LL+PV Sbjct: 195 ILDGSGKMIHSLVTIDMTTILALMYLAFVATIVGYGIWGTLLGRYETWRVAPLSLLVPVV 254 Query: 247 ALIFSVMFLGDSVTPKLIVGGLLAISGVAIT 277 L + + L + +T +G +L ++G+ I Sbjct: 255 GLASAALLLDERLTGLQFLGAVLIMAGLYIN 285 >PA4779 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 297 Score = 94.7 bits (234), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 147/280 (52%), Gaps = 4/280 (1%) Query: 1 MSAIQIVCAVAVPLLWGYQFVVIKVGVTEFPPLFFLGLRFLAIALLLVPFVRRPTRQQLG 60 M I+ A+ V L+WG FVVIKVG+ +FPPL F LRF AL L+ +R P G Sbjct: 1 MPVAHILLALLVTLIWGLNFVVIKVGLGDFPPLLFCALRFALAALPLL-VLRGPMPAPFG 59 Query: 61 PVAAISVFLGGLNFGLFYVGLGLG-SGSMSAVAYQLAPPFTVLLAWPLLAERPSLVTSAG 119 + I V LG + FGL +VG+ G +S++ Q FT+L+A L ERP+ G Sbjct: 60 RILLIGVLLGVVKFGLLFVGMAQGMPAGLSSLVLQSQVFFTILIAALWLGERPTPRGLFG 119 Query: 120 VVLAFVGVVVLAAGPGLSANVLPLLLVVGAAFAFAVSTVLTKRYGPFDPLMLMGWSSLLT 179 ++LA G+V++ L ++L LLVV AA A++ + + TKR G D L L+ W SL+ Sbjct: 120 LLLAAAGLVLIGLERPLGDSLLAFLLVVAAALAWSFANIATKRSGATDMLRLICWVSLVP 179 Query: 180 VPQVMLMSLLLEYGQAASLVTADQR--GWLALAYTIFIGGIVGFGLWFWLIARCSMGRVA 237 ++ +S L E QA + G+ AL Y F VGF +W +L+ V Sbjct: 180 PLPLLALSYLFEGPQAIERAVLNMSWGGFGALLYIAFGATTVGFAIWSFLLRHYPASLVT 239 Query: 238 PFGLLLPVFALIFSVMFLGDSVTPKLIVGGLLAISGVAIT 277 PF L +PV ++ + LG+ + ++ L G+AIT Sbjct: 240 PFALAVPVSGMLAGWLLLGERLDLDSLLACALVFVGLAIT 279