BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0247.0054.p (550 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1940 [GEPR] COG0477 Permeases of the major facilitator superf... 748 0.0 MA2503 [GEPR] COG0477 Permeases of the major facilitator superfa... 162 1e-39 RSp1417 [GEPR] COG0477 Permeases of the major facilitator superf... 103 1e-21 Cgl1114 [GEPR] COG0477 Permeases of the major facilitator superf... 100 2e-20 Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superf... 90 1e-17 >YPO1940 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 546 Score = 748 bits (1932), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/540 (72%), Positives = 450/540 (83%), Gaps = 2/540 (0%) Query: 1 MATQAISIGDIQQEERASWVPMIAIAVGQMIMSFNVASLPVAMGGMVASFGVPPTTVATG 60 MA Q++S E + SWVPMI IA+ Q++MSFNVASLPVA+GGMV SF VPPTT+AT Sbjct: 1 MANQSVS--RTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATA 58 Query: 61 IVAYSMLVAGFVMLGAKLAQRFGAVQVFRGAVVLFLIAQIAMTFSPTASVMISAQALCGA 120 IV YS+ VAGFVMLGAKL QRFG + VFR V+LF +AQ MTFSP +VMI AQAL G Sbjct: 59 IVMYSLSVAGFVMLGAKLNQRFGPLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGL 118 Query: 121 AGAVIVPSLVALIAENYAGRQQATALGALGSARAAAGVLAFVVGGLLGTYIGWRPAFAIL 180 AGA +VP+LVALIAENY G QQATALGALGSARA AGV AF++GG+LGT+IGWRPAF IL Sbjct: 119 AGAALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFLIGGILGTHIGWRPAFGIL 178 Query: 181 IVASAIAFALSFRLRPDRGRADVQIDLIGVALAASAIIFISFGFNNLNGWGVILATPNAP 240 IV S I F LSFRL+ D+GR +V ID+IGV LAASAII +SFGFNNLN WG L AP Sbjct: 179 IVLSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAP 238 Query: 241 FDLLGVSPAPILIVLGIVLGQAFLMWTHRQQSAGKTPLLALEVIDSPEERCAVYALFAVV 300 FDLLG SPAP +IVLGIVLGQAF++WT R+Q GKTPLLAL+VI SP ER AV+A+FAVV Sbjct: 239 FDLLGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVV 298 Query: 301 ALEAALNFTVPLYIQIVQGRSPIATAIAMMPFNLTVFLSAMLIVNLYDKLTPRQIGRFGF 360 ALEA LNF+VPLYIQIVQG SP+ATAIAMMPFNL+VF SAMLIV Y KLTPR+IGR+GF Sbjct: 299 ALEAMLNFSVPLYIQIVQGSSPMATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGF 358 Query: 361 GLCTVALLWLAFVVRNDWSEIPVLLGLVLFGIGQGSLVTLLFNVLVTASPKALAGDVGSL 420 CT+ALLWLAFVVRN+WSE VL+GLV+FGIGQGSLVTLLFNVLV+ASPK LAGDVGSL Sbjct: 359 ITCTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLFNVLVSASPKELAGDVGSL 418 Query: 421 RGTTQNLAAAVGTAVAGALLVGLLSTIALGRIAASPVLTNELQSQVDLSNITFVSNDRLR 480 RGTT NLA+A+GTAVAGALLVGLLS + +A +P+LT+E+Q+QV++ +I FVSNDRL Sbjct: 419 RGTTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLN 478 Query: 481 SVLEGTSGTPQQVEEAVRVNTEARLRALKIGLLIMAGLALLAVIPAGRLPNYRPGEIPDD 540 SVL TS TP+QV EAVRVN EARLRALK GLL+MA L+LLA+ PAGRLP+Y PGE+P D Sbjct: 479 SVLAQTSATPEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPAD 538 >MA2503 [GEPR] COG0477 Permeases of the major facilitator superfamily Mac Methanosarcina acetivorans str.C2A Length = 533 Score = 162 bits (411), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 136/525 (25%), Positives = 253/525 (48%), Gaps = 23/525 (4%) Query: 22 MIAIAVGQMIMSFNVASLPVAMGGMVASFGVPPTTVATGIVAYSMLVAGFVMLGAKLAQR 81 ++A+ + ++ + + V++ +++ F TTV I Y++++A F++ G K+ Sbjct: 7 LVALVLAMFVLVIDTTIMNVSISALISDFNTNVTTVQGAITLYALVMASFMITGGKIGDI 66 Query: 82 FGAVQVFRGAVVLFLIAQIAMTFSPTASVMISAQALCGAAGAVIV-PSLVALIAENYAGR 140 G + FR +V++ + + SPT V+ ++ GA +V P++ L+ NY G Sbjct: 67 IGRKRAFRLGLVIYGVGSLLTAISPTIGVLFVGWSILEGLGATLVMPAIQTLVTSNYEGE 126 Query: 141 QQATALGALGSARAAAGVLAFVVGGLLGTYIGWRPAFAILIVASAIAFALSFRL--RPDR 198 +A A G +G A+ L ++GG L T WR AFA +V I ALS + P + Sbjct: 127 DRAIAYGIIGGIVASGIALGPIIGGWLTTAYTWRLAFAGEVVIVIIVLALSRAILDAPLK 186 Query: 199 GRADVQIDLIGVALAASAIIFISFG--FNNLNGWGV------ILATPNAPFDLLGVSPAP 250 + ++D+IG L+A + I FG GW I +PF G+SP P Sbjct: 187 AGEEPKLDVIGSILSALGMGLIVFGILMAGTYGWWKARQTFSIAGIEISPF---GLSPTP 243 Query: 251 ILIVLGIVLGQAFLMWTHRQQSAGKTPLLALEVIDSPEERCAVYALFAVVALEAALNFTV 310 + I G+V+ F W S+G PL+ L+V+ + L F++ Sbjct: 244 VFIAAGVVILLGFAAWERHLISSGGMPLVRLDVLRDRRVTSGILTQMVQTLLFGGFLFSM 303 Query: 311 PLYIQIVQGRSPIATAIAMMPFNLTVFLSAMLIVNLYDKLTPRQIGRFGFGLCTVALLWL 370 L++QIV G + + T +P ++ + ++++ L + ++I + G + L Sbjct: 304 ALFLQIVLGLNAMQTGFVYLPLSIPLLIASLTASRLSIFIASKRIIQAGLVILLAGLFLA 363 Query: 371 AFVVRNDWSEIPVLLGLVLFGIGQGSLVTLLFNVLVTASPKALAGDVGSLRGTTQNLAAA 430 + + + ++ G L GIG G + + + N++++ + +L GT+QNL A Sbjct: 364 IATIDVEVRGLGLMTGFALIGIGGGLIASQVMNLVLSQVTPERTSETAALMGTSQNLGMA 423 Query: 431 VGTAVAGALLVGLLSTIALGRIAASPVLTNELQ----SQVDLSNITFVSNDRLRSVLEGT 486 +GTA+ G+LLV L+ A+ I S + +L+ S V+ N+ F+SN+ L++ LE Sbjct: 424 IGTALMGSLLVAGLAVGAITLIDDSTAIPEDLKPDLVSAVE-ENVQFLSNEELQTALE-- 480 Query: 487 SGTPQQV-EEAVRVNTEARLRALKIGLLIMAGLALLAVIPAGRLP 530 G P + E +R+N AR++ ++ LL + + + + + LP Sbjct: 481 -GVPSDLAAEILRINEIARIKGIRTSLLGLVLVTIFGIFVSAFLP 524 >RSp1417 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 467 Score = 103 bits (257), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 92/382 (24%), Positives = 173/382 (45%), Gaps = 17/382 (4%) Query: 12 QQEERASWVPMIAIAVGQMIMSFNVASLPVAMGGMVASFGVPPTTVATGIVAYSMLVAGF 71 + + WV +I ++ ++ + + A + A G + + + AY++ +A Sbjct: 5 EFDRTQKWV-LILTSIATLMAMLDAMVVATATSAIRADLGASLSALQWTMNAYNLSLAAL 63 Query: 72 VMLGAKLAQRFGAVQVFRGAVVLFLIAQIAMTFSPTASVMISAQALCGAAGAVIVPSLVA 131 +M GA L RFG +VF + +F+ A IA + +A +I+A+ + GA GA++ P +A Sbjct: 64 LMTGAALGDRFGRRRVFVTGLCVFVAASIACALARSAEWLIAARVVQGAGGALVTPLSMA 123 Query: 132 LIAENYAGRQQATALGALGSARAAAGVLAFVVGGLLGTYIGWRPAFAILIVASAIAFALS 191 L++ + ++ ALG G A +L V+GG++ + W+ F + + L+ Sbjct: 124 LLSAAFPPERRGKALGLFGGITGLALILGPVLGGVIAGNLPWQWIFWLNVPIGLPLIVLA 183 Query: 192 FRLRPDRGRADVQIDLIGVALAASAIIFISFGFNNLNGWGVILATPNAPFDLLGVSPAPI 251 R PD +D+ G L A I + WG++ + D S AP+ Sbjct: 184 VRRIPDSKGPAAALDIPGALLVMGASIGLV--------WGLMRGSSKGWSD----SEAPL 231 Query: 252 LIVLGIVLGQAFLMWTHRQQSAGKTPLLALEVIDSPEERCAVYALFAVVALEAALNFTVP 311 +V+G F++W R K P++ + + S + A F A + F +P Sbjct: 232 ALVVGAAFMICFVLWERR----AKHPMIPMRLFASRAFSSGIAACFLFYAGMYGVVFFLP 287 Query: 312 LYIQIVQGRSPIATAIAMMPFNLTVFLSAMLIVNLYDKLTPRQIGRFGFGLCTVALLWLA 371 + Q QG P A + ++P+ +T+F A L ++ D++ R + G L + W+A Sbjct: 288 QFFQSAQGHDPFAAGLRLLPWTVTLFFIAPLAGSMVDRIGERSVMVTGLLLQAIGFAWIA 347 Query: 372 FVVRNDWSEIPVLLGLVLFGIG 393 + S + ++ LV+ G G Sbjct: 348 WAASPGTSYLNLVAPLVISGAG 369 >Cgl1114 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 449 Score = 99.8 bits (247), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 97/437 (22%), Positives = 199/437 (45%), Gaps = 18/437 (4%) Query: 14 EERASWVPMIAIAVGQMIMSFNVASLPVAMGGMVASFGVPPTTVATGIVAYSMLVAGFVM 73 E RA W + A++VG + + + + VA+ + G Y + A ++ Sbjct: 6 ESRA-WKALGALSVGLFLTLLDQSLVAVALPKIQEDLGASLNQAVWVSAVYLLTFAVPLL 64 Query: 74 LGAKLAQRFGAVQVFRGAVVLFLIAQIAMTFSPTASVMISAQALCGAAGAVIVPSLVALI 133 + +L R+G ++ + +F +A +A F+P+ +I+A+A+ G G+++ P +++I Sbjct: 65 ITGRLGDRYGQRNIYLAGMAVFTLAALACVFAPSIEWLIAARAVQGLGGSLLNPQPLSII 124 Query: 134 AENYAGRQQATALGALGSARAAAGVLAFVVGGLLGTYIGWRPAFAILIVASAIAFALSFR 193 + +A ++ A G + ++AG+ V+GG+L +I WR F + + I+ + R Sbjct: 125 HKIFAHDRRGAATGVWSAVASSAGLFGPVIGGVLVGWISWRAVFLVYVPLGLISLFMVAR 184 Query: 194 LRPDRGRADVQIDLIGVALAASAIIFISFGFNNLNGWGVILATPNAPFDLLGVSPAPILI 253 P +ID + A++ A++ GV+LA P G LI Sbjct: 185 YVPKLPTGTSKIDWLSGAVSLVAVL------------GVVLALQQGPELGWGT-----LI 227 Query: 254 VLGIVLGQAFLMWTHRQQSAGKTPLLALEVIDSPEERCAVYALFAVVALEAALNFTVPLY 313 + + +G A + Q+ K PL+ L + + +++F++ ++N + LY Sbjct: 228 WVSLAVGIAAAVLFIWMQTRSKAPLMPLRIFKTRNFAIGAFSIFSLGFTVYSVNLPIMLY 287 Query: 314 IQIVQGRSPIATAIAMMPFNLTVFLSAMLIVNLYDKLTPRQIGRFGFGLCTVALLWLAFV 373 +Q QG S + ++P + + + +I L D+L P I + GFG ++ +A Sbjct: 288 LQTAQGMSSQLAGLMLVPMGIISVVMSPVIGRLVDRLAPGMISKIGFGALIFSMALMAVF 347 Query: 374 VRNDWSEIPVLLGLVLFGIGQGSLVTLLFNVLVTASPKALAGDVGSLRGTTQNLAAAVGT 433 + + S +L+ ++LFG + + P+ L G T++ + A +G Sbjct: 348 MIANLSPWWLLIPIILFGSSNAMSFAPNSVIALRDVPQDLVGSASGFYNTSRQVGAVLGA 407 Query: 434 AVAGALLVGLLSTIALG 450 A GA++ + T++ G Sbjct: 408 ATLGAVMQIGVGTVSFG 424 >Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 487 Score = 90.1 bits (222), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 91/428 (21%), Positives = 175/428 (40%), Gaps = 17/428 (3%) Query: 15 ERASWVPMIAIAVGQMIMSFNVASLPVAMGGMVASFGVPPTTVATGIVAYSMLVAGFVML 74 E+ +W +IA+ +G ++ + + V+ + A G V Y + A +++ Sbjct: 30 EKQAWPALIALCIGFFMILLDQTIVAVSTPALQADMGASYNEVIWVTSVYLLTFAVPLLV 89 Query: 75 GAKLAQRFGAVQVFRGAVVLFLIAQIAMTFSPTASVMISAQALCGAAGAVIVPSLVALIA 134 +L ++G V+ +V+F ++ +A +P +I A+ + G A++ P +A I Sbjct: 90 TGRLGDKYGPKNVYVAGMVIFTVSSLACGLAPDMFTLIIARGVQGLGAALLTPQTMATIN 149 Query: 135 ENYAGRQQATALGALGSARAAAGVLAFVVGGLLGTYIGWRPAFAILIVASAIAFALSFRL 194 +A ++ ALG GS A + ++GG++ GW+ F I + I+ + Sbjct: 150 RIFAFERRGAALGVWGSTAGLASLAGPILGGVITENWGWQWVFYINVPIGVISVIAVMKY 209 Query: 195 RPDRGRADVQIDLIGVALAASAIIFISFGFNNLN--GWGVILATPNAPFDLLGVSPAPIL 252 P+ +D + + L+ A+ F+ F F GW + I+ Sbjct: 210 VPEFPPLTRPLDPLSIVLSIVAVFFLVFAFQEGEGAGWAAWVW---------------IM 254 Query: 253 IVLGIVLGQAFLMWTHRQQSAGKTPLLALEVIDSPEERCAVYALFAVVALEAALNFTVPL 312 IV L F+ R + +G PL+ LE+ + A+ A + L Sbjct: 255 IVAAFALFAWFIYQQSRAEKSGNDPLVPLEIFKFRNFSLGNICIMAMGFTVAGTPLPIML 314 Query: 313 YIQIVQGRSPIATAIAMMPFNLTVFLSAMLIVNLYDKLTPRQIGRFGFGLCTVALLWLAF 372 Y Q G + + M+P L + + + L D+ P + GF V+++ L+ Sbjct: 315 YFQQAHGMNAMEAGFMMVPQALMAAVLSPFVGKLVDRSNPGLMAALGFSTVAVSIVLLSM 374 Query: 373 VVRNDWSEIPVLLGLVLFGIGQGSLVTLLFNVLVTASPKALAGDVGSLRGTTQNLAAAVG 432 V+ D + L+ + L GIG + + P G + TT+ L + +G Sbjct: 375 VMIFDTGLVWALVSMTLLGIGNAFVWAPNSTSTMRDLPHKFMGAGSGVFNTTRQLGSVIG 434 Query: 433 TAVAGALL 440 A GA++ Sbjct: 435 AAAIGAVM 442