BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0246.0043.p (430 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1932 [GEPR] COG0477 Permeases of the major facilitator superf... 142 2e-33 RSp0234 [GEPR] COG0477 Permeases of the major facilitator superf... 136 8e-32 PA2114 [GEPR] COG0477 Permeases of the major facilitator superfa... 134 4e-31 AF2014 [GEPR] COG0477 Permeases of the major facilitator superfa... 128 2e-29 PM0835 [GEPR] COG0477 Permeases of the major facilitator superfa... 121 4e-27 >YPO1932 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 409 Score = 142 bits (357), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 115/412 (27%), Positives = 201/412 (48%), Gaps = 23/412 (5%) Query: 2 ISAMLGYILDFYDVLIFPFLLPAIQRSMSLSLTEIGSLQALTLFGSAIGGALFGVIGDRL 61 I+A G+ LD D ++F F++ + + + G L +TL SAIGG G++ DR Sbjct: 16 IAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAIGGWGAGILADRY 75 Query: 62 GRKTSLQLAIALFSVAAIISAFAWNYWSLAVLRFITGIGLGGEYGVGMVLFNEAWKNGSR 121 GR LQ+ I FS+ ++ FA N+ + +LR + G+G GGE+ VG VL E + R Sbjct: 76 GRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGSVLMGEIVRAEHR 135 Query: 122 GLGAAALQGCAVIASSTASIVGIWLIATFSDEWSWRIGLLSGGVPILLIIFIRFFMPESK 181 G +Q I A+++ + + S+EW+WR G +P LL+++IR +PE Sbjct: 136 GKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPALLVLYIRKNVPEPA 195 Query: 182 IWLEYEAQRKAGPVVAAARTLPLADLFRNGLARQTVTAFVWLMSYMLCYYSVVSFIPTLL 241 ++L+ +++A R + +F L + TV A + YY++ +++PT L Sbjct: 196 LFLKSRHEQQAKD-----RRVSSFAIFSPALLKTTVLASLLCTGVQGGYYAITTWLPTFL 250 Query: 242 LRDMHTPGDVVRTTAVLLSVVSG--ICYLANGFFNDRAGRRFGALVPALFWVGSLVGMAV 299 + V+ T L+ ++ G + Y+ + D+ GRR ++ +L S + + Sbjct: 251 --KLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLL---SCITIFA 305 Query: 300 WGSQLYAGSKAEWPMFWLYIGFGIGNVALGV---TGVWISELYPVNLRATAVFTFYMGGR 356 + ++ L +GF +G A G+ G +++EL+P +RAT Y GR Sbjct: 306 YTQLTLTNTQM------LVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGR 359 Query: 357 GLGSIAPVIVPLAATHFGGSLLNGMVAVALPAAAVFVLASLLLPETLGRDLS 408 +G++ P +V + SL + A A + ++ SLLLPET + L Sbjct: 360 AVGALFPGLVGYLSQS--SSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE 409 >RSp0234 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 416 Score = 136 bits (343), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 127/409 (31%), Positives = 200/409 (48%), Gaps = 23/409 (5%) Query: 7 GYILDFYDVLIFPFLLPAIQRSMSLSLTEIGSLQALTLFGSAIGGALFGVIGDRLGRKTS 66 G+ LD DV +F ++P I + + TE G + +TL SA+GG + G + DRLGR + Sbjct: 22 GWALDALDVQMFSLVIPTIIAAWHIGKTEAGLVSGITLVASALGGWIAGAMTDRLGRVRT 81 Query: 67 LQLAIALFSVAAIISAFAWNYWSLAVLRFITGIGLGGEYGVGMVLFNEAWKNGSRGLGAA 126 LQ+ +A FS+A SAFA N+ L+ + G G GGE+ G VL E+ + RG Sbjct: 82 LQITVAWFSLATFASAFAQNFEQFLALKAVQGFGFGGEWAAGAVLMAESIRASHRGKAMG 141 Query: 127 ALQGCAVIASSTASIVGIWLIATFSDEWSWRIGLLSGGVPILLIIFIRFFMPESKIWLEY 186 +Q + A ++ + + +WR+ +G +P LLII+IR + E Sbjct: 142 TVQSAWAVGWGAAVLLYALTYSLVEPDLAWRVMFAAGVLPALLIIYIRRGVQEPA---PA 198 Query: 187 EAQRKAGPVVAAARTLPLADLFRNGLARQTVTAFVWLMSYMLCYYSVVSFIPTLLLRDMH 246 A+ +AGP PL D+FR + R T+ + + YY++++++PT L + H Sbjct: 199 GAKAEAGPDGMPVSRFPLLDIFRPRVLRMTLIGALLGVGAHGGYYALMTWLPTYLKTERH 258 Query: 247 TPGDVVRTTAVLLSVVSGI-C-YLANGFFNDRAGRRFGALVPALFWVGSLVGMAVWGSQL 304 V+ T L ++ C +A+ + D GRR L LF +V + V+ Sbjct: 259 L--SVLGTGGYLAVIIFAFWCGCVASAWLLDVIGRRGNIL---LFSCCCVVTVLVYLLVP 313 Query: 305 YAGSKAEWPMFWLYIGFGIGNVALGV---TGVWISELYPVNLRATAVFTFYMGGRGLGSI 361 + L +GF +G A G+ G +ELYP +R T V Y GR + + Sbjct: 314 LSDGAM------LVLGFPLGFFAAGIPASMGALFNELYPHGVRGTGVGFCYNFGRVVSAA 367 Query: 362 APVIV-PLAATHFGGSLLNGMVAVALPAAAVFVLASLLLPETLGRDLSA 409 PV+V ++A+ G+ + A+A AV A L+LPET GRDL+A Sbjct: 368 FPVLVGKMSASMSLGTAIGIDAAIAYSIVAV---AVLMLPETRGRDLAA 413 >PA2114 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 423 Score = 134 bits (337), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 119/411 (28%), Positives = 197/411 (47%), Gaps = 24/411 (5%) Query: 3 SAMLGYILDFYDVLIFPFLLPAIQRSMSLSLTEIGSLQALTLFGSAIGGALFGVIGDRLG 62 S +GY LD D + F++P + + E G + +TL SA GG + G++ DR+G Sbjct: 31 SCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAAGGWIAGILSDRIG 90 Query: 63 RKTSLQLAIALFSVAAIISAFAWNYWSLAVLRFITGIGLGGEYGVGMVLFNEAWKNGSRG 122 R +LQL + F+ + A NY L V R + G G GGE+ G VL E K RG Sbjct: 91 RVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGAVLIGEVIKARDRG 150 Query: 123 LGAAALQGCAVIASSTASIVGIWLIATFSDEWSWRIGLLSGGVPILLIIFIRFFMPESKI 182 +Q I +I+ + + E +WR + G +P L ++ +R + E +I Sbjct: 151 KAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALFVLVVRRLVKEPEI 210 Query: 183 WLEYEAQRKAGPVVAAARTLPLADLFRNGLARQTVTAFVWLMSYMLCYYSVVSFIPTLLL 242 + E QR G A + ++F G+ T+ A + + YY++ +++PT L Sbjct: 211 YREAR-QRNQG-----ADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAITAWLPTFLK 264 Query: 243 RDMHTPGDVVRTTAVLLSVVSG--ICYLANGFFNDRAGRRFGALVPALFWVGSLVGMAVW 300 + V+ T+ L V+ G + Y+ + F D GR+ + LF VGS + ++ Sbjct: 265 TERGL--TVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFV---LFAVGSFTVVLLY 319 Query: 301 GSQLYAGSKAEWPMFWLYIGFGIGNVALGV---TGVWISELYPVNLRATAVFTFYMGGRG 357 +QL + A M WL GF +G A G+ G +++EL+P +R + Y GR Sbjct: 320 -TQLPVSNGA---MLWL--GFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRA 373 Query: 358 LGSIAPVIVPLAATHFGGSLLNGMVAVALPAAAVFVLASLLLPETLGRDLS 408 + ++ P+++ + SL G+ A A + V +LA+L LPET G+ L Sbjct: 374 IAALFPMLIGMLGQKL--SLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422 >AF2014 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 401 Score = 128 bits (322), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 120/415 (28%), Positives = 198/415 (47%), Gaps = 35/415 (8%) Query: 1 MISAMLGYILDFYDVLIFPFLLPAIQRSMSLSLTEIGSLQALTLFGSAIGGALFGVIGDR 60 +++A +G+ D + + FL I R ++ EIG + + G LFG +GDR Sbjct: 13 LLAAAIGWSHDAVGLTLLNFLAEPIMREFNVGTLEIGFIFSAQYIFCIFGAMLFGEMGDR 72 Query: 61 LGRKTSLQLAIALFSVAAIISAFAWNYWSLAVLRFITGIGLGGEYGVGMVLFNEAWKNGS 120 GRK +L L+I +V +++SAFA N+W+LA+LR I+G+G+ +G+ +E + Sbjct: 73 FGRKNALILSILWVAVFSVLSAFAPNFWTLAILRLISGMGV--TWGLAFTYMSEFYSPKR 130 Query: 121 RGLGAAALQGCAVIAS--STASIVGIWLIATFSDEWSWRIGLLSGGVPILLIIFIRFFMP 178 RGL + V S S+ I+ I + WR PI +I ++P Sbjct: 131 RGLFGGLIHATFVFGFILSALSVSLIYPI------YGWRACFFVTLYPIPFLILFAKYLP 184 Query: 179 ESKIWLEYEAQRKAGPVVAAARTLPLADLFRNGLARQTV---TAFVWLMSYMLCYYSVVS 235 ES+IW ++ A+ ++L LA++ R + + T WL + Y+++V Sbjct: 185 ESRIWEKHSAEMD--------KSLRLAEIVRESRYLRLLVLATFLFWLAEF--AYHAIVD 234 Query: 236 FIPTLLLRDMHTPGDVVRTTAVLLSVVSGICYLANGFFNDRAGRRFGALVPALFWVGSLV 295 + PT ++R + + + +S+V+ I G +D GRR + A + + Sbjct: 235 WSPTFIIRQFNYRPEEASMIVLRISLVALIVLPFFGLISDYIGRRSSFAISASIGLLGCL 294 Query: 296 GMAVWGSQLYAGSKAEWPMFWLYIGFGIGNVALGVTGVWISELYPVNLRATAVFTFYMGG 355 +A + Y A +F + IGFG + + GVW SE++P +RATA + Sbjct: 295 MLAYFTLVNYNPGLALLSLFVIPIGFG----SHALFGVWSSEMFPTKVRATATSVIFSIA 350 Query: 356 RGLGSIAPVIVPLAATHFGGSLLNGMV--AVALPAAAVFVLASLLLPETLGRDLS 408 RGL S+ +IV AT SLL GM+ +A +F LLPET GR+L Sbjct: 351 RGL-SVGGLIVGYVATF--SSLLYGMLLGGIAFLLMCIF---PWLLPETKGRELE 399 >PM0835 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 405 Score = 121 bits (303), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 117/417 (28%), Positives = 189/417 (45%), Gaps = 33/417 (7%) Query: 1 MISAMLGYILDFYDVLIFPFLLPAIQRSMSLSLTEIGSLQALTLFGSAIGGALFGVIGDR 60 ++ + +GY +D +D+LI F+L AI ++L+ + GSL TL G+ GG +FG + D+ Sbjct: 13 LLGSAVGYAMDGFDLLILGFMLSAISADLALTPAQSGSLVTWTLIGAVAGGIIFGALSDK 72 Query: 61 LGRKTSLQLAIALFSVAAIISAFAWNYWSLAVLRFITGIGLGGEYGVGMVLFNEAWKNGS 120 GR L I LF+V + AFA YW L + R I GIGLGGE+G+GM L EAW Sbjct: 73 YGRVRVLTWTIVLFAVFTGLCAFAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPARH 132 Query: 121 RGLGAAALQGCAVIASSTASIVGIWLIATFSDEWSWRIGLLSGGVPILLIIFIRFFMPES 180 R A + + L WR L G P + ++R + E Sbjct: 133 R----AKASSYVALGWQVGVLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWYLRAKLHEP 188 Query: 181 KIWLEYEAQRKAGPVVAAARTLPLADLFRNGLARQTVTAFVWLMSYM-LCYYSVVSFIPT 239 +I+++ ++ A +R P L ++ + V L S YY ++ ++P Sbjct: 189 EIFVK---KQTALERQKTSRLEPFRLLIKDKATAKISAGIVVLTSVQNFGYYGIMIWMPN 245 Query: 240 LLLRDM--HTPGDVVRTTAVLLSVVSGICYLANGFFNDRAGRRFGALVPALFWVGSLVGM 297 L + + V T + ++ GI G DR GR+ L LF G+++ Sbjct: 246 FLSKQLGFSLTKSGVWTAVTICGMMFGIWLF--GQLADRIGRKPSFL---LFQFGAVI-- 298 Query: 298 AVWGSQLYAGSKAEWPMFWLYIGFGIG---NVALGVTGVWISELYPVNLRATAVFTFYMG 354 ++ S+ P + L+ G +G N +G G +SE YP RATA + Sbjct: 299 -----SIFTYSQMSDPTYMLFAGAVLGMFVNGMMGGYGALMSEAYPTQARATAQNVLFNL 353 Query: 355 GRGLGSIAPVIVPLAATHFGGSLLNGMVAVALPAAAVFV--LASL-LLPETLGRDLS 408 GR +G P++V + + L A+A A+ + +A++ L+PE G+ L Sbjct: 354 GRAVGGFGPIVVGALVSTYSFQL-----AIAFLASIYIIDMIATIFLIPELKGKQLD 405