BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0245.0006.p (215 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PH0596 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal... 78 1e-14 PAB1419 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-termina... 72 1e-12 RSp0259 Non COG 71 2e-12 YPO2703 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-termina... 71 2e-12 SPy0506 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-termina... 70 4e-12 >PH0596 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Pho Pyrococcus horikoshii Length = 206 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/172 (32%), Positives = 85/172 (49%), Gaps = 9/172 (5%) Query: 5 LRILVTGFGPFPGAPFNPTMPLVKRLSALRRPAFDDVALSSHIFDVTYAAVDRELPELIA 64 ++IL+TGF PF G NPTM +V+ LS R P + I V++ +L +++ Sbjct: 1 MKILLTGFEPFGGDDKNPTMDIVEALSE-RIPE-----VVGEILPVSFKRAREKLLKVLD 54 Query: 65 KHRPQALLMFGLA-GRTGYLRIESRARNAVTTRFPDA-GRQHARKGSIEGGADARMFGPH 122 RP + GLA GRT ++ +E A N + R PD G Q + +EGG A Sbjct: 55 DVRPDITINLGLAPGRT-HISVERVAVNMIDARIPDNDGEQPKDEPIVEGGPAAYFATIP 113 Query: 123 TEKLLRAALATGIDARASRDAGSYLCNYLSWRAIEAVNGDNDLRLAQFVHVP 174 T +++ GI A S AG+YLCN+ + + ++A F+HVP Sbjct: 114 TREIVEEMKKNGIPAVLSYTAGTYLCNFAMYLTLHTSATKGYPKIAGFIHVP 165 >PAB1419 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Pab Pyrococcus abyssi Length = 200 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 81/172 (47%), Gaps = 6/172 (3%) Query: 5 LRILVTGFGPFPGAPFNPTMPLVKRLSALRRPAFDDVALSSHIFDVTYAAVDRELPELIA 64 +++LVTGF PF G NPTM +VK L + + V++ +EL ++ Sbjct: 1 MKVLVTGFEPFGGDDKNPTMEIVKFLDGKE---IGGAKVIGRVLPVSFKRARKELVAILD 57 Query: 65 KHRPQALLMFGLA-GRTGYLRIESRARNAVTTRFPDA-GRQHARKGSIEGGADARMFGPH 122 + +P + GLA GRT ++ +E A N + R PD G + + +E G A Sbjct: 58 EIKPDVTINLGLAPGRT-HISVERVAVNIIDARIPDNDGEKPIDEPIVENGPAAYFATIP 116 Query: 123 TEKLLRAALATGIDARASRDAGSYLCNYLSWRAIEAVNGDNDLRLAQFVHVP 174 T +++ I A S AG+YLCN++ + + R A F+HVP Sbjct: 117 TREIVEEMKRNNIPAVLSYTAGTYLCNFVMYLTLHHSATKGYPRKAGFIHVP 168 >RSp0259 Non COG Length = 215 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/190 (27%), Positives = 80/190 (42%), Gaps = 4/190 (2%) Query: 7 ILVTGFGPFPGAPFNPTMPLVKRLSALRRPAFDDVALSSHIFDVTYAAVDRELPELIAKH 66 +L+TG PF P NP+ + + L R D L + + +REL I Sbjct: 4 VLITGIEPFESDPTNPSWDIARALDGER---IDGATLVARQLPCVFGRANRELVAAIEAT 60 Query: 67 RPQALLMFGLAGRTGYLRIESRARNAVTTRFPD-AGRQHARKGSIEGGADARMFGPHTEK 125 +P +L GLA L +E A N + R PD AG Q + G A + Sbjct: 61 QPSLVLALGLASGRSELSVERVAINVIDARIPDNAGNQPVDVPVVADGPAAYFSSLPIKA 120 Query: 126 LLRAALATGIDARASRDAGSYLCNYLSWRAIEAVNGDNDLRLAQFVHVPPLAHDGTAAPG 185 ++ A A G+ A S+ AG+Y CN+L + + + F+HVP PG Sbjct: 121 IVHALRAAGVPAAVSQSAGTYNCNHLFYGLMHHIATRAPRMRGGFIHVPATPELAARHPG 180 Query: 186 KSHITLEALV 195 + + L+A + Sbjct: 181 RPSLRLDAQI 190 >YPO2703 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Ype Yersinia pestis Length = 215 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 88/195 (45%), Gaps = 4/195 (2%) Query: 6 RILVTGFGPFPGAPFNPTMPLVKRLSALRRPAFDDVALSSHIFDVTYAAVDRELPELIAK 65 R+L+TGF PF G NP+ +VK+++ L V + + + L I Sbjct: 3 RVLITGFEPFGGERINPSWEVVKQMNDLM---MGGVRIVARQLPCAFGEALTALNTAIDD 59 Query: 66 HRPQALLMFGLAGRTGYLRIESRARNAVTTRFPDA-GRQHARKGSIEGGADARMFGPHTE 124 +P +L G AG + IE A N R PD G Q + I+ G A + Sbjct: 60 VQPVLVLAIGQAGGRADITIERVAINVDDARIPDNLGNQPVDQPIIQEGPAAYFTRLPIK 119 Query: 125 KLLRAALATGIDARASRDAGSYLCNYLSWRAIEAVNGDNDLRLAQFVHVPPLAHDGTAAP 184 +++ GI A S+ AG+Y+CN++ + + +N N+ F+H+P L P Sbjct: 120 AMVQGIREAGIPASVSQTAGTYVCNHVMYGLLHRLNQFNNEVKGGFIHIPYLPEQAVDHP 179 Query: 185 GKSHITLEALVDAGE 199 G ++ ++++ A E Sbjct: 180 GAPSMSAQSVLVALE 194 >SPy0506 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Spy Streptococcus pyogenes M1 GAS Length = 215 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 89/206 (43%), Gaps = 7/206 (3%) Query: 5 LRILVTGFGPFPGAPFNPTMPLVKRLSALRRPAFDDVALSSHIFDVTYAAVDRELPELIA 64 ++ILVTGF PF G NP + +K+L A A +F + L + I Sbjct: 1 MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADV----LQQHIE 56 Query: 65 KHRPQALLMFGLAG-RTGYLRIESRARNAVTTRFPDAGRQHARKGSIEGGADARMFGPHT 123 +P A+L G AG RTG L E A N R PD I A F Sbjct: 57 SFQPDAVLCIGQAGGRTG-LTPERVAINQDDARIPDNEGNQPIDTPIRADGKAAYFSTLP 115 Query: 124 EKLLRAAL-ATGIDARASRDAGSYLCNYLSWRAIEAVNGDNDLRLAQFVHVPPLAHDGTA 182 K + AA+ G+ A S AG+++CN+L ++A+ V+ A F+H+P + Sbjct: 116 IKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVD 175 Query: 183 APGKSHITLEALVDAGEAMLMELVKL 208 P + + L+ + EA + +V Sbjct: 176 KPNTAAMNLDDITRGIEAAIFAIVDF 201