BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0245.0003.p (718 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC2374_1 Non COG 886 0.0 mll7619_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domai... 846 0.0 ML1799_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain... 839 0.0 MT1540_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain... 839 0.0 Rv1493_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain... 839 0.0 >CC2374_1 Non COG Length = 579 Score = 886 bits (2290), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/583 (75%), Positives = 498/583 (85%), Gaps = 6/583 (1%) Query: 1 MTRIPDFADVAFQPVATTAPAA-SAEPWLTPEGIPVKSVYGEADLEGIDFLETWPGIAPY 59 M+ PDF +AF V APAA E W TPEG+ V + +D+ G+DF +PG+AP+ Sbjct: 1 MSTFPDFTKIAFAEV--PAPAAPKGEAWNTPEGVAVAPAFDASDVAGLDFTGGFPGVAPF 58 Query: 60 LRGPYPTMYVNQPWTIRQYAGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHP 119 +RGPYPTMYV PWT+RQYAGFSTAEDSNAFYRRNLAAGQ GLSVAFDLATHRGYDSDH Sbjct: 59 VRGPYPTMYVTNPWTVRQYAGFSTAEDSNAFYRRNLAAGQMGLSVAFDLATHRGYDSDHE 118 Query: 120 RVSGDVGMAGVAIDSIYDMRTLFAGIPLDQMSVSMTMNGAVLPILALFVAAAEEQGVPPE 179 RV GDVGMAGVAIDSI DMRTLF+GIPLD+MSVSMTMNGAVLPILAL++ AAEEQGV P+ Sbjct: 119 RVKGDVGMAGVAIDSILDMRTLFSGIPLDKMSVSMTMNGAVLPILALYIVAAEEQGVSPD 178 Query: 180 KLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAYTSQRMPKYNSISISGYHMQEAGA 239 KLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFA+TS MPK+NSISISGYHMQEAGA Sbjct: 179 KLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFAFTSANMPKFNSISISGYHMQEAGA 238 Query: 240 TQDLELAYTLADGVEYLRAGLAAGLDVDRFAPRLSFFWAIGMNFFMEVAKMRAARLLWAK 299 T DLELAYTLADGVEY RAG+AAG+ +D+FAPRLSFFWAIGMN+FMEVAKMRAARLLWA+ Sbjct: 239 TADLELAYTLADGVEYARAGVAAGMSIDQFAPRLSFFWAIGMNYFMEVAKMRAARLLWAR 298 Query: 300 LLK-QFNPKDPRSLSLRTHCQTSGWSLTAQDVFNNVMRTTIEAMAATQGHTQSLHTNALD 358 L+K +F+PKD RSLSLRTH QTSGWSL AQDVFNNV RT +EAMAA G TQSLHTN+LD Sbjct: 299 LMKREFDPKDDRSLSLRTHSQTSGWSLAAQDVFNNVARTCVEAMAAVNGQTQSLHTNSLD 358 Query: 359 EALALPTDFSARIARNTQLFLQQESGTNRIIDPWGGSYYVERLTRDLAQKAWGHIQEVEA 418 EALALPTDFSARI+RNTQLFLQ ESGT R+ DPWGGSYYVERLT +LAQKA HI+EVEA Sbjct: 359 EALALPTDFSARISRNTQLFLQMESGTTRVADPWGGSYYVERLTYELAQKALAHIEEVEA 418 Query: 419 LGGMAKAIEAGVPKLRIEEASAKTQARIDAGRQAVIGVNKFKPENEKAIDVLKVENSTVR 478 LGGMAKAIE G+PKLRIEEA+A+TQARID+G+Q+V+GVN++KPE I VLKV+N VR Sbjct: 419 LGGMAKAIEQGLPKLRIEEAAARTQARIDSGKQSVVGVNRYKPEVADDIPVLKVDNGAVR 478 Query: 479 RLQIDKLARLKKERNQKDVDAALAALTRSAGEGNGNLLALAIDAARAKATVGEISDAMEK 538 Q++KLARLK ER+ +AAL AL A G+GNLLALA+DAARAKATVGEIS A+EK Sbjct: 479 AQQLEKLARLKAERDPAATEAALTALEDGA-RGDGNLLALAVDAARAKATVGEISYALEK 537 Query: 539 VFGRHRAEIKSITGVYKREAAAMSNKVEKVQALIDAFEEAEGR 581 VFGRHRAEIKSI GVY +EA + +A+++AFE+A+GR Sbjct: 538 VFGRHRAEIKSIQGVYMKEAGN-DPTAARAKAMVEAFEQADGR 579 >mll7619_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit Mlo Mesorhizobium loti Length = 553 Score = 846 bits (2185), Expect = 0.0, Method: Compositional matrix adjust. Identities = 407/554 (73%), Positives = 475/554 (85%), Gaps = 3/554 (0%) Query: 28 LTPEGIPVKSVYGEADLEGIDFLETWPGIAPYLRGPYPTMYVNQPWTIRQYAGFSTAEDS 87 +TPEG+ VK +Y + DL+G+ L+T+PG+ P++RGPYPTMYV QPWTIRQYAGFSTAE+S Sbjct: 1 MTPEGLIVKHLYNQGDLKGLPHLDTYPGLPPFVRGPYPTMYVQQPWTIRQYAGFSTAEES 60 Query: 88 NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVSGDVGMAGVAIDSIYDMRTLFAGIPL 147 NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRV+GDVGMAGVAIDSI DMR LF GIPL Sbjct: 61 NAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPL 120 Query: 148 DQMSVSMTMNGAVLPILALFVAAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYPPAPSM 207 M+VSMTMNGAVLPI+AL++ AAEEQGV + L+GTIQNDILKEFMVRNTYIYPP PSM Sbjct: 121 GDMTVSMTMNGAVLPIMALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPKPSM 180 Query: 208 RIISDIFAYTSQRMPKYNSISISGYHMQEAGATQDLELAYTLADGVEYLRAGLAAGLDVD 267 RI+SDIF+YTS+ MPK+NSISISGYHMQEAGAT DLELAYT+ADG+EY RAG+AAGLD+D Sbjct: 181 RIVSDIFSYTSKNMPKFNSISISGYHMQEAGATADLELAYTIADGIEYARAGVAAGLDID 240 Query: 268 RFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLLKQ-FNPKDPRSLSLRTHCQTSGWSLT 326 RFAPRLSFFWAIGMNFFMEVAK+RAARLLWA L+K+ F PKD RSLSLRTHCQTSGWSLT Sbjct: 241 RFAPRLSFFWAIGMNFFMEVAKLRAARLLWATLMKKNFAPKDERSLSLRTHCQTSGWSLT 300 Query: 327 AQDVFNNVMRTTIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQESGTN 386 AQD +NN++RT IEAMAATQGHTQSLHTN+ DEA+ALPTD SARIARNTQL LQ+ESGT Sbjct: 301 AQDPYNNIIRTMIEAMAATQGHTQSLHTNSFDEAMALPTDHSARIARNTQLILQKESGTT 360 Query: 387 RIIDPWGGSYYVERLTRDLAQKAWGHIQEVEALGGMAKAIEAGVPKLRIEEASAKTQARI 446 RIIDPWGGS Y+ERLT DLA +A HI+EVEALGGMA A E G+PKLRIEEA+A+TQARI Sbjct: 361 RIIDPWGGSAYLERLTHDLAARALAHIEEVEALGGMAAATEQGIPKLRIEEAAARTQARI 420 Query: 447 DAGRQAVIGVNKFKPENEKAIDVLKVENSTVRRLQIDKLARLKKERNQKDVDAALAALTR 506 D+G Q ++GVN +PEN+ +DVLK++N+ VR Q+ KL RLK R+ V++AL ALTR Sbjct: 421 DSGEQMLVGVNAHRPENDIEVDVLKIDNAEVRARQLSKLQRLKGTRDVAAVESALDALTR 480 Query: 507 SAGEGNGNLLALAIDAARAKATVGEISDAMEKVFGRHRAEIKSITGVYKREAAAMSNKVE 566 +A +GN NLL A+ AARA ATVGEIS A+E+ FGRH A +++I+GVY R+A S V+ Sbjct: 481 AA-QGNENLLEFAVRAARANATVGEISFALERAFGRHVATVQTISGVY-RKALGDSPVVD 538 Query: 567 KVQALIDAFEEAEG 580 +Q + AFE G Sbjct: 539 GLQDKLAAFERKNG 552 >ML1799_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit Mle Mycobacterium leprae Length = 625 Score = 839 bits (2167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 419/566 (74%), Positives = 469/566 (82%), Gaps = 9/566 (1%) Query: 27 WLTPEGIPVKSVY----GEADLEGIDFLETWPGIAPYLRGPYPTMYVNQPWTIRQYAGFS 82 W TPEGI VK VY A G L ++PG PYLRGPYPTMYVNQPWTIRQYAGFS Sbjct: 60 WHTPEGIDVKPVYIAADRAAAEAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFS 119 Query: 83 TAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVSGDVGMAGVAIDSIYDMRTLF 142 TA DSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRV GDVGMAGVAIDSI DMR LF Sbjct: 120 TAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLF 179 Query: 143 AGIPLDQMSVSMTMNGAVLPILALFVAAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYP 202 GI L +SVSMTMNGAVLPILAL+V AAEEQGVPPEKL+GTIQNDILKEFMVRNTYIYP Sbjct: 180 DGIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYP 239 Query: 203 PAPSMRIISDIFAYTSQRMPKYNSISISGYHMQEAGATQDLELAYTLADGVEYLRAGLAA 262 P PSMRIISDIFAYTS +MPK+NSISISGYH+QEAGAT DLELAYTLADGV+Y++AGL A Sbjct: 240 PEPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDA 299 Query: 263 GLDVDRFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLLKQFNPKDPRSLSLRTHCQTSG 322 GLD+D FAPRLSFFW IGMNFFMEVAK+RA RLLW++L+ +F P+ P+SLSLRTH QTSG Sbjct: 300 GLDIDTFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSG 359 Query: 323 WSLTAQDVFNNVMRTTIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQE 382 WSLTAQD FNNV RT IEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQL LQQE Sbjct: 360 WSLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQE 419 Query: 383 SGTNRIIDPWGGSYYVERLTRDLAQKAWGHIQEVEALGGMAKAIEAGVPKLRIEEASAKT 442 SGT R IDPWGGSYYVE LT LA +A HI EV GGMA AI G+PKLRIEEA+A+T Sbjct: 420 SGTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAART 479 Query: 443 QARIDAGRQAVIGVNKFKPENEKAIDVLKVENSTVRRLQIDKLARLKKERNQKDVDAALA 502 QARID+GRQ V+GVNK++ + + I+VLKVENS VR Q+ KL +L+ R+Q VDAALA Sbjct: 480 QARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALA 539 Query: 503 ALT---RSAGEGNGNLLALAIDAARAKATVGEISDAMEKVFGRHRAEIKSITGVYKREA- 558 L+ + G NLLALAI+AAR +ATVGEISDA+E+V+GRH+A+I++ITGVY+RE Sbjct: 540 ELSGAAGAHGRAGDNLLALAINAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVG 599 Query: 559 -AAMSNKVEKVQALIDAFEEAEGRRP 583 A + + L+ F EA+GRRP Sbjct: 600 EAGKATDIANATELVKKFAEADGRRP 625 >MT1540_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit MtC Mycobacterium tuberculosis CDC1551 Length = 617 Score = 839 bits (2167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 422/570 (74%), Positives = 472/570 (82%), Gaps = 15/570 (2%) Query: 27 WLTPEGIPVKSVYGEADLEGIDF----LETWPGIAPYLRGPYPTMYVNQPWTIRQYAGFS 82 W TPEGI V VY AD + L ++PG P++RGPYPTMYVNQPWTIRQYAGFS Sbjct: 50 WHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFS 109 Query: 83 TAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVSGDVGMAGVAIDSIYDMRTLF 142 TA DSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRV GDVGMAGVAIDSI DMR LF Sbjct: 110 TAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLF 169 Query: 143 AGIPLDQMSVSMTMNGAVLPILALFVAAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYP 202 GI L +SVSMTMNGAVLPILAL+V AAEEQGV PE+L+GTIQNDILKEFMVRNTYIYP Sbjct: 170 DGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYP 229 Query: 203 PAPSMRIISDIFAYTSQRMPKYNSISISGYHMQEAGATQDLELAYTLADGVEYLRAGLAA 262 P PSMRIISDIFAYTS +MPK+NSISISGYH+QEAGAT DLELAYTLADGV+Y+RAGL A Sbjct: 230 PKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNA 289 Query: 263 GLDVDRFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLLKQFNPKDPRSLSLRTHCQTSG 322 GLD+D FAPRLSFFW IGMNFFMEVAK+RA RLLW++L+ QF PK +SLSLRTH QTSG Sbjct: 290 GLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLSLRTHSQTSG 349 Query: 323 WSLTAQDVFNNVMRTTIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQE 382 WSLTAQDVFNNV RT IEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQL LQQE Sbjct: 350 WSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQE 409 Query: 383 SGTNRIIDPWGGSYYVERLTRDLAQKAWGHIQEVEALGGMAKAIEAGVPKLRIEEASAKT 442 SGT R IDPWGGSYYVE LT LA++A HI EV GGMA+AI G+PKLRIEEA+A+T Sbjct: 410 SGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAART 469 Query: 443 QARIDAGRQAVIGVNKFKPENEKAIDVLKVENSTVRRLQIDKLARLKKERNQKDVDAALA 502 QARID+G+Q V+GVNK++ + I+VLKVENS VR Q+ KL RL+ R++ V AALA Sbjct: 470 QARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRAGRDEPAVRAALA 529 Query: 503 ALTRSAGE---------GNGNLLALAIDAARAKATVGEISDAMEKVFGRHRAEIKSITGV 553 LTR+A E GN NLLALAIDAARA+ATVGEIS+A+EKV+GRHRAEI++I+GV Sbjct: 530 ELTRAAAEQGRAGADGLGN-NLLALAIDAARAQATVGEISEALEKVYGRHRAEIRTISGV 588 Query: 554 YKREAAAMSNKVEKVQALIDAFEEAEGRRP 583 Y+ E N + L++ F EA+GRRP Sbjct: 589 YRDEVGKAPN-IAAATELVEKFAEADGRRP 617 >Rv1493_1 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit Mtu Mycobacterium tuberculosis H37Rv Length = 617 Score = 839 bits (2167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 422/570 (74%), Positives = 472/570 (82%), Gaps = 15/570 (2%) Query: 27 WLTPEGIPVKSVYGEADLEGIDF----LETWPGIAPYLRGPYPTMYVNQPWTIRQYAGFS 82 W TPEGI V VY AD + L ++PG P++RGPYPTMYVNQPWTIRQYAGFS Sbjct: 50 WHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFS 109 Query: 83 TAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVSGDVGMAGVAIDSIYDMRTLF 142 TA DSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRV GDVGMAGVAIDSI DMR LF Sbjct: 110 TAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLF 169 Query: 143 AGIPLDQMSVSMTMNGAVLPILALFVAAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYP 202 GI L +SVSMTMNGAVLPILAL+V AAEEQGV PE+L+GTIQNDILKEFMVRNTYIYP Sbjct: 170 DGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYP 229 Query: 203 PAPSMRIISDIFAYTSQRMPKYNSISISGYHMQEAGATQDLELAYTLADGVEYLRAGLAA 262 P PSMRIISDIFAYTS +MPK+NSISISGYH+QEAGAT DLELAYTLADGV+Y+RAGL A Sbjct: 230 PKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNA 289 Query: 263 GLDVDRFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLLKQFNPKDPRSLSLRTHCQTSG 322 GLD+D FAPRLSFFW IGMNFFMEVAK+RA RLLW++L+ QF PK +SLSLRTH QTSG Sbjct: 290 GLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLSLRTHSQTSG 349 Query: 323 WSLTAQDVFNNVMRTTIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLFLQQE 382 WSLTAQDVFNNV RT IEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQL LQQE Sbjct: 350 WSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQE 409 Query: 383 SGTNRIIDPWGGSYYVERLTRDLAQKAWGHIQEVEALGGMAKAIEAGVPKLRIEEASAKT 442 SGT R IDPWGGSYYVE LT LA++A HI EV GGMA+AI G+PKLRIEEA+A+T Sbjct: 410 SGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAART 469 Query: 443 QARIDAGRQAVIGVNKFKPENEKAIDVLKVENSTVRRLQIDKLARLKKERNQKDVDAALA 502 QARID+G+Q V+GVNK++ + I+VLKVENS VR Q+ KL RL+ R++ V AALA Sbjct: 470 QARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRAGRDEPAVRAALA 529 Query: 503 ALTRSAGE---------GNGNLLALAIDAARAKATVGEISDAMEKVFGRHRAEIKSITGV 553 LTR+A E GN NLLALAIDAARA+ATVGEIS+A+EKV+GRHRAEI++I+GV Sbjct: 530 ELTRAAAEQGRAGADGLGN-NLLALAIDAARAQATVGEISEALEKVYGRHRAEIRTISGV 588 Query: 554 YKREAAAMSNKVEKVQALIDAFEEAEGRRP 583 Y+ E N + L++ F EA+GRRP Sbjct: 589 YRDEVGKAPN-IAAATELVEKFAEADGRRP 617