BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0243.0079.p         (177 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    91   1e-18
MK0395 Non COG                                                         78   8e-15
MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    74   2e-13
MA3298_1 [R] COG4032 Predicted thiamine-pyrophosphate-binding pr...    59   4e-09

>MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mja
           Methanococcus jannaschii
          Length = 183

 Score = 91.3 bits (225), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 46/153 (30%), Positives = 84/153 (54%), Gaps = 1/153 (0%)

Query: 15  IFSILQRFEVRQVPYVPDAGHSELIERVLGSSSMRGIALTTEEEGVALLAGAWAGGQRGV 74
           I++ L+   +  +  VP A    L++ +    ++  I  T EEE   + AGA+  G++  
Sbjct: 21  IYNALKDSNIDFICSVPCANLKNLLKLIEEDKNIINIPATREEEAFGICAGAYLAGKKTA 80

Query: 75  LLMQSSGVGNCINML-SLVQIFRLPFLTLVTMRGEWAEFNPWQVPMGSNTQGILELSGIK 133
           +LMQ+SG+GN IN + SL + F++P L +++ RG+  E  P Q+PMG   + +L++  I 
Sbjct: 81  ILMQNSGIGNSINAIASLYKTFQIPTLLIISHRGDLKEQIPAQIPMGRWIEKLLDVCEIP 140

Query: 134 VLRASHPEEVREVVEAGAAQAYNACTPTAVLLS 166
             +   PEE  ++++  ++  Y    P A+L  
Sbjct: 141 TYKPKTPEEAYKLIKYASSYMYKISYPVALLFD 173


>MK0395 Non COG
          Length = 167

 Score = 78.2 bits (191), Expect = 8e-15,   Method: Compositional matrix adjust.
 Identities = 52/142 (36%), Positives = 75/142 (52%), Gaps = 2/142 (1%)

Query: 29  YVPDAGHSELIERVLGSSSMRGIALTTEEEGVALLAGAWAGGQRGVLLMQSSGVGNCINM 88
           ++P +    +I R+     +R + ++ EEEGV + AGA   G++  L+MQ+SG+GN +N 
Sbjct: 21  WLPCSLLDGIIRRLEEHPEIRTVRVSREEEGVGICAGAALAGEKPALIMQNSGLGNSVNA 80

Query: 89  L-SLVQIFRLPFLTLVTMRGEWAEFNPWQVPMGSNTQGILELSGIKVLRASHPEEVREVV 147
           L SL   +RLP L L++ RG   E  P QV MG     ILE   +       PEE+ +V+
Sbjct: 81  LCSLTLTYRLPLLMLMSHRGYLFEDIPAQVGMGKAAPKILENLNLHAFTIERPEEL-DVI 139

Query: 148 EAGAAQAYNACTPTAVLLSQRL 169
                 A  A  P  V LS RL
Sbjct: 140 PGAWKLAETAGEPVGVFLSPRL 161


>MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mth
           Methanothermobacter thermautotrophicus
          Length = 165

 Score = 73.6 bits (179), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 47/138 (34%), Positives = 68/138 (49%), Gaps = 1/138 (0%)

Query: 30  VPDAGHSELIERVLGSSSMRGIALTTEEEGVALLAGAWAGGQRGVLLMQSSGVGNCINML 89
           VP      ++E V    ++  + +T EEEG  + AGA   G+   +LMQ+SG+GN +N+L
Sbjct: 24  VPCVNLRTVLEMVDADPAIMHVPVTREEEGFGVAAGAHMAGKTTAILMQNSGLGNSVNVL 83

Query: 90  -SLVQIFRLPFLTLVTMRGEWAEFNPWQVPMGSNTQGILELSGIKVLRASHPEEVREVVE 148
            SL  ++ +P   +V+ RG   EF   QVPMG  T  IL +  I       P E RE + 
Sbjct: 84  ASLYSLYHIPITMIVSHRGTEGEFMEAQVPMGRATGDILRILEIPFRTPRSPAEARESIG 143

Query: 149 AGAAQAYNACTPTAVLLS 166
                +       AVLL 
Sbjct: 144 ELTDISLRTSKAVAVLLD 161


>MA3298_1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mac
           Methanosarcina acetivorans str.C2A
          Length = 201

 Score = 59.3 bits (142), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 46/158 (29%), Positives = 80/158 (50%), Gaps = 4/158 (2%)

Query: 13  EEIFSILQRFEVRQVPYVPDAGHSELIERVLGSSSMRGIALTTEEEGVALLAGAWAGGQR 72
           E++  I+++  +     +P      L+  V  S +   I LT EE GV + AG +  G +
Sbjct: 8   EKVIEIMKQTGIDLAATLPCDRIKNLLPLV--SENFPEIKLTREENGVGICAGIYLAGGK 65

Query: 73  GVLLMQSSGVGNCINML-SLVQIFRLPFLTLVTMRGEWAEFNPWQVPMGSNTQGILELSG 131
            ++L+QS+G+GN IN L SL    ++P   L + RG + E    QVP+G++   ILE +G
Sbjct: 66  PMMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQVPLGAHLPSILEGAG 125

Query: 132 IKVLRASHPEEVREVVEAGAAQAYNACTPTAVLLSQRL 169
           +        E++  ++E     A+    P   L+S ++
Sbjct: 126 LTYTIIGETEKL-PLLENVILDAFENSRPHIALVSPKV 162