BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0241.0002.p (480 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin2977 [GEPR] COG0477 Permeases of the major facilitator superf... 208 2e-53 Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superf... 193 8e-49 PA1262 [GEPR] COG0477 Permeases of the major facilitator superfa... 192 1e-48 Rv1250 [GEPR] COG0477 Permeases of the major facilitator superfa... 171 4e-42 MT1289 [GEPR] COG0477 Permeases of the major facilitator superfa... 171 4e-42 >lin2977 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 470 Score = 208 bits (530), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 151/427 (35%), Positives = 235/427 (55%), Gaps = 7/427 (1%) Query: 20 RADTSRRWWVLAIVVSAQFMFGVDAFIVNVAIPTIAAELHATPAQIEAVIAIYLIAYATL 79 + D + +++I++ A F+ +D IVNVA+P I LHAT IE VI+ Y +A+ + Sbjct: 3 QTDKRKTLALISIMLGA-FISLLDTTIVNVALPDITTALHATSETIEWVISGYALAFGLV 61 Query: 80 VVTGGRLGDIHGTRNVFIAGVAGFSVTSLWCGLAQSGPELIVARLAQGATAALMVPQVLA 139 ++ GRLGD G +N++I G+ F + S+ GLA S LI++R+ QG A L PQ+ A Sbjct: 62 LILAGRLGDKFGRKNIYIIGITLFLIMSVTAGLAGSENSLIISRVIQGLAAGLFFPQINA 121 Query: 140 TLHLLFSDAARARAFGIYGIVLGLAGAAGFMLGGVLVTLDLAGLGWRAVFFVNVPCGVVI 199 T+ ++S + + FGI G V+G+ A G + GG+L+ L A GWRAVFFVNVP +V Sbjct: 122 TIMDMYSGKSLGKIFGILGSVIGVGTAIGPLTGGLLIELFGATNGWRAVFFVNVPFVLVT 181 Query: 200 IAAALKIMPTVPRRAGTR---LDIPGAIVLFAGLLCLIGPLLFGHDLNWTGWVWLVMAAG 256 + A+ +P R T+ D+PG +L LL L+ PL+ ++ +L+MA Sbjct: 182 LVLAMLYLPK--RTVSTKKISFDLPGVGLLTIALLLLLFPLISNGANDFKPIDYLLMALS 239 Query: 257 IAVIAAFVRLERSVARRGGMPLIDLSLLSDRAFMGGLVAVFFFFFANLSFYLIMTMFMQK 316 I + + ++G PLI +LL + F+ G++ +F A S + ++++ Q Sbjct: 240 IPLFIILYKWSVYQEKKGNQPLIAPNLLKNNQFVSGMLLSLVYFAAFTSIFFVLSLTWQT 299 Query: 317 GLKIPPLQAGLVFVPLALTFVIASRHSGLRARHRGTLVLIEGCALQIVGLAVLVATIE-A 375 G + +GL P AL V+A+ +S G +L+ G +L IVGL + Sbjct: 300 GFNRSAILSGLAISPFALGSVLAASNSYRFIPLLGRKLLMLGVSLVIVGLGTVSIVFHLN 359 Query: 376 VAAPSALLLALLLMIFGYGQGLVMAPLSSAVLASVQPASAGAGSGMYGTTTQIGNAAGVA 435 A SA LL L L I G G GL +APL+S L++V G SGM+ T +IG++ G+A Sbjct: 360 DGAFSAWLLFLPLFIAGLGSGLTIAPLNSFTLSTVTGLDRGGASGMFNTAQRIGSSFGIA 419 Query: 436 AIGAVFF 442 +G+VFF Sbjct: 420 VVGSVFF 426 >Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 487 Score = 193 bits (490), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 134/405 (33%), Positives = 218/405 (53%), Gaps = 10/405 (2%) Query: 38 FMFGVDAFIVNVAIPTIAAELHATPAQIEAVIAIYLIAYATLVVTGGRLGDIHGTRNVFI 97 FM +D IV V+ P + A++ A+ ++ V ++YL+ +A ++ GRLGD +G +NV++ Sbjct: 45 FMILLDQTIVAVSTPALQADMGASYNEVIWVTSVYLLTFAVPLLVTGRLGDKYGPKNVYV 104 Query: 98 AGVAGFSVTSLWCGLAQSGPELIVARLAQGATAALMVPQVLATLHLLFSDAARARAFGIY 157 AG+ F+V+SL CGLA LI+AR QG AAL+ PQ +AT++ +F+ R A G++ Sbjct: 105 AGMVIFTVSSLACGLAPDMFTLIIARGVQGLGAALLTPQTMATINRIFAFERRGAALGVW 164 Query: 158 GIVLGLAGAAGFMLGGVLVTLDLAGLGWRAVFFVNVPCGVVIIAAALKIMPTVPRRAGTR 217 G GLA AG +LGGV+ GW+ VF++NVP GV+ + A +K +P P TR Sbjct: 165 GSTAGLASLAGPILGGVITE----NWGWQWVFYINVPIGVISVIAVMKYVPEFPPL--TR 218 Query: 218 LDIPGAIVL-FAGLLCLIGPLLFGHDLNWTGWVWLVMAAGIAVIAAFVRLERSVARRGGM 276 P +IVL + L+ G W WVW+++ A A+ A F+ + + G Sbjct: 219 PLDPLSIVLSIVAVFFLVFAFQEGEGAGWAAWVWIMIVAAFALFAWFIYQQSRAEKSGND 278 Query: 277 PLIDLSLLSDRAFMGGLVAVFFFFFANLSFYLIMTMFMQKGLKIPPLQAGLVFVPLALTF 336 PL+ L + R F G + + F L + ++ Q+ + ++AG + VP AL Sbjct: 279 PLVPLEIFKFRNFSLGNICIMAMGFTVAGTPLPIMLYFQQAHGMNAMEAGFMMVPQALMA 338 Query: 337 VIASRHSGLRARHRGTLVLIEGCALQIVGLAVLVATIEAVAAPSALLLALLLM-IFGYGQ 395 + S G + R L+ V +++++ ++ + + L+ AL+ M + G G Sbjct: 339 AVLSPFVG-KLVDRSNPGLMAALGFSTVAVSIVLLSMVMIFD-TGLVWALVSMTLLGIGN 396 Query: 396 GLVMAPLSSAVLASVQPASAGAGSGMYGTTTQIGNAAGVAAIGAV 440 V AP S++ + + GAGSG++ TT Q+G+ G AAIGAV Sbjct: 397 AFVWAPNSTSTMRDLPHKFMGAGSGVFNTTRQLGSVIGAAAIGAV 441 >PA1262 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 480 Score = 192 bits (488), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 157/414 (37%), Positives = 237/414 (57%), Gaps = 2/414 (0%) Query: 30 LAIVVSAQFMFGVDAFIVNVAIPTIAAELHATPAQIEAVIAIYLIAYATLVVTGGRLGDI 89 L I+++ Q + +D IVNVA+ +A L A+ ++E ++A+Y +A+A + GGRLGD Sbjct: 15 LCILLAGQLLPMIDFSIVNVALDALAHSLGASETELELIVAVYGVAFAVCLAMGGRLGDN 74 Query: 90 HGTRNVFIAGVAGFSVTSLWCGLAQSGPELIVARLAQGATAALMVPQVLATLHLLFSDAA 149 +G R +F+ GVA F+V SL CGLA S L+VAR QG AAL+VPQ+LATLH+ S A Sbjct: 75 YGRRRLFVLGVALFAVASLLCGLAGSVWLLLVARALQGVGAALVVPQILATLHVSLSGHA 134 Query: 150 RARAFGIYGIVLGLAGAAGFMLGGVLVTLDLAGLGWRAVFFVNVPCGVVIIAAALKIMPT 209 +RA YG + GLA G +LGG LV+ D+ GLGWR+VF +N+P + I+ + + +P Sbjct: 135 HSRALAAYGAIGGLAFVVGQVLGGFLVSADIGGLGWRSVFLINLPICLGILLCSRRWVPE 194 Query: 210 VPRRAGTRLDIPGAIVLFAGLLCLIGPLLFGHDLNWTGWVWLVMAAGIAVIAAFVRLERS 269 R+D PG ++L A +LCL+ PL G L+W+ L++AA + ++A R E Sbjct: 195 TRAEHAARVDAPGTLLLAALILCLLLPLALGPSLHWSWPCALLLAAAVPLLAWLWRTELR 254 Query: 270 VARRGGMPLIDLSLLSDRAFMGGLVAVFFFFFANLSFYLIMTMFMQKGLKIPPLQAGLVF 329 RR PL+ SLL + GL+ FF F + + +Q G + P+QAG F Sbjct: 255 QERRQAWPLLPPSLLRLPSIRFGLLLAILFFACWSGFMFALALALQAGAGLSPVQAGNAF 314 Query: 330 VPLALTFVIASRHSGLRARHRGTL-VLIEGCALQIVGLAVLVATIEAV-AAPSALLLALL 387 + L ++ +++ + A G + +L+ GC +Q+ GL L+ T++ V P L LA Sbjct: 315 IALGASYFVSALLTARVAARIGPVRLLLLGCVIQMCGLLGLMLTLQRVWPQPGILNLAPA 374 Query: 388 LMIFGYGQGLVMAPLSSAVLASVQPASAGAGSGMYGTTTQIGNAAGVAAIGAVF 441 ++ G+GQ +++ L+ V A AGAGS M T Q G A +GAVF Sbjct: 375 TLVIGFGQAFIVSSFFRIGLSEVPAAQAGAGSAMLATVQQASLGLGSALLGAVF 428 >Rv1250 [GEPR] COG0477 Permeases of the major facilitator superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 579 Score = 171 bits (433), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 125/402 (31%), Positives = 196/402 (48%), Gaps = 9/402 (2%) Query: 38 FMFGVDAFIVNVAIPTIAAELHATPAQIEAVIAIYLIAYATLVVTGGRLGDIHGTRNVFI 97 FM +D+ +V +A PTI A+L A + V + YL+AYA ++ GRLGD G +N+++ Sbjct: 29 FMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYL 88 Query: 98 AGVAGFSVTSLWCGLAQSGPELIVARLAQGATAALMVPQVLATLHLLFSDAARARAFGIY 157 G+ F+V SL CGL+ LI AR+ QG A L+ PQ L+T+ +F R A G + Sbjct: 89 IGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAW 148 Query: 158 GIVLGLAGAAGFMLGGVLVTLDLAGLGWRAVFFVNVPCGVVIIAAALKIMPTVPRRAGTR 217 G V +A G + GG LV +GW +FFVNVP GV+ + A ++P +P R Sbjct: 149 GTVASVASLVGPLAGGALVD----SMGWEWIFFVNVPVGVIGLILAAYLIPALPHHP-HR 203 Query: 218 LDIPGAIVLFAGLLCLIGPLLFGHDLNWTGWVWLVMAAGIAVIAAFVRLERSVARRGGMP 277 D G + AG+ ++ L G NW W+W V+ GI ++ FV + AR P Sbjct: 204 FDWFGVGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNARE---P 260 Query: 278 LIDLSLLSDRAFMGGLVAVFFFFFANLSFYLIMTMFMQKGLKIPPLQAGLVFVPLALTFV 337 LI L + +DR F + + FA L +T + Q + P ++F P A+ Sbjct: 261 LIPLEVFNDRNFSLSNLRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGG 320 Query: 338 IASRHSGLRARHRGTLVLIEGCALQIVGLAVLVATIEAVAAPSALLLALLLMIFGYGQGL 397 + + G+ L ++ G ++ +A+ E L L + G Sbjct: 321 VLAPFVGMIIDRSHPLCVL-GFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAF 379 Query: 398 VMAPLSSAVLASVQPASAGAGSGMYGTTTQIGNAAGVAAIGA 439 V +PL+ +++P AGA SG++ Q+G G A++ A Sbjct: 380 VWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAA 421 >MT1289 [GEPR] COG0477 Permeases of the major facilitator superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 579 Score = 171 bits (433), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 125/402 (31%), Positives = 196/402 (48%), Gaps = 9/402 (2%) Query: 38 FMFGVDAFIVNVAIPTIAAELHATPAQIEAVIAIYLIAYATLVVTGGRLGDIHGTRNVFI 97 FM +D+ +V +A PTI A+L A + V + YL+AYA ++ GRLGD G +N+++ Sbjct: 29 FMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYL 88 Query: 98 AGVAGFSVTSLWCGLAQSGPELIVARLAQGATAALMVPQVLATLHLLFSDAARARAFGIY 157 G+ F+V SL CGL+ LI AR+ QG A L+ PQ L+T+ +F R A G + Sbjct: 89 IGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAW 148 Query: 158 GIVLGLAGAAGFMLGGVLVTLDLAGLGWRAVFFVNVPCGVVIIAAALKIMPTVPRRAGTR 217 G V +A G + GG LV +GW +FFVNVP GV+ + A ++P +P R Sbjct: 149 GTVASVASLVGPLAGGALVD----SMGWEWIFFVNVPVGVIGLILAAYLIPALPHHP-HR 203 Query: 218 LDIPGAIVLFAGLLCLIGPLLFGHDLNWTGWVWLVMAAGIAVIAAFVRLERSVARRGGMP 277 D G + AG+ ++ L G NW W+W V+ GI ++ FV + AR P Sbjct: 204 FDWFGVGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNARE---P 260 Query: 278 LIDLSLLSDRAFMGGLVAVFFFFFANLSFYLIMTMFMQKGLKIPPLQAGLVFVPLALTFV 337 LI L + +DR F + + FA L +T + Q + P ++F P A+ Sbjct: 261 LIPLEVFNDRNFSLSNLRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGG 320 Query: 338 IASRHSGLRARHRGTLVLIEGCALQIVGLAVLVATIEAVAAPSALLLALLLMIFGYGQGL 397 + + G+ L ++ G ++ +A+ E L L + G Sbjct: 321 VLAPFVGMIIDRSHPLCVL-GFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAF 379 Query: 398 VMAPLSSAVLASVQPASAGAGSGMYGTTTQIGNAAGVAAIGA 439 V +PL+ +++P AGA SG++ Q+G G A++ A Sbjct: 380 VWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAA 421