BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0226.0018.p         (185 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    97   2e-20
MK0395 Non COG                                                         92   4e-19
MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    86   4e-17
MA3298_1 [R] COG4032 Predicted thiamine-pyrophosphate-binding pr...    66   5e-11

>MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mja
           Methanococcus jannaschii
          Length = 183

 Score = 97.4 bits (241), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 52/154 (33%), Positives = 83/154 (53%), Gaps = 1/154 (0%)

Query: 18  VAIYRTLKSFGVAQVSYVPDAGHSKLIKLSHADADIKTTVLTTEEEGVAMAAGAWLGGDR 77
           +AIY  LK   +  +  VP A    L+KL   D +I     T EEE   + AGA+L G +
Sbjct: 19  LAIYNALKDSNIDFICSVPCANLKNLLKLIEEDKNIINIPATREEEAFGICAGAYLAGKK 78

Query: 78  AVLLMQSSGVGNCVNML-SLMASCRFPLLTLVTMRGEWAEFNPWQIPMGRATPQAFEIMG 136
             +LMQ+SG+GN +N + SL  + + P L +++ RG+  E  P QIPMGR   +  ++  
Sbjct: 79  TAILMQNSGIGNSINAIASLYKTFQIPTLLIISHRGDLKEQIPAQIPMGRWIEKLLDVCE 138

Query: 137 TTVLRLENPDDAEEVVSAAASLAYDGDQQVAVLI 170
               + + P++A +++  A+S  Y     VA+L 
Sbjct: 139 IPTYKPKTPEEAYKLIKYASSYMYKISYPVALLF 172


>MK0395 Non COG
          Length = 167

 Score = 92.4 bits (228), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 55/157 (35%), Positives = 87/157 (55%), Gaps = 2/157 (1%)

Query: 19  AIYRTLKSFGVAQVSYVPDAGHSKLIKLSHADADIKTTVLTTEEEGVAMAAGAWLGGDRA 78
           AI   L+  G+    ++P +    +I+      +I+T  ++ EEEGV + AGA L G++ 
Sbjct: 6   AIVEALEEAGITFACWLPCSLLDGIIRRLEEHPEIRTVRVSREEEGVGICAGAALAGEKP 65

Query: 79  VLLMQSSGVGNCVNML-SLMASCRFPLLTLVTMRGEWAEFNPWQIPMGRATPQAFEIMGT 137
            L+MQ+SG+GN VN L SL  + R PLL L++ RG   E  P Q+ MG+A P+  E +  
Sbjct: 66  ALIMQNSGLGNSVNALCSLTLTYRLPLLMLMSHRGYLFEDIPAQVGMGKAAPKILENLNL 125

Query: 138 TVLRLENPDDAEEVVSAAASLAYDGDQQVAVLISQRM 174
               +E P++  +V+  A  LA    + V V +S R+
Sbjct: 126 HAFTIERPEEL-DVIPGAWKLAETAGEPVGVFLSPRL 161


>MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mth
           Methanothermobacter thermautotrophicus
          Length = 165

 Score = 85.9 bits (211), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 1/153 (0%)

Query: 19  AIYRTLKSFGVAQVSYVPDAGHSKLIKLSHADADIKTTVLTTEEEGVAMAAGAWLGGDRA 78
           A+Y  +K  G+     VP      ++++  AD  I    +T EEEG  +AAGA + G   
Sbjct: 8   AVYAGMKDAGIDFAVSVPCVNLRTVLEMVDADPAIMHVPVTREEEGFGVAAGAHMAGKTT 67

Query: 79  VLLMQSSGVGNCVNML-SLMASCRFPLLTLVTMRGEWAEFNPWQIPMGRATPQAFEIMGT 137
            +LMQ+SG+GN VN+L SL +    P+  +V+ RG   EF   Q+PMGRAT     I+  
Sbjct: 68  AILMQNSGLGNSVNVLASLYSLYHIPITMIVSHRGTEGEFMEAQVPMGRATGDILRILEI 127

Query: 138 TVLRLENPDDAEEVVSAAASLAYDGDQQVAVLI 170
                 +P +A E +     ++    + VAVL+
Sbjct: 128 PFRTPRSPAEARESIGELTDISLRTSKAVAVLL 160


>MA3298_1 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mac
           Methanosarcina acetivorans str.C2A
          Length = 201

 Score = 65.9 bits (159), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 5/121 (4%)

Query: 20  IYRTLKSFGVAQVSYVPDAGHSKLIKL-SHADADIKTTVLTTEEEGVAMAAGAWLGGDRA 78
           +   +K  G+   + +P      L+ L S    +IK   LT EE GV + AG +L G + 
Sbjct: 10  VIEIMKQTGIDLAATLPCDRIKNLLPLVSENFPEIK---LTREENGVGICAGIYLAGGKP 66

Query: 79  VLLMQSSGVGNCVNML-SLMASCRFPLLTLVTMRGEWAEFNPWQIPMGRATPQAFEIMGT 137
           ++L+QS+G+GN +N L SL  +C+ PL  L + RG + E    Q+P+G   P   E  G 
Sbjct: 67  MMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQVPLGAHLPSILEGAGL 126

Query: 138 T 138
           T
Sbjct: 127 T 127