BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0223.0022.p (277 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv0851c [IQR] COG1028 Dehydrogenases with different specificitie... 188 1e-47 MT0874 [IQR] COG1028 Dehydrogenases with different specificities... 187 2e-47 RSc1769 [IQR] COG1028 Dehydrogenases with different specificitie... 186 4e-47 PA3277 [IQR] COG1028 Dehydrogenases with different specificities... 144 2e-34 PA1537 [IQR] COG1028 Dehydrogenases with different specificities... 137 3e-32 >Rv0851c [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mtu Mycobacterium tuberculosis H37Rv Length = 275 Score = 188 bits (477), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 112/278 (40%), Positives = 150/278 (53%), Gaps = 9/278 (3%) Query: 1 MRELAGKAAFVTGAASGIGLAIATAFAREGMKVMLADIETGPLDKAVDALRAGGADVHGV 60 M G+ A +TG ASGIGLA T FAR G +V+L D++ L +AV+ LRA G DVH V Sbjct: 1 MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSV 60 Query: 61 VCDVADPLSVDRAAEASFRAFGRVHVLCNNAGVAAGGGIDPISIDDWRWVIDVNLMGVVH 120 +CDV V A+ +FR G V V+ +NAG+ GG I ++ DDWRWVIDV+L G +H Sbjct: 61 MCDVRHREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIH 120 Query: 121 GIRSFLPHIRQHGEGGHIVNTASMAGIRSGLGLSPYSATKFAVVSLSEGLAMQLRPLGIG 180 + +FLP + + G GGH+V TAS AG+ GL Y K+ VV L+E LA ++ GIG Sbjct: 121 TVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIG 180 Query: 181 VSVLCPSFVRTR-IGESGRNRGEQYGPARQLDPASPMAAVVAEIARRLEAGLDPASVAGQ 239 VSVLCP V T + S R RG + P+ + L +A Sbjct: 181 VSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPL--------QDDNLGVDDIAQL 232 Query: 240 VLAAIRDDQLYIFTHPGMRAEVEERFSAILTAMDAVSA 277 AI ++LY+ H RA + RF I D +A Sbjct: 233 TADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAA 270 >MT0874 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MtC Mycobacterium tuberculosis CDC1551 Length = 278 Score = 187 bits (476), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 111/273 (40%), Positives = 149/273 (54%), Gaps = 9/273 (3%) Query: 6 GKAAFVTGAASGIGLAIATAFAREGMKVMLADIETGPLDKAVDALRAGGADVHGVVCDVA 65 G+ A +TG ASGIGLA T FAR G +V+L D++ L +AV+ LRA G DVH V+CDV Sbjct: 9 GRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHSVMCDVR 68 Query: 66 DPLSVDRAAEASFRAFGRVHVLCNNAGVAAGGGIDPISIDDWRWVIDVNLMGVVHGIRSF 125 V A+ +FR G V V+ +NAG+ GG I ++ DDWRWVIDV+L G +H + +F Sbjct: 69 HREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAF 128 Query: 126 LPHIRQHGEGGHIVNTASMAGIRSGLGLSPYSATKFAVVSLSEGLAMQLRPLGIGVSVLC 185 LP + + G GGH+V TAS AG+ GL Y K+ VV L+E LA ++ GIGVSVLC Sbjct: 129 LPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIGVSVLC 188 Query: 186 PSFVRTR-IGESGRNRGEQYGPARQLDPASPMAAVVAEIARRLEAGLDPASVAGQVLAAI 244 P V T + S R RG + P+ + L +A AI Sbjct: 189 PMVVETNLVANSERIRGAACAQSSTTGSPGPLPL--------QDDNLGVDDIAQLTADAI 240 Query: 245 RDDQLYIFTHPGMRAEVEERFSAILTAMDAVSA 277 ++LY+ H RA + RF I D +A Sbjct: 241 LANRLYVLPHAASRASIRRRFERIDRTFDEQAA 273 >RSc1769 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 300 Score = 186 bits (472), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 119/278 (42%), Positives = 157/278 (56%), Gaps = 10/278 (3%) Query: 1 MRELAGKAAFVTGAASGIGLAIATAFAREGMKVMLADIETGPLDKAVDALRAGGADVHGV 60 M++ AG A +TG ASG G A A A GMK++LADI+ LD AV RA G +V GV Sbjct: 1 MKQFAGGVAVITGGASGFGKAFARLGAGLGMKLVLADIQQDALDAAVAGFRAQGVEVIGV 60 Query: 61 VCDVADPLSVDRAAEASFRAFGRVHVLCNNAGVAAGGGIDPISIDDWRWVIDVNLMGVVH 120 DV+ V A+A+ R FG+V++L NNAGV AGG I S DW WV+ VNL GV+H Sbjct: 61 RVDVSREADVQALADAAIRTFGKVNLLFNNAGVGAGGLIWENSQQDWDWVLGVNLHGVIH 120 Query: 121 GIRSFLPHI-----RQHGEGGHIVNTASMAGIRSGLGLSPYSATKFAVVSLSEGLAMQLR 175 G+R F P + + GHIVNTASMAG+ + + Y+ +K AVV+L+E L L Sbjct: 121 GVRIFTPLMLAEAAKDPSYAGHIVNTASMAGLLNAPAMGIYNVSKHAVVALTESLYQDLS 180 Query: 176 PLG--IGVSVLCPSFVRTRIGESGRNRGEQYGPARQLDPASPMAAVVAEIARRLEAGLDP 233 + I SVLCP FV T I +S RNR + A P A + + AG Sbjct: 181 LVTEQIRCSVLCPYFVPTGITQSHRNRPQDL--ANAAPPTRSQLVAQAMTDKAVSAGKVS 238 Query: 234 ASVAGQV-LAAIRDDQLYIFTHPGMRAEVEERFSAILT 270 A GQ+ AIRD++ YI++HP A V+ RF I++ Sbjct: 239 AEQVGQMTFDAIRDERFYIYSHPHALAPVQHRFEDIVS 276 >PA3277 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 270 Score = 144 bits (363), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 86/221 (38%), Positives = 130/221 (58%), Gaps = 5/221 (2%) Query: 10 FVTGAASGIGLAIATAFAREGMKVMLADIETGPLDKAVDALRAGGADVHGVVCDVADPLS 69 +TGA SG+G IA +AR+G ++ LAD+ L +++ +R G D CDV D Sbjct: 6 MITGAGSGLGREIALRWARDGWRLALADVNEAGLAESLKLVREAGGDGFTQRCDVRDYSQ 65 Query: 70 VDRAAEASFRAFGRVHVLCNNAGVAAGGGIDPISIDDWRWVIDVNLMGVVHGIRSFLPHI 129 + A++ FG + V+ NNAGVA+GG +S++DW W I +NL+GVV G ++FLP + Sbjct: 66 LTALAQSCEEKFGGIDVIVNNAGVASGGFFGELSLEDWDWQIAINLIGVVKGCKAFLPLL 125 Query: 130 RQHGEGGHIVNTASMAGIRSGLGLSPYSATKFAVVSLSEGLAMQLRPLGIGVSVLCPSFV 189 + G IVN ASMA + G +S Y+ K VV+LSE L ++L + +GV V+CPSF Sbjct: 126 ER--SKGKIVNIASMAALMQGPAMSNYNVAKAGVVALSESLLVELALVEVGVHVVCPSFF 183 Query: 190 RTRIGESGRNRG-EQYGPARQLDPASPMAAVVAEIARRLEA 229 +T + +S R E +L +SP++A A+IA + A Sbjct: 184 QTNLLDSFRGPSPEMKHQVGKLLESSPISA--ADIADYIHA 222 >PA1537 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pae Pseudomonas aeruginosa Length = 295 Score = 137 bits (345), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 74/200 (37%), Positives = 115/200 (57%), Gaps = 3/200 (1%) Query: 1 MRELAGKAAFVTGAASGIGLAIATAFAREGMKVMLADIETGPLDKAVDALRAGGADVHGV 60 M+ K A +TGA SGIG A+A R+G + LAD+ L++ L + G V Sbjct: 1 MKSFENKVAAITGAGSGIGRALAVELGRQGCHLALADVNAAALEETRQLLASSGVRVSTA 60 Query: 61 VCDVADPLSVDRAAEASFRAFGRVHVLCNNAGVAAGGGIDPISIDDWRWVIDVNLMGVVH 120 V DVAD V A+ + GRV+++ NNAGVA G ++ ++ W++++N GVV+ Sbjct: 61 VVDVADREQVQAWADKAASEHGRVNLIFNNAGVAHAGTVEGSDYSEYEWIMNINFWGVVN 120 Query: 121 GIRSFLPHIRQHGEGGHIVNTASMAGIRSGLGLSPYSATKFAVVSLSEGLAMQLRPLGIG 180 G ++FLPH++ G GH+VN +S+ G+ + G+S Y+ATK+AV +E L +L G Sbjct: 121 GTKAFLPHLKASG-NGHVVNVSSVFGLFAQPGMSAYNATKYAVRGFTESLRQELDMEDSG 179 Query: 181 VSVLC--PSFVRTRIGESGR 198 VS C P ++T I ++ R Sbjct: 180 VSASCVHPGGIKTNIAKTAR 199