BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0219.0001.p (1257 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc3907_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1380 0.0 SMc03112_2 [E] COG1410 Methionine synthase I, cobalamin-binding ... 1343 0.0 BMEI1759_2 [E] COG1410 Methionine synthase I, cobalamin-binding ... 1342 0.0 CC2137 Non COG 1176 0.0 ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1131 0.0 >AGc3907_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 919 Score = 1380 bits (3573), Expect = 0.0, Method: Compositional matrix adjust. Identities = 665/912 (72%), Positives = 762/912 (83%), Gaps = 9/912 (0%) Query: 304 HKPRVVPEIAPRLRLSGLEPFTLTDAIPFVNVGERTNVTGSARFRKLITAGDYTAALQVA 363 +KPR +PE P + LSGLEPF LT IPFVNVGERTNVTGSARFRKLITAGDYTAAL VA Sbjct: 3 YKPREIPEHKPFMSLSGLEPFVLTKDIPFVNVGERTNVTGSARFRKLITAGDYTAALAVA 62 Query: 364 RDQVENGAQVIDVNMDEGLLDSEAAMVTFLNLVAAEPDIARVPVMVDSSKFHVIEAGLKC 423 RDQVENGAQ+ID+NMDEGL+DSE AMV FLNL+AAEPDIARVPVM+DSSKF +IEAGLKC Sbjct: 63 RDQVENGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPVMIDSSKFEIIEAGLKC 122 Query: 424 IQGKPIVNSISLKEGEEKFIHEATVAKRHGAAVVVMAFDETGQADTFKRKTEISKRAYDI 483 +QGK IVNSISLKEGEEKF+ +A + +GAAVVVMAFDE GQADT++RK EI RAY + Sbjct: 123 VQGKSIVNSISLKEGEEKFLQQARLVHNYGAAVVVMAFDEVGQADTYQRKVEICARAYKL 182 Query: 484 LVGRLDFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRANLPGAHISGGVSNLSF 543 L + PEDIIFDPN+FA+ATG+EEHNNYGVDFIEAT+ IR +P HISGGVSNLSF Sbjct: 183 LTEKAGLSPEDIIFDPNVFAVATGIEEHNNYGVDFIEATKTIRETMPLTHISGGVSNLSF 242 Query: 544 SFRGNEPVREAMHSVFLYHAIHAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGA 603 SFRGNEPVREAMH+VFLYHAI GMDMGIVNAGQ+ VYD+ID ELR+ CEDV+LNR A Sbjct: 243 SFRGNEPVREAMHAVFLYHAIQVGMDMGIVNAGQLAVYDNIDAELREACEDVVLNRRDDA 302 Query: 604 SERLLALAEKFRGK-EKQTKETDLAWRDWPVEKRLSHALVHGITEFIEADTEAARQNASR 662 +ERLL +AE+FRG EKQ K DL+WR++PVEKRL HALV+GIT++IEADTE ARQ A+R Sbjct: 303 TERLLEVAERFRGTGEKQAKVQDLSWREYPVEKRLEHALVNGITDYIEADTEEARQQAAR 362 Query: 663 PLDVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSARVMKQAVAYLMPFMEEEKARNLANGI 722 PL VIEGPLMAGMNVVGDLFG GKMFLPQVVKSARVMKQAVA L+P+MEEEK N Sbjct: 363 PLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPYMEEEKRLN----- 417 Query: 723 TGG--RNAAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPANKIIETAKAEG 780 GG R+AAGK+++ATVKGDVHDIGKNIVG+VL CNN+E+IDLGVMVP KI+ETA AE Sbjct: 418 -GGSERSAAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPTTKILETAIAEK 476 Query: 781 ADIIGLSGLITPSLDEMSFLAGELQRQGMNLPLLIGGATTSRVHTAVKIDPNYPGGPVVH 840 D+IGLSGLITPSLDEM +A E++RQG ++PLLIGGATTSRVHTAVKI P Y G ++ Sbjct: 477 VDVIGLSGLITPSLDEMVHVAAEMERQGFDIPLLIGGATTSRVHTAVKIHPRYEQGQAIY 536 Query: 841 VNDASRAVGVASSLLSAEKKQAYAAEVRAEYAKISTAHFRAQADKKRLKLGEARANKVAI 900 V DASRAVGV S+LLS E+K AY +RAEYAK++ AH R + +K+RL L AR N I Sbjct: 537 VTDASRAVGVVSALLSEEQKPAYIDGIRAEYAKVAEAHARNEREKQRLPLSRARENAHKI 596 Query: 901 DFAAAPPKKPAFFGLKSFDAYDLAELADYIDWTPFFQTWELTGRFPAILDDPKVGEVARS 960 D+++ KP FFG K F+ YDL EL+ YIDWTPFFQTWEL GRFPAIL+D K GE AR Sbjct: 597 DWSSYSVVKPQFFGTKVFETYDLEELSRYIDWTPFFQTWELKGRFPAILEDEKQGEAARQ 656 Query: 961 LYADARKMLDTLIKEKWFTARATVGFWPANAVGDDIEVYADETRKQKIATFHTLRQQLEK 1020 LYADA+ ML +I+EKWF RA +GFWPANAVGDDI ++ DE RK+++ATF TLRQQL K Sbjct: 657 LYADAQAMLAKIIEEKWFRPRAVIGFWPANAVGDDIRLFTDEGRKEELATFFTLRQQLSK 716 Query: 1021 REGRFNAALSDFIAPVETGVPDYIGGFVVTAGIGEDAVADRFKNANDDYSSILCKALADR 1080 R+GR N ALSDF+APV++GV DY+GGFVVTAGI E A+A+RF+ ANDDYSSIL KALADR Sbjct: 717 RDGRPNVALSDFVAPVDSGVADYVGGFVVTAGIEEVAIAERFERANDDYSSILVKALADR 776 Query: 1081 LAEAFAERMHQRVRKEFWAYAPGEAWSADELILEKYDGIRPAPGYPAQPDHTEKRTLFAL 1140 AEAFAERMH+RVRKEFW YAP EA + D+LI E Y GIRPAPGYPAQPDHTEK+TLFAL Sbjct: 777 FAEAFAERMHERVRKEFWGYAPDEALAGDDLIGEAYAGIRPAPGYPAQPDHTEKKTLFAL 836 Query: 1141 LDAENTAGVKLTESFAMWPGSSVSGLYFSHPESFYFGVGKIERDQVEDYAARKAMTVAEI 1200 LDA N AGV+LTES+AMWPGSSVSGLY HPES+YFGV K+ERDQV DYA RK M V E+ Sbjct: 837 LDATNAAGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVLDYARRKDMPVTEV 896 Query: 1201 ERWLAPVLNYIP 1212 ERWL PVLNY+P Sbjct: 897 ERWLGPVLNYVP 908 >SMc03112_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Sme Sinorhizobium meliloti Length = 913 Score = 1343 bits (3475), Expect = 0.0, Method: Compositional matrix adjust. Identities = 647/908 (71%), Positives = 751/908 (82%), Gaps = 4/908 (0%) Query: 306 PRVVPEIAPRLRLSGLEPFTLTDAIPFVNVGERTNVTGSARFRKLITAGDYTAALQVARD 365 PR VPEI R+RLSGLEPFTLTD IPFVNVGERTNVTGSA+FRKLITAGDY AAL VARD Sbjct: 1 PRRVPEIDRRMRLSGLEPFTLTDEIPFVNVGERTNVTGSAKFRKLITAGDYAAALDVARD 60 Query: 366 QVENGAQVIDVNMDEGLLDSEAAMVTFLNLVAAEPDIARVPVMVDSSKFHVIEAGLKCIQ 425 QV NGAQ+IDVNMDEGL+DS+ MV FLNLVA+EPDIARVPVM+DSSK+ VIEAGLKC+Q Sbjct: 61 QVANGAQIIDVNMDEGLIDSKQVMVEFLNLVASEPDIARVPVMIDSSKWEVIEAGLKCVQ 120 Query: 426 GKPIVNSISLKEGEEKFIHEATVAKRHGAAVVVMAFDETGQADTFKRKTEISKRAYDILV 485 GK +VNSISLKEGE F+H A + + +GAAVVVMAFDE GQADT RK EI +RAY +L Sbjct: 121 GKALVNSISLKEGEAAFLHHARLVRAYGAAVVVMAFDEKGQADTKTRKVEICRRAYRLLT 180 Query: 486 GRLDFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRANLPGAHISGGVSNLSFSF 545 + FPPEDIIFDPNIFA+ATG+EEHNNYGVDFIEAT I A LP H+SGGVSNLSFSF Sbjct: 181 EEVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEATHEIIAALPHVHVSGGVSNLSFSF 240 Query: 546 RGNEPVREAMHSVFLYHAIHAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASE 605 RGNEPVREAMH++FLYHAI AGMDMGIVNAGQ+ VYD IDPELR+TCEDV+LNR ++E Sbjct: 241 RGNEPVREAMHAIFLYHAIQAGMDMGIVNAGQLAVYDAIDPELRETCEDVVLNRRADSTE 300 Query: 606 RLLALAEKFRGKE-KQTKETDLAWRDWPVEKRLSHALVHGITEFIEADTEAARQNASRPL 664 RLL +AE++RGK Q KE DLAWR+WPVEKRL HALV+GITEFIEADTE AR A RPL Sbjct: 301 RLLEIAERYRGKGGSQGKEKDLAWREWPVEKRLEHALVNGITEFIEADTEEARLAAERPL 360 Query: 665 DVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSARVMKQAVAYLMPFMEEEKARNLANGITG 724 VIEGPLMAGMNVVGDLFG GKMFLPQVVKSARVMKQAVA L+P MEEEK ANG Sbjct: 361 HVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPHMEEEKR---ANGGGE 417 Query: 725 GRNAAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPANKIIETAKAEGADII 784 R +AGKI++ATVKGDVHDIGKNIVG+VL CNN+E+IDLGVMVP+ KI+E A+ + DI+ Sbjct: 418 ARESAGKILMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPSAKILEVAREQKVDIV 477 Query: 785 GLSGLITPSLDEMSFLAGELQRQGMNLPLLIGGATTSRVHTAVKIDPNYPGGPVVHVNDA 844 GLSGLITPSLDEM+ +A EL+R+G ++PLLIGGATTSRVHTAVKI+P Y G V+V DA Sbjct: 478 GLSGLITPSLDEMAHVASELEREGFDVPLLIGGATTSRVHTAVKINPRYSLGQTVYVTDA 537 Query: 845 SRAVGVASSLLSAEKKQAYAAEVRAEYAKISTAHFRAQADKKRLKLGEARANKVAIDFAA 904 SRAVGV SSLLS E + +Y VRAEY K++ AH R +A+K+RL L +ARAN ID+ A Sbjct: 538 SRAVGVVSSLLSPEVRDSYKKTVRAEYLKVADAHARNEAEKRRLPLSQARANAFRIDWDA 597 Query: 905 APPKKPAFFGLKSFDAYDLAELADYIDWTPFFQTWELTGRFPAILDDPKVGEVARSLYAD 964 PK P+F G + F+ +DLAELA YIDWTPFFQTWEL G FP ILDD + G AR L+ D Sbjct: 598 HQPKVPSFLGTRVFEGWDLAELARYIDWTPFFQTWELKGVFPKILDDERQGAAARQLFED 657 Query: 965 ARKMLDTLIKEKWFTARATVGFWPANAVGDDIEVYADETRKQKIATFHTLRQQLEKREGR 1024 A+ M++ ++ E WF +A +GFWPA ++GDD+ ++ADE R+ ++ATF TLRQQ+ KR+GR Sbjct: 658 AQAMVEKIVAEAWFAPKAVIGFWPAASMGDDVRLFADEVREAELATFFTLRQQMVKRDGR 717 Query: 1025 FNAALSDFIAPVETGVPDYIGGFVVTAGIGEDAVADRFKNANDDYSSILCKALADRLAEA 1084 N AL+DF+AP +G DY+GGFVVTAGI E A+A+RF+ ANDDYSSI+ KALADR AEA Sbjct: 718 PNVALADFVAPAASGKRDYVGGFVVTAGIEEVAIAERFERANDDYSSIMVKALADRFAEA 777 Query: 1085 FAERMHQRVRKEFWAYAPGEAWSADELILEKYDGIRPAPGYPAQPDHTEKRTLFALLDAE 1144 FAERMH+ VRKE W YAP EA++ ELI E Y GIRPAPGYPAQPDHTEK TLF LLDAE Sbjct: 778 FAERMHEYVRKELWGYAPDEAFTPQELIAEPYAGIRPAPGYPAQPDHTEKETLFRLLDAE 837 Query: 1145 NTAGVKLTESFAMWPGSSVSGLYFSHPESFYFGVGKIERDQVEDYAARKAMTVAEIERWL 1204 GV+LTES+AMWPGSSVSGLY HP+S+YFGV KIERDQVEDYA RK M+V E+ERWL Sbjct: 838 AAIGVRLTESYAMWPGSSVSGLYVGHPDSYYFGVAKIERDQVEDYADRKRMSVREVERWL 897 Query: 1205 APVLNYIP 1212 +P+LNY+P Sbjct: 898 SPILNYVP 905 >BMEI1759_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Bme Brucella melitensis Length = 918 Score = 1342 bits (3472), Expect = 0.0, Method: Compositional matrix adjust. Identities = 651/915 (71%), Positives = 751/915 (82%), Gaps = 12/915 (1%) Query: 303 PHKPRVVPEIAPRLRLSGLEPFTLTDAIPFVNVGERTNVTGSARFRKLITAGDYTAALQV 362 P KP VP P +RLSGLEPFTLT IPFVN+GERTNVTGSARFRKL+ AGD+ AAL V Sbjct: 3 PRKPAKVP---PLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDV 59 Query: 363 ARDQVENGAQVIDVNMDEGLLDSEAAMVTFLNLVAAEPDIARVPVMVDSSKFHVIEAGLK 422 ARDQV NGAQ+ID+NMDEGL+DSE AMV FLNL+AAEPDIARVP+M+DSSK+ VIEAGLK Sbjct: 60 ARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLK 119 Query: 423 CIQGKPIVNSISLKEGEEKFIHEATVAKRHGAAVVVMAFDETGQADTFKRKTEISKRAYD 482 C+QGK +VNSISLKEGEE F+H A + + +GAAVV+MAFDETGQADT RK EI RAY Sbjct: 120 CVQGKAVVNSISLKEGEEAFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYK 179 Query: 483 ILVGRLDFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRANLPGAHISGGVSNLS 542 IL ++ FPPEDIIFDPNIFA+ATG+EEHNNYGVDFIEATR I LP HISGGVSNLS Sbjct: 180 ILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLS 239 Query: 543 FSFRGNEPVREAMHSVFLYHAIHAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNR--- 599 FSFRGNEPVREAMH+VFLYHAI AGMDMGIVNAGQ+ VYD ID ELR+ CEDV+LNR Sbjct: 240 FSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTK 299 Query: 600 -DPGASERLLALAEKFRGK-EKQTKETDLAWRDWPVEKRLSHALVHGITEFIEADTEAAR 657 A+ERLL +AE+FR ++ + DL+WR+WPVEKRL HALV+GITE+IEADTE AR Sbjct: 300 TGESATERLLEIAERFRDSGSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEAR 359 Query: 658 QNASRPLDVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSARVMKQAVAYLMPFMEEEKARN 717 A RPL VIEGPLMAGMNVVGDLFG GKMFLPQVVKSARVMKQAVA L+PFMEEEK N Sbjct: 360 LAAERPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLN 419 Query: 718 LANGITGGRNAAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPANKIIETAK 777 G R +AGK+++ATVKGDVHDIGKNIVG+VL CNN+E+IDLGVMVP+ KI++ A+ Sbjct: 420 GGEG----RQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVAR 475 Query: 778 AEGADIIGLSGLITPSLDEMSFLAGELQRQGMNLPLLIGGATTSRVHTAVKIDPNYPGGP 837 E DIIGLSGLITPSLDEM+ +A E++R+G ++PLLIGGATTSRVHTAVKI Y G Sbjct: 476 DEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQ 535 Query: 838 VVHVNDASRAVGVASSLLSAEKKQAYAAEVRAEYAKISTAHFRAQADKKRLKLGEARANK 897 V+V DASRAVGV S+LLS E KQAY +R EYAK++ AH R +A+K+RL + ARAN Sbjct: 536 AVYVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANP 595 Query: 898 VAIDFAAAPPKKPAFFGLKSFDAYDLAELADYIDWTPFFQTWELTGRFPAILDDPKVGEV 957 +D+ P KP F G K F+ YDLAE+A YIDWTPFFQTWEL GR+PAIL+D K GE Sbjct: 596 HQLDWENYEPVKPTFTGTKVFETYDLAEIARYIDWTPFFQTWELRGRYPAILEDEKQGEA 655 Query: 958 ARSLYADARKMLDTLIKEKWFTARATVGFWPANAVGDDIEVYADETRKQKIATFHTLRQQ 1017 AR L+ADA+ ML +I EKWFT RA VGFWPANAVGDDI ++ DE+RK+++AT TLRQQ Sbjct: 656 ARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQ 715 Query: 1018 LEKREGRFNAALSDFIAPVETGVPDYIGGFVVTAGIGEDAVADRFKNANDDYSSILCKAL 1077 L KR+GR N A++DF+APVE+G DY+GGFVVTAGIGE A+A+RF+ ANDDYS+IL KAL Sbjct: 716 LTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKAL 775 Query: 1078 ADRLAEAFAERMHQRVRKEFWAYAPGEAWSADELILEKYDGIRPAPGYPAQPDHTEKRTL 1137 ADR AEAFAE MH+RVRKEFWAYAP EA++ +ELI E Y GIRPAPGYPAQPDHTEK TL Sbjct: 776 ADRFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTL 835 Query: 1138 FALLDAENTAGVKLTESFAMWPGSSVSGLYFSHPESFYFGVGKIERDQVEDYAARKAMTV 1197 F LLDA GV+LTES+AMWPGSSVSGLY HPES+YFGV K+ERDQVEDYA RK M V Sbjct: 836 FRLLDATANTGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDV 895 Query: 1198 AEIERWLAPVLNYIP 1212 +ERWL P+LNY+P Sbjct: 896 EAVERWLTPILNYVP 910 >CC2137 Non COG Length = 899 Score = 1176 bits (3042), Expect = 0.0, Method: Compositional matrix adjust. Identities = 585/891 (65%), Positives = 689/891 (77%), Gaps = 19/891 (2%) Query: 332 FVNVGERTNVTGSARFRKLITAGDYTAALQVARDQVENGAQVIDVNMDEGLLDSEAAMVT 391 FVN+GERTNVTGSA+F+KLI G+Y AL VAR QVE GAQVIDVNMDEGLLDS+ AMVT Sbjct: 9 FVNIGERTNVTGSAKFKKLIVEGNYPEALSVARQQVEAGAQVIDVNMDEGLLDSQQAMVT 68 Query: 392 FLNLVAAEPDIARVPVMVDSSKFHVIEAGLKCIQGKPIVNSISLKEGEEKFIHEATVAKR 451 FLNL+AAEPDIARVPVM+DSSK+ VIEAGLKC+QGK IVNSISLKEGEEKF+ +AT+ R Sbjct: 69 FLNLMAAEPDIARVPVMIDSSKWEVIEAGLKCVQGKAIVNSISLKEGEEKFLEQATLCLR 128 Query: 452 HGAAVVVMAFDETGQADTFKRKTEISKRAYDILVGRLDFPPEDIIFDPNIFAIATGLEEH 511 +GAAVVVMAFDE GQADT KRK EI RAY+ LV ++ FPPEDIIFDPNIFA+ATG+EEH Sbjct: 129 YGAAVVVMAFDEVGQADTEKRKVEICTRAYNTLVDKVGFPPEDIIFDPNIFAVATGIEEH 188 Query: 512 NNYGVDFIEATRWIRANLPGAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIHAGMDMG 571 +NY VDFIEATR I+ LP A +SGGVSN+SFSFRGNEPVR A+HSVFLYHAI+AGMDMG Sbjct: 189 DNYAVDFIEATRRIKQMLPYARVSGGVSNVSFSFRGNEPVRRAIHSVFLYHAINAGMDMG 248 Query: 572 IVNAGQMIVYDDIDPELRQTCEDVILN---RDP--GASERLLALAEKFRGKEKQTKETDL 626 IVNAG + VYDDIDP LR+ EDVILN RDP +ERL+ +A +++G++ Q + +L Sbjct: 249 IVNAGDLPVYDDIDPALREAVEDVILNRPQRDPVMTNTERLVEMAPRYKGEKGQQQVANL 308 Query: 627 AWRDWPVEKRLSHALVHGITEFIEADTEAARQNASRPLDVIEGPLMAGMNVVGDLFGDGK 686 WR V +RL+HALVHGITEFIE DTE AR A RPL VIEGPLM GMNVVGDLFG GK Sbjct: 309 EWRKGTVNERLTHALVHGITEFIEQDTEEARLAAERPLHVIEGPLMDGMNVVGDLFGAGK 368 Query: 687 MFLPQVVKSARVMKQAVAYLMPFMEEEKARNLANGITGGRNAAGKIVLATVKGDVHDIGK 746 MFLPQVVKSARVMKQAVA+LMPFME EK R AAGK+++ATVKGDVHDIGK Sbjct: 369 MFLPQVVKSARVMKQAVAWLMPFMEAEKEGQ-------ERKAAGKVLMATVKGDVHDIGK 421 Query: 747 NIVGIVLQCNNFEVIDLGVMVPANKIIETAKAEGADIIGLSGLITPSLDEMSFLAGELQR 806 NIVG+VLQCNN+EV+DLGVMVPA++I++ AK D+IGLSGLITPSLDEM F+A E++R Sbjct: 422 NIVGVVLQCNNYEVVDLGVMVPADRILDEAKKHKVDMIGLSGLITPSLDEMVFVAAEMER 481 Query: 807 QGMNLPLLIGGATTSRVHTAVKIDPNYPGGPVVHVNDASRAVGVASSLLSAEKKQAYAAE 866 QG ++PLLIGGATTSR HTAVKI+P Y GP +V DASRAVGV S LLS ++ AE Sbjct: 482 QGFDIPLLIGGATTSRTHTAVKIEPAYRRGPTTYVVDASRAVGVVSGLLSEGERDRIIAE 541 Query: 867 VRAEYAKISTAHFRAQADKKRLKLGEARANKVAIDFAAAPPKKPAFFGLKSFDAYDLAEL 926 RAEY K+ + R Q K R + EAR AID+ P KPAF G + F+ LAEL Sbjct: 542 TRAEYVKVREQYARGQTTKARASIQEARKRAFAIDWKGYAPPKPAFIGTRVFEP-SLAEL 600 Query: 927 ADYIDWTPFFQTWELTGRFPAILDDPKVGEVARSLYADARKMLDTLIKEKWFTARATVGF 986 +IDW+PFF +WEL GRFP IL+D VG+ A LY DAR MLD +++EKWF A+ +GF Sbjct: 601 VPFIDWSPFFASWELIGRFPQILEDDVVGQAATDLYRDARAMLDKVVEEKWFGAKGVIGF 660 Query: 987 WPANAVGDDIEVYADETRKQKIATFHTLRQQLEK-----REGRFNAALSDFIAPVETGVP 1041 WPA A GDDI +Y DETR + + HTLRQQ++K E + N ALSDF+AP+ G Sbjct: 661 WPAQAQGDDIVLYTDETRVAEFSRLHTLRQQMDKGADKSGEAKANVALSDFVAPIGQGA- 719 Query: 1042 DYIGGFVVTAGIGEDAVADRFKNANDDYSSILCKALADRLAEAFAERMHQRVRKEFWAYA 1101 DY+GGF VTAG GED + +FK A DDY++I+ ALADRLAEAFAE +H + R E W YA Sbjct: 720 DYVGGFAVTAGHGEDEIVAKFKAAGDDYNAIMASALADRLAEAFAEWLHYKARVELWGYA 779 Query: 1102 PGEAWSADELILEKYDGIRPAPGYPAQPDHTEKRTLFALLDAENTAGVKLTESFAMWPGS 1161 E + LI EKY GIRPAPGYPAQPDHTEK TLF LLDAE G++LTES+AM PG+ Sbjct: 780 ADEDADVERLIAEKYQGIRPAPGYPAQPDHTEKGTLFKLLDAEAATGLQLTESYAMTPGA 839 Query: 1162 SVSGLYFSHPESFYFGVGKIERDQVEDYAARKAMTVAEIERWLAPVLNYIP 1212 +VSGL+FSH ++ YFGVGKI+ DQVEDYA RK + ERWL+P+LNY P Sbjct: 840 AVSGLFFSHRQAHYFGVGKIDADQVEDYARRKGWDMETAERWLSPILNYDP 890 >ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ecs Escherichia coli O157:H7 Length = 901 Score = 1131 bits (2926), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/907 (62%), Positives = 674/907 (74%), Gaps = 14/907 (1%) Query: 306 PRVVPEIAPRLRLSGLEPFTLTDAIPFVNVGERTNVTGSARFRKLITAGDYTAALQVARD 365 PR +PEI RLSGLEP + D FVNVGERTNVTGSA+F++LI Y+ AL VAR Sbjct: 4 PRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQ 63 Query: 366 QVENGAQVIDVNMDEGLLDSEAAMVTFLNLVAAEPDIARVPVMVDSSKFHVIEAGLKCIQ 425 QVENGAQ+ID+NMDEG+LD+EAAMV FLNL+A EPDIARVP+M+DSSK+ VIE GLKCIQ Sbjct: 64 QVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKCIQ 123 Query: 426 GKPIVNSISLKEGEEKFIHEATVAKRHGAAVVVMAFDETGQADTFKRKTEISKRAYDILV 485 GK IVNSIS+KEG + FIH A + +R+GAAVVVMAFDE GQADT RK EI +RAY IL Sbjct: 124 GKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKILT 183 Query: 486 GRLDFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRANLPGAHISGGVSNLSFSF 545 + FPPEDIIFDPNIFA+ATG+EEHNNY DFI A I+ LP A ISGGVSN+SFSF Sbjct: 184 EEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSF 243 Query: 546 RGNEPVREAMHSVFLYHAIHAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASE 605 RGN+PVREA+H+VFLY+AI GMDMGIVNAGQ+ +YDD+ ELR EDVILNR +E Sbjct: 244 RGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTE 303 Query: 606 RLLALAEKFRG-KEKQTKETDLA-WRDWPVEKRLSHALVHGITEFIEADTEAARQNASRP 663 RLL LAEK+RG K T A WR W V KRL ++LV GITEFIE DTE ARQ A+RP Sbjct: 304 RLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRP 363 Query: 664 LDVIEGPLMAGMNVVGDLFGDGKMFLPQVVKSARVMKQAVAYLMPFMEEEKARNLANGIT 723 ++VIEGPLM GMNVVGDLFG+GKMFLPQVVKSARVMKQAVAYL PF+E K + N Sbjct: 364 IEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGKTN--- 420 Query: 724 GGRNAAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPANKIIETAKAEGADI 783 GK+V+ATVKGDVHDIGKNIVG+VLQCNN+E++DLGVMVPA KI+ TAK AD+ Sbjct: 421 ------GKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADL 474 Query: 784 IGLSGLITPSLDEMSFLAGELQRQGMNLPLLIGGATTSRVHTAVKIDPNYPGGPVVHVND 843 IGLSGLITPSLDEM +A E++RQG +PLLIGGATTS+ HTAVKI+ NY GP V+V + Sbjct: 475 IGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNY-SGPTVYVQN 533 Query: 844 ASRAVGVASSLLSAEKKQAYAAEVRAEYAKISTAHFRAQADKKRLKLGEARANKVAIDFA 903 ASR VGV ++LLS ++ + A R EY + H R + + L AR N A D+ Sbjct: 534 ASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQ 593 Query: 904 AAPPKKPAFFGLKSFDAYDLAELADYIDWTPFFQTWELTGRFPAILDDPKVGEVARSLYA 963 A P G++ +A + L +YIDWTPFF TW L G++P IL+D VG A+ L+ Sbjct: 594 AYTPPVAHRLGVQEVEA-SIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFK 652 Query: 964 DARKMLDTLIKEKWFTARATVGFWPANAVGDDIEVYADETRKQKIATFHTLRQQLEKREG 1023 DA MLD L EK R VG +PAN VGDDIE+Y DETR I H LRQQ EK G Sbjct: 653 DANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEK-TG 711 Query: 1024 RFNAALSDFIAPVETGVPDYIGGFVVTAGIGEDAVADRFKNANDDYSSILCKALADRLAE 1083 N L+DF+AP +G DYIG F VT G+ EDA+AD F+ +DDY+ I+ KALADRLAE Sbjct: 712 FANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAE 771 Query: 1084 AFAERMHQRVRKEFWAYAPGEAWSADELILEKYDGIRPAPGYPAQPDHTEKRTLFALLDA 1143 AFAE +H+RVRK +W YAP E S +ELI E Y GIRPAPGYPA P+HTEK T++ LL+ Sbjct: 772 AFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEV 831 Query: 1144 ENTAGVKLTESFAMWPGSSVSGLYFSHPESFYFGVGKIERDQVEDYAARKAMTVAEIERW 1203 E G+KLTESFAMWPG+SVSG YFSHP+S Y+ V +I+RDQVEDYA RK M+V+++ERW Sbjct: 832 EKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVSDVERW 891 Query: 1204 LAPVLNY 1210 LAP L Y Sbjct: 892 LAPNLGY 898