BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0214.0014.p (324 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin0543 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Lin Liste... 143 5e-34 SA1994 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Sau Staphy... 136 6e-32 SPy1704 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spy Strep... 135 1e-31 SPy1919 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spy Strep... 132 1e-30 SP1190 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spn Strept... 129 7e-30 >lin0543 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Lin Listeria innocua Length = 338 Score = 143 bits (360), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 100/319 (31%), Positives = 156/319 (48%), Gaps = 17/319 (5%) Query: 2 VALDQRPPLFDAIAKAKGITRDQVEYSDVTAAKRLLVENLAPHCSSMLFDPNFAVPAAID 61 +A+DQR L I +AKG + DV K+L+ E L P+ S++L D + PA I Sbjct: 25 LAIDQRGSLKKMIQQAKGTENKK----DVEDFKQLVSEELTPYASAILLDLEYGTPA-IK 79 Query: 62 LLPPRCGLIMTLEEHRVEETAGGRKSRAIANWSVEKIRAMGGDAVKVLAWYRPDADAAVN 121 GL+ + E+ + T G+ I + S +I+ GGDAVK+L +Y PD A +N Sbjct: 80 ARHEGSGLLTSYEKTGYDATTPGKLPDLIEDLSALRIKENGGDAVKILVYYDPDEPAEIN 139 Query: 122 QHQKRFVREIGEECARHDVPYVLELLVYPFLGSANHTADYVESPGKLPGLVIDSVREFAK 181 + + F+ IG EC D+P+ LE + Y + + + +Y + P V S++EF+K Sbjct: 140 EIKYAFLERIGAECRAVDIPFFLEPITYDAKVTDSGSLEYAKLK---PAKVKASIKEFSK 196 Query: 182 PEYGVDLLKLESPLAANSLPARDGSTEARAAQKEFDAIGDI--CRERS-IPWVLLSGGAA 238 P YGVD+LKLE P+ + +G E A + +A C + S +P++ LS G Sbjct: 197 PRYGVDVLKLEVPV---NFKYVEGFAEGEVAYTQDEAARHFEECSDLSPLPFIYLSAGVT 253 Query: 239 PEKFERVLDFA--YAAGAGGFLAGRTIWLDAV-LKNFPDLTAVSASLRKDGLGVLERLNK 295 E F + + FA + G L GR W D + + A+ LR G + L+K Sbjct: 254 SEMFHKTIQFANQHNVQYSGVLCGRATWADGIEVYGKQGDDALREWLRTQGKENITSLDK 313 Query: 296 LTTAKGTPWKARFPVFTDI 314 L PW ++ F D+ Sbjct: 314 LLDEGAVPWWTKYGSFEDV 332 >SA1994 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Sau Staphylococcus aureus N315 Length = 326 Score = 136 bits (343), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 93/314 (29%), Positives = 154/314 (49%), Gaps = 20/314 (6%) Query: 2 VALDQRPPLFDAIAKAKGITRDQVEYSDVTAAKRLLVENLAPHCSSMLFDPNFAVPAAID 61 +A DQR L +AK + ++ + + K L+ E L + SS+L DP + +PA+ D Sbjct: 24 LAFDQRGALKRMMAKHQ---TEEPTVAQIEQLKVLVAEELTQYASSILLDPEYGLPAS-D 79 Query: 62 LLPPRCGLIMTLEEHRVEETAGGRKSRAIANWSVEKIRAMGGDAVKVLAWYRPDADAAVN 121 CGL++ E+ + A GR + WS ++++ G +AVK L +Y D +N Sbjct: 80 ARNKDCGLLLAYEKTGYDVNAKGRLPDCLVEWSAKRLKEQGANAVKFLLYYDVDDAEEIN 139 Query: 122 QHQKRFVREIGEECARHDVPYVLELLVYPFLGSANHTADYVESPGKLPGLVIDSVREFAK 181 +K ++ IG EC D+P+ LE+L Y N + ++ + P V ++++ F++ Sbjct: 140 IQKKAYIERIGSECVAEDIPFFLEVLTYDDNIPDNGSVEFAKVK---PRKVNEAMKLFSE 196 Query: 182 PEYGVDLLKLESPLAANSLPARDGSTEARAAQKEFDA---IGDICRERSIPWVLLSGGAA 238 P + VD+LK+E P+ ++ +G E + +A D +P++ LS G + Sbjct: 197 PRFNVDVLKVEVPV---NMKYVEGFAEGEVVYTKEEAAQHFKDQDAATHLPYIYLSAGVS 253 Query: 239 PEKFERVLDFAYAAGA--GGFLAGRTIWLDAV---LKNFPDLTAVSASLRKDGLGVLERL 293 E F+ L FA+ AGA G L GR W AV ++ D A LR G ++ L Sbjct: 254 AELFQETLKFAHEAGAKFNGVLCGRATWSGAVQVYIEQGED--AAREWLRTTGFKNIDDL 311 Query: 294 NKLTTAKGTPWKAR 307 NK+ T WK R Sbjct: 312 NKVLKDTATSWKQR 325 >SPy1704 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spy Streptococcus pyogenes M1 GAS Length = 325 Score = 135 bits (339), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 93/318 (29%), Positives = 157/318 (49%), Gaps = 26/318 (8%) Query: 2 VALDQRPPLFDAIAKAKGITRDQVEYSDVTAAKRLLVENLAPHCSSMLFDPNFAVPAAID 61 +A DQR L +A + + + + K L+ E L P+ SS+L DP + + A Sbjct: 23 LAFDQRGALKQMMAAHQ---EGEATVTQIETLKVLVSEELTPYASSILLDPEYGL-LATK 78 Query: 62 LLPPRCGLIMTLEEHRVEETAGGRKSRAIANWSVEKIRAMGGDAVKVLAWYRPDADAAVN 121 + + GL++ E+ + T R + WSV++++A G DA+K L +Y D D +N Sbjct: 79 VRANQTGLLLAYEKTGYDATTTSRLPDCLVEWSVKRLKAAGADAIKFLLYYDVDGDEQIN 138 Query: 122 QHQKRFVREIGEECARHDVPYVLELLVYPFLGSANHTADYVE-SPGKLPGLVIDSVREFA 180 ++ ++ IG EC D+P+ LELL Y S N++A Y + P K+ G ++ F+ Sbjct: 139 LQKQAYIERIGSECTAEDIPFFLELLSYDERISDNNSAAYAKLKPHKVNG----AMSVFS 194 Query: 181 KPEYGVDLLKLESPLAANSLPARDGSTEARAAQKEFDAIGDICRERS---IPWVLLSGGA 237 +GVD+LK+E P+ ++ +G TE + +AI + + +P++ LS G Sbjct: 195 DKRFGVDVLKVEVPV---NMAYVEGFTEGEVHYSQAEAIKAFQDQEAASHLPYIYLSAGV 251 Query: 238 APEKFERVLDFAYAAGA--GGFLAGRTIWLDAVLKNFP-DLTAVSASLRK----DGLGVL 290 + + F+ L FA AAGA G L GR W +V P +T RK +G + Sbjct: 252 SAKLFQETLYFAAAAGAQFSGVLCGRATWAGSV----PVYITKGEDEARKWLCTEGFQNI 307 Query: 291 ERLNKLTTAKGTPWKARF 308 + LN++ +PW + Sbjct: 308 DELNRVLEETASPWTEKI 325 >SPy1919 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spy Streptococcus pyogenes M1 GAS Length = 327 Score = 132 bits (331), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/318 (30%), Positives = 156/318 (49%), Gaps = 26/318 (8%) Query: 2 VALDQRPPLFDAIAK--AKGITRDQVEYSDVTAAKRLLVENLAPHCSSMLFDPNFAVPAA 59 +A DQR L +A+ K T +Q+E K L+ E L P SS+L DP + +PA+ Sbjct: 25 LAFDQRGALKRMMAQHQTKEPTVEQIE-----ELKSLVSEELTPFASSILLDPEYGLPAS 79 Query: 60 IDLLPPRCGLIMTLEEHRVEETAGGRKSRAIANWSVEKIRAMGGDAVKVLAWYRPDADAA 119 + GL++ E+ + T R + WS ++I+ G +AVK L +Y D D Sbjct: 80 -RVRSEEAGLLLAYEKTGYDATTTSRLPDCLDVWSAKRIKEAGAEAVKFLLYYDIDGDQD 138 Query: 120 VNQHQKRFVREIGEECARHDVPYVLELLVYPFLGSANHTADYVESPGKLPGLVIDSVREF 179 VN+ +K ++ IG EC D+P+ LE+L Y + N + ++ + V ++++ F Sbjct: 139 VNEQKKAYIERIGSECRAEDIPFYLEILTYDEKIADNASPEFAKVKAH---KVNEAMKVF 195 Query: 180 AKPEYGVDLLKLESPLAANSLPA-RDGS---TEARAAQKEFDAIGDICRERSIPWVLLSG 235 +K +GVD+LK+E P+ + DG T+ AAQ A D +P++ LS Sbjct: 196 SKERFGVDVLKVEVPVNMKFVEGFADGEVLFTKEEAAQ----AFRDQEASTDLPYIYLSA 251 Query: 236 GAAPEKFERVLDFAYAAGA--GGFLAGRTIWLDAV---LKNFPDLTAVSASLRKDGLGVL 290 G + + F+ L FA +GA G L GR W +V ++ P A LR +G + Sbjct: 252 GVSAKLFQDTLVFAAESGAKFNGVLCGRATWAGSVKVYIEEGPQ--AAREWLRTEGFKNI 309 Query: 291 ERLNKLTTAKGTPWKARF 308 + LNK+ +PW + Sbjct: 310 DELNKVLDKTASPWTEKM 327 >SP1190 [G] COG3684 Tagatose-1,6-bisphosphate aldolase Spn Streptococcus pneumoniae TIGR4 Length = 326 Score = 129 bits (325), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 89/312 (28%), Positives = 150/312 (48%), Gaps = 16/312 (5%) Query: 2 VALDQRPPLFDAIAKAKGITRDQVEYSDVTAAKRLLVENLAPHCSSMLFDPNFAVPAAID 61 +A DQR L + K + ++ + + K L+ + L + SSML DP + +PA Sbjct: 24 LAFDQRGALKRLMVKHQ---TEEPTVAQMEELKVLVADELTKYASSMLLDPEYGLPAT-K 79 Query: 62 LLPPRCGLIMTLEEHRVEETAGGRKSRAIANWSVEKIRAMGGDAVKVLAWYRPDADAAVN 121 L + GL++ E+ + T+ R + WS ++I+ G DAVK L +Y D+ +N Sbjct: 80 ALDEKAGLLLAYEKTGYDTTSTKRLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELN 139 Query: 122 QHQKRFVREIGEECARHDVPYVLELLVYPFLGSANHTADYVESPGKLPGLVIDSVREFAK 181 Q ++ ++ IG EC D+P+ LE+L Y A VE P VI +++ F+ Sbjct: 140 QEKQAYIERIGSECVAEDIPFFLEILAYD---EKIADAGSVEYAKVKPHKVIGAMKVFSD 196 Query: 182 PEYGVDLLKLESPLAANSLPARDGSTEARAAQKEFDAIGDICRE---RSIPWVLLSGGAA 238 P + +D+LK+E P+ ++ +G E +A + ++P++ LS G + Sbjct: 197 PRFNIDVLKVEVPV---NIKYVEGFAEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVS 253 Query: 239 PEKFERVLDFAYAAGA--GGFLAGRTIWLDAVLKNFPDLTAVS-ASLRKDGLGVLERLNK 295 + F+ L FA+ +GA G L GR W +V D A + +R G ++ LNK Sbjct: 254 AKLFQDTLVFAHESGANFNGVLCGRATWAGSVEAYIKDGEAAARECVRTTGFENIDELNK 313 Query: 296 LTTAKGTPWKAR 307 + T WK R Sbjct: 314 VLQRTATSWKER 325