BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0212.0010.p (535 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 318 2e-86 PA5160 [GEPR] COG0477 Permeases of the major facilitator superfa... 312 2e-84 STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 310 8e-84 emrB [GEPR] COG0477 Permeases of the major facilitator superfami... 302 1e-81 ECs3548 [GEPR] COG0477 Permeases of the major facilitator superf... 302 1e-81 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 318 bits (815), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 173/498 (34%), Positives = 281/498 (56%), Gaps = 17/498 (3%) Query: 31 VSIATFMEVLDTTIANVALRHIAGGLAVGIDESTYVITSYLVANAIVLSISGWLSTVIGR 90 +S+ATFM+VLD+TIANVA+ IAG L + T+VITS+ VANAI + ++GWL+ +G Sbjct: 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGE 77 Query: 91 KRFYMICVGTFAFASLLCGLAWSLEALVLFRIIQGLGGGGMATSEQAILADSFPPAKRGQ 150 R ++ G F AS LCG++ SL L+ FR+IQGL G + Q++L +++PPAKR Sbjct: 78 VRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSM 137 Query: 151 AFAIYGVAVVVAPVIGPTLGGWITDTYSWHWIFLINVPMGLLSLFLVGMLVKEPSGAEQE 210 A A++ + +VVAP+ GP LGG+I+D Y W WIF IN+P+GL+ + L G +K +E Sbjct: 138 ALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLK-----GRE 192 Query: 211 RKQLLKDGLRVDYIGFVLVAIGLGSLEFVLDEGQRKDWFGSNMIVGFAFASAICLIALVP 270 K ++ +D IG VL+ +G+G+L+ +LD+G+ DWF S I+ + + + L+ Sbjct: 193 TKTEIRP---IDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIV 249 Query: 271 WELTRKEPIVDLRLLGRRQFGSCFLVMLCTGAVLISSTQLLPQLLQTELNYTALLAGLAL 330 WELT P++DL L R F L + + + LLPQLLQ YTA AGLA Sbjct: 250 WELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLAS 309 Query: 331 SPGGIVTLILMPVVGHLVSRVQPKYLIAIGGCIVAFSM-WHLTGLNGDITYGYAALARIF 389 +P GI+ ++L P++G R+ + L+ + A W + +G +A + F Sbjct: 310 APVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFF 369 Query: 390 LSAGLPFLFLPVTTASYDGVPPDKTNQASALINVARNIGGSMGVALAQTALAQRQQFHQS 449 + F+P+TT + G+PP++ AS+L N R + GS+G ++ T QR+ H + Sbjct: 370 QGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQRESLHHA 429 Query: 450 RLVEHAAPSDLGYQQTIDTMTRFFQAQGSNASDAASQAVAWVGQILQRQVDLLAYIDVFW 509 +L E P + Q + + +Q QA A++ + + Q +++ ++FW Sbjct: 430 QLTEFVNPYNPNATQAYQELEKLGMSQ--------QQASAYLAREITNQGLIISANEIFW 481 Query: 510 MLSIIGLVMIPLALIIKP 527 + + + L+++ L +P Sbjct: 482 LSAGVFLMLLALIWFARP 499 >PA5160 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 509 Score = 312 bits (799), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 183/497 (36%), Positives = 279/497 (56%), Gaps = 19/497 (3%) Query: 31 VSIATFMEVLDTTIANVALRHIAGGLAVGIDESTYVITSYLVANAIVLSISGWLSTVIGR 90 +S+ATFM+VLDTTIANVAL I+G L V ++ T+VITS+ V+NAI L ++GWL+ +G Sbjct: 19 LSLATFMQVLDTTIANVALPTISGNLGVSSEQGTWVITSFAVSNAIALPLTGWLARRVGE 78 Query: 91 KRFYMICVGTFAFASLLCGLAWSLEALVLFRIIQGLGGGGMATSEQAILADSFPPAKRGQ 150 R ++ F AS LCG+A S+ +LV FR +QG G + Q +L +PPAKRG Sbjct: 79 VRLFIAATLLFVLASFLCGIAQSMPSLVGFRALQGFVAGPLYPITQTLLISIYPPAKRGM 138 Query: 151 AFAIYGVAVVVAPVIGPTLGGWITDTYSWHWIFLINVPMGLLSLFLVGMLVKEPSGAEQE 210 A A+ + VVAP+ GP LGGWITD YSW WIF INVP+GL + F+V +K Sbjct: 139 ALALLAMVTVVAPIAGPILGGWITDDYSWPWIFFINVPVGLFAAFVVYQQLK-------A 191 Query: 211 RKQLLKDGLRVDYIGFVLVAIGLGSLEFVLDEGQRKDWFGSNMIVGFAFASAICLIALVP 270 R ++K +DY+G + + +G+G+L+ VLD+G DWF SN IVG A +AI L + Sbjct: 192 RPVVIKKA-PMDYVGLIALVVGVGALQIVLDKGNDLDWFESNFIVGGALIAAIALAFFII 250 Query: 271 WELTRKEPIVDLRLLGRRQFGSCFLVMLCTGAVLISSTQLLPQLLQTELNYTALLAGLAL 330 WE T + PIV+LRL R F + L ++ A LLPQ LQT++ YTA AGLA Sbjct: 251 WEFTDRHPIVNLRLFAHRNFAAGTLALVLGYAAFFGINLLLPQWLQTQMGYTATWAGLAA 310 Query: 331 SPGGIVTLILMPVVGHLVSRVQPKYLIAIGGCIVAFSMWHLTGLNGDITYGYAALARIFL 390 +P GI+ + L P+VG + + L + +A + + ++ Y + A+ ++ + Sbjct: 311 APIGILPVFLSPLVGRYANHFDLRMLAGLSFLAMAITCFMRANFTTEVDYQHIAIVQLIM 370 Query: 391 SAGLPFLFLPVTTASYDGVPPDKTNQASALINVARNIGGSMGVALAQTALAQRQQFHQSR 450 G+ F F+P+ + +PPD+ S L R +GGS +L +R H + Sbjct: 371 GLGVAFFFMPILSILLSDLPPDQIADGSGLATFLRTLGGSFAASLTTWIWHRRATQHHAY 430 Query: 451 LVEHAAPSDLGYQQTIDTMTRFFQAQGSNASDAASQAVAWVGQILQRQVDLLAYIDVFWM 510 L E+ + D +T+ Q G+ ++AA + +++Q Q +++ ID F M Sbjct: 431 LSENISLYDPATHETLA------QLGGNTQANAAL-----LDRMVQSQAYMMSTIDYFTM 479 Query: 511 LSIIGLVMIPLALIIKP 527 L + L ++ + + +P Sbjct: 480 LGWLFLALLVIIWLARP 496 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 310 bits (793), Expect = 8e-84, Method: Compositional matrix adjust. Identities = 181/508 (35%), Positives = 278/508 (54%), Gaps = 27/508 (5%) Query: 26 LIAFVVSIATFMEVLDTTIANVALRHIAGGLAVGIDESTYVITSYLVANAIVLSISGWLS 85 ++ +S+ATFM+VLD+TIANVA+ IAG L + + T+VITS+ VANAI + ++GWL+ Sbjct: 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLA 73 Query: 86 TVIGRKRFYMICVGTFAFASLLCGLAWSLEALVLFRIIQGLGGGGMATSEQAILADSFPP 145 G + +M FA AS CG++ SL L+ FR++QG+ G + Q++L +++PP Sbjct: 74 KRFGEVKLFMWSTVAFAAASWACGVSSSLNMLIFFRVVQGVVAGPLIPLSQSLLLNNYPP 133 Query: 146 AKRGQAFAIYGVAVVVAPVIGPTLGGWITDTYSWHWIFLINVPMGLLSLFLVGMLVKEPS 205 AKR A A++ + V+VAP+ GP LGG+I+D Y W WIF INVP+G +++ L+ + Sbjct: 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG-IAVVLMTLHTLRGR 192 Query: 206 GAEQERKQLLKDGLRVDYIGFVLVAIGLGSLEFVLDEGQRKDWFGSNMIVGFAFASAICL 265 ER+ R+D +G L+ IG+GSL+ +LD G+ DWF S I+ + I + Sbjct: 193 ETHTERR-------RIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVIAI 245 Query: 266 IALVPWELTRKEPIVDLRLLGRRQFG-SCFLV----MLCTGAVLISSTQLLPQLLQTELN 320 L+ WELT PIVDL L R F C + ML GA++ LLPQLLQ Sbjct: 246 SFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIV-----LLPQLLQEVYG 300 Query: 321 YTALLAGLALSPGGIVTLILMPVVGHLVSRVQPKYLIAIGGCIVAFSM-WHLTGLNGDIT 379 YTA AGLA +P GI+ +IL P++G ++ + L+ + A W + Sbjct: 301 YTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMD 360 Query: 380 YGYAALARIFLSAGLPFLFLPVTTASYDGVPPDKTNQASALINVARNIGGSMGVALAQTA 439 +G +A + + F+P+TT + G+PP++ AS+L N R + GS+G ++ T Sbjct: 361 FGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTM 420 Query: 440 LAQRQQFHQSRLVEHAAPSDLGYQQTIDTMTRFFQAQGSNASDAASQAVAWVGQILQRQV 499 R+ H ++L E S Y TM + G QA W+ Q + Q Sbjct: 421 WTDRESLHHAQLTE----SVTAYNPNAQTMYDKLEGLGMT----HQQASGWIAQQITNQG 472 Query: 500 DLLAYIDVFWMLSIIGLVMIPLALIIKP 527 +++ ++FWM + I LV++ L KP Sbjct: 473 LIISANEIFWMSAGIFLVLLGLVWFAKP 500 >emrB [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 512 Score = 302 bits (774), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 177/519 (34%), Positives = 283/519 (54%), Gaps = 27/519 (5%) Query: 15 ERSAAGGHNPYLIAFVVSIATFMEVLDTTIANVALRHIAGGLAVGIDESTYVITSYLVAN 74 ++ G ++ +S+ATFM+VLD+TIANVA+ IAG L + + T+VITS+ VAN Sbjct: 3 QQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVAN 62 Query: 75 AIVLSISGWLSTVIGRKRFYMICVGTFAFASLLCGLAWSLEALVLFRIIQGLGGGGMATS 134 AI + ++GWL+ +G + ++ FA AS CG++ SL L+ FR+IQG+ G + Sbjct: 63 AISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPL 122 Query: 135 EQAILADSFPPAKRGQAFAIYGVAVVVAPVIGPTLGGWITDTYSWHWIFLINVPMGLLSL 194 Q++L +++PPAKR A A++ + V+VAP+ GP LGG+I+D Y W WIF INVP+G+ + Sbjct: 123 SQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVV 182 Query: 195 FLVGMLVKEPSGAEQERKQLLKDGLRVDYIGFVLVAIGLGSLEFVLDEGQRKDWFGSNMI 254 + ++ ++ + R+D +G L+ IG+GSL+ +LD G+ DWF S I Sbjct: 183 LMTLQTLR--------GRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEI 234 Query: 255 VGFAFASAICLIALVPWELTRKEPIVDLRLLGRRQFG-SCFLV----MLCTGAVLISSTQ 309 + + + + L+ WELT PIVDL L R F C + ML GA++ Sbjct: 235 IILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIV----- 289 Query: 310 LLPQLLQTELNYTALLAGLALSPGGIVTLILMPVVGHLVSRVQPKYLIAIGGCIVAFSM- 368 LLPQLLQ YTA AGLA +P GI+ +IL P++G ++ + L+ + A Sbjct: 290 LLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFY 349 Query: 369 WHLTGLNGDITYGYAALARIFLSAGLPFLFLPVTTASYDGVPPDKTNQASALINVARNIG 428 W + +G +A + + F+P+TT + G+PP++ AS+L N R + Sbjct: 350 WRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLA 409 Query: 429 GSMGVALAQTALAQRQQFHQSRLVEHAAPSDLGYQQTIDTMTRFFQAQGSNASDAASQAV 488 GS+G ++ T R+ H ++L E P + Q + Q +G + QA Sbjct: 410 GSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQ------AMYSQLEGLGMTQ--QQAS 461 Query: 489 AWVGQILQRQVDLLAYIDVFWMLSIIGLVMIPLALIIKP 527 W+ Q + Q +++ ++FWM + I LV++ L KP Sbjct: 462 GWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKP 500 >ECs3548 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 512 Score = 302 bits (774), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 177/519 (34%), Positives = 283/519 (54%), Gaps = 27/519 (5%) Query: 15 ERSAAGGHNPYLIAFVVSIATFMEVLDTTIANVALRHIAGGLAVGIDESTYVITSYLVAN 74 ++ G ++ +S+ATFM+VLD+TIANVA+ IAG L + + T+VITS+ VAN Sbjct: 3 QQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVAN 62 Query: 75 AIVLSISGWLSTVIGRKRFYMICVGTFAFASLLCGLAWSLEALVLFRIIQGLGGGGMATS 134 AI + ++GWL+ +G + ++ FA AS CG++ SL L+ FR+IQG+ G + Sbjct: 63 AISIPLTGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPL 122 Query: 135 EQAILADSFPPAKRGQAFAIYGVAVVVAPVIGPTLGGWITDTYSWHWIFLINVPMGLLSL 194 Q++L +++PPAKR A A++ + V+VAP+ GP LGG+I+D Y W WIF INVP+G+ + Sbjct: 123 SQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVV 182 Query: 195 FLVGMLVKEPSGAEQERKQLLKDGLRVDYIGFVLVAIGLGSLEFVLDEGQRKDWFGSNMI 254 + ++ ++ + R+D +G L+ IG+GSL+ +LD G+ DWF S I Sbjct: 183 LMTLQTLR--------GRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEI 234 Query: 255 VGFAFASAICLIALVPWELTRKEPIVDLRLLGRRQFG-SCFLV----MLCTGAVLISSTQ 309 + + + + L+ WELT PIVDL L R F C + ML GA++ Sbjct: 235 IILTVVAVVAICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIV----- 289 Query: 310 LLPQLLQTELNYTALLAGLALSPGGIVTLILMPVVGHLVSRVQPKYLIAIGGCIVAFSM- 368 LLPQLLQ YTA AGLA +P GI+ +IL P++G ++ + L+ + A Sbjct: 290 LLPQLLQEVYGYTATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFY 349 Query: 369 WHLTGLNGDITYGYAALARIFLSAGLPFLFLPVTTASYDGVPPDKTNQASALINVARNIG 428 W + +G +A + + F+P+TT + G+PP++ AS+L N R + Sbjct: 350 WRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLA 409 Query: 429 GSMGVALAQTALAQRQQFHQSRLVEHAAPSDLGYQQTIDTMTRFFQAQGSNASDAASQAV 488 GS+G ++ T R+ H ++L E P + Q + Q +G + QA Sbjct: 410 GSIGTSITTTMWTNRESMHHAQLTESVNPFNPNAQ------AMYSQLEGLGMTQ--QQAS 461 Query: 489 AWVGQILQRQVDLLAYIDVFWMLSIIGLVMIPLALIIKP 527 W+ Q + Q +++ ++FWM + I LV++ L KP Sbjct: 462 GWIAQQITNQGLIISANEIFWMSAGIFLVLLGLVWFAKP 500