BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0203.0014.p         (186 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

mll3567 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [a...   197   2e-50
Rv3509c [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [a...   181   8e-46
ML0354 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [ac...   181   9e-46
CC0393 Non COG                                                        176   3e-44
PA4901 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [ac...    69   4e-12

>mll3567 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate
           synthase, pyruvate dehydrogenase (cytochrome),
           glyoxylate carboligase, phosphonopyruvate decarboxylase]
           Mlo Mesorhizobium loti
          Length = 517

 Score =  197 bits (500), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 93/127 (73%), Positives = 106/127 (83%)

Query: 1   MNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDKVPGMRCVLGLFEGVVTGAADGYFR 60
           MNGA+ L   L+A  V VCF NPGTSEMHFVAALD+ P MRCVLGLFEGVVTGAADGY R
Sbjct: 1   MNGADVLCDVLLANDVTVCFANPGTSEMHFVAALDRKPEMRCVLGLFEGVVTGAADGYAR 60

Query: 61  MKGTPASTLLHLGPGLANGLANLHNAKKAHSGIVNIVGQHATYHIGYNAPLTSDIEGLAR 120
           M   PA+TLLH GPGLANGLAN+HNA++A S ++NIVG HA+YH+  +APLTSDIEGLA 
Sbjct: 61  MTDRPAATLLHTGPGLANGLANMHNARRAFSPMINIVGDHASYHLPLDAPLTSDIEGLAA 120

Query: 121 PMSSWVR 127
           PMS+WVR
Sbjct: 121 PMSNWVR 127


>Rv3509c [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate
           synthase, pyruvate dehydrogenase (cytochrome),
           glyoxylate carboligase, phosphonopyruvate decarboxylase]
           Mtu Mycobacterium tuberculosis H37Rv
          Length = 515

 Score =  181 bits (459), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 92/138 (66%), Positives = 107/138 (77%), Gaps = 4/138 (2%)

Query: 1   MNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDKVPGMRCVLGLFEGVVTGAADGYFR 60
           MNGA++L+ TLV GGVDVCF NPGTSEMHFVAALD VP MR +L LFEGV TGAADGY R
Sbjct: 1   MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGAADGYAR 60

Query: 61  MKGTPASTLLHLGPGLANGLANLHNAKKAHSGIVNIVGQHATYHIGYNAPLTSDIEGLAR 120
           + G PA+ LLHLGPGL NGLANLHNA++A   +V +VG HATYH  Y+APL SDI+ +A 
Sbjct: 61  IAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDAVAG 120

Query: 121 PMSSWVRTSPDARSAAAD 138
            +S WVR +     AAAD
Sbjct: 121 TVSGWVRRT----EAAAD 134


>ML0354 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate
           synthase, pyruvate dehydrogenase (cytochrome),
           glyoxylate carboligase, phosphonopyruvate decarboxylase]
           Mle Mycobacterium leprae
          Length = 515

 Score =  181 bits (459), Expect = 9e-46,   Method: Compositional matrix adjust.
 Identities = 89/138 (64%), Positives = 103/138 (74%)

Query: 1   MNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDKVPGMRCVLGLFEGVVTGAADGYFR 60
           MNGA++++ TLV GGVDVCF NPGTSEMHFVAALD V GMR VL LFEGV TGAADGY R
Sbjct: 1   MNGAQAMISTLVDGGVDVCFANPGTSEMHFVAALDTVAGMRGVLTLFEGVATGAADGYAR 60

Query: 61  MKGTPASTLLHLGPGLANGLANLHNAKKAHSGIVNIVGQHATYHIGYNAPLTSDIEGLAR 120
           + G PA  LLHLGPGL NGLANLHNA++A   +V +VG HATYH  Y+APL SDI+ LA 
Sbjct: 61  IAGRPAVVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAG 120

Query: 121 PMSSWVRTSPDARSAAAD 138
            +S W+  + D      D
Sbjct: 121 TVSGWLHRTMDTADVGVD 138


>CC0393 Non COG
          Length = 512

 Score =  176 bits (446), Expect = 3e-44,   Method: Compositional matrix adjust.
 Identities = 85/134 (63%), Positives = 101/134 (75%)

Query: 1   MNGAESLVRTLVAGGVDVCFTNPGTSEMHFVAALDKVPGMRCVLGLFEGVVTGAADGYFR 60
           MNGA++L+ TL   GV  CF NPGTSEM FV+ALD+ P MR VL LFEGV TGAADGY R
Sbjct: 1   MNGADALITTLADNGVTACFANPGTSEMQFVSALDREPRMRSVLCLFEGVATGAADGYGR 60

Query: 61  MKGTPASTLLHLGPGLANGLANLHNAKKAHSGIVNIVGQHATYHIGYNAPLTSDIEGLAR 120
           M G PA TLLHLGPG ANG ANLHNA++A + +VN++G HATYH  ++APL SDI  LA 
Sbjct: 61  MAGKPACTLLHLGPGYANGAANLHNARRAFTPVVNVIGDHATYHRDFDAPLNSDIAALAA 120

Query: 121 PMSSWVRTSPDARS 134
           P S WV+++  A S
Sbjct: 121 PNSVWVKSAETADS 134


>PA4901 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate
           synthase, pyruvate dehydrogenase (cytochrome),
           glyoxylate carboligase, phosphonopyruvate decarboxylase]
           Pae Pseudomonas aeruginosa
          Length = 528

 Score = 69.3 bits (168), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 43/112 (38%), Positives = 56/112 (50%), Gaps = 3/112 (2%)

Query: 15  GVDVCFTNPGTSEMHFVAALDKVPGMRCVLGLFEGVVTGAADGYFRMKGTPASTLLHLGP 74
           G+   F NPG++E+ F+   D     R +LGL EG V G ADG+    G PA   LH   
Sbjct: 16  GLTTVFGNPGSNELPFLK--DFPEDFRYILGLHEGAVVGMADGFALASGRPAFVNLHAAA 73

Query: 75  GLANGLANLHNAKKAHSGIVNIVGQHATYHIGYNAPLTS-DIEGLARPMSSW 125
           G  NG+  L NA  +HS +V   GQ     IG  A L + D   L +P+  W
Sbjct: 74  GTGNGMGALTNAWYSHSPLVITAGQQVRSMIGVEAMLANVDAGQLPKPLVKW 125