BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0200.0092.p (430 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 164 5e-40 SSO2127 [GEPR] COG0477 Permeases of the major facilitator superf... 151 3e-36 TVN1396 [GEPR] COG0477 Permeases of the major facilitator superf... 145 2e-34 VCA0554 [GEPR] COG0477 Permeases of the major facilitator superf... 125 2e-28 Ta0197 [GEPR] COG0477 Permeases of the major facilitator superfa... 125 3e-28 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 164 bits (414), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 119/389 (30%), Positives = 199/389 (51%), Gaps = 25/389 (6%) Query: 40 YGWTFFVPDIQKKFGWDRASIQWAFTLFVL-FETWLVPVEGWFVDKYGPRIVVLVGGILC 98 Y W+ FV + FGW + F++F+L F +VP G D+ GPR V ++GG+L Sbjct: 22 YAWSVFVNPLMNTFGWSKTIASLPFSIFLLIFALMMVP-AGRTQDRIGPRKVAMLGGVLL 80 Query: 99 ALGWAINAQATTLNGYYLGM----IIAGIGAGGVYGTCVGNALKWFPDKRGLAAGITAAG 154 +G+ ++ ++ Y + +IAG G G Y + A KWFP++ GLA G+ G Sbjct: 81 GVGFLLSGLIESIQSPYWLIFSYGVIAGAGCGLGYACPIPVARKWFPERVGLATGLVVMG 140 Query: 155 FGAGSALTVAPIQAMIKDS-GFQTTFLYFGLGQGIIIVLLSFFLLAPKAGQVPAVVAN-- 211 FG SAL AP++ ++ D+ G TTF G+ I+ V + L P ++PAV A+ Sbjct: 141 FGM-SALIFAPLERILIDTYGISTTFYILGVILLIVAVFAASLLSNPP--ELPAVQASNP 197 Query: 212 --ANIIQTRRNYQPTEVLRQPIFWLMYFMFVIVGAGGLMVTANLKPIAVDWKVDSVPVTL 269 ++ + P+E+LR F++++ F + GLMV ++ P A + ++ + Sbjct: 198 AKVEVVTGKPELGPSEMLRDYRFYVLWLSFFFMALAGLMVIGHIAPYAQERGLEPL---- 253 Query: 270 MAVTMTAVTFAATIDRVLNGLTRPFFGWISDMIGRENTMFIAFGMEGIGIWMLYLWGHDP 329 A FA +I V N + RP G +SD IGR TMF+ F ++GI + Sbjct: 254 ------AAAFAVSILSVANAVGRPGAGALSDKIGRAMTMFVLFLIQGITLIAFPHVALTL 307 Query: 330 VWFVLLSGFVFFAWGEIYSLFPSTCTDTFGAKFATTNAGLLYTAKGTAALLVPI-ANYMQ 388 + + + + F +G +SLFPS D FG K N GL++T+ G L+ PI A Y+ Sbjct: 308 ITIYICAAIIGFNYGANFSLFPSATGDFFGTKNLGVNYGLVFTSYGVGGLVGPIMAGYVF 367 Query: 389 QSSGNWDKVFIIAAGANILASLLAIALLK 417 +G+++ F++A ++A+ ++ L + Sbjct: 368 DVTGSYEIAFLVAGVLALIAAFMSFLLRR 396 >SSO2127 [GEPR] COG0477 Permeases of the major facilitator superfamily Sso Sulfolobus solfataricus Length = 430 Score = 151 bits (382), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 125/420 (29%), Positives = 205/420 (48%), Gaps = 22/420 (5%) Query: 20 YRWTQLAIGVAAMVMIANYQYGWTFFVPDIQKKFGWDRAS--IQWAFTLFVLFETWLVPV 77 +RW + +M +++ Y+Y WT + + + F S + +T++++ + + V Sbjct: 12 FRWMLVVGATISMALVSVYEYSWTLYTVPLGRVFHVAPGSPALGLTYTIYIIVQALSMFV 71 Query: 78 EGWFVDKYGPRIVVLVGGILCALGWAINAQATTLNGYYLGMIIAGIGAGGVYGTCVGNAL 137 G D+YGPR++ ++GGI+ +G+ +A A +L YL IG G +YGT + A+ Sbjct: 72 AGRIADRYGPRLISMLGGIITGIGYISSAFAKSLPILYLTYGFGSIGVGIIYGTAISTAV 131 Query: 138 KWFPDKRGLAAGITAAGFGAGSALTVAPIQAMIKDSGFQTTFLYFGLGQGIIIVLLSFFL 197 KWFPDKRGLA GI GFG GS IQ +I + F Y G+ Q I+I LL+FF Sbjct: 132 KWFPDKRGLATGIIEIGFGGGSFALSPLIQYIITSISYTAAFTYMGIVQLIVITLLAFFF 191 Query: 198 LAPKAGQVPA-------VVANANIIQTRRNYQPTEVLRQPIFWLMYFMFVIVGAGGLMVT 250 P +P I +++ +Y +++++ +W++Y F ++ GL + Sbjct: 192 AYPPPQWLPKGFNAEEYEKKRKMIKRSKNDYTVSQMVKTWQWWVIYIAFFLIAGSGLSII 251 Query: 251 ANLKPIAVDWKVDSVPVTLMAVTMTAVTFAATIDRVLNGLTRPFFGWISDMIGRENTMFI 310 +L P S+ ++ AV A + NGL R G +SD +GR TM + Sbjct: 252 GHLIPYG-----RSLGFSIAAV------IAVFLFPFANGLGRFVMGTVSDYLGRPYTMTL 300 Query: 311 AFGMEGIGIWMLYLWGHDPVWFVLLSGFVFFAWGEIYSLFPSTCTDTFGAKFATTNAGLL 370 +FG+ GI + + ++ L F WG ++SLFP D +G K + N GL Sbjct: 301 SFGISGISMLSIAFIPKIASLYLALIFLTAFTWGPLFSLFPPLVGDYYGPKHSGANYGLT 360 Query: 371 YTAKGTAALLVPIANYMQQSSGNWDKVFIIAAGANILASLLAIALLKPWRKIVVAKSATA 430 YTAK A + + +S + II I++++LA+ L P KI A+ A A Sbjct: 361 YTAKALAGIFAGYGASILFTSYGIKETLIITGSMAIMSAILALTLRPP--KIPTAQIAGA 418 >TVN1396 [GEPR] COG0477 Permeases of the major facilitator superfamily Tvo Thermoplasma volcanium Length = 375 Score = 145 bits (366), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 36/354 (10%) Query: 29 VAAMVMIAN--YQYGWTFFVPDIQKKFGWDRASIQWAFTLFVLFETWLVPVEGWFVDKYG 86 +A +VM N YQY W F P + K FG + S+Q AFTLF +F T + G+F D+ G Sbjct: 8 IALLVMCFNSLYQYSWNVFEPLLAKGFGVEIVSVQIAFTLFAVFSTTFQGIGGYFADRDG 67 Query: 87 PRIVVLVGGILCALGWAINAQATTLNGYYLGMIIAGIGAGGVYGTCVGNALKWFPDKRGL 146 PR V + ++ A G+ ++ ++ +Y+ I IG G +YG A+KW+ +RG Sbjct: 68 PRNVSIAAALMSAFGFVASSLVHSIYLFYVIWSIGSIGEGILYGIATNLAVKWYSGRRGF 127 Query: 147 AAGITAAGFGAGSALTVAPIQAMIKDSGFQTTFLYFGLGQGIIIVLLSFFLLAPKAGQVP 206 A G + GFG GS++ ++ K S F+ ++ GL + I++ LL F+ P +G Sbjct: 128 AVGFVSLGFGLGSSIANIFLE---KASEFRFPMMFIGLAELIVLPLLLSFVKYPSSGLT- 183 Query: 207 AVVANANIIQTRRNYQPTEVLRQPIFWLMYFMFVIVGAGGLMVTANLKPIAVDWKVDSVP 266 +P+ ++ P FW++Y FV G+ L+V ++ + + +P Sbjct: 184 -------------GERPSRNIKNPRFWILYLSFVF-GSIPLIVISS----SFGFIGSKLP 225 Query: 267 VTLMAVTMTAVTFAATIDRVLNGLTRPFFGWISDMIGRENTMFIAFGMEGIGIWMLYLWG 326 AV + +I +L+G++RP G ISD IGR ++ + I I L+L Sbjct: 226 ELEFAVLV-------SIFPLLSGISRPIIGAISDAIGRPASVLLI--DVAIFIGALFLVL 276 Query: 327 HDPVWFVLLSGFVFFAWGEIYSLFPSTCTDTFGAKFATTNAGLLYTAKGTAALL 380 + ++ V+L GF G + SL+ S D FG +F+T N G+ YT K + + Sbjct: 277 RNFIFAVVLIGFF---GGSMISLYFSLIGDVFGTRFSTANNGIFYTGKAVSGFM 327 >VCA0554 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 410 Score = 125 bits (314), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 117/402 (29%), Positives = 190/402 (47%), Gaps = 27/402 (6%) Query: 40 YGWTFFVPDIQKKFGWDRASIQWAFTLFVLFETWLVPVEGWFVDKYGPRIVVLVGGILCA 99 Y W+ F + FGW A + + + + + V G D+ GPR ++++G L Sbjct: 25 YAWSVFNKALVTDFGWSAADASSPYAIATIAFSVCLLVAGILQDRMGPRNILILGTTLTG 84 Query: 100 LGWAINAQATT---LNGYYLGMIIAGIGAGGVYGTCVGNALKWF-PDKRGLAAGITAAGF 155 LG + A++ LN + M AGIG G Y +A+KWF P K+G+ G+ AAGF Sbjct: 85 LGMIASGFASSVLMLNLTFGVMTGAGIGFG--YACLSPSAMKWFHPSKKGMVNGLIAAGF 142 Query: 156 GAGSALTVAPI-QAMIKDSGFQTTFLYFGLGQGIIIVLLSFFLLAPKAGQVPA-----VV 209 G +A+ +AP+ A+I G QT+F+ G G I V L+ + P AG VPA Sbjct: 143 GL-AAIYLAPLTSALITHLGIQTSFMILGAGVLAIAVPLACTINNPPAGYVPAEPKLKAG 201 Query: 210 ANANIIQTRRNYQPTEVLRQPIFWLMYFMFVIVGAGGLMVTANLKPIAVDWKVDSVPVTL 269 A ++ N +L+ P F+ ++ M+ + + GLM+ N+ IA SV L Sbjct: 202 QEAKVVAKVANLSWKAMLKTPQFYALWLMYALAASVGLMIIGNITNIA------SVQANL 255 Query: 270 MAVTMTAVTFAATIDRVLNGLTRPFFGWISDMIGRENTMFIAFGMEGIGIWMLYLWGHDP 329 + A+I + N R G +SD IG T+ +AF ++G G +L+ Sbjct: 256 -----PNAVYLASILAIFNSGGRVAAGILSDKIGGVRTLLLAFLLQG-GNMVLFATFDSE 309 Query: 330 VWFVLLSGFVFFAWGEIYSLFPSTCTDTFGAKFATTNAGLLYTAKGT-AALLVPIANYMQ 388 ++ + +G + ++FPS + +G K TN G+LYT+ G A+ + Y Sbjct: 310 FTLIIGTAIAAVGYGTLLAVFPSITAEFYGLKNYGTNYGVLYTSWGIGGAIGAAVVGYSM 369 Query: 389 QSSGNWDKVFIIAAGANILASLLAIALLKPWRKIVVAKSATA 430 G ++ + I+A + LLA+ + KP VA+ TA Sbjct: 370 THGGGYNLAYTISAAMMAVCILLAL-ITKPISAEKVAQLQTA 410 >Ta0197 [GEPR] COG0477 Permeases of the major facilitator superfamily Tac Thermoplasma acidophilum Length = 371 Score = 125 bits (313), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 100/363 (27%), Positives = 172/363 (47%), Gaps = 48/363 (13%) Query: 25 LAIGVAAMVMIANYQYGWTFFVPDIQKKFGWDRASIQWAFTLFVLFETWLVPVEGWFVDK 84 L I + M M + YQY W P I ++ AFTLF +F T V G+F D+ Sbjct: 6 LVIALVVMSMNSLYQYSWNVLEPMISIDLHTSTVYVEVAFTLFTVFSTTFQGVGGYFADR 65 Query: 85 YGPRIVVLVGGILCALGWAINAQATTLNGYYLGMIIAGIGAGGVYGTCVGNALKWFPDKR 144 GP + ++ IL A G+ + ++ +Y I IG G +YG A+KW+ + R Sbjct: 66 DGPARIGMISAILSAFGFLGGSFVHSIYEFYAVWSIGSIGEGILYGIATNLAVKWYSNIR 125 Query: 145 GLAAGITAAGFGAGSALTVAPIQAMIKDSGFQTTFLYFGLGQGIIIVLLSFFLLAPK--- 201 G A GI + GFG GS +VA + ++ +GF+ L GL + +++ +L + P Sbjct: 126 GFAVGIVSLGFGLGS--SVANV-FLVHATGFRAPMLIIGLMEIVLMPILMYLTRYPGTSL 182 Query: 202 AGQVPAVVANANIIQTRRNYQPTEVLRQPIFWLMYFMFVIVGAGGLMVTANLKPIAVDWK 261 G+ P RRN L P+FW++Y FV L+++++ I Sbjct: 183 TGERP-----------RRN------LSSPVFWILYASFVFGSVPLLVISSSFGYIG--RH 223 Query: 262 VDSVPVTLMAVTMTAVTFAATIDRVLNGLTRPFFGWISDMIGRENTMFIAFGMEGIGIWM 321 + ++ +L+ +I +++G++RP GW+SD IGR ++ + I +++ Sbjct: 224 LPALEFSLL----------VSIFPLMSGISRPMIGWLSDRIGRSASVMM------IDVFI 267 Query: 322 L----YLWGHDPVWFVLLSGFVFFAWGEIYSLFPSTCTDTFGAKFATTNAGLLYTAKGTA 377 + +L + +++ GF G + SL+ S D FG +F+T N G+ YT K + Sbjct: 268 IAGSAFLVARQYIPAIVIIGFF---GGSMISLYFSYIGDVFGTRFSTANNGVFYTGKSIS 324 Query: 378 ALL 380 + Sbjct: 325 GFI 327