BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0200.0067.p (236 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMb20210 [IQR] COG1028 Dehydrogenases with different specificiti... 331 7e-91 CAC3574 [IQR] COG1028 Dehydrogenases with different specificitie... 132 6e-31 AF1207 [IQR] COG1028 Dehydrogenases with different specificities... 131 1e-30 STM1195 [IQR] COG1028 Dehydrogenases with different specificitie... 129 8e-30 fabG [IQR] COG1028 Dehydrogenases with different specificities (... 128 1e-29 >SMb20210 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 237 Score = 331 bits (849), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 159/235 (67%), Positives = 190/235 (80%) Query: 1 MGAEQKVAIITGASQGLGEAIVKGYRDRNWRVVANSRSIKPSTDSDVLTVAGDIGDPEVA 60 M +QKV +ITGASQG+G +V+ YRDRN+RVVA SRSIKPS D D+ TVAGDI PE A Sbjct: 1 MRNQQKVVVITGASQGIGAGLVRAYRDRNYRVVATSRSIKPSADPDIHTVAGDISKPETA 60 Query: 61 DRIVKQALGRFGRIDTLVNNAGIFLAKPFTDYTDQDYAQVLATNLNGFFYITRRVAREME 120 DRIV++ + RFGRID+LVNNAG+FLAKPF + T +DY L N+ GFF+IT+R A EM Sbjct: 61 DRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFHITQRAAAEML 120 Query: 121 KQGSGHIVQITTSLVDHANSNVPSVLASLTKGGLNAATKSLAIEYAAKGIRVNAVSPGVI 180 KQGSGHIV ITTSLVD +PS LASLTKGGLNA T+SLA+E++ G+RVNAVSPGVI Sbjct: 121 KQGSGHIVSITTSLVDQPMVGMPSALASLTKGGLNAVTRSLAMEFSRSGVRVNAVSPGVI 180 Query: 181 RTPMHAPATHDFLARQHPVGRMGEAKDIVDAVLFLENSGFVTGEILHVDGGQSAG 235 +TPMH TH LA HPVGRMGE +D+VDAVL+LE++GF+TGEILHVDGGQ+AG Sbjct: 181 KTPMHPAETHSTLAGLHPVGRMGEIRDVVDAVLYLEHAGFITGEILHVDGGQNAG 235 >CAC3574 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 249 Score = 132 bits (332), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 85/242 (35%), Positives = 131/242 (54%), Gaps = 17/242 (7%) Query: 6 KVAIITGASQGLGEAIVKGYRDRNWRVVANSRSIKPSTD----------SDVLTVAGDIG 55 KVA++TGA +GLG AI +V N RS + T S + V DI Sbjct: 8 KVAVVTGAGRGLGRAIALKLAAEGANLVVNYRSSEAETQKLIKEIEELGSKAVAVKADIS 67 Query: 56 DPEVADRIVKQALGRFGRIDTLVNNAGIFLAKPFTDYTDQDYAQVLATNLNGFFYITRRV 115 + A+ I+K+AL +G +D LVNNAGI ++D+ V+ NL G F + Sbjct: 68 KYDEAETIIKKALDEYGTVDILVNNAGITKDNLLLRMKEEDFDSVINVNLKGAFNCIKHT 127 Query: 116 AREMEKQGSGHIVQITTSLVDHANSNVPSVLASLTKGGLNAATKSLAIEYAAKGIRVNAV 175 +R M K+ SG I+ I++ V N V + K G+ TKS+A E A++GI VNAV Sbjct: 128 SRVMLKKKSGKIINISS--VIGLIGNAGQVNYAAAKAGIIGMTKSVAKELASRGITVNAV 185 Query: 176 SPGVIRTPMHAPAT---HDFLARQHPVGRMGEAKDIVDAVLFLEN--SGFVTGEILHVDG 230 +PG+I++ M T + + P+ ++GEA+D+ + VLFL + S ++TG++++VDG Sbjct: 186 APGIIKSDMTDALTDKQRESIVAAVPLNKVGEAEDVANLVLFLASDLSSYITGQVINVDG 245 Query: 231 GQ 232 G Sbjct: 246 GM 247 >AF1207 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Afu Archaeoglobus fulgidus Length = 281 Score = 131 bits (330), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 21/247 (8%) Query: 6 KVAIITGASQGLGEAIVKGYRDRNWRVVANSR------SIKPSTDS---DVLTVAGDIGD 56 KVAI+TGA+ GLG I G D VV R +K S + L V DI Sbjct: 36 KVAIVTGATGGLGGPIALGLADFGCDVVVVGRRLEVLEKLKESIEKLGQRALAVKCDITS 95 Query: 57 PEVADRIVKQALGRFGRIDTLVNNAGIFLAKPFTDYTDQDYAQVLATNLNGFFYITRRVA 116 E +V + + FGRID LVN AGI + KP +Y +D+ +V+ N+ G F + R V Sbjct: 96 EEDVANLVNRTVEEFGRIDILVNCAGINIPKPAEEYPLEDWNKVMDANVTGVFLVCREVG 155 Query: 117 REMEKQGSGHIVQITTSLVDHANSNVPS--VLASLTKGGLNAATKSLAIEYAAKGIRVNA 174 + M KQ G I+ +++ ++ +P + +K +N TK LA E+A I VNA Sbjct: 156 KVMVKQNGGKIINVSSV---RSSYGMPKNYIAYCSSKAAVNMITKQLACEWAKYNILVNA 212 Query: 175 VSPGVIRTPMHA-----PATHDFLARQHPVGRMGEAKDIVDAVLFL--ENSGFVTGEILH 227 ++P VI TP+ A P + + +GR G D++ AV+F + S FVTG+IL+ Sbjct: 213 IAPTVIATPLTAHIMKDPELSKTMKSRILLGRWGYPDDLIGAVVFFASDASNFVTGQILY 272 Query: 228 VDGGQSA 234 +DGG ++ Sbjct: 273 IDGGVTS 279 >STM1195 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sty Salmonella typhimurium LT2 Length = 244 Score = 129 bits (323), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 85/243 (34%), Positives = 131/243 (53%), Gaps = 13/243 (5%) Query: 1 MGAEQKVAIITGASQGLGEAIVKGYRDRNWRVVANSRSIKPSTD-SDVLTVAG-----DI 54 M E K+A++TGAS+G+G AI + R +V+ + S + + SD L G ++ Sbjct: 1 MSFEGKIALVTGASRGIGRAIAETLVARGAKVIGTATSENGAKNISDYLGANGKGLMLNV 60 Query: 55 GDPEVADRIVKQALGRFGRIDTLVNNAGIFLAKPFTDYTDQDYAQVLATNLNGFFYITRR 114 DP + +++ FG +D LVNNAGI D ++ ++ TNL+ F +++ Sbjct: 61 TDPASIESVLENIRAEFGEVDILVNNAGITRDNLLMRMKDDEWNDIIETNLSSVFRLSKA 120 Query: 115 VAREMEKQGSGHIVQITTSLVDHANSNVPSVLASLTKGGLNAATKSLAIEYAAKGIRVNA 174 V R M K+ G I+ I + + N+ + A+ K GL +KSLA E A++GI VN Sbjct: 121 VMRAMMKKRCGRIITIGSVVGTMGNAGQANYAAA--KAGLIGFSKSLAREVASRGITVNV 178 Query: 175 VSPGVIRTPMHAPATHDFLA---RQHPVGRMGEAKDIVDAVLFL--ENSGFVTGEILHVD 229 V+PG I T M + D A Q P GR+G A++I AV FL + + ++TGE LHV+ Sbjct: 179 VAPGFIETDMTRALSDDQRAGILAQVPAGRLGGAQEIASAVAFLASDEASYITGETLHVN 238 Query: 230 GGQ 232 GG Sbjct: 239 GGM 241 >fabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Eco Escherichia coli K12 Length = 244 Score = 128 bits (322), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 85/243 (34%), Positives = 132/243 (54%), Gaps = 13/243 (5%) Query: 1 MGAEQKVAIITGASQGLGEAIVKGYRDRNWRVVANSRSIKPSTD-SDVLTVAG-----DI 54 M E K+A++TGAS+G+G AI + R +V+ + S + SD L G ++ Sbjct: 1 MNFEGKIALVTGASRGIGRAIAETLAARGAKVIGTATSENGAQAISDYLGANGKGLMLNV 60 Query: 55 GDPEVADRIVKQALGRFGRIDTLVNNAGIFLAKPFTDYTDQDYAQVLATNLNGFFYITRR 114 DP + ++++ FG +D LVNNAGI D+++ ++ TNL+ F +++ Sbjct: 61 TDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKA 120 Query: 115 VAREMEKQGSGHIVQITTSLVDHANSNVPSVLASLTKGGLNAATKSLAIEYAAKGIRVNA 174 V R M K+ G I+ I + + N + A+ K GL +KSLA E A++GI VN Sbjct: 121 VMRAMMKKRHGRIITIGSVVGTMGNGGQANYAAA--KAGLIGFSKSLAREVASRGITVNV 178 Query: 175 VSPGVIRTPMHAPATHDFLA---RQHPVGRMGEAKDIVDAVLFL--ENSGFVTGEILHVD 229 V+PG I T M + D A Q P GR+G A++I +AV FL + + ++TGE LHV+ Sbjct: 179 VAPGFIETDMTRALSDDQRAGILAQVPAGRLGGAQEIANAVAFLASDEAAYITGETLHVN 238 Query: 230 GGQ 232 GG Sbjct: 239 GGM 241