BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0197.0002.p (273 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv2307c [R] COG1073 Hydrolases of the alpha/beta superfamily Mtu... 131 2e-30 MT2364 [R] COG1073 Hydrolases of the alpha/beta superfamily MtC ... 129 6e-30 SMa0171 [R] COG1073 Hydrolases of the alpha/beta superfamily Sme... 116 4e-26 all8511 [R] COG1073 Hydrolases of the alpha/beta superfamily Nos... 107 4e-23 STM2547 [R] COG1073 Hydrolases of the alpha/beta superfamily Sty... 96 9e-20 >Rv2307c [R] COG1073 Hydrolases of the alpha/beta superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 281 Score = 131 bits (330), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/274 (33%), Positives = 148/274 (54%), Gaps = 10/274 (3%) Query: 4 LALAILKWLLIAAVVIYLGGLVALYV--KQRELLFPIPPVGRTAPAAAGLPEAKEHVLTT 61 ++L + L + A+V + V +++ +QR L++ P G A++ LP ++ V+ T Sbjct: 1 MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIY-FPSAGPVPSASSVLPAGRDVVVET 59 Query: 62 GDGEKVIVWHVPAKPGR--PVVLFFHGNGDFLAGRVARFKAITADGTGLVALSFHGYAGS 119 DG ++ W+ P G P VL +GN + R A+ G ++ + GY G+ Sbjct: 60 QDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGN 119 Query: 120 SGSPSEQGLLQDAAAAYAFATARYRAE--QIVAWGFSLGTGVAVALAAEHPLGKLILEAP 177 G PSEQGL DA AA + + + + +I +G SLG VAV LA + P L+L +P Sbjct: 120 PGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSP 179 Query: 178 YTSTADVAGAHFWYVPVRLLMRDQFHSDRLIARVKAPLLIMHGADDPVIPIRFGERLFGL 237 +TS A+V H+ ++P+R L+ D + S IA V AP+L++ G D ++P ERL Sbjct: 180 FTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAA 239 Query: 238 AHEPRQFVRLPGGGHDN---LDDFGAMATARRFI 268 A EP+++V +PG GH++ LD + RRF+ Sbjct: 240 AAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFL 273 >MT2364 [R] COG1073 Hydrolases of the alpha/beta superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 281 Score = 129 bits (325), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 88/263 (33%), Positives = 138/263 (52%), Gaps = 7/263 (2%) Query: 13 LIAAVVIYLGGLVALYVKQRELLFPIPPVGRTAPAAAGLPEAKEHVLTTGDGEKVIVWHV 72 ++A V + G++ Q+ L P G A++ LP ++ V+ T DG ++ W+ Sbjct: 11 VVAIVALVASGVITFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYF 70 Query: 73 PAKPGR--PVVLFFHGNGDFLAGRVARFKAITADGTGLVALSFHGYAGSSGSPSEQGLLQ 130 P G P VL +GN + R A+ G ++ + GY G+ G PSEQGL Sbjct: 71 PHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAA 130 Query: 131 DAAAAYAFATARYRAE--QIVAWGFSLGTGVAVALAAEHPLGKLILEAPYTSTADVAGAH 188 DA AA + + + + +I G SLG VAV LA + P L+L +P+TS A+V H Sbjct: 131 DARAAQEWLSGQSDVDPARIAYXGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVH 190 Query: 189 FWYVPVRLLMRDQFHSDRLIARVKAPLLIMHGADDPVIPIRFGERLFGLAHEPRQFVRLP 248 + ++P+R L+ D + S IA V AP+L++ G D ++P ERL A EP+++V +P Sbjct: 191 YPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVP 250 Query: 249 GGGHDN---LDDFGAMATARRFI 268 G GH++ LD + RRF+ Sbjct: 251 GVGHNDPELLDGRVMLDAIRRFL 273 >SMa0171 [R] COG1073 Hydrolases of the alpha/beta superfamily Sme Sinorhizobium meliloti Length = 254 Score = 116 bits (291), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 79/200 (39%), Positives = 111/200 (55%), Gaps = 6/200 (3%) Query: 16 AVVIYLGGLVALYVKQRELLFPIPPVGRTA-PAAAGLPEAKEHVLTTGDGEKVIVWHVPA 74 A Y+ + Y+ QR LL+P G +A PA + + T DGE + + Sbjct: 14 AAFAYISLVSLTYLSQRALLYP----GASATPAPERASWGQNASIQTPDGETLHGLYSRG 69 Query: 75 KPGRPVVLFFHGNGDFLAGRVARFKAITADGTGLVALSFHGYAGSSGSPSEQGLLQDAAA 134 +PG+P VLFF GN D ++ +A+ A G GL+ALS+ GY GSSG+P+E GLL D A Sbjct: 70 EPGQPSVLFFLGNADRVSNYGFFAQALAARGIGLLALSYRGYPGSSGTPNEHGLLIDGIA 129 Query: 135 AYAFATARYRAEQIVAWGFSLGTGVAVALAAEHPLGKLILEAPYTSTADVAGAHFWYVPV 194 A+ + AR +IV G SLG+GVAV A + P +IL + Y S +A ++ + PV Sbjct: 130 AFDWLAAR-SGNEIVVLGQSLGSGVAVDTAGKRPAVAVILVSAYLSVLSLAQTYYPFFPV 188 Query: 195 RLLMRDQFHSDRLIARVKAP 214 LL +D F SD IA V+ P Sbjct: 189 ALLTKDPFRSDLKIAGVRQP 208 >all8511 [R] COG1073 Hydrolases of the alpha/beta superfamily Nos Nostoc sp. PCC 7120 Length = 245 Score = 107 bits (266), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 109/210 (51%), Gaps = 13/210 (6%) Query: 59 LTTGDGEKVIVWHVPAKPGRPVVLFFHGNGDFLAGRVARFKAITAD-GTGLVALSFHGYA 117 L +G K+ H+ + +++ HGN + L G + +F D G ++A + GY Sbjct: 28 LKSGGETKISAVHLVNPTAKYTIIYAHGNAEDL-GEIRQFLEQLRDLGFNVLAYDYRGYG 86 Query: 118 GSSGSPSEQGLLQDAAAAYAFATARYRA--EQIVAWGFSLGTGVAVALAAEHPLGKLILE 175 S+G P+E QD AAY + T + + I+ +G S+G G AV LAA P+G LI+E Sbjct: 87 TSAGRPTENNAYQDIDAAYNYLTKDLKILPKNIIVFGRSVGGGSAVDLAARQPVGGLIIE 146 Query: 176 APYTSTADVAGAHFWYVPVRLLMRDQFHSDRLIARVKAPLLIMHGADDPVIPIRFGERLF 235 + +TS V VP+++L D+F++ I +V P+LIMHG D +IP ++L+ Sbjct: 147 STFTSAFQVV------VPIKILPFDKFNNLEKIKKVNCPVLIMHGQADEIIPFTHAQKLY 200 Query: 236 GLAHEPRQFVRLPGGGHDNLDDFGAMATAR 265 + P+ + + H +DF +A R Sbjct: 201 AASPSPKLKLWVDNASH---NDFYGVAGQR 227 >STM2547 [R] COG1073 Hydrolases of the alpha/beta superfamily Sty Salmonella typhimurium LT2 Length = 292 Score = 95.9 bits (237), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 82/265 (30%), Positives = 121/265 (45%), Gaps = 39/265 (14%) Query: 12 LLIAAVVIYLGGLVALYVKQRELLFPIPPVGRTAPAAAGLPEAKEHVLTTGDGEKVIVWH 71 L I V IYL VA+ +P V PA EA+ T DG + W Sbjct: 16 LFIIVVCIYLLPRVAI----NAFYYPDNKVYGPTPA-----EAESITFTAKDGTHLHGWF 66 Query: 72 VPAKPGRP-----VVLFFHGNGDFLAGRVARFKAITADGTGLVALSFHGYAGSSGSPSEQ 126 +P GRP V+ HGN ++ + L + G+ S G+PS++ Sbjct: 67 IPTAFGRPENAVATVIHVHGNAGNMSAHWPLVSWLPERNVNLFMFDYRGFGESEGTPSQE 126 Query: 127 GLLQDAAAAYAFATARYRA----EQIVAWGFSLGTGVAVALAAEHPLG------------ 170 GLL D +A + R+RA E++V G SLG G V A H +G Sbjct: 127 GLLDDTKSAIDYV--RHRADVNPERLVLLGQSLG-GNNVLAAVGHCVGCANMRYADQAGI 183 Query: 171 -KLILEAPYTSTADVAGAHFWYVPVR-LLMRDQFHSDRLIARVK-APLLIMHGADDPVIP 227 +IL++ + S + +A +P L+ D++ +DR IA V P+LI+HG D VIP Sbjct: 184 RAIILDSTFLSYSSIANQ---MIPGSGYLLDDRYSADRNIASVSPIPVLILHGTADHVIP 240 Query: 228 IRFGERLFGLAHEPRQFVRLPGGGH 252 + E+L+ LA EP+Q + +P G H Sbjct: 241 WQDSEKLYALAREPKQKIFIPDGDH 265