BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0195.0046.p (442 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC2354 [GEPR] COG0477 Permeases of the major facilitator superfa... 349 9e-96 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 345 1e-94 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 345 1e-94 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 343 5e-94 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 343 5e-94 >CC2354 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 430 Score = 349 bits (895), Expect = 9e-96, Method: Compositional matrix adjust. Identities = 187/421 (44%), Positives = 267/421 (63%), Gaps = 11/421 (2%) Query: 2 SDDVEKRAIGKMMRRLIPFLILCYFVAYLDRVNVGFAKLHMNAALGLSEAAYGLGAGLFF 61 S +E+ +G++ RRL+P L Y +AY+DR NV +AKL M +ALGLSEAAYGLGA LFF Sbjct: 5 SSALERATVGRVTRRLMPLFCLMYLIAYIDRQNVSYAKLDMVSALGLSEAAYGLGASLFF 64 Query: 62 IGYFFFEVPSNILLERFGARRWIARIMISWGIVSAAFAFIPQMSAASGLSSEWIFYFLRL 121 IGYF FE P+N++L R GAR W ARIM SWG+V+ A F + +FY LR Sbjct: 65 IGYFLFEAPANLILARVGARVWFARIMFSWGLVTLALGFTQNAA---------MFYVLRF 115 Query: 122 LLGACEAGFFPGIIFYLTLWFPSVYRARVISLFMLAIPISSIIGAPISGLLLNLSG-AGL 180 LLG EAGFFPG+++ LTLW+P +RAR++ LFM+A ++ +GA I GLLL + G GL Sbjct: 116 LLGVAEAGFFPGVLYVLTLWYPQAHRARMVGLFMIASAFANAVGAAIGGLLLGMDGFLGL 175 Query: 181 TGWQWLFVCEALPSVLVGFAVLTFLPDFPRQASWLQPDEVKWIQTTLERERQQTEAVEHI 240 GWQW+F+ P+VL+ VL LP P A WL E W+ +TL ER E +H Sbjct: 176 AGWQWVFLVTGAPAVLLAPYVLWRLPSGPSDARWLPDVEKSWLASTLAAERGG-EVDDHR 234 Query: 241 SVLQSLTDSRVLACAFVYFCLNAASYGVAFFLPTIIKAFGVTDTQTGLIAALPFVFGAVG 300 +++ D RVL A +Y + ++YG++++LPTI+K+FGV++T G I +P++ AV Sbjct: 235 GAWKAIFDPRVLMLAGLYIGMPLSAYGLSYWLPTIVKSFGVSNTVNGFINVIPWLLVAVA 294 Query: 301 MVLLGRHSDKTGERRYHVAGALTLAAVGIGLAGLVSNPVLIVALLCLAQIGVSAVPPMFW 360 + + RH+ + G +H+AG + LAAV + L+ ++ L +LC+A + A P+FW Sbjct: 295 LWFVPRHAARHGASAWHIAGPVLLAAVALSLSVILPGAALKFTMLCIAAPAIFAAQPVFW 354 Query: 361 PMPAGILTGASAAAGIAAINSLGNLSGFAGPFAVGYLKDLTGSFTAGLLLLAVMGLIGAL 420 +P L+G AAAGIA IN++GNL GF V ++D TGS A +L LA + L+ +L Sbjct: 355 SLPPSFLSGPRAAAGIATINAVGNLGGFIAQNLVPVVRDATGSELAPMLALAAVLLVTSL 414 Query: 421 V 421 + Sbjct: 415 L 415 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 345 bits (886), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 202/422 (47%), Positives = 266/422 (63%), Gaps = 16/422 (3%) Query: 6 EKRAIGKMMRRLIPFLILCYFVAYLDRVNVGFAKLHMNAALGLSEAAYGLGAGLFFIGYF 65 E+ K+ RLIPFL+LCY VAYLDRVNVGFAKL M L SE YGLGAG+FFIGYF Sbjct: 24 EEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGIFFIGYF 83 Query: 66 FFEVPSNILLERFGARRWIARIMISWGIVSAAFAFIPQMSAASGLSSEWIFYFLRLLLGA 125 FEVPSN++L R GAR WIARIMISWG++SAA F+ ++ +FY +R LLG Sbjct: 84 LFEVPSNVILHRVGARMWIARIMISWGLISAAMMFV---------TTPAMFYVMRFLLGL 134 Query: 126 CEAGFFPGIIFYLTLWFPSVYRARVISLFMLAIPISSIIGAPISGLLLNLSGA--GLTGW 183 EAGFFPGII YLT W+P+ R R + FM A+ +S +IG PISG L G GL GW Sbjct: 135 AEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGW 194 Query: 184 QWLFVCEALPSVLVGFAVLTFLPDFPRQASWLQPDEVKWIQTTLERERQQTEAVEHISVL 243 QW+F+ E +PSV++G VL +L + A WL +E + + E Q E +++ Sbjct: 195 QWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDAPIAAIM 254 Query: 244 QSLTDSRVLACAFVYFCLNAASYGVAFFLPTIIKAFGVTDT-QTGLIAALPFVFGAVGMV 302 S RV + +YF YGV+F+LPT+IK GV D GL+ A+P+ V MV Sbjct: 255 AS---PRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMV 311 Query: 303 LLGRHSDKTGERRYHVAGALTLAAVGIGLAGL-VSNPVLIVALLCLAQIGVSAVPPMFWP 361 L+ R +D+T ERR+H+A A+G+ L+ + +N L +A L L +G+ P+FW Sbjct: 312 LVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWS 371 Query: 362 MPAGILTGASAAAGIAAINSLGNLSGFAGPFAVGYLKDLTGSFTAGLLLLAVMGLIGALV 421 +P L G AAAGIA INSLGNL+GF P+AVG+LKD T S +G+ LLA ++GAL+ Sbjct: 372 LPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGALL 431 Query: 422 TI 423 T+ Sbjct: 432 TL 433 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 345 bits (884), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 193/419 (46%), Positives = 261/419 (62%), Gaps = 18/419 (4%) Query: 6 EKRAIGKMMRRLIPFLILCYFVAYLDRVNVGFAKLHMNAALGLSEAAYGLGAGLFFIGYF 65 E A K + L+P L+LCY + YLDRVNVGFAKL M L S+ YGLGAG+FFIGYF Sbjct: 18 ENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIGYF 77 Query: 66 FFEVPSNILLERFGARRWIARIMISWGIVSAAFAFIPQMSAASGLSSEWIFYFLRLLLGA 125 F E+PSN++L R GAR WIARIMI+WGI+SA AF+ ++ FY +R LLG Sbjct: 78 FLEIPSNLILHRVGARLWIARIMITWGIISACMAFV---------TTPMSFYVMRFLLGV 128 Query: 126 CEAGFFPGIIFYLTLWFPSVYRARVISLFMLAIPISSIIGAPISGLLLNLSGA--GLTGW 183 EAGFFPGII Y++ WFPS R RV LF++++P+S IIGAP+SG ++ G GW Sbjct: 129 AEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGW 188 Query: 184 QWLFVCEALPSVLVGFAVLTFLPDFPRQASWLQPDEVKWIQTTLERERQQTEAVEHISVL 243 QW+F+ E +PSVLVG ++ L D A+WL E +QT +E E H + Sbjct: 189 QWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAH---YAHSRLR 245 Query: 244 QSLTDSRVLACAFVYFCLNAASYGVAFFLPTIIKAFGVTDT-QTGLIAALPFVFGAVGMV 302 + RV +YFCL + Y + F+LPT+I+ GV D G + A+P AV M+ Sbjct: 246 DAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMI 305 Query: 303 LLGRHSDKTGERRYHVAGALTLAAVGIGLAGLVSNPVLIVALLCLA--QIGVSAVPPMFW 360 ++ R +D+ ERR+H+A L AVGI L+ S+ + +VA++CL +G + P+FW Sbjct: 306 VVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNI-VVAMVCLTIGAMGALSTIPLFW 364 Query: 361 PMPAGILTGASAAAGIAAINSLGNLSGFAGPFAVGYLKDLTGSFTAGLLLLAVMGLIGA 419 +P L G++AAAGIA INS GNL GF P+ +GYLKDLT S T G+L+++ IGA Sbjct: 365 SLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGA 423 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 343 bits (880), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 192/424 (45%), Positives = 269/424 (63%), Gaps = 14/424 (3%) Query: 3 DDVEKRAIGKMMRRLIPFLILCYFVAYLDRVNVGFAKLHMNAALGLSEAAYGLGAGLFFI 62 + VE K+ R+IP L++CY +AYLDRVNVGFAKL M+ LG SEA YGLGAGLFFI Sbjct: 30 EVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFI 89 Query: 63 GYFFFEVPSNILLERFGARRWIARIMISWGIVSAAFAFIPQMSAASGLSSEWIFYFLRLL 122 GYFFFE+PSNILL + GAR WIARIMI+WG++SA FAF+ +EW FY LR L Sbjct: 90 GYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFV---------QTEWQFYILRFL 140 Query: 123 LGACEAGFFPGIIFYLTLWFPSVYRARVISLFMLAIPISSIIGAPISGLLLNL--SGAGL 180 LGA EAGF+PG+I YLT WFPS R + +LF P + I G P+SG +++ AG Sbjct: 141 LGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGW 200 Query: 181 TGWQWLFVCEALPSVLVGFAVLTFLPDFPRQASWLQPDEVKWIQTTLERERQQTEAVEHI 240 GWQW+FV EA+P+V++G +L +L + + A WL +E I +E + + +A H Sbjct: 201 QGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEAD-SKGKAASH- 258 Query: 241 SVLQSLTDSRVLACAFVYFCLNAASYGVAFFLPTIIKAFGVTDTQT-GLIAALPFVFGAV 299 S++ + + + +YFC +G+ ++PT+I+A GVT T GL+ A+PF+ + Sbjct: 259 SLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAII 318 Query: 300 GMVLLGRHSDKTGERRYHVAGALTLAAVGIGLAGLVSNPVLIVALLCLAQIGVSAVPPMF 359 MV+ R +D ERR+H+ L AVG +A +N + + L +A GV A P+F Sbjct: 319 AMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLF 378 Query: 360 WPMPAGILTGASAAAGIAAINSLGNLSGFAGPFAVGYLKDLTGSFTAGLLLLAVMGLIGA 419 W +P IL+GA+AAAGIA INS+ NL+GF P+ VG ++D T S G+ +LA ++GA Sbjct: 379 WSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGA 438 Query: 420 LVTI 423 + + Sbjct: 439 AIVL 442 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 343 bits (880), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 184/425 (43%), Positives = 262/425 (61%), Gaps = 12/425 (2%) Query: 6 EKRAIGKMMRRLIPFLILCYFVAYLDRVNVGFAKLHMNAALGLSEAAYGLGAGLFFIGYF 65 E+ + K+ R++PF+ Y ++YLDR N+G+A L MN L LS A+G +G+FFIGYF Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 66 FFEVPSNILLERFGARRWIARIMISWGIVSAAFAFIPQMSAASGLSSEWIFYFLRLLLGA 125 FEVPSN++L RFGARRWIARI+++WG+V+ AF+ + Y LR LLG Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQ---------LYALRFLLGV 136 Query: 126 CEAGFFPGIIFYLTLWFPSVYRARVISLFMLAIPISSIIGAPISGLLLN-LSGAGLTGWQ 184 EAGFFPGII YLT WF + A ++LF AIP+S ++GAP+S +++ + +GW+ Sbjct: 137 AEAGFFPGIIVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIMDHVHWLQWSGWR 196 Query: 185 WLFVCEALPSVLVGFAVLTFLPDFPRQASWLQPDEVKWIQTTLERERQQTEAVEHISVLQ 244 W+ + E P+V+ G +L D P+ A WL E W+ LER+R+ A H++ L+ Sbjct: 197 WMLLLEGAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLK 256 Query: 245 SLTDSRVLACAFVYFCLNAASYGVAFFLPTIIKAF--GVTDTQTGLIAALPFVFGAVGMV 302 +T RVL AF+YF S G+ +++P IIK F ++ T+ GLIA LP+VF M+ Sbjct: 257 VMTHPRVLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMI 316 Query: 303 LLGRHSDKTGERRYHVAGALTLAAVGIGLAGLVSNPVLIVALLCLAQIGVSAVPPMFWPM 362 R SD ERR H A L +AA+ AG + +P + +A+L L+ G+ A FW + Sbjct: 317 WWSRRSDLRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWAL 376 Query: 363 PAGILTGASAAAGIAAINSLGNLSGFAGPFAVGYLKDLTGSFTAGLLLLAVMGLIGALVT 422 P LT ++AA IA INS+GNL GF GPFA+GY K S TAGLL LA + + ++T Sbjct: 377 PTLFLTRSTAAVSIAVINSVGNLGGFVGPFAIGYFKGQMHSTTAGLLFLAGLLAVSFVMT 436 Query: 423 IRLRI 427 +RLR+ Sbjct: 437 LRLRV 441