BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0190.0008.p (293 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MT0390 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, m... 170 3e-42 PAE1939 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, ... 167 2e-41 SSO2434 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, ... 164 2e-40 SSO2636 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, ... 159 1e-38 Rv0375c [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, ... 157 2e-38 >MT0390 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs MtC Mycobacterium tuberculosis CDC1551 Length = 300 Score = 170 bits (431), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 109/277 (39%), Positives = 154/277 (55%), Gaps = 7/277 (2%) Query: 6 FAYARATSVVNALELLAMHGDKAKVLSGGQSLMPAMNLRLLSPDILVDIGGLAELRGITV 65 F Y RATSV +A+ LL G+ A+V++GG SL+P M LR+ +P+ LVDI LA G V Sbjct: 7 FEYERATSVDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDLAPELGYVV 66 Query: 66 RG-----DVLVVGALTRHVDLLRSPEIALHARLLRDAVAHVAHPAIRNRGTIGGSLAHAD 120 G +++ +GA+TRH ++L S +A + RDA +A P +RNRGT+GGSL AD Sbjct: 67 VGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRGTLGGSLCQAD 126 Query: 121 PASELPACVVALDATIVVRGSAGERRIAATEFFRGIYETALLPDELLVAVEVPVAGQGST 180 PA +L LDA + +G +GER IA +F G YETAL +E+L+ V +P+ S+ Sbjct: 127 PAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLIEVRIPLRHNTSS 186 Query: 181 FFFQEYARRHGDYAVVGLAARAVVAAGRFSALRLGFFAVGDRPL-LAVAAGKLINATVTP 239 + + RR GD+A+ A + A R+G AV P+ LA + L+ T Sbjct: 187 AYAK-VERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALAELSAGLVGQPATE 245 Query: 240 ALLAEAATALADELDPQEDQQATAAMRRHLAMVLLRR 276 + AEA A P D + TA +RHLA L R Sbjct: 246 EVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVR 282 >PAE1939 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Pya Pyrobaculum aerophilum Length = 272 Score = 167 bits (424), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 109/282 (38%), Positives = 156/282 (55%), Gaps = 11/282 (3%) Query: 1 MKAAAFAYARATSVVNALELLAMHGDKAKVLSGGQSLMPAMNLRLLSPDILVDIGGLAEL 60 M F Y RATS+ AL+LL+ D A L+GGQSL+P + LR +S +LVDI L+EL Sbjct: 1 MYPPNFEYVRATSLDEALKLLSSRDDSAP-LAGGQSLIPLLKLRAVSYGLLVDISRLSEL 59 Query: 61 RGITVRGDVLVVGALTRHVDLLRSPEIALHARLLRDAVAHVAHPAIRNRGTIGGSLAHAD 120 R G+V+ +GALTRH +L SP LR + + IR+ GT+GGSLAHAD Sbjct: 60 R-YARYGEVVELGALTRHFELEESP-----CPFLRQVASRIGDVQIRSLGTLGGSLAHAD 113 Query: 121 PASELPACVVALDATIVVRGSAGERRIAATEFFRGIYETALLPDELLVAVEVPVAGQGST 180 P + PA ++AL + + G G R + A +FF+G Y TAL EL+ V +G+ Sbjct: 114 PFGDWPAAMLALGGVVKIIGPGGRREVEAEKFFKGAYSTALERGELVAGVAFKCPQRGA- 172 Query: 181 FFFQEYARRHGDYAVVGLAARAVVAAGRFSALRLGFFAVGDRPL-LAVAAGKLINATVTP 239 + +++RRH D+A+ +A V GR +++ DRP+ L L +A + P Sbjct: 173 --YVKFSRRHNDFALAAVAVTGEVKEGRVFNVKIAALGAADRPVRLRKVEAVLESAPLRP 230 Query: 240 ALLAEAATALADELDPQEDQQATAAMRRHLAMVLLRRCVAAL 281 ++ EA A E +P D +A+A RRHL V LRR + L Sbjct: 231 EVIDEAVEAARREANPPSDFRASAEYRRHLIGVALRRALGRL 272 >SSO2434 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Sso Sulfolobus solfataricus Length = 278 Score = 164 bits (415), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 97/285 (34%), Positives = 160/285 (56%), Gaps = 8/285 (2%) Query: 1 MKAAAFAYARATSVVNALELLAMHGDKAKVLSGGQSLMPAMNLRLLSPDILVDIGGLAEL 60 M F+Y +V ALE L H D AK L+GG SL+P + LR+ P LV+I L EL Sbjct: 1 MYPPKFSYVIPDNVKEALEFLETHDD-AKPLAGGHSLIPMLKLRIFRPSYLVEIRRLPEL 59 Query: 61 RGITVRGDVLVVGALTRHVDLLRSPEIALHARLLRDAVAHVAHPAIRNRGTIGGSLAHAD 120 + I + G+V+ +G + H D++++ + LL + + +A P +RN GTIGGS++H D Sbjct: 60 KYIKMEGNVVKIGPIVTHYDIIKA-----NIPLLSETASKIADPQVRNMGTIGGSISHLD 114 Query: 121 PASELPACVVALDATIVVRGSAGERRIAATEFFRGIYETALLPDELLVAVEVPVAGQGST 180 P+++ PA ++A++A + +R + GER + F + ++ L P EL+ +EVP+ + Sbjct: 115 PSADYPAALIAMNAKVRIRSTKGERVENFSSFAKDMFTPDLNPGELVTEIEVPLL-KDYK 173 Query: 181 FFFQEYARRHGDYAVVGLAARAVVAAGRFSALRLGFFAVGDRPLLAVAAGK-LINATVTP 239 F +Q+ RR GD+A+VG+A V R+G AV + A A K L++ ++ Sbjct: 174 FSYQKLERRAGDFAIVGVAVALKVNGDVIEDARIGLTAVNKTAVRASEAEKILLSGKISE 233 Query: 240 ALLAEAATALADELDPQEDQQATAAMRRHLAMVLLRRCVAALLAR 284 L+ EAAT D +P D + +A ++ + V+ +R + A L R Sbjct: 234 KLIEEAATKAMDYANPTSDIRGSAEYKKKMVKVMTKRAILAALNR 278 >SSO2636 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Sso Sulfolobus solfataricus Length = 282 Score = 159 bits (401), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 87/279 (31%), Positives = 158/279 (56%), Gaps = 3/279 (1%) Query: 1 MKAAAFAYARATSVVNALELLAMHGDKAKVLSGGQSLMPAMNLRLLSPDILVDIGGLAEL 60 M F Y R +S A + L H D A+ L+GGQSL+P + LR++SP+ +VD+ + L Sbjct: 1 MYPPDFTYVRVSSSEEATKFLESH-DDARPLAGGQSLIPMLKLRVISPNYIVDLNPITSL 59 Query: 61 RGITVRGDVLVVGALTRHVDLLRSPEIALHARLLRDAVAHVAHPAIRNRGTIGGSLAHAD 120 + + +GALTR+ ++L++ + ++ LL AV V +RN GTIGGS A+AD Sbjct: 60 SYVRSSFNSTKIGALTRYNEILKNDLVRVNVPLLHQAVRVVGDMQVRNLGTIGGSAANAD 119 Query: 121 PASELPACVVALDATIVVRGSAGERRIAATEFFRGIYETALLPDELLVAVEVPVAGQGST 180 P++++P + AL+A I++ ++G R + A +FF+G + T L E++ + +P +G Sbjct: 120 PSADIPTVLTALNAEIILSSASGNRSVNALDFFKGAFATDLRKGEIISEIVLPNL-EGYR 178 Query: 181 FFFQEYARRHGDYAVVGLAARAVVAAGRFSALRLGFFAVGDRPLLAVAAGK-LINATVTP 239 +++ RR GD+A+V LA + +RL + VG+RP A+ K ++ + Sbjct: 179 TIYKKVVRRAGDFALVSLALAIKLRQNEIEDIRLAYGGVGERPFRALEVEKSVMGKRLND 238 Query: 240 ALLAEAATALADELDPQEDQQATAAMRRHLAMVLLRRCV 278 L+ E + ++ +++P D + ++ RR + V+ R+ + Sbjct: 239 ELVEEIVSKVSSQVNPPSDTRGSSWYRREVMKVITRKAL 277 >Rv0375c [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Mtu Mycobacterium tuberculosis H37Rv Length = 286 Score = 157 bits (398), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 102/267 (38%), Positives = 147/267 (55%), Gaps = 7/267 (2%) Query: 16 NALELLAMHGDKAKVLSGGQSLMPAMNLRLLSPDILVDIGGLAELRGITVRG-----DVL 70 +A+ LL G+ A+V++GG SL+P M LR+ +P+ LVDI LA G V G +++ Sbjct: 3 HAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDLAPELGYVVVGGINNPNLV 62 Query: 71 VVGALTRHVDLLRSPEIALHARLLRDAVAHVAHPAIRNRGTIGGSLAHADPASELPACVV 130 +GA+TRH ++L S +A + RDA +A P +RNRGT+GGSL ADPA +L Sbjct: 63 RLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRGTLGGSLCQADPAEDLSTVCT 122 Query: 131 ALDATIVVRGSAGERRIAATEFFRGIYETALLPDELLVAVEVPVAGQGSTFFFQEYARRH 190 LDA + +G +GER IA +F G YETAL +E+L+ V +P+ S+ + + RR Sbjct: 123 VLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLIEVRIPLRHNTSSAYAK-VERRV 181 Query: 191 GDYAVVGLAARAVVAAGRFSALRLGFFAVGDRPL-LAVAAGKLINATVTPALLAEAATAL 249 GD+A+ A + A R+G AV P+ LA + L+ T + AEA Sbjct: 182 GDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALAELSAGLVGQPATEEVFAEAGRRA 241 Query: 250 ADELDPQEDQQATAAMRRHLAMVLLRR 276 A P D + TA +RHLA L R Sbjct: 242 AQACTPVTDVRGTAEYKRHLAGELTVR 268