BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0184.0070.p (420 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 161 2e-39 BH2694 [GEPR] COG0477 Permeases of the major facilitator superfa... 130 8e-30 mlr2429 [GEPR] COG0477 Permeases of the major facilitator superf... 122 1e-27 VCA0554 [GEPR] COG0477 Permeases of the major facilitator superf... 118 2e-26 BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superf... 117 6e-26 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 161 bits (408), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 123/398 (30%), Positives = 205/398 (51%), Gaps = 11/398 (2%) Query: 19 WYVVTAAFVVTLIGFGSAYTFSSFVESLQREFGASRGSVSLVFSFAGFLYFGLGMI-SGP 77 W V+ A F++ L+ G Y +S FV L FG S+ SL FS L F L M+ +G Sbjct: 5 WLVIFAGFLLNLM-LGIVYAWSVFVNPLMNTFGWSKTIASLPFSIF-LLIFALMMVPAGR 62 Query: 78 LADRWGARRLAGLGMVLVGLGMVLAGQAQTILQVY-AAYSIGIGAGVGCA--YVPTLGAV 134 DR G R++A LG VL+G+G +L+G ++I Y +S G+ AG GC Y + Sbjct: 63 TQDRIGPRKVAMLGGVLLGVGFLLSGLIESIQSPYWLIFSYGVIAGAGCGLGYACPIPVA 122 Query: 135 QRWFVRRRGFASGLAVSGIGVGTLVMPPLATWLITSLGWRDAYVVLGVVAAVVGIGASLL 194 ++WF R G A+GL V G G+ L+ PL LI + G + +LGV+ +V + A+ L Sbjct: 123 RKWFPERVGLATGLVVMGFGMSALIFAPLERILIDTYGISTTFYILGVILLIVAVFAASL 182 Query: 195 IADDPRRYG-TGPDGDPLDTVSGAPLRQGVSIRAAVRTARFAGLYAACLVSAFGVFVPFV 253 +++ P + ++ V+G P G S +R RF L+ + A + Sbjct: 183 LSNPPELPAVQASNPAKVEVVTGKP-ELGPS--EMLRDYRFYVLWLSFFFMALAGLMVIG 239 Query: 254 HLVPFAVDHQVAPTLAVLLLGMIGVGSTAGRFFLGGIADRVGRDAFLVAMYLGMAVSL-A 312 H+ P+A + + P A + ++ V + GR G ++D++GR + ++L ++L A Sbjct: 240 HIAPYAQERGLEPLAAAFAVSILSVANAVGRPGAGALSDKIGRAMTMFVLFLIQGITLIA 299 Query: 313 IWAIAGTFWSLTVFALLFGLFYGGWVAILPAVVTDHFGGRNVGGIIGILYTSVAVGTLLG 372 +A T ++ + A + G YG ++ P+ D FG +N+G G+++TS VG L+G Sbjct: 300 FPHVALTLITIYICAAIIGFNYGANFSLFPSATGDFFGTKNLGVNYGLVFTSYGVGGLVG 359 Query: 373 PSAAGFAYDIGHSYFIPVAISAAANLVAALIAIVTMRT 410 P AG+ +D+ SY I ++ L+AA ++ + R Sbjct: 360 PIMAGYVFDVTGSYEIAFLVAGVLALIAAFMSFLLRRK 397 >BH2694 [GEPR] COG0477 Permeases of the major facilitator superfamily Bha Bacillus halodurans Length = 418 Score = 130 bits (326), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 121/417 (29%), Positives = 190/417 (45%), Gaps = 11/417 (2%) Query: 12 RAKPFYGWYVVTAAFVVTLIGFGSAYTFSSFVESLQREFGASRGSVSLVFSFAGFLYFGL 71 + K YGW +V F+ L G +F +FV+ + EF RGS+SL+ S F+ +G+ Sbjct: 2 KRKIHYGWIIVAVTFLTFLAVQGVRLSFGAFVQPWETEFSMDRGSISLI-STLSFIVYGI 60 Query: 72 GM-ISGPLADRWGARRLAGLGMVLVGLGMVLAGQAQTILQVYAAYSIGIGAGVGCA-YVP 129 + G L DR GAR + +LVG+ VL A ++ Y + + GVG A V Sbjct: 61 SQPLIGKLVDRLGARFILSCSTLLVGVSFVLTTMATQPWHLFILYGVVVSIGVGGASNVA 120 Query: 130 TLGAVQRWFVRRRGFASGLAVSGIGVGTLVMPPLATWLITSLGWRDAYVVLGVVAAVVGI 189 + WF ++RG A G+ +G G G +++ P + LI L W+ V+LG AV+ Sbjct: 121 ATVVITNWFNKKRGLAFGIIEAGFGAGQMILVPGSLMLIQWLDWKATVVILGFFLAVIVF 180 Query: 190 G-ASLLIADDPRRYGTGPDG--DPLDTVSGAPLRQGVSIRAAVRTARFAGL---YAACLV 243 LL+ + P P G + + +P S + R F L +A C Sbjct: 181 PIVLLLLRNHPSEKQVEPIGGVREEEETNTSPNSATFSNWSVFRMRPFWFLVLPFAICGF 240 Query: 244 SAFGVFVPFVHLVPFAVDHQVAPTLAVLLLGMIGVGSTAGRFFLGGIADRVGRDAFLVAM 303 + G+ HL+P + DH + ++ + ++ + G G IADR FL + Sbjct: 241 TTTGLMD--THLIPLSHDHGFSTSVTSAAVSLLAGFNIVGILLSGVIADRWSSRKFLFLL 298 Query: 304 YLGMAVSLAIWAIAGTFWSLTVFALLFGLFYGGWVAILPAVVTDHFGGRNVGGIIGILYT 363 Y+ A+SL I + L FA+LFGL VA + T +F ++G +IG L+ Sbjct: 299 YVARALSLVILVHSHDPLLLLGFAILFGLVDFATVAPTQLLATQYFKRYSIGLMIGWLFL 358 Query: 364 SVAVGTLLGPSAAGFAYDIGHSYFIPVAISAAANLVAALIAIVTMRTASPIASVAQA 420 S VG+ LG G Y+ SY + + +S +VAA+ + V QA Sbjct: 359 SHQVGSALGAYVPGLLYEQTGSYTVSLYVSIVILIVAAICNLFLPEPNKQRNDVKQA 415 >mlr2429 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 400 Score = 122 bits (307), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 109/374 (29%), Positives = 184/374 (49%), Gaps = 14/374 (3%) Query: 17 YGWYVVTAAFVVTLIGFGSAYTFSSFVESLQREFGASRGSVSLVFSFAGFLYFGLGMIS- 75 Y W +V +++ + G+ ++ + F+E + + SR +S + FL GLG + Sbjct: 5 YRWVIVATGALMSCVAIGTMFSLAIFLEPMALDTQWSRAGISSAMTL-NFLVMGLGGFAW 63 Query: 76 GPLADRWGARRLAGLGMVLVGLGMVLAGQAQTILQVYAAYSIGIGAGVGCAYVPTLGAVQ 135 G L+DR+GAR + +G VL+GL +V+A +A ++L +Y + +G + P + Sbjct: 64 GALSDRFGARIVVAIGAVLLGLALVVASRAGSLLTFQISYGVLVGLAASAFFAPMIALTT 123 Query: 136 RWFVRRRGFASGLAVSGIGVGTLVMPPLATWLITSLGWRDAYVVLGVVAAVVGIGASLLI 195 WF R A L +G+GV + + P A WLI++ WR A +G++A V+ + A LL+ Sbjct: 124 AWFDTNRSLAVSLVSAGMGVAPMTISPFARWLISAYEWRTAMFDIGIMAWVLLLPAVLLV 183 Query: 196 ADDPRRYGTGPDGDPLDTVSGAPLRQGVSIRAAVRTARFAGL---YAACLVSAFGVFVPF 252 P+ P+ GA G+S+ A+R+ +F L + C + G P Sbjct: 184 RQPPKPAVAAGASAPV--AEGA----GMSVAQALRSPQFIVLGLTFFTCCAAHSG---PI 234 Query: 253 VHLVPFAVDHQVAPTLAVLLLGMIGVGSTAGRFFLGGIADRVGRDAFLVAMYLGMAVSLA 312 H+V +A+ VAP AV + + G+ GR G +ADR+G L+ + AV +A Sbjct: 235 FHMVSYAMLCGVAPMAAVTIYSVEGLAGLGGRLLYGVLADRLGVKPVLITGLVIQAVVIA 294 Query: 313 IWAIAGTFWSLTVFALLFGLFYGGWVAILPAVVTDHFGGRNVGGIIGILYTSVAVGTLLG 372 + V A++FG YGG + + + ++FG R +G + G ++G LG Sbjct: 295 AYLSVSQLDQFYVLAVIFGATYGGVMPLYAVLAREYFGQRILGTVFGAATMLSSLGMALG 354 Query: 373 PSAAGFAYDIGHSY 386 P A G +D SY Sbjct: 355 PLAGGMVFDAYASY 368 >VCA0554 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 410 Score = 118 bits (296), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 108/408 (26%), Positives = 199/408 (48%), Gaps = 15/408 (3%) Query: 21 VVTAAFVVTLIGFGSAYTFSSFVESLQREFGASRGSVSLVFSFAGFLYFGLGMISGPLAD 80 ++ A F + L G Y +S F ++L +FG S S ++ A + +++G L D Sbjct: 10 ILLAGFCINLC-LGILYAWSVFNKALVTDFGWSAADASSPYAIATIAFSVCLLVAGILQD 68 Query: 81 RWGARRLAGLGMVLVGLGMVLAGQAQTILQVYAAYSIGIGAGVGCAYVPTLGAVQRWF-V 139 R G R + LG L GLGM+ +G A ++L + + + GAG+G Y + +WF Sbjct: 69 RMGPRNILILGTTLTGLGMIASGFASSVLMLNLTFGVMTGAGIGFGYACLSPSAMKWFHP 128 Query: 140 RRRGFASGLAVSGIGVGTLVMPPLATWLITSLGWRDAYVVLGVVAAVVGIGASLLIADDP 199 ++G +GL +G G+ + + PL + LIT LG + ++++LG + + + I + P Sbjct: 129 SKKGMVNGLIAAGFGLAAIYLAPLTSALITHLGIQTSFMILGAGVLAIAVPLACTINNPP 188 Query: 200 RRYGTGPDGDPLDTVSGAPLRQGV---SIRAAVRTARFAGLYAACLVSAFGVFVPFV--- 253 Y P L A + V S +A ++T +F YA L+ A V + Sbjct: 189 AGYV--PAEPKLKAGQEAKVVAKVANLSWKAMLKTPQF---YALWLMYALAASVGLMIIG 243 Query: 254 HLVPFAVDHQVAPTLAVLLLGMIGVGSTAGRFFLGGIADRVGRDAFLVAMYLGMAVSLAI 313 ++ A P AV L ++ + ++ GR G ++D++G L+ +L ++ + Sbjct: 244 NITNIASVQANLPN-AVYLASILAIFNSGGRVAAGILSDKIGGVRTLLLAFLLQGGNMVL 302 Query: 314 WAIAGTFWSLTVFALLFGLFYGGWVAILPAVVTDHFGGRNVGGIIGILYTSVAVGTLLGP 373 +A + ++L + + + YG +A+ P++ + +G +N G G+LYTS +G +G Sbjct: 303 FATFDSEFTLIIGTAIAAVGYGTLLAVFPSITAEFYGLKNYGTNYGVLYTSWGIGGAIGA 362 Query: 374 SAAGFAYDIGHSYFIPVAISAAANLVAALIAIVTMR-TASPIASVAQA 420 + G++ G Y + ISAA V L+A++T +A +A + A Sbjct: 363 AVVGYSMTHGGGYNLAYTISAAMMAVCILLALITKPISAEKVAQLQTA 410 >BS_ybfB [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 416 Score = 117 bits (292), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 113/401 (28%), Positives = 193/401 (48%), Gaps = 6/401 (1%) Query: 17 YGWYVVTAAFVVTLIGFGSAYTFSSFVESLQREFGASRGSVSLVFSFAGFLYFGLGM-IS 75 Y W +V+ F++ L G +F +FVE +R+F R ++SL+ S F+ +G+ + Sbjct: 6 YAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRSTISLI-STVSFIVYGISQPVI 64 Query: 76 GPLADRWGARRLAGLGMVLVGLGMVLAGQAQTILQVYAAYSIGIGAGVGCA-YVPTLGAV 134 G L D+WGAR + +L G+ + L + Q++ Y +G+ GVG A V V Sbjct: 65 GRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFLLYGLGVSLGVGGASNVAASVLV 124 Query: 135 QRWFVRRRGFASGLAVSGIGVGTLVMPPLATWLITSLGWRDAYVVLGVVAAVVGIGASLL 194 WF ++RG A G+ +G G G +++ P + LI W+ VVLG++ V+ A+LL Sbjct: 125 VNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHWFSWKLTVVVLGLLLIVIVFPAALL 184 Query: 195 -IADDPRRYGTGPDGD-PLDTVSGAPLRQGVSIRAAVRTARFAGLYAACLVSAF-GVFVP 251 + ++P T P G AP +S+ R +F L L+ F V + Sbjct: 185 MLRNNPSEKNTEPIGGLAASEKETAPKTTALSVAGMFRMRQFWFLIFPFLICGFTTVGLM 244 Query: 252 FVHLVPFAVDHQVAPTLAVLLLGMIGVGSTAGRFFLGGIADRVGRDAFLVAMYLGMAVSL 311 HL+PF+ DH + T+ + ++ + AG G +ADR L +Y A+S+ Sbjct: 245 DTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAGILLSGIVADRWSSRKILCILYAVRALSI 304 Query: 312 AIWAIAGTFWSLTVFALLFGLFYGGWVAILPAVVTDHFGGRNVGGIIGILYTSVAVGTLL 371 I + + L FA+LFGL VA + T +F ++G +IG L + +G+ L Sbjct: 305 VILIYSHEPYLLLAFAILFGLVDFATVAPTQMLATQYFQNYSIGLMIGWLSLAHQIGSAL 364 Query: 372 GPSAAGFAYDIGHSYFIPVAISAAANLVAALIAIVTMRTAS 412 G G Y + Y + +S ++A+++ ++ A+ Sbjct: 365 GAYVPGVIYTVTGEYTLAFYLSIGMLVLASVMNVMLREPAA 405