BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0183.0020.p (206 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value all2910 [P] COG0288 Carbonic anhydrase Nos Nostoc sp. PCC 7120 143 2e-34 YPO0819 [P] COG0288 Carbonic anhydrase Ype Yersinia pestis 138 9e-33 Rv3588c [P] COG0288 Carbonic anhydrase Mtu Mycobacterium tubercu... 136 3e-32 MT3694 [P] COG0288 Carbonic anhydrase MtC Mycobacterium tubercul... 136 3e-32 DR2238 [P] COG0288 Carbonic anhydrase Dra Deinococcus radiodurans 135 6e-32 >all2910 [P] COG0288 Carbonic anhydrase Nos Nostoc sp. PCC 7120 Length = 243 Score = 143 bits (361), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 79/193 (40%), Positives = 115/193 (59%), Gaps = 5/193 (2%) Query: 4 PDAALDRLVKGNLRYVEGVSRRHDFKHER-EALAGGQNPFAGILSCADSRIAPEYAFDTG 62 P AL L+ GN R+V+ + + ++ +++A Q PFA IL CADSR+ E FD G Sbjct: 55 PQKALKLLLDGNQRFVKRKPKYPNQSRQKLQSIAKAQYPFAAILGCADSRVPAEIVFDQG 114 Query: 63 RGDLFVCRVAGNFASDETIASLEYASAVLNVPLFMVLGHDSCGAVDAAIKSLKDNTTLPG 122 GDLFV RVAGN ASD IASLEYA++VL+ L +VLGH CGAV A++K + LPG Sbjct: 115 LGDLFVVRVAGNIASDMAIASLEYATSVLDTRLIVVLGHTKCGAVAASVK----DEPLPG 170 Query: 123 HLPSLVNAIAPAVKATEGKGGDRLANAIRQNVIDNVAKLKSATPILSAAVDQGKLRVVGA 182 + L +I PA+ K D A+ N+ KL+ + IL+ V++G ++++GA Sbjct: 171 RIGYLAESIRPALSKLPSKSKDVNKAAVIANIQYQAEKLQQKSTILAQLVNKGTVQIIGA 230 Query: 183 VYRLTDGKVELVT 195 Y + G V +++ Sbjct: 231 AYDIDTGTVSVIS 243 >YPO0819 [P] COG0288 Carbonic anhydrase Ype Yersinia pestis Length = 251 Score = 138 bits (347), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 76/198 (38%), Positives = 119/198 (60%), Gaps = 11/198 (5%) Query: 2 LAPDAALDRLVKGNLRYVEGVSRRHDFKHEREALAGGQNPFAGILSCADSRIAPEYAFDT 61 L PD ++ L +GN R+ G + +HD+ ++ A A GQ P A ILSC DSR E DT Sbjct: 57 LTPDQIVESLKQGNKRFTSGKALQHDYLAQKRASAEGQFPAAVILSCIDSRAPAEIILDT 116 Query: 62 GRGDLFVCRVAGNFASDETIASLEYASAVLNVPLFMVLGHDSCGAVDAAIKSLKDNTTLP 121 G G+ F RVAGN A+D+ I SLE+ASA + +V+GH +CGA+ AI DN L Sbjct: 117 GIGETFNARVAGNIANDDLIGSLEFASAAAGAKVILVMGHTACGAIKGAI----DNVEL- 171 Query: 122 GHLPSLVNAIAPAVKATEGKG-----GDRLANAI-RQNVIDNVAKLKSATPILSAAVDQG 175 G+L L+N I PA++ T+ G ++ +A+ + NV + + +++ + I+ +G Sbjct: 172 GNLTGLLNRIKPAIEVTQFDGEKSSKNEKYVDAVAKTNVKNTMDEIRKNSEIIRKLEQEG 231 Query: 176 KLRVVGAVYRLTDGKVEL 193 K+++VG++Y L +G+VE Sbjct: 232 KVKIVGSMYNLNNGEVEF 249 >Rv3588c [P] COG0288 Carbonic anhydrase Mtu Mycobacterium tuberculosis H37Rv Length = 207 Score = 136 bits (343), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 80/192 (41%), Positives = 110/192 (57%), Gaps = 3/192 (1%) Query: 4 PDAALDRLVKGNLRYVEGVSRR--HDFKHEREALAGGQNPFAGILSCADSRIAPEYAFDT 61 P AA L +GN R+V G + H R LA GQ P A I CADSR+A E FD Sbjct: 6 PVAAWKALKEGNERFVAGRPQHPSQSVDH-RAGLAAGQKPTAVIFGCADSRVAAEIIFDQ 64 Query: 62 GRGDLFVCRVAGNFASDETIASLEYASAVLNVPLFMVLGHDSCGAVDAAIKSLKDNTTLP 121 G GD+FV R AG+ + S+EYA VLNVPL +VLGHDSCGAV+AA+ ++ D T Sbjct: 65 GLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPG 124 Query: 122 GHLPSLVNAIAPAVKATEGKGGDRLANAIRQNVIDNVAKLKSATPILSAAVDQGKLRVVG 181 G++ +V +AP+V G R+ +++V + VA L + + +S + G L +VG Sbjct: 125 GYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVG 184 Query: 182 AVYRLTDGKVEL 193 Y+L DG+ L Sbjct: 185 VTYQLDDGRAVL 196 >MT3694 [P] COG0288 Carbonic anhydrase MtC Mycobacterium tuberculosis CDC1551 Length = 207 Score = 136 bits (343), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 80/192 (41%), Positives = 110/192 (57%), Gaps = 3/192 (1%) Query: 4 PDAALDRLVKGNLRYVEGVSRR--HDFKHEREALAGGQNPFAGILSCADSRIAPEYAFDT 61 P AA L +GN R+V G + H R LA GQ P A I CADSR+A E FD Sbjct: 6 PVAAWKALKEGNERFVAGRPQHPSQSVDH-RAGLAAGQKPTAVIFGCADSRVAAEIIFDQ 64 Query: 62 GRGDLFVCRVAGNFASDETIASLEYASAVLNVPLFMVLGHDSCGAVDAAIKSLKDNTTLP 121 G GD+FV R AG+ + S+EYA VLNVPL +VLGHDSCGAV+AA+ ++ D T Sbjct: 65 GLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPG 124 Query: 122 GHLPSLVNAIAPAVKATEGKGGDRLANAIRQNVIDNVAKLKSATPILSAAVDQGKLRVVG 181 G++ +V +AP+V G R+ +++V + VA L + + +S + G L +VG Sbjct: 125 GYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVG 184 Query: 182 AVYRLTDGKVEL 193 Y+L DG+ L Sbjct: 185 VTYQLDDGRAVL 196 >DR2238 [P] COG0288 Carbonic anhydrase Dra Deinococcus radiodurans Length = 264 Score = 135 bits (340), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 81/200 (40%), Positives = 113/200 (56%), Gaps = 6/200 (3%) Query: 1 VLAPDAALDRLVKGNLRYVEGVSRRHDF-KHEREALAGGQNPFAGILSCADSRIAPEYAF 59 V P+AA+ L++GN R+ G +RR D +ER A GQ P+A IL+C+DSR+ E F Sbjct: 61 VATPEAAIQTLMEGNARFFGGQARRPDIGANERRAQIIGQTPYAAILACSDSRVPVELVF 120 Query: 60 DTGRGDLFVCRVAGNFASDETIASLEYASAVLNVPLFMVLGHDSCGAVDAAIKSLKDNTT 119 D G G LFV RVAGN + + +LEYA L+V L MV+GH+ CGAV AA+ Sbjct: 121 DQGLGQLFVVRVAGNVVGESGLGTLEYAIRHLDVHLVMVMGHEGCGAVAAALMPDDKIAE 180 Query: 120 LPGHLPSLVNAIAPAVK---ATEGKGGDRLANAIRQNVIDNVAKLKSATPILSAAVDQGK 176 P HL SL+ I P+V+ A K R+ A+ NV VA L+ ++ A G+ Sbjct: 181 EPPHLQSLIGRIRPSVENLPAIRDKKA-RMREAVINNVRRQVALLRRQA-VIQEAEASGQ 238 Query: 177 LRVVGAVYRLTDGKVELVTD 196 +RV+G Y + G V+ + D Sbjct: 239 IRVIGGYYEIGSGAVDFLVD 258