BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0176.0011.p (662 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEI1492 [O] COG5265 ABC-type transport system involved in Fe-S ... 784 0.0 mlr7818 [O] COG5265 ABC-type transport system involved in Fe-S c... 769 0.0 AGc1966 [O] COG5265 ABC-type transport system involved in Fe-S c... 758 0.0 SMc00550 [O] COG5265 ABC-type transport system involved in Fe-S ... 738 0.0 RSc0478 [O] COG5265 ABC-type transport system involved in Fe-S c... 619 e-176 >BMEI1492 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Bme Brucella melitensis Length = 628 Score = 784 bits (2025), Expect = 0.0, Method: Compositional matrix adjust. Identities = 385/624 (61%), Positives = 476/624 (76%), Gaps = 7/624 (1%) Query: 20 AAEKGTLLGTLVHLWPYIWPGDRADLKMRVIWSVVLLLFAKLATLSVPFTFKWAIDALNG 79 +AE G L TL +LWPY+WP DR DL+MRV+W+ L+ +K+ + VP+ FKW +ALNG Sbjct: 8 SAESGETLKTLRNLWPYMWPSDRPDLRMRVVWATFYLVLSKIVLILVPYFFKWVTNALNG 67 Query: 80 TGSAPVAASNWVVWLIASPVLMTISYGAVRIVMAVLTQWRDGIFARVAMHAVRRLAYITF 139 AP ++ ++ V++ ++Y A +IV A L Q RD +FA V +AVR+LAY TF Sbjct: 68 QLHAPY----YIPVVLVGAVMLVLAYNAAKIVQAGLNQLRDALFASVGQYAVRQLAYKTF 123 Query: 140 VHMHELSLRFHLERKTGGLTRVLERGRSGIETIVRMVILQLIPTIVEVALLAAVLLWQFD 199 VHMHELSLRFHLER+TGGL+RV+ERG GIETIVR IL +PTI+E AL A + + + Sbjct: 124 VHMHELSLRFHLERRTGGLSRVIERGTKGIETIVRFTILNTLPTILEFALTAVIFAFAYG 183 Query: 200 WRYVLAVLLTVVVFMYFTYIATEWRIEIRRRMNDSDTEANTKAIDSLLNYETVKYFGAEE 259 Y++ V TV ++ +FT A++WRI IRR MNDSDT+ANTKAIDSLLN+ETVKYFG E Sbjct: 184 LSYLVVVAATVWLYTWFTIRASDWRINIRREMNDSDTDANTKAIDSLLNFETVKYFGNEA 243 Query: 260 REARRYDRSMERYEQASVKTYTSLAVLNTGQAIIFTAGLTATMLMCAFGIRNGTHTVGDF 319 EA+R+D +M RYE+A+ +T+TSL LN GQA+IF AG+ M+M A ++ GT ++GDF Sbjct: 244 MEAKRFDGAMARYEKAATQTWTSLGWLNFGQAVIFGAGMAIVMVMSAMEVQKGTQSLGDF 303 Query: 320 VLINSMMIQLYQPLNFMGMVYREIKQAIIDIEKMFDVLARDPEVKDIPGAQPLAVSAGSV 379 V IN++++QL PLNF+G +YREI+Q + DIE+MFD+L EVKD PGA L V +G++ Sbjct: 304 VFINALLMQLSIPLNFIGFIYREIRQGLTDIEQMFDLLDVKQEVKDKPGAPALKVDSGAI 363 Query: 380 RFEDVRFAYEADRPILKGLSFEVPAGKTVAIVGPSGAGKSTISRLLFRLYDVSSGRILID 439 F+DV FAY+ RPIL+G+SF+VPAGKTVAIVGPSGAGKSTISRLLFR YD+ SG I ID Sbjct: 364 SFKDVHFAYDPQRPILRGISFDVPAGKTVAIVGPSGAGKSTISRLLFRFYDIQSGSITID 423 Query: 440 GQDIKTVTQASLRSAIGMVPQDTVLFNDTIRYNIRYGRWDAGDDEVEEAARLAQIDGFIR 499 GQD++ VTQ SLR IGMVPQDTVLFNDTI YNIRYGR DA +++VE+AA LAQI GFI+ Sbjct: 424 GQDVRDVTQESLRKFIGMVPQDTVLFNDTIAYNIRYGRTDASEEDVEKAAELAQIAGFIK 483 Query: 500 MSPQGYETQVGERGLKLSGGEKQRVAIARTVLKGPPILVLDEATSALDSHTEHEIQGALE 559 P GY++ VGERGLKLSGGEKQRVAIART+LK PPIL+LDEATSALD+ TE EIQ AL+ Sbjct: 484 HLPDGYKSMVGERGLKLSGGEKQRVAIARTILKAPPILILDEATSALDTATEQEIQSALD 543 Query: 560 RVSRNRTSLVIAHRLSTIVGADEIIVLDQGRIAERGTHARLLAADGLYASMWNRQREAEE 619 VSR RT+LVIAHRLST++GADEIIVL G IAERGTH LL GLYASMW+RQREA E Sbjct: 544 IVSRGRTTLVIAHRLSTVIGADEIIVLKDGLIAERGTHRHLLDQKGLYASMWDRQREASE 603 Query: 620 ARERLAQV---DDEGTAPNRLPPA 640 A ERL QV DD G P A Sbjct: 604 AEERLRQVRESDDMGVVLRGTPAA 627 >mlr7818 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Mlo Mesorhizobium loti Length = 627 Score = 769 bits (1986), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/598 (62%), Positives = 461/598 (77%), Gaps = 4/598 (0%) Query: 27 LGTLVHLWPYIWPGDRADLKMRVIWSVVLLLFAKLATLSVPFTFKWAIDALNGTGSAPVA 86 L TL +LWPY+WP DRADL+ RV W+ +LL+ AKL ++ P+ FKWA DAL G P Sbjct: 13 LTTLRNLWPYMWPADRADLRARVTWATLLLVVAKLTLVAGPYFFKWATDALAGGFKTPPP 72 Query: 87 ASNWVVWLIASPVLMTISYGAVRIVMAVLTQWRDGIFARVAMHAVRRLAYITFVHMHELS 146 ++++ +PV++ ++Y +R+V Q RD +FARV HAVR+LA+ TFVHMH+LS Sbjct: 73 LPSFML----APVMLVVAYNVLRLVQLGFNQLRDALFARVGQHAVRQLAFRTFVHMHQLS 128 Query: 147 LRFHLERKTGGLTRVLERGRSGIETIVRMVILQLIPTIVEVALLAAVLLWQFDWRYVLAV 206 LRFHLER+TGGL+R++ERG GIETIVR ++L PTI+E AL A + + + W+YV V Sbjct: 129 LRFHLERRTGGLSRIIERGTKGIETIVRFIMLNTAPTILEFALTAGIFGFTYGWKYVAVV 188 Query: 207 LLTVVVFMYFTYIATEWRIEIRRRMNDSDTEANTKAIDSLLNYETVKYFGAEEREARRYD 266 +TV V+++FT A++WRI IRR MNDSDT+ANTKAIDSLLN+ETVKYF E EA R+D Sbjct: 189 AITVWVYVWFTVKASDWRISIRRDMNDSDTDANTKAIDSLLNFETVKYFTNERMEADRFD 248 Query: 267 RSMERYEQASVKTYTSLAVLNTGQAIIFTAGLTATMLMCAFGIRNGTHTVGDFVLINSMM 326 RSM RYE A+ KT+TSL LN GQ +IF G M M A ++ T TVGDFV IN+M+ Sbjct: 249 RSMARYEIAATKTWTSLGWLNFGQGVIFGLGTVVVMCMSALEVQAHTQTVGDFVFINAML 308 Query: 327 IQLYQPLNFMGMVYREIKQAIIDIEKMFDVLARDPEVKDIPGAQPLAVSAGSVRFEDVRF 386 +QL PLNF+G +YREI+Q + DIE MFD+L E+ D P A+PL+VSAG V F DV F Sbjct: 309 VQLSVPLNFIGFIYREIRQGLTDIEHMFDLLDVPQEIVDRPDAKPLSVSAGKVEFRDVHF 368 Query: 387 AYEADRPILKGLSFEVPAGKTVAIVGPSGAGKSTISRLLFRLYDVSSGRILIDGQDIKTV 446 +Y+ +R ILKG+SFEVPAGKTVAIVGPSGAGKSTISRLLFR YDV +G++LIDGQDI+ V Sbjct: 369 SYDPNRKILKGVSFEVPAGKTVAIVGPSGAGKSTISRLLFRFYDVQAGQVLIDGQDIRDV 428 Query: 447 TQASLRSAIGMVPQDTVLFNDTIRYNIRYGRWDAGDDEVEEAARLAQIDGFIRMSPQGYE 506 TQ SLRS +GMVPQDTVLFNDTI YNIRYGR A ++EV +AA LAQI FI P GY+ Sbjct: 429 TQDSLRSMLGMVPQDTVLFNDTIAYNIRYGRVGASEEEVRKAAELAQIGPFIEKLPDGYK 488 Query: 507 TQVGERGLKLSGGEKQRVAIARTVLKGPPILVLDEATSALDSHTEHEIQGALERVSRNRT 566 + VGERGLKLSGGEKQRVAIART+LK PPIL+LDEATSALDSHTE EIQ AL+ VS+ RT Sbjct: 489 SMVGERGLKLSGGEKQRVAIARTILKAPPILMLDEATSALDSHTEQEIQAALDLVSKGRT 548 Query: 567 SLVIAHRLSTIVGADEIIVLDQGRIAERGTHARLLAADGLYASMWNRQREAEEARERL 624 ++VIAHRLST++ ADEIIVL G+IAERGTH L+ GLYASMW+RQREA EA ERL Sbjct: 549 TIVIAHRLSTVISADEIIVLKDGQIAERGTHVELMRKHGLYASMWDRQREATEAEERL 606 >AGc1966 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 629 Score = 758 bits (1956), Expect = 0.0, Method: Compositional matrix adjust. Identities = 382/616 (62%), Positives = 464/616 (75%), Gaps = 10/616 (1%) Query: 29 TLVHLWPYIWPGDRADLKMRVIWSVVLLLFAKLATLSVPFTFKWAIDALNGTGSAPVAAS 88 TL++LWPY+WP R DLKMRVIW+ V L+ AKL ++VP+ FKWA DALNG + + Sbjct: 19 TLINLWPYMWPEGRWDLKMRVIWATVFLIVAKLVLIAVPYFFKWATDALNG----KLDMA 74 Query: 89 NWVVWLIASPVLMTISYGAVRIVMAVLTQWRDGIFARVAMHAVRRLAYITFVHMHELSLR 148 V + V + I+Y R++ L Q RD +FA V HAVR+LAY TFVHMH LSLR Sbjct: 75 GLVPAFLLGAVALVIAYNLTRLIQVGLNQLRDSLFASVGQHAVRQLAYRTFVHMHRLSLR 134 Query: 149 FHLERKTGGLTRVLERGRSGIETIVRMVILQLIPTIVEVALLAAVLLW-QFDWRYVLAVL 207 FHLERKTGGL+RV+ERG GIETIVR IL PT +E LL A++ W + + YVL + Sbjct: 135 FHLERKTGGLSRVIERGTKGIETIVRFTILNTAPTFIEF-LLTAIIFWASYGFSYVLVTV 193 Query: 208 LTVVVFMYFTYIATEWRIEIRRRMNDSDTEANTKAIDSLLNYETVKYFGAEEREARRYDR 267 +TV +++FT A+ WRI IRR MNDSDT+ANTKAIDSLLN+ETVKYFG EE EARR+D Sbjct: 194 VTVWAYIWFTVRASNWRIGIRRAMNDSDTDANTKAIDSLLNFETVKYFGNEEMEARRFDV 253 Query: 268 SMERYEQASVKTYTSLAVLNTGQAIIFTAGLTATMLMCAFGIRNGTHTVGDFVLINSMMI 327 +MERYE++++ +TSL LN GQ +IF G T M+M A ++ G T+GDFV +N++++ Sbjct: 254 AMERYEKSAISIWTSLGWLNFGQGVIFGIGSTIMMVMSALAVQRGEQTIGDFVFVNALLL 313 Query: 328 QLYQPLNFMGMVYREIKQAIIDIEKMFDVLARDPEVKDIPGAQPLAVSAGSVRFEDVRFA 387 QL PLNF+G VYREI+Q + DIE+MFD+L + EV D P A+PLA G++ F DV FA Sbjct: 314 QLSVPLNFIGFVYREIRQGLTDIEQMFDLLEVEAEVTDRPDAKPLAAGPGAISFRDVHFA 373 Query: 388 YEADRPILKGLSFEVPAGKTVAIVGPSGAGKSTISRLLFRLYDVSSGRILIDGQDIKTVT 447 Y+ +RPILKG+SF+VPAGKTVAIVGPSGAGKSTISRLL+R YD+ G + IDGQDI+ VT Sbjct: 374 YDPERPILKGVSFDVPAGKTVAIVGPSGAGKSTISRLLYRFYDIQEGAVTIDGQDIRDVT 433 Query: 448 QASLRSAIGMVPQDTVLFNDTIRYNIRYGRWDAGDDEVEEAARLAQIDGFIRMSPQGYET 507 Q SLRS IGMVPQDTVLFNDT+ YNIRYGR A D+E++ AA AQI FI P GY T Sbjct: 434 QKSLRSMIGMVPQDTVLFNDTLAYNIRYGRPSATDEELKAAADAAQISAFIGKLPDGYAT 493 Query: 508 QVGERGLKLSGGEKQRVAIARTVLKGPPILVLDEATSALDSHTEHEIQGALERVSRNRTS 567 VGERGLKLSGGEKQRVAIART+LK PPIL+LDEATSALD+HTE EIQ AL+ VS+NRT+ Sbjct: 494 MVGERGLKLSGGEKQRVAIARTILKAPPILILDEATSALDTHTEQEIQSALDIVSKNRTT 553 Query: 568 LVIAHRLSTIVGADEIIVLDQGRIAERGTHARLLAADGLYASMWNRQREAEEARERLAQV 627 LVIAHRLST++ ADEIIVL +G IAERGTHA L+A DGLYASMW+RQREA A E L V Sbjct: 554 LVIAHRLSTVIHADEIIVLKEGLIAERGTHASLMAHDGLYASMWSRQREAIRAEEMLRHV 613 Query: 628 ---DDEGTAPNRLPPA 640 DD G +R PA Sbjct: 614 RESDDLGVV-DRGEPA 628 >SMc00550 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Sme Sinorhizobium meliloti Length = 627 Score = 738 bits (1905), Expect = 0.0, Method: Compositional matrix adjust. Identities = 373/622 (59%), Positives = 465/622 (74%), Gaps = 7/622 (1%) Query: 20 AAEKGTLLGTLVHLWPYIWPGDRADLKMRVIWSVVLLLFAKLATLSVPFTFKWAIDALNG 79 +A+ + T+ +LWPY+WP DR DLK+RV+W+ V+L+ AK + VP+ FKWA DALN Sbjct: 8 SADSANPIETIANLWPYMWPADRIDLKLRVVWATVILVIAKAVLVLVPYFFKWATDALNN 67 Query: 80 TGSAPVAASNWVVWLIASPVLMTISYGAVRIVMAVLTQWRDGIFARVAMHAVRRLAYITF 139 A ++ + V++ ++Y R++ A L Q RD +FA V HAVR+LAY TF Sbjct: 68 KPDA----LGFLPQFLTGAVMLVLAYNLARLLQAGLNQLRDALFASVGQHAVRQLAYKTF 123 Query: 140 VHMHELSLRFHLERKTGGLTRVLERGRSGIETIVRMVILQLIPTIVEVALLAAVLLWQFD 199 VHMH+LSLRFHLER+TGGL+R++ERG GIETIVR IL +PT++E L A + W + Sbjct: 124 VHMHQLSLRFHLERRTGGLSRIIERGTKGIETIVRFTILNSVPTLIEFLLTAVIFWWGYG 183 Query: 200 WRYVLAVLLTVVVFMYFTYIATEWRIEIRRRMNDSDTEANTKAIDSLLNYETVKYFGAEE 259 + Y+L +TV ++++FT A++WRI IRR MNDSDT+ANTKAIDSLLN+ETVKYFG EE Sbjct: 184 FTYLLVTAVTVWLYIWFTVRASDWRIAIRRSMNDSDTDANTKAIDSLLNFETVKYFGNEE 243 Query: 260 REARRYDRSMERYEQASVKTYTSLAVLNTGQAIIFTAGLTATMLMCAFGIRNGTHTVGDF 319 EA+R+D+SMERYE+A+ + +TSL LN GQA+IF AG M + A ++ G T+GDF Sbjct: 244 MEAKRFDKSMERYERAATQVWTSLGWLNFGQALIFGAGTAVMMTISALAVQRGEQTIGDF 303 Query: 320 VLINSMMIQLYQPLNFMGMVYREIKQAIIDIEKMFDVLARDPEVKDIPGAQPLAVSAGSV 379 V IN+M+IQL PLNF+G VYREI+Q + DIE MFD+L EV D P A+ L + G++ Sbjct: 304 VFINAMLIQLAIPLNFIGFVYREIRQGLTDIEHMFDLLDVRAEVVDRPNAKELKIERGAI 363 Query: 380 RFEDVRFAYEADRPILKGLSFEVPAGKTVAIVGPSGAGKSTISRLLFRLYDVSSGRILID 439 F++V+FAY+ RPILKG+SFEVPAGKTVA+VGPSGAGKST+SRLL+R YDV G I ID Sbjct: 364 AFKNVQFAYDPARPILKGISFEVPAGKTVAVVGPSGAGKSTLSRLLYRFYDVQEGSITID 423 Query: 440 GQDIKTVTQASLRSAIGMVPQDTVLFNDTIRYNIRYGRWDAGDDEVEEAARLAQIDGFIR 499 GQD++ VTQ SLRS IGMVPQDTVLFNDTI YNIRYGR A D EVE AA AQI FIR Sbjct: 424 GQDVRDVTQKSLRSVIGMVPQDTVLFNDTIAYNIRYGRVTASDAEVEAAAEAAQIADFIR 483 Query: 500 MSPQGYETQVGERGLKLSGGEKQRVAIARTVLKGPPILVLDEATSALDSHTEHEIQGALE 559 P+G+ VGERGLKLSGGEKQRVAIART+LK PPIL+LDEATSALD+ TE EIQ AL+ Sbjct: 484 DLPEGFRAMVGERGLKLSGGEKQRVAIARTILKAPPILILDEATSALDTKTEQEIQAALD 543 Query: 560 RVSRNRTSLVIAHRLSTIVGADEIIVLDQGRIAERGTHARLLAADGLYASMWNRQREAEE 619 VSRNRT+LVIAHRLST++ ADEIIVL G IAERGTH L+ GLYASMW+RQREA + Sbjct: 544 IVSRNRTTLVIAHRLSTVINADEIIVLKDGVIAERGTHGELIDRGGLYASMWSRQREATQ 603 Query: 620 ARERLAQV---DDEGTAPNRLP 638 A E+L +V DD G +P Sbjct: 604 AEEQLKRVRESDDLGIVDRGMP 625 >RSc0478 [O] COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Rso Ralstonia solanacearum Length = 592 Score = 619 bits (1595), Expect = e-176, Method: Compositional matrix adjust. Identities = 312/595 (52%), Positives = 416/595 (69%), Gaps = 13/595 (2%) Query: 29 TLVHLWPYIWPGDRADLKMRVIWSVVLLLFAKLATLSVPFTFKWAIDALNGTGSAPVAAS 88 T+ L PY+W K RV ++ L+ AK+A L VP K IDA+N + + P A Sbjct: 7 TIRSLLPYLWA-----YKWRVALALSFLIAAKVANLGVPMVMKRLIDAMNVSPTDPRA-- 59 Query: 89 NWVVWLIASPVLMTISYGAVRIVMAVLTQWRDGIFARVAMHAVRRLAYITFVHMHELSLR 148 L+ PV + + YG +R+ ++ ++ R+ +F++V +VR LA F H+H LSLR Sbjct: 60 -----LLVVPVGIILGYGLLRLSTSLFSELREILFSKVTESSVRTLALQVFRHLHALSLR 114 Query: 149 FHLERKTGGLTRVLERGRSGIETIVRMVILQLIPTIVEVALLAAVLLWQFDWRYVLAVLL 208 FHLER+TGG++R +ERG GI++++ + ++PT+VEV L+ ++D + L Sbjct: 115 FHLERQTGGMSRDIERGTRGIQSLISYSLYSILPTLVEVGLVITYFFVKYDAWFALITFC 174 Query: 209 TVVVFMYFTYIATEWRIEIRRRMNDSDTEANTKAIDSLLNYETVKYFGAEEREARRYDRS 268 +V ++ FT T WR RRRMN+ D+ AN KAIDSLLN+ETVKYFG EE E RRYD + Sbjct: 175 ALVSYIVFTVTVTNWRTHFRRRMNELDSRANQKAIDSLLNFETVKYFGNEEYETRRYDEN 234 Query: 269 MERYEQASVKTYTSLAVLNTGQAIIFTAGLTATMLMCAFGIRNGTHTVGDFVLINSMMIQ 328 + +Y A++++ SL++LN GQ +I L + G+ G T+GD VL+N++M+Q Sbjct: 235 LRKYRAAAIRSQHSLSLLNFGQQLIVAVALILILYRATQGVAAGHMTLGDLVLVNTLMLQ 294 Query: 329 LYQPLNFMGMVYREIKQAIIDIEKMFDVLARDPEVKDIPGAQPLAVSAGSVRFEDVRFAY 388 +Y PLNF+G++YRE+KQA+ D+++MF +L + EV D P AQPLAV AG VRF V F Y Sbjct: 295 IYIPLNFLGVIYRELKQAVTDMDRMFKLLHTNREVADRPDAQPLAVRAGEVRFAHVDFGY 354 Query: 389 EADRPILKGLSFEVPAGKTVAIVGPSGAGKSTISRLLFRLYDVSSGRILIDGQDIKTVTQ 448 E++R IL + F +PAG T A+VG SG+GKST++RLLFR YD +SG I IDGQD++ VTQ Sbjct: 355 ESNRQILFDVDFTIPAGTTTAVVGQSGSGKSTLARLLFRFYDATSGAIQIDGQDVRDVTQ 414 Query: 449 ASLRSAIGMVPQDTVLFNDTIRYNIRYGRWDAGDDEVEEAARLAQIDGFIRMSPQGYETQ 508 AS+R+AIG+VPQDTVLFND+I YNI YGR DA +EV AAR AQI GF+ P+GY+T Sbjct: 415 ASVRAAIGIVPQDTVLFNDSIYYNIAYGRPDATREEVIAAARAAQIHGFVESLPEGYDTP 474 Query: 509 VGERGLKLSGGEKQRVAIARTVLKGPPILVLDEATSALDSHTEHEIQGALERVSRNRTSL 568 VGERGLKLSGGEKQRVAIART+LK PPILV DEATSALDS TEH IQ L R+++N T+L Sbjct: 475 VGERGLKLSGGEKQRVAIARTLLKRPPILVFDEATSALDSRTEHAIQEELMRLAQNHTTL 534 Query: 569 VIAHRLSTIVGADEIIVLDQGRIAERGTHARLLAADGLYASMWNRQ-REAEEARE 622 VIAHRLSTIVGA +I+V++ GRI ERGTHA LL A+G YA MW Q RE E +E Sbjct: 535 VIAHRLSTIVGAHQILVMEHGRIIERGTHASLLRAEGRYAQMWRMQAREPERVQE 589