BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0175.0009.p (432 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2114 [GEPR] COG0477 Permeases of the major facilitator superfa... 470 e-132 YPO1932 [GEPR] COG0477 Permeases of the major facilitator superf... 436 e-122 RSp0234 [GEPR] COG0477 Permeases of the major facilitator superf... 383 e-106 PM0835 [GEPR] COG0477 Permeases of the major facilitator superfa... 193 7e-49 HI1104 [GEPR] COG0477 Permeases of the major facilitator superfa... 183 7e-46 >PA2114 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 423 Score = 470 bits (1210), Expect = e-132, Method: Compositional matrix adjust. Identities = 236/407 (57%), Positives = 301/407 (73%), Gaps = 2/407 (0%) Query: 23 YRDMNLQERRTFWACASGWTLDGMDFMIYPLVIGTIITLWKVDPGTAGLAGTVTLLASAV 82 YR ++ QERR FW+C G+ LDGMD + VI T+I LW + G AG T+TLLASA Sbjct: 18 YRALDKQERRAFWSCKIGYGLDGMDTQMLSFVIPTLIALWGIGTGEAGFIHTMTLLASAA 77 Query: 83 GGWLGGYLSDRIGRVKTLQLTIIWFSFFSLVCAVVQNFDQLLVARALLGLGFGGEWAAGA 142 GGW+ G LSDRIGRV TLQLT++WF+FF+ +C + QN++QLLVAR L+G GFGGEW AGA Sbjct: 78 GGWIAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWTAGA 137 Query: 143 VLIGEAIRPQYRGRAVGSVQSGWAVGWGLAVLAQAILFSVLPAENAWRWMFVIGALPALL 202 VLIGE I+ + RG+AVG VQSGWA+GWGL + +++FS+LP E AWR +F++G LPAL Sbjct: 138 VLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLPALF 197 Query: 203 VFYLRRYVTEPEISAATMAQAQASGSGPAALWEIFHGPILKTTLLASLVGTGMQGGYYAI 262 V +RR V EPEI A+ + G+ + +EIF +L TL ASL+ TG GGYYAI Sbjct: 198 VLVVRRLVKEPEIYRE--ARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYAI 255 Query: 263 TFWVPRFLTTERKLSVVGSTGYLATLIIGSFIGYLVGAWLADRIGRRNLFLIFSIGAIAV 322 T W+P FL TER L+V+G++GYLA +I+GS++GY+V A+L D IGR+ F++F++G+ V Sbjct: 256 TAWLPTFLKTERGLTVLGTSGYLAMVILGSYVGYVVSAFLTDLIGRKKNFVLFAVGSFTV 315 Query: 323 VLLYTQLPLSNEVLWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIG 382 VLLYTQLP+SN + LGFPLGFFASG FSGMG+FLTEL+PTR+RGSGQGFCYN GR I Sbjct: 316 VLLYTQLPVSNGAMLWLGFPLGFFASGIFSGMGSFLTELFPTRIRGSGQGFCYNAGRAIA 375 Query: 383 ALFPFLVGALSTTTTLANAIAIFAVAAYGVFFLAAYALPETRGRVLH 429 ALFP L+G L +L I FA +YGV LAA +LPETRG+ L Sbjct: 376 ALFPMLIGMLGQKLSLGLGIGAFAAVSYGVVILAALSLPETRGKQLE 422 >YPO1932 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 409 Score = 436 bits (1121), Expect = e-122, Method: Compositional matrix adjust. Identities = 218/407 (53%), Positives = 294/407 (72%), Gaps = 1/407 (0%) Query: 23 YRDMNLQERRTFWACASGWTLDGMDFMIYPLVIGTIITLWKVDPGTAGLAGTVTLLASAV 82 + D+N ER+TF A GW LD +DFM++ VI T++ LW++D G AG+ TVTLL SA+ Sbjct: 4 FSDLNQTERKTFIAAFGGWALDALDFMVFTFVIATLMALWQIDAGQAGMLSTVTLLFSAI 63 Query: 83 GGWLGGYLSDRIGRVKTLQLTIIWFSFFSLVCAVVQNFDQLLVARALLGLGFGGEWAAGA 142 GGW G L+DR GRV+ LQ+TI+WFS +++ QNF+ + + RAL GLGFGGEWA G+ Sbjct: 64 GGWGAGILADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWAVGS 123 Query: 143 VLIGEAIRPQYRGRAVGSVQSGWAVGWGLAVLAQAILFSVLPAENAWRWMFVIGALPALL 202 VL+GE +R ++RG+AVG+VQSGWA+GWG A L ++FSVL E AWR +F IG LPALL Sbjct: 124 VLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLPALL 183 Query: 203 VFYLRRYVTEPEISAATMAQAQASGSGPAALWEIFHGPILKTTLLASLVGTGMQGGYYAI 262 V Y+R+ V EP + + + QA ++ + IF +LKTT+LASL+ TG+QGGYYAI Sbjct: 184 VLYIRKNVPEPALFLKSRHEQQAKDRRVSS-FAIFSPALLKTTVLASLLCTGVQGGYYAI 242 Query: 263 TFWVPRFLTTERKLSVVGSTGYLATLIIGSFIGYLVGAWLADRIGRRNLFLIFSIGAIAV 322 T W+P FL ER LSV+G+ GYL +I GSF+GY+ GA+L D++GRR +IFS+ + Sbjct: 243 TTWLPTFLKLERNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLGRRANLIIFSLLSCIT 302 Query: 323 VLLYTQLPLSNEVLWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIG 382 + YTQL L+N + VLGFPLGF ASG FSGMGAFLTEL+P+ +R +GQGF Y+FGR +G Sbjct: 303 IFAYTQLTLTNTQMLVLGFPLGFSASGIFSGMGAFLTELFPSAVRATGQGFTYSFGRAVG 362 Query: 383 ALFPFLVGALSTTTTLANAIAIFAVAAYGVFFLAAYALPETRGRVLH 429 ALFP LVG LS +++LA AI +FA +AY + + + LPET+ + L Sbjct: 363 ALFPGLVGYLSQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNKQLE 409 >RSp0234 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 416 Score = 383 bits (984), Expect = e-106, Method: Compositional matrix adjust. Identities = 207/416 (49%), Positives = 279/416 (67%), Gaps = 7/416 (1%) Query: 19 LLAFYRDMNLQERRTFWACASGWTLDGMDFMIYPLVIGTIITLWKVDPGTAGLAGTVTLL 78 + ++++++ E+RTFWAC GW LD +D ++ LVI TII W + AGL +TL+ Sbjct: 1 MFGWFKEISAGEKRTFWACFGGWALDALDVQMFSLVIPTIIAAWHIGKTEAGLVSGITLV 60 Query: 79 ASAVGGWLGGYLSDRIGRVKTLQLTIIWFSFFSLVCAVVQNFDQLLVARALLGLGFGGEW 138 ASA+GGW+ G ++DR+GRV+TLQ+T+ WFS + A QNF+Q L +A+ G GFGGEW Sbjct: 61 ASALGGWIAGAMTDRLGRVRTLQITVAWFSLATFASAFAQNFEQFLALKAVQGFGFGGEW 120 Query: 139 AAGAVLIGEAIRPQYRGRAVGSVQSGWAVGWGLAVLAQAILFSVLPAENAWRWMFVIGAL 198 AAGAVL+ E+IR +RG+A+G+VQS WAVGWG AVL A+ +S++ + AWR MF G L Sbjct: 121 AAGAVLMAESIRASHRGKAMGTVQSAWAVGWGAAVLLYALTYSLVEPDLAWRVMFAAGVL 180 Query: 199 PALLVFYLRRYVTEPEISAATMAQAQASGSG-PAA---LWEIFHGPILKTTLLASLVGTG 254 PALL+ Y+RR V EP A A+A+A G P + L +IF +L+ TL+ +L+G G Sbjct: 181 PALLIIYIRRGVQEP---APAGAKAEAGPDGMPVSRFPLLDIFRPRVLRMTLIGALLGVG 237 Query: 255 MQGGYYAITFWVPRFLTTERKLSVVGSTGYLATLIIGSFIGYLVGAWLADRIGRRNLFLI 314 GGYYA+ W+P +L TER LSV+G+ GYLA +I + G + AWL D IGRR L+ Sbjct: 238 AHGGYYALMTWLPTYLKTERHLSVLGTGGYLAVIIFAFWCGCVASAWLLDVIGRRGNILL 297 Query: 315 FSIGAIAVVLLYTQLPLSNEVLWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFC 374 FS + VL+Y +PLS+ + VLGFPLGFFA+G + MGA ELYP +RG+G GFC Sbjct: 298 FSCCCVVTVLVYLLVPLSDGAMLVLGFPLGFFAAGIPASMGALFNELYPHGVRGTGVGFC 357 Query: 375 YNFGRGIGALFPFLVGALSTTTTLANAIAIFAVAAYGVFFLAAYALPETRGRVLHA 430 YNFGR + A FP LVG +S + +L AI I A AY + +A LPETRGR L A Sbjct: 358 YNFGRVVSAAFPVLVGKMSASMSLGTAIGIDAAIAYSIVAVAVLMLPETRGRDLAA 413 >PM0835 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 405 Score = 193 bits (490), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 135/408 (33%), Positives = 207/408 (50%), Gaps = 9/408 (2%) Query: 25 DMNLQERRTFWACASGWTLDGMDFMIYPLVIGTIITLWKVDPGTAGLAGTVTLLASAVGG 84 ++N + A G+ +DG D +I ++ I + P +G T TL+ + GG Sbjct: 4 NVNKDGWKALLGSAVGYAMDGFDLLILGFMLSAISADLALTPAQSGSLVTWTLIGAVAGG 63 Query: 85 WLGGYLSDRIGRVKTLQLTIIWFSFFSLVCAVVQNFDQLLVARALLGLGFGGEWAAGAVL 144 + G LSD+ GRV+ L TI+ F+ F+ +CA Q + LL+ R + G+G GGE+ G L Sbjct: 64 IIFGALSDKYGRVRVLTWTIVLFAVFTGLCAFAQGYWDLLIYRTIAGIGLGGEFGIGMAL 123 Query: 145 IGEAIRPQYRGRAVGSVQSGWAVGWGLAVLAQAILFSVLPAENAWRWMFVIGALPALLVF 204 EA ++R +A V GW VG VL A+L +L WR MF++G PA + + Sbjct: 124 AAEAWPARHRAKASSYVALGWQVG----VLGAALLTPLLLPHIGWRGMFLVGIFPAFVAW 179 Query: 205 YLRRYVTEPEISAATMAQAQASGSGPAALWEIFHGPILKTTLLASLVG-TGMQG-GYYAI 262 YLR + EPEI + + + + + A +V T +Q GYY I Sbjct: 180 YLRAKLHEPEIFVKKQTALERQKTSRLEPFRLLIKDKATAKISAGIVVLTSVQNFGYYGI 239 Query: 263 TFWVPRFLTTERKLSVVGSTGYLATLIIGSFIGYLVGAWLADRIGRRNLFLIFSIGAIAV 322 W+P FL+ + S+ S + A I G G + LADRIGR+ FL+F GA+ Sbjct: 240 MIWMPNFLSKQLGFSLTKSGVWTAVTICGMMFGIWLFGQLADRIGRKPSFLLFQFGAVIS 299 Query: 323 VLLYTQLPLSNEVLWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIG 382 + Y+Q+ +L+ G LG F +G G GA ++E YPT+ R + Q +N GR +G Sbjct: 300 IFTYSQMSDPTYMLFA-GAVLGMFVNGMMGGYGALMSEAYPTQARATAQNVLFNLGRAVG 358 Query: 383 ALFPFLVGALSTTTTLANAIAIFAVAAYGVFFLAA-YALPETRGRVLH 429 P +VGAL +T + AIA F + Y + +A + +PE +G+ L Sbjct: 359 GFGPIVVGALVSTYSFQLAIA-FLASIYIIDMIATIFLIPELKGKQLD 405 >HI1104 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 407 Score = 183 bits (464), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 131/397 (32%), Positives = 206/397 (51%), Gaps = 9/397 (2%) Query: 37 CASGWTLDGMDFMIYPLVIGTIITLWKVDPGTAGLAGTVTLLASAVGGWLGGYLSDRIGR 96 A G+ +DG D +I ++ I + P G T TL+ + GG L G LSD+ GR Sbjct: 16 SAVGYGMDGFDLLILGFMLSAISADLNLTPAQGGSLVTWTLIGAVFGGILFGALSDKYGR 75 Query: 97 VKTLQLTIIWFSFFSLVCAVVQNFDQLLVARALLGLGFGGEWAAGAVLIGEAIRPQYRGR 156 V+ L TI+ F+ F+ +CA+ Q + LL+ R + G+G GGE+ G L EA ++R + Sbjct: 76 VRVLTWTILLFAVFTGLCAIAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWPARHRAK 135 Query: 157 AVGSVQSGWAVGWGLAVLAQAILFSVLPAENAWRWMFVIGALPALLVFYLRRYVTEPEI- 215 A V GW VG VL A+L +L WR MF++G PA + ++LR ++ EPEI Sbjct: 136 AASYVALGWQVG----VLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWFLRSHLHEPEIF 191 Query: 216 -SAATMAQAQASGSGPAALWEIFHGPILKTTL-LASLVGTGMQG-GYYAITFWVPRFLTT 272 T Q+S + +++ + + L +V T +Q GYY I W+P FL+ Sbjct: 192 TQKQTALSTQSSFTDKLRSFQLLIKDKATSKISLGIVVLTSVQNFGYYGIMIWLPNFLSK 251 Query: 273 ERKLSVVGSTGYLATLIIGSFIGYLVGAWLADRIGRRNLFLIFSIGAIAVVLLYTQLPLS 332 + S+ S + A + G G + LADRIGR+ FL+F +GA+ +++Y+QL Sbjct: 252 QLGFSLTKSGLWTAVTVCGMMAGIWIFGQLADRIGRKPSFLLFQLGAVISIVVYSQLT-D 310 Query: 333 NEVLWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIGALFPFLVGAL 392 +++ + G LG F +G G GA + E YPT R + Q +N GR +G P +VG++ Sbjct: 311 PDIMLLAGAFLGMFVNGMLGGYGALMAEAYPTEARATAQNVLFNIGRAVGGFGPVVVGSV 370 Query: 393 STTTTLANAIAIFAVAAYGVFFLAAYALPETRGRVLH 429 + AIA+ A+ + +PE +G+ L Sbjct: 371 VLAYSFQTAIALLAIIYVIDMLATIFLIPELKGKALD 407