BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0156.0056.p (292 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMA1721 [I] COG1562 Phytoene/squalene synthetase NmA Neisseria m... 128 1e-29 NMB1521 [I] COG1562 Phytoene/squalene synthetase Nme Neisseria m... 127 3e-29 VNG1458G [I] COG1562 Phytoene/squalene synthetase Hbs Halobacter... 78 2e-14 VNG1680G [I] COG1562 Phytoene/squalene synthetase Hbs Halobacter... 71 2e-12 Rv3397c [I] COG1562 Phytoene/squalene synthetase Mtu Mycobacteri... 64 5e-10 >NMA1721 [I] COG1562 Phytoene/squalene synthetase NmA Neisseria meningitidis Z2491 Length = 276 Score = 128 bits (322), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 89/238 (37%), Positives = 127/238 (53%), Gaps = 10/238 (4%) Query: 16 ENFPVASWIIHPRHRALILAFYNFVRTADDIADHATLPAEEKLRYLDLMEAEL--LGNGD 73 ENFPV S I+ R R + A Y F RTADD+AD ++P+E +L LD + EL L +G Sbjct: 13 ENFPVGSLILPRRLRKPVHAVYAFARTADDMADEGSMPSEARLAGLDALRRELDVLASGG 72 Query: 74 TQKEAVNLRRAFAERSMPPRHAL----DVLVAFRLDVTKLRYENWDDVIDYCRYSAMPVG 129 + + R AE +P L D+L AF DV K RY ++ ++ DYCR SA PVG Sbjct: 73 RSAHPL-IARLDAEAVVPFGLDLQPFYDLLSAFSQDVVKTRYAHFGELADYCRRSANPVG 131 Query: 130 RFMLDVHGE-DTSTWAASDALCAGLQINNHLQDCGKDYRNLNRVYLPRDALAAAGATVEM 188 R ML ++G+ D A SD +C LQ+ N QD D++ RVY+P+D L G + Sbjct: 132 RIMLALYGKTDAVCVAQSDGICTALQLVNFWQDVAVDWQK-GRVYIPQDDLLKFGVSEGQ 190 Query: 189 LGEAKSQPALLKCLQALAVRTEALLDQSKSLAAEVKDFRLGLEISVIQAFADKIVNML 246 + E ++ A + + R +L LA E+K R+GLE+ +I A I+ L Sbjct: 191 IAEGRADAAFQRLMAYECRRAFRMLKAGSPLARELKG-RIGLELRMIVLGAQLILQKL 247 >NMB1521 [I] COG1562 Phytoene/squalene synthetase Nme Neisseria meningitidis MC58 Length = 275 Score = 127 bits (320), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 88/238 (36%), Positives = 127/238 (53%), Gaps = 10/238 (4%) Query: 16 ENFPVASWIIHPRHRALILAFYNFVRTADDIADHATLPAEEKLRYLDLMEAEL--LGNGD 73 ENFPV S I+ R R + A Y F RTADD+AD ++P+E +L L+ ++ EL L +G Sbjct: 12 ENFPVGSLILPRRLRKPVHAVYAFARTADDMADEGSMPSEARLAGLEGLQRELDVLASGG 71 Query: 74 TQKEAVNLRRAFAERSMPPRHAL----DVLVAFRLDVTKLRYENWDDVIDYCRYSAMPVG 129 + + R AE +P L D+L AF DV K RY N+ ++ DYCR SA PVG Sbjct: 72 RSAHPL-IARLDAEAVVPFGLDLQPFYDLLSAFSQDVVKTRYGNFGELADYCRRSANPVG 130 Query: 130 RFMLDVHGE-DTSTWAASDALCAGLQINNHLQDCGKDYRNLNRVYLPRDALAAAGATVEM 188 R ML ++G+ D A SD +C LQ+ N QD D++ RVY+P+D L G + E Sbjct: 131 RIMLALYGKTDAVCVAQSDGICTALQLVNFWQDVAVDWQK-GRVYIPQDDLLKFGVSEEQ 189 Query: 189 LGEAKSQPALLKCLQALAVRTEALLDQSKSLAAEVKDFRLGLEISVIQAFADKIVNML 246 + ++ A + + R +L LA E+ R+GLE+ +I A I+ L Sbjct: 190 IAAGRADAAFQRLMAYECRRAFRMLKAGSPLARELNG-RIGLELRMIVLGAQLILQKL 246 >VNG1458G [I] COG1562 Phytoene/squalene synthetase Hbs Halobacterium sp. NRC-1 Length = 322 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 96/209 (45%), Gaps = 9/209 (4%) Query: 8 RSGKTHRDENFPVASWIIHPRHRALILAFYNFVRTADDIAD-HATLPAEEKLRYLDLMEA 66 R+G+T F +A+ + R R Y F R D+I D A P +E+ R L + A Sbjct: 16 RTGRT-----FHIATRFLPERVRYPTYVLYAFFRLTDEIVDDEAPGPPDEQRRRLAHVRA 70 Query: 67 ELLGNGDTQKEAVNLRRAFAERSMPPRHALDVLV-AFRLDVTKLRYENWDDVIDYCRYSA 125 LG+ D + A E PR + + A + DV RY + DD+ +Y R S+ Sbjct: 71 AALGDRDPDDPVLAAFAALREDHDIPREEVTTFIDAMQQDVDTARYRSHDDLAEYLRGSS 130 Query: 126 MPVGRFMLDVHGEDTSTWAASDALCAG--LQINNHLQDCGKDYRNLNRVYLPRDALAAAG 183 + VG ML + A A G Q+ N L+D +D + +R+YLP LAA G Sbjct: 131 VAVGYMMLSIMDAPEPERARPHAASLGEAFQLTNFLRDVREDVLDYDRIYLPSQTLAAHG 190 Query: 184 ATVEMLGEAKSQPALLKCLQALAVRTEAL 212 A+ + + + P + ++A RTE L Sbjct: 191 ASHDDIAALSATPQVRDAIRAELDRTERL 219 >VNG1680G [I] COG1562 Phytoene/squalene synthetase Hbs Halobacterium sp. NRC-1 Length = 322 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/192 (31%), Positives = 92/192 (47%), Gaps = 16/192 (8%) Query: 8 RSGKTHRDENFPVASWIIHPRHRALILAFYNFVRTADDIADHATL--PAEEKLRYLDLME 65 R+GKT F +A+ ++ R R Y F R ADD+ D P ++ L+ + Sbjct: 16 RTGKT-----FHLATRLLPTRVRHATYVLYAFFRVADDVVDTTADRDPGVQR-EELEGIR 69 Query: 66 AELLGNGDTQKEAVNLRRAFAERSMPPRHALD------VLVAFRLDVTKLRYENWDDVID 119 A LG D + A + A R + RH + + A + D+ K RYE+ ++ + Sbjct: 70 AAALGARDPESVAADTEVLAAFRELATRHGISDEDIHTFIDAMQADLEKTRYESHAELEE 129 Query: 120 YCRYSAMPVGRFMLDVH--GEDTSTWAASDALCAGLQINNHLQDCGKDYRNLNRVYLPRD 177 Y R SA+ VG M+DV E + + AL Q++N L+D +D +RVYLP + Sbjct: 130 YMRGSAVAVGYMMMDVMEVAEPETAAPHAAALAEAFQLSNFLRDVAEDVHEYDRVYLPAE 189 Query: 178 ALAAAGATVEML 189 + A G TVE L Sbjct: 190 SRADHGVTVEQL 201 >Rv3397c [I] COG1562 Phytoene/squalene synthetase Mtu Mycobacterium tuberculosis H37Rv Length = 302 Score = 63.5 bits (153), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 6/175 (3%) Query: 17 NFPVASWIIHPRHRALILAFYNFVRTADDIADHATLPAEEKLRYLDLMEAELLGNGDTQK 76 NF ++ RA + A Y R DD+AD P E K+ LD + L N D Sbjct: 21 NFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAP-ETKITELDAIRKSL-DNIDDSS 78 Query: 77 EAVNLRRAFAERSMPPRHAL--DVLVAFRLDVTKLRYENWDDVIDYCRYSAMPVGRFMLD 134 + V + A A R P A+ +++ R+++ ++D++I YCR A +G+ L Sbjct: 79 DPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLS 138 Query: 135 VHGE-DTSTWAASDALCAGLQINNHLQDCGKDYRNLNRVYLPRDALAAAGATVEM 188 + G T+T ++ L LQ N L+D +D+ N R+YLPRD L G + + Sbjct: 139 IFGPVSTATSRYAEQLGIALQQTNILRDVREDFLN-GRIYLPRDELDRLGVRLRL 192