BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0156.0017.p (379 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC3482 [GEPR] COG0477 Permeases of the major facilitator superf... 248 2e-65 CAC0560 [GEPR] COG0477 Permeases of the major facilitator superf... 228 1e-59 YPO3263 [GEPR] COG0477 Permeases of the major facilitator superf... 201 2e-51 ECs3543 [GEPR] COG0477 Permeases of the major facilitator superf... 192 8e-49 Z3982 [GEPR] COG0477 Permeases of the major facilitator superfam... 192 1e-48 >CAC3482 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 394 Score = 248 bits (632), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 140/373 (37%), Positives = 211/373 (56%), Gaps = 27/373 (7%) Query: 10 QQAPELTRARTLAMAICAGIAVANIYYNQPLLGLIEASYPNSS-AIGLIPTATQFGYAVG 68 + L + + M+I G+ VAN+YY QPLL I ++ S ++G TQ GYAVG Sbjct: 10 ENKSILNKLLIMVMSIACGLTVANLYYIQPLLADISKTFNVSEISVGSAAMLTQIGYAVG 69 Query: 69 LLFLVPLGDLVERRRLIAAQFVILAAALAFAAVAPSALALIAASLMLGVAATVAQQIVPF 128 ++ ++PLGD+ ERR LI + +LA + + L +S +G + + Q I+P Sbjct: 70 MVLILPLGDIKERRNLITTILLFSVISLASMFFSSNIYILTISSFAVGFTSIIPQLIIPL 129 Query: 129 AATLADDRTRGAAVGTVVSGILGGILLSRTKK-----------------------KKXVR 165 AA L++ + RG +GTV+SG+L GIL+SRT +R Sbjct: 130 AAQLSNQKDRGRIIGTVMSGLLIGILVSRTFSGILGAYWGWRVVYIIAAIMMIFLMIALR 189 Query: 166 LILPRHHVPQGIGYPAALRTLVHLLVEEPTLRLAAATQAMLFASFIAFWTVLSLHLREPA 225 +LP + Y L+++ L+ EP LR A+ AM+FA+F AFWT L+ L+ P Sbjct: 190 KLLPVSKPSSNVKYIELLKSMFQLIKSEPVLREASINGAMMFAAFSAFWTSLTFLLQSPH 249 Query: 226 FGLGPEIAGLFGVIGASGMLAAPLAGRVADKRGPHLVIAIAAAVSLSSWAIF--GGWNAV 283 + +G + AGLFG++G SG LAAPL GR+ADK+GP +I I + S+ +F G+ + Sbjct: 250 YNMGSQAAGLFGLVGVSGALAAPLVGRIADKKGPRFIIGICIPIITISYLLFLLLGFK-I 308 Query: 284 TGLIVGVVLLDAGVNAALVSNQHLIFALRPEARSRLNTVFMTAMFVGGSLGSLGASWAYT 343 GLI+GV+LLD GV + VSNQ + +L + R+R+NTV+M + F+GG+ GS S+ Y Sbjct: 309 FGLILGVMLLDLGVQSGNVSNQTRVHSLNEKMRNRINTVYMVSFFLGGAFGSFMGSFTYV 368 Query: 344 HLSWLGVCGYGAA 356 H W GVC +G + Sbjct: 369 HFGWYGVCIFGIS 381 >CAC0560 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 441 Score = 228 bits (582), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 134/372 (36%), Positives = 196/372 (52%), Gaps = 25/372 (6%) Query: 8 TDQQAPELTRARTLAMAICAGIAVANIYYNQPLLGLIEASYPNSSA-IGLIPTATQFGYA 66 T +++ EL + MA+ + VAN+YY QPLLG I S+ + A G + T TQ GYA Sbjct: 41 TIKESFELNKFIIFIMALTCTVTVANLYYCQPLLGQIAKSFNVTEANAGFVVTLTQVGYA 100 Query: 67 VGLLFLVPLGDLVERRRLIAAQFVILAAALAFAAVAPSALALIAASLMLGVAATVAQQIV 126 +G+LFLVPLGD+ ER++LI ++++ L A ++ + L+ S ++G V Q IV Sbjct: 101 LGMLFLVPLGDIKERKKLIIEMLLLVSVFLFAAFISRNYYVLLVTSFLIGFTTIVPQLIV 160 Query: 127 PFAATLADDRTRGAAVGTV-------------VSGILGGIL----------LSRTKKKKX 163 PFAA L+ RG +G V SGI+G IL L Sbjct: 161 PFAAHLSKPEERGQVIGNVLSGLLIGILLSRVFSGIIGDILGWRNVYLIASLLMVSFLFI 220 Query: 164 VRLILPRHHVPQGIGYPAALRTLVHLLVEEPTLRLAAATQAMLFASFIAFWTVLSLHLRE 223 + + P+ I Y + ++ L+ E LR A+ A++F SF FWT L L Sbjct: 221 IVFLFPKSKPTSKISYKKLIFSMWGLIKREKVLREASINGALMFGSFSIFWTALVFLLES 280 Query: 224 PAFGLGPEIAGLFGVIGASGMLAAPLAGRVADKRGPHLVIAIAAAVSLSSWAIFGGWN-A 282 + +G + AG FG++G G LAAP+ G+VADK+ P + A S ++ F G Sbjct: 281 KVYNMGSKEAGFFGLVGIVGALAAPVVGKVADKKTPRFAVGFAIIFSTIAYVCFWGMGYK 340 Query: 283 VTGLIVGVVLLDAGVNAALVSNQHLIFALRPEARSRLNTVFMTAMFVGGSLGSLGASWAY 342 + GL++GV+LLD G VSNQ + A+ + RSR+NTVFM + F+GGS+GS A+ + Sbjct: 341 IYGLVIGVILLDLGNQTGQVSNQARVQAISDQERSRINTVFMVSYFIGGSIGSFVAAVFW 400 Query: 343 THLSWLGVCGYG 354 W GVC G Sbjct: 401 QKFGWSGVCAIG 412 >YPO3263 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 399 Score = 201 bits (512), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 147/397 (37%), Positives = 215/397 (54%), Gaps = 33/397 (8%) Query: 9 DQQAPELTRARTLAMAICAGIAVANIYYNQPLLGLIEASYPNS-SAIGLIPTATQFGYAV 67 P L+ A + M++ G+AVA+ YY QPLL I ++ S + G I TA Q GYAV Sbjct: 3 KTDTPGLSPALIVLMSVATGLAVASNYYAQPLLETIATNFNLSVNQAGFIVTAAQLGYAV 62 Query: 68 GLLFLVPLGDLVERRRLIAAQFVILAAALAFAAVAPSALALIAASLMLGVAATVAQQIVP 127 GL+FLVPLGD+ ERR LI ++ A + A++ + +I + + G+ + VAQ +VP Sbjct: 63 GLMFLVPLGDMFERRGLIVGMTLLAAGGMLITAMSQNLTMMIIGTALTGLFSVVAQLLVP 122 Query: 128 FAATLADDRTRGAAVGTVVSGILGGILLSRTKKKKXVRL--------------------- 166 AATLA RG VG ++SG+L GILL+RT L Sbjct: 123 LAATLAAPEKRGKVVGIIMSGLLLGILLARTVAGALATLGGWRTIYWVASALMFIMALVL 182 Query: 167 --ILPRHHVPQGIGYPAALRTLVHLLVEEPTLRLAAATQAMLFASFIAFWTVLSLHLREP 224 LPR+ G+ Y L ++ L + P LR A A+ FA+F WT ++ L P Sbjct: 183 WRCLPRYKQHTGLNYGQLLGSIFALFIHTPVLRTRALLGALSFANFSVLWTSMAFLLAAP 242 Query: 225 AFGLGPEIAGLFGVIGASGMLAAPLAGRVADKRGPHLVIAIAAAVSLSSWA-IFGGWNAV 283 FG GLFG++GA+G L A AG++ADK + + + L SW I G +++ Sbjct: 243 PFGYSEATIGLFGLVGAAGALMATKAGQLADKGKARVTTSAGLVLLLLSWLPIAFGQHSI 302 Query: 284 TGLIVGVVLLDAGVNAALVSNQHLIFALRPEARSRLNTVFMTAMFVGGSLGSLGASWAYT 343 LI+G+++LD V A V+NQ +++ + PEAR+RL +MT+ F+GG+LGSL ++ AY Sbjct: 303 IALIIGIIVLDLAVQAVHVTNQSVMYRMMPEARNRLTAGYMTSYFIGGALGSLISAAAYQ 362 Query: 344 HLSWLGVCGYGAALATAGLLLQLPTVLS-RAGKTSHH 379 H W GV +TAGL+L L +++ GK S Sbjct: 363 HAGWYGV-------STAGLVLCLLNIVTWLVGKRSDQ 392 >ECs3543 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 394 Score = 192 bits (489), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 142/376 (37%), Positives = 204/376 (54%), Gaps = 25/376 (6%) Query: 14 ELTRARTLAMAICAGIAVANIYYNQPLLGLIEASYP-NSSAIGLIPTATQFGYAVGLLFL 72 EL+ A + M+I G+AVA+ YY QPLL I ++ ++S+ G I TA Q GYA GLLFL Sbjct: 7 ELSPALIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFL 66 Query: 73 VPLGDLVERRRLIAAQFVILAAALAFAAVAPSALALIAASLMLGVAATVAQQIVPFAATL 132 VPLGD+ ERRRLI + ++ A + A + S +I + + G+ + VAQ +VP AATL Sbjct: 67 VPLGDMFERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATL 126 Query: 133 ADDRTRGAAVGTVVSGILGGILLSRTKKKKXVRLI-----------------------LP 169 A RG VGT++SG+L GILL+RT L LP Sbjct: 127 ASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLP 186 Query: 170 RHHVPQGIGYPAALRTLVHLLVEEPTLRLAAATQAMLFASFIAFWTVLSLHLREPAFGLG 229 + + YP L ++ + + LR A + FA+F WT ++ L P F Sbjct: 187 QMKSETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSILWTSMAFLLAAPPFNYS 246 Query: 230 PEIAGLFGVIGASGMLAAPLAGRVADKRGPHLVIAIAAAVSLSSW-AIFGGWNAVTGLIV 288 + GLFG+ GA+G L A AG ADK H + L SW AI+ G +V LI+ Sbjct: 247 DGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAIWFGHTSVLALII 306 Query: 289 GVVLLDAGVNAALVSNQHLIFALRPEARSRLNTVFMTAMFVGGSLGSLGASWAYTHLSWL 348 G+++LD V ++NQ +I+ + P+AR+RL +MT+ F+GG+ GSL ++ A+ H W Sbjct: 307 GILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGWA 366 Query: 349 GVCGYGAALATAGLLL 364 GVC GA +A LL+ Sbjct: 367 GVCLAGATIALVNLLV 382 >Z3982 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 394 Score = 192 bits (488), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 142/376 (37%), Positives = 204/376 (54%), Gaps = 25/376 (6%) Query: 14 ELTRARTLAMAICAGIAVANIYYNQPLLGLIEASYP-NSSAIGLIPTATQFGYAVGLLFL 72 EL+ A + M+I G+AVA+ YY QPLL I ++ ++S+ G I TA Q GYA GLLFL Sbjct: 7 ELSPALIVLMSIATGLAVASNYYAQPLLDTIARNFSLSASSAGFIVTAAQLGYAAGLLFL 66 Query: 73 VPLGDLVERRRLIAAQFVILAAALAFAAVAPSALALIAASLMLGVAATVAQQIVPFAATL 132 VPLGD+ ERRRLI + ++ A + A + S +I + + G+ + VAQ +VP AATL Sbjct: 67 VPLGDMFERRRLIVSMTLLAAGGMLITASSQSLAMMILGTALTGLFSVVAQILVPLAATL 126 Query: 133 ADDRTRGAAVGTVVSGILGGILLSRTKKKKXVRLI-----------------------LP 169 A RG VGT++SG+L GILL+RT L LP Sbjct: 127 ASPDKRGKVVGTIMSGLLLGILLARTVAGLLANLGGWRTVFWVASVLMALMALALWRGLP 186 Query: 170 RHHVPQGIGYPAALRTLVHLLVEEPTLRLAAATQAMLFASFIAFWTVLSLHLREPAFGLG 229 + + YP L ++ + + LR A + FA+F WT ++ L P F Sbjct: 187 QMKSETHLNYPQLLGSVFSMFISNKILRTRALLGCLTFANFSIXWTSMAFLLAAPPFNYS 246 Query: 230 PEIAGLFGVIGASGMLAAPLAGRVADKRGPHLVIAIAAAVSLSSW-AIFGGWNAVTGLIV 288 + GLFG+ GA+G L A AG ADK H + L SW AI+ G +V LI+ Sbjct: 247 DGVIGLFGLAGAAGALGARPAGGFADKGKSHHTTTFGLLLLLLSWLAIWFGHTSVLALII 306 Query: 289 GVVLLDAGVNAALVSNQHLIFALRPEARSRLNTVFMTAMFVGGSLGSLGASWAYTHLSWL 348 G+++LD V ++NQ +I+ + P+AR+RL +MT+ F+GG+ GSL ++ A+ H W Sbjct: 307 GILVLDLTVQGVHITNQTVIYRIHPDARNRLTAGYMTSYFIGGAAGSLISASAWQHGGWA 366 Query: 349 GVCGYGAALATAGLLL 364 GVC GA +A LL+ Sbjct: 367 GVCLAGATIALVNLLV 382