BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0146.0040.p (272 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC0246 [IQR] COG1028 Dehydrogenases with different specificities... 169 9e-42 CC0094 [IQR] COG1028 Dehydrogenases with different specificities... 162 7e-40 Rv2002 [IQR] COG1028 Dehydrogenases with different specificities... 162 8e-40 TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 162 8e-40 SA2260 [IQR] COG1028 Dehydrogenases with different specificities... 161 1e-39 >CC0246 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 261 Score = 169 bits (427), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 111/265 (41%), Positives = 154/265 (58%), Gaps = 15/265 (5%) Query: 3 GQVEGKVALVTGGASGIGEAIVELFAQEGATVVATDIDELRGPELAARLKKA-GREVVF- 60 G+V GK A +TGGA G+G A + A+EGA V DI+ +A + A G F Sbjct: 6 GRVAGKKAFITGGAQGLGAAAGRMLAKEGAKVALADINLAGAQAVADEINAAHGAGTAFA 65 Query: 61 LPQDVTSEERWIEVIADIGKRYGRLDIMVSNAGIGIGAPSIVEMSLADWRRQTAINIDGV 120 DVT E++WI+V+ G L ++V+NAGIG P I + W++ ++N+D V Sbjct: 66 FELDVTQEDQWIDVLEKATAAMGGLSVLVNNAGIGGDGP-IESLDFGLWKKVMSVNVDSV 124 Query: 121 FLSVKHSLPLMRKHGGGSIIMMSSLAGLRGAATLSGYSATKGAVRLFAKSIAMECAQVND 180 FL KH+L MR H GSII +SS+AGL Y+A+K AV L +K+IA+ CA++ Sbjct: 125 FLGAKHALTHMRAHQPGSIINLSSIAGLIANGNSPAYNASKAAVWLLSKNIALYCAKMKL 184 Query: 181 GIRVNSVHPGIIDTPIWGKIPTGATGAGQNAPIDPEER-ARFA--TPLGRAGQAIEIAQG 237 IR NS+HP IDTPI G +A EE A+ A PLGR G+ +IA Sbjct: 185 DIRSNSIHPTFIDTPILD---------GFSARFGKEEAFAKLARQVPLGRIGEPTDIANA 235 Query: 238 VLYLASDASRYVTGTELVIDGGMNA 262 VLYLASD S+++TG E+ +DGG++A Sbjct: 236 VLYLASDESKFMTGAEIKVDGGISA 260 >CC0094 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ccr Caulobacter vibrioides Length = 296 Score = 162 bits (410), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 106/268 (39%), Positives = 154/268 (57%), Gaps = 15/268 (5%) Query: 1 MAGQVEGKVALVTGGASGIGEAIVELFAQEGATVVATDIDELRGPELAARLKKAGREVVF 60 M G++ GKVA++TGG SGIG VELF EGA VVA D+ + +G L R +V F Sbjct: 1 MVGRLNGKVAVITGGCSGIGLGTVELFVAEGACVVAADLQDEKGRMLEQRFPD---QVRF 57 Query: 61 LPQDVTSEERWIEVIADIGKRYGRLDIMVSNAGIGIGAPSIVEMSLADWRRQTAINIDGV 120 DVT+++ + +A +G LDI+ +NAG G S+ E++ W + A+ + G Sbjct: 58 ARCDVTADDDLAKTMALAESSFGGLDILFNNAGHGGTPASVPELTAEAWDKTFALLVRGP 117 Query: 121 FLSVKHSLPLMRKHGGGSIIMMSSLAGLRGAATLSGYSATKGAVRLFAKSIAMECAQVND 180 + + H+LPLM+K GGGSII +S+AGL+ YS+ K AV ++ A E + Sbjct: 118 AMGMTHALPLMQKRGGGSIINTASIAGLQAGFGPLAYSSAKAAVIHMSRCAAAELSPQK- 176 Query: 181 GIRVNSVHPGIIDTPIWGK---IP--TGATGAGQNAPIDPEERARFATPLGRAGQAIEIA 235 IRVN++ PG+I T I+G +P A Q A I P+ + P+ ++G +IA Sbjct: 177 -IRVNAICPGLIATSIFGASMGLPREVADQMAAQIASIGPKIQ-----PIPKSGLPEDIA 230 Query: 236 QGVLYLASDASRYVTGTELVIDGGMNAG 263 LYLASD SR+VTGT +V+DGG+ G Sbjct: 231 AAALYLASDDSRFVTGTHIVVDGGITVG 258 >Rv2002 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mtu Mycobacterium tuberculosis H37Rv Length = 260 Score = 162 bits (410), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 106/263 (40%), Positives = 150/263 (57%), Gaps = 22/263 (8%) Query: 1 MAGQVEGKVALVTGGASGIGEAIVELFAQEGATVVATDIDELRGPELAARLKKAGREVVF 60 M+G++ GKVALV+GGA G+G + V EGA VV DI + G +AA L A R + Sbjct: 1 MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADAAR---Y 57 Query: 61 LPQDVTSEERWIEVIADIGKRYGRLDIMVSNAGIGIGAPSIVEMSLADWRRQTAINIDGV 120 + DVT +W + +G L ++V+NAGI + +I + +L +W+R +N+ GV Sbjct: 58 VHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGI-LNIGTIEDYALTEWQRILDVNLTGV 116 Query: 121 FLSVKHSLPLMRKHGGGSIIMMSSLAGLRGAATLSGYSATKGAVRLFAKSIAMECAQVND 180 FL ++ + M++ G GSII +SS+ GL G GY+ATK AVR KS A+E Sbjct: 117 FLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGP--S 174 Query: 181 GIRVNSVHPGIIDTPIWGKIPTGATGAGQNAPIDPEERARFATPLGRAGQAIEIAQGVLY 240 GIRVNS+HPG++ TP+ +P F T LGRA + +E++ V+Y Sbjct: 175 GIRVNSIHPGLVKTPMTDWVP----------------EDIFQTALGRAAEPVEVSNLVVY 218 Query: 241 LASDASRYVTGTELVIDGGMNAG 263 LASD S Y TG E V+DGG AG Sbjct: 219 LASDESSYSTGAEFVVDGGTVAG 241 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 162 bits (410), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 105/257 (40%), Positives = 147/257 (57%), Gaps = 14/257 (5%) Query: 4 QVEGKVALVTGGASGIGEAIVELFAQEGATVVATDIDELRGPELAARLKKAGREVVFLPQ 63 ++EGKV L+TG ASGIG+A LFAQEGATV+A DI + L + +V Sbjct: 2 RLEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVL 61 Query: 64 DVTSEERWIEVIADIGKRYGRLDIMVSNAGIGIGAPSIVEMSLADWRRQTAINIDGVFLS 123 +VT ++ EV+ + ++YGR+D++V+NAGI A +V M DW +N+ GVF Sbjct: 62 NVTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDA-LLVRMKEEDWDAVINVNLKGVFNV 120 Query: 124 VKHSLPLMRKHGGGSIIMMSSLAGLRGAATLSGYSATKGAVRLFAKSIAMECAQVNDGIR 183 + +P M K GSI+ +SS+ G+ G + Y+A+K V K+ A E A N IR Sbjct: 121 TQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRN--IR 178 Query: 184 VNSVHPGIIDTPIWGKIPTGATGAGQNAPIDPEERARFATPLGRAGQAIEIAQGVLYLAS 243 VN+V PG I+TP+ K+P A E A PLGR G+ E+AQ +L+LAS Sbjct: 179 VNAVAPGFIETPMTEKLPEKA-----------RETALSRIPLGRFGKPEEVAQVILFLAS 227 Query: 244 DASRYVTGTELVIDGGM 260 D S YVTG + IDGG+ Sbjct: 228 DESSYVTGQVIGIDGGL 244 >SA2260 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sau Staphylococcus aureus N315 Length = 272 Score = 161 bits (408), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 101/260 (38%), Positives = 154/260 (59%), Gaps = 9/260 (3%) Query: 4 QVEGKVALVTGGASGIGEAIVELFAQEGATVVATDIDELRGPELAARLKKAGREVVFLPQ 63 ++E KVA+VTG ++GIG+A AQEGA V+A DI E E ++K G Sbjct: 3 RLENKVAVVTGASTGIGQASAIALAQEGAYVLAVDIAEAVS-ETVDKIKSNGDNAKAYNV 61 Query: 64 DVTSEERWIEVIADIGKRYGRLDIMVSNAGIGIGAPSIVEMSLADWRRQTAINIDGVFLS 123 D++ E++ ++ ++DI +++GR+D++ +NAG+ A I E + + + +++ G L Sbjct: 62 DISDEQQVVDFVSDIKEQFGRIDVLFNNAGVDNAAGRIHEYPIDVYDKIMNVDMRGTILM 121 Query: 124 VKHSLPLMRKHGGGSIIMMSSLAGLRGAATLSGYSATKGAVRLFAKSIAMECAQVNDGIR 183 K LPLM GGSI+ SS +G SGY+A KGAV F KSIA+E + DGIR Sbjct: 122 TKMMLPLMMNQ-GGSIVNTSSFSGQAEDLYRSGYNAAKGAVINFTKSIAIEYGR--DGIR 178 Query: 184 VNSVHPGIIDTPIWGKIP-TGATGAGQNAPIDPEERARFATPLGRAGQAIEIAQGVLYLA 242 N++ PG I+TP+ K+ T AG+ E ++ TPLGR G+ E+A+ V++LA Sbjct: 179 SNAIAPGTIETPLVDKLTGTSEDDAGKTF----RENQKWMTPLGRLGKPEEVAKLVVFLA 234 Query: 243 SDASRYVTGTELVIDGGMNA 262 SD S ++TG + IDGG+ A Sbjct: 235 SDDSSFITGETIRIDGGVMA 254