BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0146.0025.p (348 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value TM1782 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Tm... 312 7e-85 PA0662 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Pa... 301 1e-81 CAC2390 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase C... 288 1e-77 sll0080 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase S... 284 2e-76 alr3537 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase N... 278 2e-74 >TM1782 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Tma Thermotoga maritima Length = 339 Score = 312 bits (800), Expect = 7e-85, Method: Compositional matrix adjust. Identities = 160/344 (46%), Positives = 221/344 (64%), Gaps = 7/344 (2%) Query: 5 KIGILGASGYTGADAVRLLARHPNAEITALTANTHAGKAMSEVFPHFFMLHLPKLVEWEK 64 + GI+GA+GYTG + VRLL HP A+IT L++ T+AGK + E+FP + + EK Sbjct: 3 RAGIIGATGYTGLELVRLLKNHPEAKITYLSSRTYAGKKLEEIFPSTLENSILSEFDPEK 62 Query: 65 VDWTRLDAVFCGLPHGTTQEIIAAVLKTNPGIKILDMSADFRLRDKDSYAQWYGHEHRAL 124 V D +F LP G + +++ + G+KI+D+ ADFR D Y +WYG E Sbjct: 63 VS-KNCDVLFTALPAGASYDLVREL----KGVKIIDLGADFRFDDPGVYREWYGKELSGY 117 Query: 125 ELQDEAVYGLTELYREKVTAARLVACPGCYPTAVLLALVPLAKAKLIDVDDIIIDAKSGV 184 E + VYGL EL+RE++ A++V PGCYPT+V+LAL P K L+D + I++DAKSGV Sbjct: 118 E-NIKRVYGLPELHREEIKNAQVVGNPGCYPTSVILALAPALKHNLVDPETILVDAKSGV 176 Query: 185 TGAGRGLKQNTLFSEAGEGLSPYSIGSHRHSAEIEQEIGAAAGSAVTVNFTPHLIPMARG 244 +GAGR K + LFSE E L PY++ HRH E+EQE+G +G V V FTPHL+PM RG Sbjct: 177 SGAGRKEKVDYLFSEVNESLRPYNVAKHRHVPEMEQELGKISGKKVNVVFTPHLVPMTRG 236 Query: 245 EFCTSYVRLNGATPDDLRAELERAYANEPFVYVTKKGVLPQTQNVRGSNYVQIGVVADRI 304 T YV+ + + + A LE Y NEPFV+V G+ P T+ GSN+V IG+ + Sbjct: 237 ILSTIYVKTDKSLEEIHEAYLE-FYKNEPFVHVLPMGIYPSTKWCYGSNHVFIGMQMEER 295 Query: 305 KNRAIVLSTLDNLVKGSAGQAIQNMNLMFGLPETTGLEQIALFP 348 N I++S +DNLVKG++GQA+QNMN+MFGL ET GLE ++P Sbjct: 296 TNTLILMSAIDNLVKGASGQAVQNMNIMFGLDETKGLEFTPIYP 339 >PA0662 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Pae Pseudomonas aeruginosa Length = 344 Score = 301 bits (772), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 159/347 (45%), Positives = 220/347 (63%), Gaps = 8/347 (2%) Query: 5 KIGILGASGYTGADAVRLLARHPNAEITALTANTHAGKAMSEVFPHFFMLHLPKLVEWEK 64 K+GI+G +GYTG + +RLLA+HP A + +T+ + AG +++++P+ H L ++ Sbjct: 3 KVGIVGGTGYTGVELLRLLAQHPQARVEVITSRSEAGVKVADMYPNLRG-HYDDL-QFSV 60 Query: 65 VDWTRL---DAVFCGLPHGTTQEIIAAVLKTNPGIKILDMSADFRLRDKDSYAQWYGHEH 121 D RL D VF PHG + +L + G +++D+SADFRL D + +A+WYG H Sbjct: 61 PDAQRLGACDVVFFATPHGVAHALAGELL--DAGTRVIDLSADFRLADAEEWARWYGQPH 118 Query: 122 RALELQDEAVYGLTELYREKVTAARLVACPGCYPTAVLLALVPLAKAKLIDVDDIIIDAK 181 A L DEAVYGL E+ REK+ ARL+A PGCYPTA L L+PL +A L D +I D K Sbjct: 119 GAPALLDEAVYGLPEVNREKIRQARLIAVPGCYPTATQLGLIPLLEAGLADASRLIADCK 178 Query: 182 SGVTGAGRGLKQNTLFSEAGEGLSPYSIGSHRHSAEIEQEIGAAAGSAVTVNFTPHLIPM 241 SGV+GAGRG K +LF EAGE + Y++ HRH EI Q + A+G V + F PHL PM Sbjct: 179 SGVSGAGRGAKVGSLFCEAGESMMAYAVKGHRHLPEISQGLRRASGGDVGLTFVPHLTPM 238 Query: 242 ARGEFCTSYVRLNGATPDDLRAELERAYANEPFVYVTKKGVLPQTQNVRGSNYVQIGVVA 301 RG T Y + + DL+A E+ YA+EPFV V G P+T++VRG+N +I V Sbjct: 239 IRGIHATLYAHVADRSV-DLQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHR 297 Query: 302 DRIKNRAIVLSTLDNLVKGSAGQAIQNMNLMFGLPETTGLEQIALFP 348 + + +VLS +DNLVKG++GQA+QNMN++FGL E GL AL P Sbjct: 298 PQGGDLVVVLSVIDNLVKGASGQALQNMNILFGLDERLGLSHAALLP 344 >CAC2390 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Cac Clostridium acetobutylicum Length = 345 Score = 288 bits (737), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 141/345 (40%), Positives = 208/345 (60%), Gaps = 7/345 (2%) Query: 7 GILGASGYTGADAVRLLARHPNAEITALTANTHAGKAMSEVFPHFFMLHLPKLVEWEKV- 65 GI+GA+GY G LL HPN + L +++H + + + +F + ++ +V Sbjct: 5 GIIGATGYAGEVLTWLLNNHPNVNLVFLASHSHGNSSFNSTYGNFTNVIENLCIDDNEVE 64 Query: 66 -DWTRLDAVFCGLPHGTTQEIIAAVLKTNPGIKILDMSADFRLRDKDSYAQWYGHEHRAL 124 + +D +F LP G T I+ ++ +K++D+ AD+RL+ + Y +WY H Sbjct: 65 DNLDNIDILFTALPSGKTFSIVKKAVE--EKVKVIDLGADYRLKSAEVYKEWYNINHECK 122 Query: 125 ELQDEAVYGLTELYREKVTAARLVACPGCYPTAVLLALVPLAKAKLIDVDDIIIDAKSGV 184 +L +AVYGL+E+YREK+ + L+A PGCYPTA LAL+PL K LID IIIDAKSGV Sbjct: 123 KLLKDAVYGLSEIYREKIKTSNLIANPGCYPTASSLALIPLLKNNLIDTSSIIIDAKSGV 182 Query: 185 TGAGRGLKQNTLFSEAGEGLSPYSIGSHRHSAEIEQEIGAAAGSAVTVNFTPHLIPMARG 244 +GAGR N LF E + + Y + SHRH+ EIEQ + A +T+ FTPHL+PM RG Sbjct: 183 SGAGRKASTNNLFIECNDSIKAYGVASHRHTPEIEQTLTNEAKEKITLTFTPHLVPMNRG 242 Query: 245 EFCTSYVRLNGATP-DDLRAELERAYANEPFVYVTKKGVLPQTQNVRGSNYVQIGVVADR 303 Y L +++ ++ Y NEPF+ + LP+T+ V+GSNY I + D+ Sbjct: 243 ILSVCYSNLKKEIELNEVYDIYKKFYKNEPFIRII--DTLPETRWVKGSNYCDIAIRIDK 300 Query: 304 IKNRAIVLSTLDNLVKGSAGQAIQNMNLMFGLPETTGLEQIALFP 348 N+ IVLS +DNL+KG+A QA+QNMN+M+GL E TG++ +FP Sbjct: 301 RTNKIIVLSAIDNLMKGAASQAVQNMNIMYGLAEKTGIDLTPMFP 345 >sll0080 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Syn Synechocystis Length = 351 Score = 284 bits (726), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 162/352 (46%), Positives = 210/352 (59%), Gaps = 11/352 (3%) Query: 3 KKKIGILGASGYTGADAVRLLARHPNAEITALTANTHAGKAMSEVFPHFFMLHLPKLVEW 62 K ++GI+GASGY G VRLL HP E+T L ++ AGK S+++PH + H L Sbjct: 5 KARVGIIGASGYGGIQLVRLLLEHPQVELTYLAGHSSAGKPYSDLYPH--LTHRVNLT-I 61 Query: 63 EKVDW----TRLDAVFCGLPHGTTQEIIAAVLKTNPGIKILDMSADFRLRDKDSYAQWYG 118 E +D +R DAVF GLP+G ++ A+L G K+LD+SAD+R R+ ++Y +WY Sbjct: 62 EPIDLEAIASRCDAVFLGLPNGLACDMAPALLAK--GCKVLDLSADYRFRNLNTYTEWYK 119 Query: 119 HEHRALELQDEAVYGLTELYREKVTAARLVACPGCYPTAVLLALVPLAKAKLIDVDDIII 178 + + ++AVYGL ELYR+ + A+L+ CPGCYPTA LLAL PL K I + II Sbjct: 120 KDRQDQATNNQAVYGLPELYRDAIRDAQLIGCPGCYPTASLLALSPLLKQGFIVPETAII 179 Query: 179 DAKSGVTGAGRGLKQNTLFSEAGEGLSPYSIGSHRHSAEIEQEIGAAAGSAVTVNFTPHL 238 DAKSG +G GR K N L +EA L Y + HRH+ EIEQ AG+ + V FTPHL Sbjct: 180 DAKSGTSGGGREAKVNMLLAEAEGSLGAYGVAKHRHTPEIEQIASDLAGTELRVQFTPHL 239 Query: 239 IPMARGEFCTSYVRLN--GATPDDLRAELERAYANEPFVYVTKKGVLPQTQNVRGSNYVQ 296 IPM RG T Y L G DDL Y PFV + GV PQT+ G+N Sbjct: 240 IPMVRGILATVYATLRDPGLVRDDLITIYSAFYRASPFVKILPHGVYPQTKWAWGTNLCY 299 Query: 297 IGVVADRIKNRAIVLSTLDNLVKGSAGQAIQNMNLMFGLPETTGLEQIALFP 348 IG+ D R IVLS +DNLVKG AGQA+Q +NLM G E+ GL Q+A +P Sbjct: 300 IGIEVDPRTGRVIVLSAIDNLVKGQAGQAVQCLNLMMGWEESLGLPQLAFYP 351 >alr3537 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase Nos Nostoc sp. PCC 7120 Length = 352 Score = 278 bits (710), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 158/349 (45%), Positives = 207/349 (59%), Gaps = 11/349 (3%) Query: 6 IGILGASGYTGADAVRLLARHPNAEITALTANTHAGKAMSEVFPHFFMLHLPKLVEWEKV 65 +GI+GASGY G VRLL HP E+ L + GK+ + ++PH + H KL E+V Sbjct: 9 VGIVGASGYGGVQLVRLLMDHPEIELVYLGGESSVGKSFASLYPH--LAHAVKL-SIEEV 65 Query: 66 D----WTRLDAVFCGLPHGTTQEIIAAVLKTNPGIKILDMSADFRLRDKDSYAQWYGHEH 121 D R + VF +P+G +I+ +L+ G K+LD+SAD+R R+ +Y WYG E Sbjct: 66 DPEVIARRCEVVFLSMPNGLACQIVPTLLEK--GCKVLDLSADYRFRNLTTYTTWYGVER 123 Query: 122 RALELQDEAVYGLTELYREKVTAARLVACPGCYPTAVLLALVPLAKAKLIDVDDIIIDAK 181 D A+YGL ELYR++++ A+LV CPG YPTA LLAL PL K LI + I+DAK Sbjct: 124 SDRTTADTAIYGLPELYRDRISEAQLVGCPGSYPTASLLALSPLLKQGLIVPETAIVDAK 183 Query: 182 SGVTGAGRGLKQNTLFSEAGEGLSPYSIGSHRHSAEIEQEIGAAAGSAVTVNFTPHLIPM 241 SG +G GR K L +EA L+PYS+ HRH+ EIEQ AG VTV FTPHL+P+ Sbjct: 184 SGTSGGGREAKTYLLLAEADNSLAPYSVVRHRHTPEIEQICSDLAGHEVTVQFTPHLVPI 243 Query: 242 ARGEFCTSYVRLN--GATPDDLRAELERAYANEPFVYVTKKGVLPQTQNVRGSNYVQIGV 299 RG T Y L G DDL Y N P+V V + G+ PQT+ GSN IGV Sbjct: 244 VRGILATVYATLRDPGLVGDDLTTIYTAFYRNSPWVKVCESGIYPQTKWAAGSNLCYIGV 303 Query: 300 VADRIKNRAIVLSTLDNLVKGSAGQAIQNMNLMFGLPETTGLEQIALFP 348 D R IV+S +DNL+KG AGQAIQ +N+M G ET GL ++ +P Sbjct: 304 EVDPRTGRVIVMSVIDNLIKGQAGQAIQCLNIMMGWDETLGLPKMGFYP 352