BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0146.0017.p (280 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC2607 [IQR] COG1028 Dehydrogenases with different specificitie... 199 7e-51 SP0320 [IQR] COG1028 Dehydrogenases with different specificities... 198 1e-50 SPy0636 [IQR] COG1028 Dehydrogenases with different specificitie... 194 2e-49 AGc2598 [IQR] COG1028 Dehydrogenases with different specificitie... 193 3e-49 RSp0947 [IQR] COG1028 Dehydrogenases with different specificitie... 192 7e-49 >CAC2607 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 267 Score = 199 bits (505), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 112/251 (44%), Positives = 150/251 (59%), Gaps = 5/251 (1%) Query: 30 FDLSGRVAIVTGGNGGIGLGMARGLADAGAAVAVVGRNEAKSKAAVEDLGKRGAKAIAVA 89 F L G++A+VTG + GIG +AR A+AGA + N+ ++ G KA Sbjct: 7 FSLEGKIALVTGASYGIGFAIARSYANAGATIVFNDINQDLVDKGLKAYEAEGIKAHGYV 66 Query: 90 TDVTDKAAVAAMVERVVRELGRIDILVNNAGMSIRKPPHELELEEWSKVIDTNLTSAFMC 149 DVTD+ V V++V +E+G IDILVNNAG+ R P E++ E++ KVID +L + F+ Sbjct: 67 CDVTDEDKVNGFVKKVEKEVGLIDILVNNAGIIKRIPMLEMKAEDFRKVIDVDLNAPFIV 126 Query: 150 SKAAYPALKASGHGKIINIGSMMSIFGASFAAAYAASKGGIVQYTRACANAWAPDNIQVN 209 SKA P + GHGKIINI SMMS G +AYAA+KGG+ TR A+ + NIQ N Sbjct: 127 SKAVIPGMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEYGEHNIQCN 186 Query: 210 AILPGWIDTDLTKGARQQVAG-----LHERVLARTPAARWGAIDDFAGIAVFLASPASDF 264 I PG+I T T R+ A + ++A+TPAARWG +D G AVFLAS AS+F Sbjct: 187 GIGPGYIATPQTAPLRELQADGSKHPFDQFIIAKTPAARWGTPEDLMGPAVFLASDASNF 246 Query: 265 VTGTAIPVDGG 275 V G + VDGG Sbjct: 247 VNGHVLYVDGG 257 >SP0320 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Spn Streptococcus pneumoniae TIGR4 Length = 271 Score = 198 bits (503), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 112/259 (43%), Positives = 156/259 (60%), Gaps = 5/259 (1%) Query: 22 TTTMKNGQFDLSGRVAIVTGGNGGIGLGMARGLADAGAAVAVVGRNEAKSKAAVEDLGKR 81 T+ QF L G++A++TG + GIG +A+ A+AGA + N+ +E + Sbjct: 3 NTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVFNDINQDLVNKGIEAYREV 62 Query: 82 GAKAIAVATDVTDKAAVAAMVERVVRELGRIDILVNNAGMSIRKPPHELELEEWSKVIDT 141 G +A DVTD+ + AMV+++ +E+G IDILVNNAG+ R P E+ ++ KVID Sbjct: 63 GIQAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGIIRRVPMCEMSAADFRKVIDI 122 Query: 142 NLTSAFMCSKAAYPALKASGHGKIINIGSMMSIFGASFAAAYAASKGGIVQYTRACANAW 201 +L + F+ SKA P++ GHGKIINI SMMS G +AYAA+KGG+ TR A+ + Sbjct: 123 DLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTRNIASEY 182 Query: 202 APDNIQVNAILPGWIDTDLTKGAR--QQVAGLH---ERVLARTPAARWGAIDDFAGIAVF 256 NIQ N I PG+I T T R Q+ H + ++A+TPAARWG +D G AVF Sbjct: 183 GGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFDQFIIAKTPAARWGNTEDLMGPAVF 242 Query: 257 LASPASDFVTGTAIPVDGG 275 LAS AS+FV G + VDGG Sbjct: 243 LASDASNFVNGHILYVDGG 261 >SPy0636 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Spy Streptococcus pyogenes M1 GAS Length = 264 Score = 194 bits (493), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 113/259 (43%), Positives = 158/259 (61%), Gaps = 12/259 (4%) Query: 25 MKNGQFDLSGRVAIVTGGNGGIGLGMARGLADAGAAVAVVGRNEAKSKAAVEDLG---KR 81 M+N F L G++A++TG + GIG +A+ A AGA + N+ K + + L + Sbjct: 1 MEN-MFSLQGKIALITGASYGIGFEIAKAYAQAGATIVF---NDIKQELVDKGLAAYREL 56 Query: 82 GAKAIAVATDVTDKAAVAAMVERVVRELGRIDILVNNAGMSIRKPPHELELEEWSKVIDT 141 G +A DVTD+A + MV ++ E+G IDILVNNAG+ R P E+ E++ +VID Sbjct: 57 GIEAHGYVCDVTDEAGIQQMVSQIEDEVGAIDILVNNAGIIRRTPMLEMAAEDFRQVIDI 116 Query: 142 NLTSAFMCSKAAYPALKASGHGKIINIGSMMSIFGASFAAAYAASKGGIVQYTRACANAW 201 +L + F+ SKA P++ A GHGKIINI SMMS G +AYAA+KGG+ T+ A+ + Sbjct: 117 DLNAPFIVSKAVLPSMIAKGHGKIINICSMMSELGRETVSAYAAAKGGLKMLTKNIASEF 176 Query: 202 APDNIQVNAILPGWIDTDLTKGARQQVAG-----LHERVLARTPAARWGAIDDFAGIAVF 256 NIQ N I PG+I T T R++ A + ++A+TPAARWG +D AG AVF Sbjct: 177 GEANIQCNGIGPGYIATPQTAPLRERQADGSRHPFDQFIIAKTPAARWGTTEDLAGPAVF 236 Query: 257 LASPASDFVTGTAIPVDGG 275 LAS AS+FV G + VDGG Sbjct: 237 LASDASNFVNGHILYVDGG 255 >AGc2598 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 256 Score = 193 bits (491), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 112/246 (45%), Positives = 146/246 (59%), Gaps = 1/246 (0%) Query: 30 FDLSGRVAIVTGGNGGIGLGMARGLADAGAAVAVVGRNEAKSKAAVEDLGKRGAKAIAVA 89 FDL GR A+VTG + G+G MA GLA AGA + + G + ++ V++ G A AVA Sbjct: 7 FDLGGRTALVTGSSRGLGRAMAEGLAVAGARILINGTDPSRVAQTVQEFRNVGHDAEAVA 66 Query: 90 TDVTDKAAVAAMVERVVRELGRIDILVNNAGMSIRKPPHELELEEWSKVIDTNLTSAFMC 149 DVT ++ + R+ + +DILVNNAG+ RKP ELE +W +VIDTNLTSAFM Sbjct: 67 FDVTSESEIIEAFARLDEQGIDVDILVNNAGIQFRKPMIELETADWQRVIDTNLTSAFMI 126 Query: 150 SKAAYPALKASGHGKIINIGSMMSIFGASFAAAYAASKGGIVQYTRACANAWAPDNIQVN 209 + A + G+GKI+NIGS+ S + A Y +KGGI TRA A WA IQ N Sbjct: 127 GREAAKRMIPRGYGKIVNIGSLTSELARATVAPYTVAKGGIKMLTRAMAAEWAQYGIQAN 186 Query: 210 AILPGWIDTDLTKGARQQVAGLHERVLARTPAARWGAIDDFAGIAVFLASPASDFVTGTA 269 AI PG++ TD+ + A V ARTPA RWG + G AVFL++ ASD+V G Sbjct: 187 AIGPGYMLTDMNQ-ALIDNPEFDAWVKARTPAKRWGKPQELVGTAVFLSASASDYVNGQI 245 Query: 270 IPVDGG 275 I VDGG Sbjct: 246 IYVDGG 251 >RSp0947 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Rso Ralstonia solanacearum Length = 258 Score = 192 bits (488), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 110/248 (44%), Positives = 144/248 (58%), Gaps = 1/248 (0%) Query: 30 FDLSGRVAIVTGGNGGIGLGMARGLADAGAAVAVVGRNEAKSKAAVEDLGKRGAKAIAVA 89 FDLSGR A++TG + GIG +A GLA AGA V + R K A + L +GA A Sbjct: 9 FDLSGRTALITGASSGIGFALAGGLARAGARVVLNARGPEKLAQAADSLRAQGADVHTAA 68 Query: 90 TDVTDKAAVAAMVERVVRELGRIDILVNNAGMSIRKPPHELELEEWSKVIDTNLTSAFMC 149 DVT AVA + RV ELG IDILVNNAGM R P + E ++W +++ TN+ S F+ Sbjct: 69 FDVTQSTAVAEGIARVEAELGPIDILVNNAGMQRRAPLEQFETDQWHELMKTNVDSVFLV 128 Query: 150 SKAAYPALKASGHGKIINIGSMMSIFGASFAAAYAASKGGIVQYTRACANAWAPDNIQVN 209 +A + G GKIINI S+ S G A Y ASKG + T+ A W P +QVN Sbjct: 129 GQAVARYMIPRGRGKIINICSVQSELGRPGIAPYTASKGAVKMLTKGMAIDWGPHGLQVN 188 Query: 210 AILPGWIDTDLTKGARQQVAGLHERVLARTPAARWGAIDDFAGIAVFLASPASDFVTGTA 269 + PG+ T+LT+ A A ++ RTP+ RWG ++D G A+FLAS ASDFV G Sbjct: 189 GLGPGYFKTELTQ-ALVANAEFTAWLVGRTPSRRWGDVEDLTGAAIFLASKASDFVNGHI 247 Query: 270 IPVDGGYS 277 + VDGG + Sbjct: 248 LYVDGGVT 255