BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0141.0002.p (401 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMc00172 [GEPR] COG0477 Permeases of the major facilitator super... 149 2e-35 VC0302 [GEPR] COG0477 Permeases of the major facilitator superfa... 140 4e-33 hcaT [GEPR] COG0477 Permeases of the major facilitator superfami... 135 2e-31 ZhcaT [GEPR] COG0477 Permeases of the major facilitator superfam... 134 3e-31 ECs3402 [GEPR] COG0477 Permeases of the major facilitator superf... 134 3e-31 >SMc00172 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 407 Score = 149 bits (375), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 113/373 (30%), Positives = 179/373 (47%), Gaps = 5/373 (1%) Query: 17 RRFANRLAAFYATLFGMTGVHLPFFTVWLKAIGIDATWIGIITAVPPVTRFTVLPLVTAA 76 R FA R+A ++ + G +P+F VWL ++ + IGI+ AVP R PL Sbjct: 16 RHFALRIALLFSAPLIVNGFAMPYFPVWLSSLSLSDFEIGIVLAVPMFVRVITAPLAGVL 75 Query: 77 AERRQMLRGAIIATGFATAFGFAVIGTQRQPFVLLAIYALTCCVWTPMVPLTDAYALRGV 136 A+R +I +G + G V+ + + +L IY L V++P VP+ +A AL GV Sbjct: 76 ADRIGERTIVLIWSGILSFAGAVVLFYAQSFWPVLVIYTLQSAVYSPYVPIVEAIALSGV 135 Query: 137 RQFGLSYGPLRLWGSAAFAVCALLSGFLLRYVAEVDLIWIITAVTVLGALVGLTLRPLG- 195 R++G Y +R+WGS AF +L G+L+ V ++ + A L L+ + +G Sbjct: 136 RRWGFDYAQMRVWGSVAFIGATMLGGWLIGVVGGQMVLPAMAAGFALTILLAVAAPRVGR 195 Query: 196 -RRVAAVTP-AAGAPKLLRNPTFLAIIVSSALIQGSHGAYYIFASIAWQQAGFSGLTIAC 253 RR + +T P+ LR ++V L+ SH + F++I WQ G+SG I Sbjct: 196 PRRPSPITAITEPPPQSLRQADLQLLLVGVTLVNSSHAMLFAFSAIYWQHIGYSGTQIGI 255 Query: 254 LWVLGVIAEIVLFAASPRFTLPSAVLVMIAASS--AAARWAITAQDPPLAVLAVVQLGHG 311 LW GV AE+++F + +V MI + A RW I D + V+Q H Sbjct: 256 LWSAGVSAEVLMFFLARAIVRRFSVWTMIFSGCLLAVVRWLIFPMDLGFSGYFVLQCFHA 315 Query: 312 LSFGLTQVGIMGLMVHHVPVHVMARAQGYLTACGGIVASTTAIVSGMVYARFGLGVYDMM 371 ++ + G+ +V V A AQG GI + +SG YA FG+ + M Sbjct: 316 FTYAIMHTGMQHKLVERVAEEQEASAQGLYFFYTGIFTAIFTFLSGYFYAWFGVDGFYSM 375 Query: 372 AAMAATGGLVMWL 384 +A+A +G L +L Sbjct: 376 SAVALSGCLFTFL 388 >VC0302 [GEPR] COG0477 Permeases of the major facilitator superfamily Vch Vibrio cholerae Length = 396 Score = 140 bits (354), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 122/375 (32%), Positives = 190/375 (50%), Gaps = 28/375 (7%) Query: 23 LAAFYATLFGMTGVHLPFFTVWLKAIGIDATWIGIITAVPPVTRFTVLPLVTAAAERRQM 82 ++ ++ F GV+LPF+++W + G+ AT IG++ + TR ++T R + Sbjct: 10 ISQYFIGFFFAYGVYLPFWSLWFEDQGVSATDIGVLVGIGFATRCVANLVLTPRLHRVEQ 69 Query: 83 LRGAIIATGFA----TAFGFAVIGTQRQPFVLLAIYALT---CCVWTPMVPLTDAYALRG 135 L A+ FA F F G+ F L+A+ + CC P+VP++DA A Sbjct: 70 LMPALRWLSFAAMLFVGFHFFTGGS----FWLMALATVLFNLCC--GPVVPISDAMANYY 123 Query: 136 VRQFGLSYGPLRLWGSAAFAVCALLSGFLLRYVAEVDLIW---IITAVTVLGALVGLTLR 192 + L YG RLWGS AF + + GFL+ + +++ + AV+ L +L +T Sbjct: 124 AKLKMLDYGRTRLWGSIAFIAGSTVVGFLVAKWGSLMILYTALVGVAVSWLLSLRQITPM 183 Query: 193 PLGRRVA-AVTPAAGAPKLLRNPTFLAIIVSSALIQGSHGAYYIFASIAWQQAGFSGLTI 251 P+ A AV P +LL + ++ ALIQGSH AYY F SI W+QAG S I Sbjct: 184 PVTEHEAHAVRPKL--KELLTEWPVVKFLLLVALIQGSHAAYYSFGSIYWKQAGHSEDII 241 Query: 252 ACLWVLGVIAEIVLFAASPRFTLPSAV--LVMIAASSAAARWAITAQDPPLAVLAVVQLG 309 LW LGV+AE+++FA S R+ ++ L +A+ ARW +TA + L +QL Sbjct: 242 GYLWSLGVVAEVLVFAFSKRWFAGWSLRTLFFVASLGVIARWGLTASTTTILALVAIQLL 301 Query: 310 HGLSFGLTQVGIMGLMVHHVPVHVMARAQGYLTA--CGGIVASTTAIVSGMVYARFGLGV 367 HG++F + + + + H P + M Q A G ++A+ T + SG Y +G V Sbjct: 302 HGVTFAIAHIAAIQ-YIQHAPQNKMVALQALYNAIPLGAVIAAVTTL-SGWGYEHWGAAV 359 Query: 368 YDMMAAMAATGGLVM 382 + MAAM GGL + Sbjct: 360 FWAMAAM---GGLAL 371 >hcaT [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 379 Score = 135 bits (340), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 118/363 (32%), Positives = 185/363 (50%), Gaps = 16/363 (4%) Query: 23 LAAFYATLFGMTGVHLPFFTVWLKAIGIDATWIGIITAVPPVTRFT-VLPLVTAAAERRQ 81 LA Y T F G+ LPF++VWLK IG+ IG++ V RF L + ++ + Sbjct: 9 LALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSR 68 Query: 82 MLRGAIIATGFATAFGFAVIGTQRQPFVLLAIYALTCCVWTPMVPLTDAYALRGVRQFGL 141 ++ + F A +++L + ++P+VPLTDA A +QF L Sbjct: 69 LISALRVLALLTLLFAVAFWAGAHVAWLMLVMIGFNL-FFSPLVPLTDALANTWQKQFPL 127 Query: 142 SYGPLRLWGSAAFAVCALLSGFL---LRYVAEVDLIWIITAVTVLGALVGLTLRPLG--R 196 YG +RLWGS AF + + L+G L Y + L+ + A +LG L+ T++P G R Sbjct: 128 DYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILALLTLGVASMLLGFLIRPTIQPQGASR 187 Query: 197 RVAAVTPAAGAPKLLRNPTFLAIIVSSALIQGSHGAYYIFASIAWQQAGFSGLTIACLWV 256 + + +A + +N FLA + L+QG+H AYY F++I WQ AG+S + LW Sbjct: 188 QQESTGWSAWLALVRQNWRFLACV---CLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWS 244 Query: 257 LGVIAEIVLFAASPR-FTLPSA-VLVMIAASSAAARWAITAQDPPLAVLAVVQLGHGLSF 314 LGV+AE+++FA S + F SA +++I+A RW I L L VVQ+ H +F Sbjct: 245 LGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTF 304 Query: 315 GLTQVGIMGLMVHHVPVHVMARAQGYLTAC--GGIVASTTAIVSGMVYARFGLGVYDMMA 372 + + M + V+ R Q +A GG +A T + +G +Y G GV+ +MA Sbjct: 305 TVCHLAAMRYIAARQGSEVI-RLQAVYSAVAMGGSIAIMT-VFAGFLYQYLGHGVFWVMA 362 Query: 373 AMA 375 +A Sbjct: 363 LVA 365 >ZhcaT [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 379 Score = 134 bits (338), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 118/363 (32%), Positives = 185/363 (50%), Gaps = 16/363 (4%) Query: 23 LAAFYATLFGMTGVHLPFFTVWLKAIGIDATWIGIITAVPPVTRFT-VLPLVTAAAERRQ 81 LA Y T F G+ LPF++VWLK IG+ IG++ V RF L + ++ + Sbjct: 9 LALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSR 68 Query: 82 MLRGAIIATGFATAFGFAVIGTQRQPFVLLAIYALTCCVWTPMVPLTDAYALRGVRQFGL 141 ++ + F A +++L + ++P+VPLTDA A +QF L Sbjct: 69 LISALRVLALLTLLFAVAFWAGAHVAWLMLVMIGFNL-FFSPLVPLTDALANTWQKQFPL 127 Query: 142 SYGPLRLWGSAAFAVCALLSGFL---LRYVAEVDLIWIITAVTVLGALVGLTLRPLG--R 196 YG +RLWGS AF + + L+G L Y + L+ + A +LG L+ T++P G R Sbjct: 128 DYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILVLLTLGVASMLLGFLIRPTIQPQGASR 187 Query: 197 RVAAVTPAAGAPKLLRNPTFLAIIVSSALIQGSHGAYYIFASIAWQQAGFSGLTIACLWV 256 + + +A + +N FLA + L+QG+H AYY F++I WQ AG+S + LW Sbjct: 188 QQESTGWSAWLALVRQNWRFLACV---CLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWS 244 Query: 257 LGVIAEIVLFAASPR-FTLPSA-VLVMIAASSAAARWAITAQDPPLAVLAVVQLGHGLSF 314 LGV+AE+++FA S + F SA +++I+A RW I L L VVQ+ H +F Sbjct: 245 LGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTF 304 Query: 315 GLTQVGIMGLMVHHVPVHVMARAQGYLTAC--GGIVASTTAIVSGMVYARFGLGVYDMMA 372 + + M + V+ R Q +A GG +A T + +G +Y G GV+ +MA Sbjct: 305 TVCHLAAMRYIAARQGSEVI-RLQAVYSAVAMGGSIAIMT-VFAGFLYQYLGHGVFWVMA 362 Query: 373 AMA 375 +A Sbjct: 363 LVA 365 >ECs3402 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 379 Score = 134 bits (338), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 118/363 (32%), Positives = 185/363 (50%), Gaps = 16/363 (4%) Query: 23 LAAFYATLFGMTGVHLPFFTVWLKAIGIDATWIGIITAVPPVTRFT-VLPLVTAAAERRQ 81 LA Y T F G+ LPF++VWLK IG+ IG++ V RF L + ++ + Sbjct: 9 LALGYFTYFFSYGIFLPFWSVWLKGIGLTPETIGLLLGAGLVARFLGSLLIAPRVSDPSR 68 Query: 82 MLRGAIIATGFATAFGFAVIGTQRQPFVLLAIYALTCCVWTPMVPLTDAYALRGVRQFGL 141 ++ + F A +++L + ++P+VPLTDA A +QF L Sbjct: 69 LISALRVLALLTLLFAVAFWAGAHVAWLMLVMIGFNL-FFSPLVPLTDALANTWQKQFPL 127 Query: 142 SYGPLRLWGSAAFAVCALLSGFL---LRYVAEVDLIWIITAVTVLGALVGLTLRPLG--R 196 YG +RLWGS AF + + L+G L Y + L+ + A +LG L+ T++P G R Sbjct: 128 DYGKVRLWGSVAFVIGSALTGKLVTMFDYRVILVLLTLGVASMLLGFLIRPTIQPQGASR 187 Query: 197 RVAAVTPAAGAPKLLRNPTFLAIIVSSALIQGSHGAYYIFASIAWQQAGFSGLTIACLWV 256 + + +A + +N FLA + L+QG+H AYY F++I WQ AG+S + LW Sbjct: 188 QQESTGWSAWLALVRQNWRFLACV---CLLQGAHAAYYGFSAIYWQAAGYSASAVGYLWS 244 Query: 257 LGVIAEIVLFAASPR-FTLPSA-VLVMIAASSAAARWAITAQDPPLAVLAVVQLGHGLSF 314 LGV+AE+++FA S + F SA +++I+A RW I L L VVQ+ H +F Sbjct: 245 LGVVAEVIIFALSNKLFRRCSARDMLLISAICGVVRWGIMGATTALPWLIVVQILHCGTF 304 Query: 315 GLTQVGIMGLMVHHVPVHVMARAQGYLTAC--GGIVASTTAIVSGMVYARFGLGVYDMMA 372 + + M + V+ R Q +A GG +A T + +G +Y G GV+ +MA Sbjct: 305 TVCHLAAMRYIAARQGSEVI-RLQAVYSAVAMGGSIAIMT-VFAGFLYQYLGHGVFWVMA 362 Query: 373 AMA 375 +A Sbjct: 363 LVA 365