BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0137.0059.p (479 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin2977 [GEPR] COG0477 Permeases of the major facilitator superf... 211 4e-54 PA1262 [GEPR] COG0477 Permeases of the major facilitator superfa... 208 2e-53 Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superf... 179 2e-44 RSp1417 [GEPR] COG0477 Permeases of the major facilitator superf... 173 8e-43 CAP0109 [GEPR] COG0477 Permeases of the major facilitator superf... 161 3e-39 >lin2977 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 470 Score = 211 bits (536), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 152/467 (32%), Positives = 253/467 (54%), Gaps = 13/467 (2%) Query: 20 DPRRWLALPVLLTGAFLPILDFNVVNLALPAIRDNLGASPSEVQFVISAYAATYAVFLIT 79 D R+ LAL ++ GAF+ +LD +VN+ALP I L A+ +++VIS YA + + LI Sbjct: 5 DKRKTLALISIMLGAFISLLDTTIVNVALPDITTALHATSETIEWVISGYALAFGLVLIL 64 Query: 80 GGRLGDLLGRRQMFLTGVAGFTIASVLCGIAWSPAMLVAGRILQGLTATVMAPQVLASIR 139 GRLGD GR+ +++ G+ F I SV G+A S L+ R++QGL A + PQ+ A+I Sbjct: 65 AGRLGDKFGRKNIYIIGITLFLIMSVTAGLAGSENSLIISRVIQGLAAGLFFPQINATIM 124 Query: 140 VLFPAAEQGRALGFYGATFGLANICGQLLGGVLVSAHPFGLAWQAIFLINLPIGLAAFVG 199 ++ G+ G G+ G+ G L GG+L+ W+A+F +N+P L V Sbjct: 125 DMYSGKSLGKIFGILGSVIGVGTAIGPLTGGLLIELFGATNGWRAVFFVNVPFVLVTLVL 184 Query: 200 GLLYLVDSRAAHAQRL--DVGGVILLSLTLGLLVYPLI-EGRESGWPVWIVAMLLASPLM 256 +LYL R +++ D+ GV LL++ L LL++PLI G P+ + M L+ PL Sbjct: 185 AMLYL-PKRTVSTKKISFDLPGVGLLTIALLLLLFPLISNGANDFKPIDYLLMALSIPLF 243 Query: 257 LAAFVRFEARLEARGGDPLVALHLLRNSDFVIGLLMALAFY-MLSSFYLTFAVYLQSGLH 315 + + ++ E +G PL+A +LL+N+ FV G+L++L ++ +S + ++ Q+G + Sbjct: 244 IILY-KWSVYQEKKGNQPLIAPNLLKNNQFVSGMLLSLVYFAAFTSIFFVLSLTWQTGFN 302 Query: 316 QSPLEAGLATLPFAAGFFVSSLVSSLVMQWLGPRTLTLGFALQVTGFGVVMLSV---GGA 372 +S + +GLA PFA G +++ S + LG + L LG +L + G G V + GA Sbjct: 303 RSAILSGLAISPFALGSVLAASNSYRFIPLLGRKLLMLGVSLVIVGLGTVSIVFHLNDGA 362 Query: 373 LPQSLEF-GLICGGLGFGTVMPSVIKAVIGSIDPRHAGLASGMMISTFQIGAALGVAVIG 431 L F L GLG G + + + ++ G ASGM + +IG++ G+AV+G Sbjct: 363 FSAWLLFLPLFIAGLGSGLTIAPLNSFTLSTVTGLDRGGASGMFNTAQRIGSSFGIAVVG 422 Query: 432 GVFYSLLGP---HPRADDYAHAFTIALGCNVALLALGGWLSLWLPRE 475 VF+ LG +A ++ + +++ N+ LL + L LP+ Sbjct: 423 SVFFRTLGNTTATSKASAFSDSLQMSMYVNIFLLVVCFLLIFRLPKS 469 >PA1262 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 480 Score = 208 bits (530), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 172/457 (37%), Positives = 252/457 (55%), Gaps = 11/457 (2%) Query: 16 PATVDPRRW--LALPVLLTGAFLPILDFNVVNLALPAIRDNLGASPSEVQFVISAYAATY 73 P+TV R L +LL G LP++DF++VN+AL A+ +LGAS +E++ +++ Y + Sbjct: 2 PSTVSSSRLGLAGLCILLAGQLLPMIDFSIVNVALDALAHSLGASETELELIVAVYGVAF 61 Query: 74 AVFLITGGRLGDLLGRRQMFLTGVAGFTIASVLCGIAWSPAMLVAGRILQGLTATVMAPQ 133 AV L GGRLGD GRR++F+ GVA F +AS+LCG+A S +L+ R LQG+ A ++ PQ Sbjct: 62 AVCLAMGGRLGDNYGRRRLFVLGVALFAVASLLCGLAGSVWLLLVARALQGVGAALVVPQ 121 Query: 134 VLASIRVLFPAAEQGRALGFYGATFGLANICGQLLGGVLVSAHPFGLAWQAIFLINLPIG 193 +LA++ V RAL YGA GLA + GQ+LGG LVSA GL W+++FLINLPI Sbjct: 122 ILATLHVSLSGHAHSRALAAYGAIGGLAFVVGQVLGGFLVSADIGGLGWRSVFLINLPIC 181 Query: 194 LAAFVGGLLYLVDSRAAHAQRLDVGGVILLSLTLGLLVYPLIEGRESGWPVWIVAMLLAS 253 L + ++ ++RA HA R+D G +LL+ + L+ PL G W +L A+ Sbjct: 182 LGILLCSRRWVPETRAEHAARVDAPGTLLLAALILCLLLPLALGPSLHWSWPCALLLAAA 241 Query: 254 PLMLAAFVRFEARLEARGGDPLVALHLLRNSDFVIGLLMALAFYML-SSFYLTFAVYLQS 312 +LA R E R E R PL+ LLR GLL+A+ F+ S F A+ LQ+ Sbjct: 242 VPLLAWLWRTELRQERRQAWPLLPPSLLRLPSIRFGLLLAILFFACWSGFMFALALALQA 301 Query: 313 GLHQSPLEAGLATLPFAAGFFVSSLVSSLVMQWLGP-RTLTLGFALQVTGFGVVMLSVGG 371 G SP++AG A + A +FVS+L+++ V +GP R L LG +Q+ G +ML++ Sbjct: 302 GAGLSPVQAGNAFIALGASYFVSALLTARVAARIGPVRLLLLGCVIQMCGLLGLMLTLQR 361 Query: 372 ALPQ----SLEFGLICGGLGFGTVMPSVIKAVIGSIDPRHAGLASGMMISTFQIGAALGV 427 PQ +L + G G ++ S + + + AG S M+ + Q LG Sbjct: 362 VWPQPGILNLAPATLVIGFGQAFIVSSFFRIGLSEVPAAQAGAGSAMLATVQQASLGLGS 421 Query: 428 AVIGGVFYSLLGPHPRADDYAHAFTIALGCNVALLAL 464 A++G VF L H DY A L L+ L Sbjct: 422 ALLGAVFAHRLERH---GDYLEATQTTLAVEFVLMTL 455 >Cgl1213 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 487 Score = 179 bits (453), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 136/428 (31%), Positives = 224/428 (52%), Gaps = 16/428 (3%) Query: 14 ARPATVDPRR--WLALPVLLTGAFLPILDFNVVNLALPAIRDNLGASPSEVQFVISAYAA 71 A PA P + W AL L G F+ +LD +V ++ PA++ ++GAS +EV +V S Y Sbjct: 22 AYPAMPLPEKQAWPALIALCIGFFMILLDQTIVAVSTPALQADMGASYNEVIWVTSVYLL 81 Query: 72 TYAVFLITGGRLGDLLGRRQMFLTGVAGFTIASVLCGIAWSPAMLVAGRILQGLTATVMA 131 T+AV L+ GRLGD G + +++ G+ FT++S+ CG+A L+ R +QGL A ++ Sbjct: 82 TFAVPLLVTGRLGDKYGPKNVYVAGMVIFTVSSLACGLAPDMFTLIIARGVQGLGAALLT 141 Query: 132 PQVLASIRVLFPAAEQGRALGFYGATFGLANICGQLLGGVLVSAHPFGLAWQAIFLINLP 191 PQ +A+I +F +G ALG +G+T GLA++ G +LGGV+ WQ +F IN+P Sbjct: 142 PQTMATINRIFAFERRGAALGVWGSTAGLASLAGPILGGVITE----NWGWQWVFYINVP 197 Query: 192 IGLAAFVGGLLYLVDSRAAHAQRLDVGGVILLSLTLGLLVYPLIEGRESGWPVWIVAMLL 251 IG+ + + + Y V + LD ++L + + LV+ EG +GW W+ M++ Sbjct: 198 IGVISVIAVMKY-VPEFPPLTRPLDPLSIVLSIVAVFFLVFAFQEGEGAGWAAWVWIMIV 256 Query: 252 ASPLMLAAFVRFEARLEARGGDPLVALHLLRNSDFVIG--LLMALAFYMLSSFYLTFAVY 309 A+ + A F+ ++R E G DPLV L + + +F +G +MA+ F + + L +Y Sbjct: 257 AAFALFAWFIYQQSRAEKSGNDPLVPLEIFKFRNFSLGNICIMAMGFTVAGT-PLPIMLY 315 Query: 310 LQSGLHQSPLEAGLATLPFA-AGFFVSSLVSSLVMQWLGPRTLTLGFALQVTGFGVVMLS 368 Q + +EAG +P A +S V LV + LGF+ +V+LS Sbjct: 316 FQQAHGMNAMEAGFMMVPQALMAAVLSPFVGKLVDRSNPGLMAALGFS--TVAVSIVLLS 373 Query: 369 VGGALPQSLEFGLICG---GLGFGTVMPSVIKAVIGSIDPRHAGLASGMMISTFQIGAAL 425 + L + L+ G+G V + + + + G SG+ +T Q+G+ + Sbjct: 374 MVMIFDTGLVWALVSMTLLGIGNAFVWAPNSTSTMRDLPHKFMGAGSGVFNTTRQLGSVI 433 Query: 426 GVAVIGGV 433 G A IG V Sbjct: 434 GAAAIGAV 441 >RSp1417 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 467 Score = 173 bits (439), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 149/452 (32%), Positives = 227/452 (50%), Gaps = 24/452 (5%) Query: 36 LPILDFNVVNLALPAIRDNLGASPSEVQFVISAYAATYAVFLITGGRLGDLLGRRQMFLT 95 + +LD VV A AIR +LGAS S +Q+ ++AY + A L+TG LGD GRR++F+T Sbjct: 23 MAMLDAMVVATATSAIRADLGASLSALQWTMNAYNLSLAALLMTGAALGDRFGRRRVFVT 82 Query: 96 GVAGFTIASVLCGIAWSPAMLVAGRILQGLTATVMAPQVLASIRVLFPAAEQGRALGFYG 155 G+ F AS+ C +A S L+A R++QG ++ P +A + FP +G+ALG +G Sbjct: 83 GLCVFVAASIACALARSAEWLIAARVVQGAGGALVTPLSMALLSAAFPPERRGKALGLFG 142 Query: 156 ATFGLANICGQLLGGVLVSAHPFGLAWQAIFLINLPIGLAAFVGGLLYLVDSRAAHAQRL 215 GLA I G +LGGV+ P WQ IF +N+PIGL V + + DS+ A L Sbjct: 143 GITGLALILGPVLGGVIAGNLP----WQWIFWLNVPIGLPLIVLAVRRIPDSKGPAAA-L 197 Query: 216 DV-GGVILLSLTLGLLVYPLIEGRESGWPVWIVAMLLASPLML---AAFVRFEARLEARG 271 D+ G ++++ ++G LV+ L+ G GW +PL L AAF+ E R Sbjct: 198 DIPGALLVMGASIG-LVWGLMRGSSKGWSD------SEAPLALVVGAAFMICFVLWERRA 250 Query: 272 GDPLVALHLLRNSDFVIGLLMALAFYM-LSSFYLTFAVYLQSGLHQSPLEAGLATLPFAA 330 P++ + L + F G+ FY + + QS P AGL LP+ Sbjct: 251 KHPMIPMRLFASRAFSSGIAACFLFYAGMYGVVFFLPQFFQSAQGHDPFAAGLRLLPWTV 310 Query: 331 G-FFVSSLVSSLVMQWLGPRT-LTLGFALQVTGFGVVMLSVG-GALPQSLEFGLICGGLG 387 FF++ L S+V + +G R+ + G LQ GF + + G +L L+ G G Sbjct: 311 TLFFIAPLAGSMVDR-IGERSVMVTGLLLQAIGFAWIAWAASPGTSYLNLVAPLVISGAG 369 Query: 388 FGTVMPSVIKAVIGSIDPRHAGLASGMMISTFQIGAALGVAVIGGVFYSLLGPHPRADDY 447 P+ KAV+G++ + G ASG+ +G A G+A I V +S+ G D+ Sbjct: 370 ISMAGPAAQKAVLGAVTVQDIGKASGVFNMFRILGGATGIA-IAVVAFSIWGNLGSEKDF 428 Query: 448 AHAFTIALGCNVALLALGGWLS-LWLPREPAA 478 + F +G A+L++ LS W P AA Sbjct: 429 SEGFAHVMGV-CAVLSMAAVLSATWQPTHRAA 459 >CAP0109 [GEPR] COG0477 Permeases of the major facilitator superfamily Cac Clostridium acetobutylicum Length = 545 Score = 161 bits (407), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 126/420 (30%), Positives = 214/420 (50%), Gaps = 36/420 (8%) Query: 33 GAFLPILDFNVVNLALPAIRDNLGASPSEVQFVISAYAATYAVFLITGGRLGDLLGRRQM 92 G F+ +LD +VN+ LP + + + + + +V++AY +AV ++T RL D GR+++ Sbjct: 16 GFFMTLLDTTIVNITLPKMTEYFNTNMNHISWVVNAYNLAFAVIILTASRLADQFGRKKI 75 Query: 93 FLTGVAGFTIASVLCGIAWSPAMLVAGRILQGLTATVMAPQVLASIRVLFPAAEQGRALG 152 F+ GV FTIAS+L GI+ S +L+ R LQGL+A + P + +FP ++G + Sbjct: 76 FIGGVFLFTIASLLAGISNSLEVLIFLRALQGLSAAFVVPVTMPLSAEIFPPEKRGTIMS 135 Query: 153 FYGATFGLANICGQLLGGVLVSAHPFGLAWQAIFLINLPIGLAAFVGGLLYLVDS-RAAH 211 +GA GLA G LGG+L W+ IF IN+PIG + ++ +S A Sbjct: 136 LWGAFAGLAAASGPTLGGILTQF----FNWRYIFFINVPIGCLCIFLTIKFIKESYDQAA 191 Query: 212 AQRLDVGGVILLSLTLGLLVYPLIEGRESGWPVWIVAMLLASPLMLAAFVRFEARLEARG 271 ++ +D GG I +S + L + LI+ E GW L A+ A + +E + Sbjct: 192 SKSIDFGGNITISAAMFFLTFALIKVNEKGWTSSFTLSLFAAS---AITLIIFIIIELKV 248 Query: 272 GDPLVALHLLRNSDFVIG----LLMALAFYMLSSFYLTFAVYLQSGLHQSPLEAGL--AT 325 +P+++L L ++ F G L+ L M S++L+F + GL++ L AGL +T Sbjct: 249 NEPMLSLSLFKSLQFTNGSISLFLLGLGM-MCGSYFLSFFLTQIKGLNE--LSAGLIIST 305 Query: 326 LPFAAGFFVSSLVSSLVMQWLGPRTLTLGFALQVTGFGVVMLSVGGALPQSLE------- 378 + ++ FF S+V++++ + +G R ++ FG+ +L L SL Sbjct: 306 MSLSSMFF--SIVAAILTKKVGKRF--------ISAFGIFLLCFSCYLNSSLTQNSSNID 355 Query: 379 --FGLICGGLGFGTVMPSVIKAVIGSIDPRHAGLASGMMISTFQIGAALGVAVIGGVFYS 436 LI G G G M +++ + I ++ G+ASG+ T +G LGVA+ +F S Sbjct: 356 VILRLIITGAGTGLSMATLLSSTIANVPINKIGIASGIDNMTRTLGTVLGVALFLTIFTS 415