BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0135.0001.p (551 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv1442 [C] COG0243 Anaerobic dehydrogenases, typically selenocys... 501 e-141 MT1487 [C] COG0243 Anaerobic dehydrogenases, typically selenocys... 501 e-141 HI0643 [C] COG0243 Anaerobic dehydrogenases, typically selenocys... 434 e-121 YPO0794 [C] COG0243 Anaerobic dehydrogenases, typically selenocy... 423 e-118 bisC [C] COG0243 Anaerobic dehydrogenases, typically selenocyste... 414 e-115 >Rv1442 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing Mtu Mycobacterium tuberculosis H37Rv Length = 766 Score = 501 bits (1290), Expect = e-141, Method: Compositional matrix adjust. Identities = 278/533 (52%), Positives = 346/533 (64%), Gaps = 9/533 (1%) Query: 22 RCAMISRSRPAPTALMLGIVHTLVSEGLHDQAFLDRYTEGWPVFLRYLTGESDGVSKNAE 81 RC ++ A+MLG+ + L +E L D+AFL RY G+ F RYL G DG+ K E Sbjct: 235 RCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPE 294 Query: 82 WAAAICGIEAGIIRALARRLAGRRALITVSHSLQRAEHGEQPVWMGMVLAAALGQIGLPG 141 WAAA+ G+ AG +R LARR+A R LIT S SLQR EHGEQ VWM LAA LGQIGLPG Sbjct: 295 WAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQIGLPG 354 Query: 142 GGYAYSLGAIGYYGRRVNAVPGPTLGQGRNGVADFIPVARIADMLLNPGTTYRYNGETRT 201 GG+ + + G G A P L QG N V+ FIPVA I+++L PG YNG Sbjct: 355 GGFGHGYSSNGV-GNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLE 413 Query: 202 YPDIRLVYWAGGNPFHHHQDLNRLRKAFARLDTLVVHELAWTATARHADIVLPSTMTLER 261 PDI+ VYWAGGNPFHHHQ+L RLR+A +R+DT+VVHE WTA A+HADIV+P+T + ER Sbjct: 414 LPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFER 473 Query: 262 EDIGYSSNDPLMVAMHRIAEPFGLARDDYEIFADLAERLGAREPFTEGRTSRQWLEHLFE 321 +D S +P ++AM + P+ ARDDY F+ LA RLG + FTEGR++R+WLEH+++ Sbjct: 474 DDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYD 533 Query: 322 PTRKALAARGLEAPSFEEFWARGSLVVPQHLDDGGSLRRFREDPLARPLPTPSGRIEIFS 381 K A PSF EFW G L +P L FR DP A PL TPSGRIEIFS Sbjct: 534 ---KWSAELDFPVPSFAEFWRTGRLELPTRTGLTW-LADFRADPAAHPLGTPSGRIEIFS 589 Query: 382 QKIASHGDADCPGHPVWLEKTD----TPTSGAPCFLVANQPVTRLHSQLDFGGHSLDAKH 437 + + DC GHP W E ++ + P L+ANQP TRLHSQLD GG S+ +K Sbjct: 590 DTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLHSQLDHGGASMASKI 649 Query: 438 RGREVARMNPRDAKPRGIADGDIIRIFNARGACLAAVHVTDGIAPGVVQLPTGAWYDPMD 497 RGRE R++P DA R + DGDI+R+FN RGACLA V + DG+ P VVQL TGAW+DP D Sbjct: 650 RGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPAD 709 Query: 498 PEEEAPLCVHGNPNVLTRDIGTSSFAQGCTGQLTSVEVERFNGNLPPIRAFDP 550 P + +CVHGNPN L+ D GTSS A G TGQ V++ERF G LPP+RA +P Sbjct: 710 PRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEP 762 >MT1487 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing MtC Mycobacterium tuberculosis CDC1551 Length = 766 Score = 501 bits (1290), Expect = e-141, Method: Compositional matrix adjust. Identities = 278/533 (52%), Positives = 346/533 (64%), Gaps = 9/533 (1%) Query: 22 RCAMISRSRPAPTALMLGIVHTLVSEGLHDQAFLDRYTEGWPVFLRYLTGESDGVSKNAE 81 RC ++ A+MLG+ + L +E L D+AFL RY G+ F RYL G DG+ K E Sbjct: 235 RCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPE 294 Query: 82 WAAAICGIEAGIIRALARRLAGRRALITVSHSLQRAEHGEQPVWMGMVLAAALGQIGLPG 141 WAAA+ G+ AG +R LARR+A R LIT S SLQR EHGEQ VWM LAA LGQIGLPG Sbjct: 295 WAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQIGLPG 354 Query: 142 GGYAYSLGAIGYYGRRVNAVPGPTLGQGRNGVADFIPVARIADMLLNPGTTYRYNGETRT 201 GG+ + + G G A P L QG N V+ FIPVA I+++L PG YNG Sbjct: 355 GGFGHGYSSNGV-GNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLE 413 Query: 202 YPDIRLVYWAGGNPFHHHQDLNRLRKAFARLDTLVVHELAWTATARHADIVLPSTMTLER 261 PDI+ VYWAGGNPFHHHQ+L RLR+A +R+DT+VVHE WTA A+HADIV+P+T + ER Sbjct: 414 LPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFER 473 Query: 262 EDIGYSSNDPLMVAMHRIAEPFGLARDDYEIFADLAERLGAREPFTEGRTSRQWLEHLFE 321 +D S +P ++AM + P+ ARDDY F+ LA RLG + FTEGR++R+WLEH+++ Sbjct: 474 DDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYD 533 Query: 322 PTRKALAARGLEAPSFEEFWARGSLVVPQHLDDGGSLRRFREDPLARPLPTPSGRIEIFS 381 K A PSF EFW G L +P L FR DP A PL TPSGRIEIFS Sbjct: 534 ---KWSAELDFPVPSFAEFWRTGRLELPTRTGLTW-LADFRADPAAHPLGTPSGRIEIFS 589 Query: 382 QKIASHGDADCPGHPVWLEKTD----TPTSGAPCFLVANQPVTRLHSQLDFGGHSLDAKH 437 + + DC GHP W E ++ + P L+ANQP TRLHSQLD GG S+ +K Sbjct: 590 DTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLHSQLDHGGASMASKI 649 Query: 438 RGREVARMNPRDAKPRGIADGDIIRIFNARGACLAAVHVTDGIAPGVVQLPTGAWYDPMD 497 RGRE R++P DA R + DGDI+R+FN RGACLA V + DG+ P VVQL TGAW+DP D Sbjct: 650 RGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPAD 709 Query: 498 PEEEAPLCVHGNPNVLTRDIGTSSFAQGCTGQLTSVEVERFNGNLPPIRAFDP 550 P + +CVHGNPN L+ D GTSS A G TGQ V++ERF G LPP+RA +P Sbjct: 710 PRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEP 762 >HI0643 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing Hin Haemophilus influenzae Length = 825 Score = 434 bits (1116), Expect = e-121, Method: Compositional matrix adjust. Identities = 242/558 (43%), Positives = 312/558 (55%), Gaps = 28/558 (5%) Query: 15 ANSCWSVRCAMISRSRPAPTALMLGIVHTLVSEGLHDQAFLDRYTEGWPVFLRYLTGESD 74 + +C + I + LMLGI HTLV +G HD+ FL +YT G+ F YL G++D Sbjct: 265 SETCQMLNAEWIPVNTATDVPLMLGIAHTLVEQGKHDKDFLKKYTSGYAKFEEYLLGKTD 324 Query: 75 GVSKNAEWAAAICGIEAGIIRALARRLAGRRALITVSHSLQRAEHGEQPVWMGMVLAAAL 134 G K AEWAA ICG+ A I+ LA A +R ++ +QR HGEQ WM + LA+ L Sbjct: 325 GQPKTAEWAAKICGVPAETIKQLAADFASKRTMLMGGWGMQRQRHGEQTHWMLVTLASML 384 Query: 135 GQIGLPGGG----YAYSLGAI-----GYYGRRVNAVPGPTLGQGR---NGVADFIPVARI 182 GQIGLPGGG Y YS G + G G + A P G + P+ARI Sbjct: 385 GQIGLPGGGFGLSYHYSNGGVPTATGGIIG-SITASPSGKAGAKTWLDDTSKSAFPLARI 443 Query: 183 ADMLLNPGTTYRYNGETRTYPDIRLVYWAGGNPFHHHQDLNRLRKAFARLDTLVVHELAW 242 AD+LL+PG +YNG TYPDI+ VYWAGGNPF HHQD N L KAF + D ++V+E+ W Sbjct: 444 ADVLLHPGKKIQYNGTEITYPDIKAVYWAGGNPFVHHQDTNTLVKAFQKPDVVIVNEVNW 503 Query: 243 TATARHADIVLPSTMTLEREDIGYSSNDPLMVA--MHRIAEPFGLARDDYEIFADLAERL 300 T TAR ADIVLP+T + ER D+ + + +M M ++ P A++DY+IF +LA+R Sbjct: 504 TPTARMADIVLPATTSYERNDLTMAGDYSMMSVYPMKQVVPPQFEAKNDYDIFVELAKRA 563 Query: 301 GAREPFTEGRTSRQWLEHLFEPTRKALAARGLEAPSFEEFWARGSLVVPQHLDDGGSLRR 360 G E +TEG+T +WLE + A A + P F++FWA P + G + ++ Sbjct: 564 GVEEQYTEGKTEMEWLEEFYNAAFSAARANRVAMPRFDKFWAENK---PLSFEAGEAAKK 620 Query: 361 ------FREDPLARPLPTPSGRIEIFSQKIASHGDADCPGHPVWLEKTD---TPTSGAPC 411 FREDPL PL TPSG+IEIFS + DC GHP W+E + T P Sbjct: 621 WVRYGEFREDPLLNPLGTPSGKIEIFSDVVEKMNYNDCKGHPSWMEPEEFAGNVTEEYPL 680 Query: 412 FLVANQPVTRLHSQLDFGGHSLDAKHRGREVARMNPRDAKPRGIADGDIIRIFNARGACL 471 LV P RLHSQL RE ++P DA RGI DGDI+RI + RG L Sbjct: 681 ALVTPHPYYRLHSQLAHTSLRQKYAVNDREPVMIHPEDAAARGIKDGDIVRIHSKRGQVL 740 Query: 472 AAVHVTDGIAPGVVQLPTGAWYDPMD-PEEEAPLCVHGNPNVLTRDIGTSSFAQGCTGQL 530 A VT+ I G V L GAWYDPM E E PLC +G NVLTRD GTS AQG + Sbjct: 741 AGAAVTENIIKGTVALHEGAWYDPMYLGESEKPLCKNGCANVLTRDEGTSKLAQGNSPNT 800 Query: 531 TSVEVERFNGNLPPIRAF 548 V++E+F G P + F Sbjct: 801 CIVQIEKFIGVAPEVTVF 818 >YPO0794 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing Ype Yersinia pestis Length = 753 Score = 423 bits (1087), Expect = e-118, Method: Compositional matrix adjust. Identities = 234/510 (45%), Positives = 311/510 (60%), Gaps = 4/510 (0%) Query: 34 TALMLGIVHTLVSEGLHDQAFLDRYTEGWPVFLRYLTGESDGVSKNAEWAAAICGIEAGI 93 ALML + + + HD+AFL + G+ Y+ G +DG++K +WA++I GI A Sbjct: 244 VALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIPAAR 303 Query: 94 IRALARRLAGRRALITVSHSLQRAEHGEQPVWMGMVLAAALGQIGLPGGGYAYSLGAIGY 153 I LA++L G R+ +T S+S+QRA GEQP WM + L+A LGQ+GLPGGG+++ G++ Sbjct: 304 IAQLAQQLIGVRSFMTCSYSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGSMNG 363 Query: 154 YGRRVNAVPGPTLGQGRNGVADFIPVARIADMLLNPGTTYRYNGETRTYPDIRLVYWAGG 213 G PGP + G+N IPVARI DMLL PG Y++ GET TYPDI LV+WAGG Sbjct: 364 VGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPGQPYQFQGETHTYPDIHLVHWAGG 423 Query: 214 NPFHHHQDLNRLRKAFARLDTLVVHELAWTATARHADIVLPSTMTLEREDIGYSSNDPLM 273 NPFHHHQ LNRL + + + DT++V ++ WT A+ ADIVLP T +LER DIG SS D + Sbjct: 424 NPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRDRYV 483 Query: 274 VAMHRIAEPFGLARDDYEIFADLAERLGAREPFTEGRTSRQWLEHLFEPTRKALAARGLE 333 +AMH+ P AR D++IFADLA+RLG RE FTEGR W+ H+++ A + +E Sbjct: 484 LAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSHDVE 543 Query: 334 APSFEEFWARGSLVVPQHLDDGGSLRRFREDPLARPLPTPSGRIEIFSQKIASHGDADCP 393 P FE FW +G + +P FREDP A PL TPSG+IE+FS+KIAS+ D Sbjct: 544 WPDFETFWQQGYVGLPAPSKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYNDFA 603 Query: 394 GHPVW---LEKTDTPTSGA-PCFLVANQPVTRLHSQLDFGGHSLDAKHRGREVARMNPRD 449 H W +E P + P L++ QP RLHSQLD + K GRE M+P D Sbjct: 604 PHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQLDPAPLAQSNKTAGRETLYMHPLD 663 Query: 450 AKPRGIADGDIIRIFNARGACLAAVHVTDGIAPGVVQLPTGAWYDPMDPEEEAPLCVHGN 509 A R I +G +++ N RG CLA V +TDG+ GVV + TGAW+DP + + GN Sbjct: 664 AASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQSGN 723 Query: 510 PNVLTRDIGTSSFAQGCTGQLTSVEVERFN 539 PNVLT DIGTS QG VEV + Sbjct: 724 PNVLTLDIGTSRLTQGPNAMSCLVEVALYE 753 >bisC [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing Eco Escherichia coli K12 Length = 739 Score = 414 bits (1065), Expect = e-115, Method: Compositional matrix adjust. Identities = 236/530 (44%), Positives = 317/530 (59%), Gaps = 16/530 (3%) Query: 34 TALMLGIVHTLVSEGLHDQAFLDRYTEGWPVFLRYLTGESDGVSKNAEWAAAICGIEAGI 93 ALMLGI HTLV G HD+AFL R T G+ VF YL GESDG++K AEWAA ICG+ A Sbjct: 209 VALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVGAAK 268 Query: 94 IRALARRLAGRRALITVSHSLQRAEHGEQPVWMGMVLAAALGQIGLPGGGYAYSLG-AIG 152 IR LA ++ +QR + GEQ WM + LAA LGQIG PGGG+ S A G Sbjct: 269 IRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANG 328 Query: 153 YYGRRVNAVPGPTLGQ--GRNGVADFIPVARIADMLLNPGTTYRYNGETRTYPDIRLVYW 210 R +AV G G D IPVARI + L NPG Y++NG R +PDIR ++W Sbjct: 329 GNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWW 388 Query: 211 AGGNPFHHHQDLNRLRKAFARLDTLVVHELAWTATARHADIVLPSTMTLEREDI---GYS 267 AGG F HHQD NRL +A+ + + +V+ E WTA A+HADIVLP+T + ER D+ G Sbjct: 389 AGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDY 448 Query: 268 SNDPLMVAMHRIAEPFGLARDDYEIFADLAERL--GAREPFTEGRTSRQWLEHLFEPTRK 325 SN L V M ++ P AR+D+++FA+L+ER G FTEG++ QWLE + R+ Sbjct: 449 SNQHL-VPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQ 507 Query: 326 ALAARGLEAPSFEEFWARGSLV-VPQHLDDGGSLR--RFREDPLARPLPTPSGRIEIFSQ 382 A++ +E P F EFW L+ +P++ D +R F DPLA PL T SG+IEIFSQ Sbjct: 508 RGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPLAHPLKTASGKIEIFSQ 567 Query: 383 KIASHGDADCPGHPVWLEKTDTPTSGAPCFL--VANQPVTRLHSQLDFGGHSLDAKHRGR 440 +IA +G DCPGHP+WLE + + P L ++ P RLHSQL++ R Sbjct: 568 RIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANR 627 Query: 441 EVARMNPRDAKPRGIADGDIIRIFNARGACLAAVHVTDGIAPGVVQLPTGAWYDPMDPEE 500 E ++P DA+ RGI DGD +R++NARG LA +++GI PGV+ + GAW D +D Sbjct: 628 EPVTIHPDDAQERGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPD-LDLTA 686 Query: 501 EAPLCVHGNPNVLTRDIGTSSFAQGCTGQLTSVEVERFNGNLPPIRAFDP 550 + +C +G NVLT+D+ +S GC G +E++NG + AF+P Sbjct: 687 DG-ICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEP 735