BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0132.0037.p (384 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv3540c [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacteri... 229 1e-59 MT3644 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacteriu... 229 1e-59 PA1016 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas ... 137 4e-32 AF0018 [I] COG0183 Acetyl-CoA acetyltransferase Afu Archaeoglobu... 100 7e-21 MTH793 [I] COG0183 Acetyl-CoA acetyltransferase Mth Methanotherm... 97 6e-20 >Rv3540c [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacterium tuberculosis H37Rv Length = 386 Score = 229 bits (583), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 140/385 (36%), Positives = 202/385 (52%), Gaps = 12/385 (3%) Query: 2 AVIGIGETEYYRHGASPDPEFKLALKAILAACEDAGLDPREIDGFSSYSDDRSEASRLAA 61 A++GIG T++ ++ S E +LA +A+L A DAGL P ++DG ++++ D + +A Sbjct: 7 AIVGIGATDFSKN--SGRSELRLAAEAVLDALADAGLSPTDVDGLTTFTMDTNTEIAVAR 64 Query: 62 ALGTHRLRSATMQWGGGGGGCSAAVANAAASIVAGLADCVVVFRSLAQGQYGRFGQAAGI 121 A G L + GGG C A V +AA ++ G+AD VV +R+ + RFGQ Sbjct: 65 AAGIGELTFFSKIHYGGGAAC-ATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQVQTR 123 Query: 122 HTVSGE-----RSYLMPYGVLAPPQRFAMRVQRYMHEHGVRQEALRAIALASYHHAQANP 176 T + + S+ P+G+ P + AM +RYMH G A+++A HA NP Sbjct: 124 LTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGATSRDFGAVSVADRKHAANNP 183 Query: 177 RAVMRGKPLDVERYDASRWIVEPFHLYDCCMENDGAAALVLVSAERASDFRHKPAYLLGA 236 +A GKP+ +E + SRWI EP L DCC E DGA A+V+ SA RA D + +P + A Sbjct: 184 KAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAIVVTSAARARDLKQRPVVIEAA 243 Query: 237 AFGSG--HRAAATAHNAPLYATANFGTVASDLYRMAGVGPSDVGVVQAYENFTGGVVMAL 294 A G + + L G V L+ +G+ P+DV Y++FT ++ L Sbjct: 244 AQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFTLIQL 303 Query: 295 AEHGFFRPEKANDFLTFDNLIAPSGRLPLNTSGGNLAECYMHGFELVLEAVRQVRGASAS 354 E GF +A DF+ D I GRLP+NT GG L E Y+HG + E VRQ+RG S + Sbjct: 304 EELGFCGKGEAKDFIA-DGAIEVGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSVN 362 Query: 355 QARRNDVALVIGGPMVTPASNLILG 379 + LV G V P S LILG Sbjct: 363 PVAGVEHVLVTAGTGV-PTSGLILG 386 >MT3644 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacterium tuberculosis CDC1551 Length = 386 Score = 229 bits (583), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 140/385 (36%), Positives = 202/385 (52%), Gaps = 12/385 (3%) Query: 2 AVIGIGETEYYRHGASPDPEFKLALKAILAACEDAGLDPREIDGFSSYSDDRSEASRLAA 61 A++GIG T++ ++ S E +LA +A+L A DAGL P ++DG ++++ D + +A Sbjct: 7 AIVGIGATDFSKN--SGRSELRLAAEAVLDALADAGLSPTDVDGLTTFTMDTNTEIAVAR 64 Query: 62 ALGTHRLRSATMQWGGGGGGCSAAVANAAASIVAGLADCVVVFRSLAQGQYGRFGQAAGI 121 A G L + GGG C A V +AA ++ G+AD VV +R+ + RFGQ Sbjct: 65 AAGIGELTFFSKIHYGGGAAC-ATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQVQTR 123 Query: 122 HTVSGE-----RSYLMPYGVLAPPQRFAMRVQRYMHEHGVRQEALRAIALASYHHAQANP 176 T + + S+ P+G+ P + AM +RYMH G A+++A HA NP Sbjct: 124 LTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGATSRDFGAVSVADRKHAANNP 183 Query: 177 RAVMRGKPLDVERYDASRWIVEPFHLYDCCMENDGAAALVLVSAERASDFRHKPAYLLGA 236 +A GKP+ +E + SRWI EP L DCC E DGA A+V+ SA RA D + +P + A Sbjct: 184 KAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAIVVTSAARARDLKQRPVVIEAA 243 Query: 237 AFGSG--HRAAATAHNAPLYATANFGTVASDLYRMAGVGPSDVGVVQAYENFTGGVVMAL 294 A G + + L G V L+ +G+ P+DV Y++FT ++ L Sbjct: 244 AQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFTLIQL 303 Query: 295 AEHGFFRPEKANDFLTFDNLIAPSGRLPLNTSGGNLAECYMHGFELVLEAVRQVRGASAS 354 E GF +A DF+ D I GRLP+NT GG L E Y+HG + E VRQ+RG S + Sbjct: 304 EELGFCGKGEAKDFIA-DGAIEVGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSVN 362 Query: 355 QARRNDVALVIGGPMVTPASNLILG 379 + LV G V P S LILG Sbjct: 363 PVAGVEHVLVTAGTGV-PTSGLILG 386 >PA1016 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas aeruginosa Length = 383 Score = 137 bits (345), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 123/393 (31%), Positives = 190/393 (48%), Gaps = 27/393 (6%) Query: 1 VAVIGIGETEYYRHGASPD-PEFKLALKAILAACEDAGLDPREIDG-FSSYSDDRSEASR 58 A++GIG G +P +L +A L A DAGL +ID F++ S Sbjct: 9 TAIVGIGSAGV---GEAPGYSAIELLGQASLKAIADAGLKLSDIDAIFAATSSHAFPTLS 65 Query: 59 LAAALGTH-RLRSATMQWGGGGGGCSAAVANAAASIVAGLADCVVVFRSLAQGQYGRFGQ 117 +A LG + T GG + A ++ AGL D ++ YG + Sbjct: 66 VAEYLGIRPKFVDGTNI---GGSSFELHLLQATLALEAGLCDAALIC-------YGSNQR 115 Query: 118 AAG--IHTVSGERSYLMPYGVLAPPQRFAMRVQRYMHEHGVRQEALRAIALASYHHAQAN 175 AG + ++S + + PY P +A+ R+MH++G +E L +A+++ A N Sbjct: 116 TAGGRLVSMSEPQWHETPYKPRHPITAYALAASRHMHQYGTTREQLAEVAVSARQWANLN 175 Query: 176 PRAVMRGKPLDVERYDASRWIVEPFHLYDCCMENDGAAALVLVSAERASDFRHKPAYLLG 235 P A RG PL V+ A+R + +P DCC+ DG A V+V AERA D + P Y LG Sbjct: 176 PEAFARG-PLSVDDVLAARMVSDPLSAADCCLVTDGGGACVVVRAERARDLPNAPVYFLG 234 Query: 236 AAFGSGHRAAATAHNAPLYATANFGTVASDLYRMAGVGPSDVGVVQAYENFTGGVVMALA 295 AA HR+ + + + A + A +MAGV +D+ +V Y+ FT ++ L Sbjct: 235 AAGAQWHRSIVSMPDLTVTAASE---SAPRAMQMAGVRHADIDLVMLYDAFTINTLLFLE 291 Query: 296 EHGFFRPEKANDFLTFDNLIAPSGRLPLNTSGGNLAECY--MHGFELVLEAVRQV-RGAS 352 + GF + F+ IAP G L +NT+GG L+ + M+G L++EAV Q+ R A Sbjct: 292 DLGFCAKGEGGPFVQ-GGRIAPGGELAVNTNGGGLSCVHPGMYGMFLIIEAVTQLRRQAG 350 Query: 353 ASQARRNDVALVIG-GPMVTPASNLILGSEATL 384 Q + DVAL+ G G ++ +LG+ TL Sbjct: 351 ERQLAKADVALLHGNGGTLSSQVTALLGTGDTL 383 >AF0018 [I] COG0183 Acetyl-CoA acetyltransferase Afu Archaeoglobus fulgidus Length = 391 Score = 100 bits (248), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 96/360 (26%), Positives = 158/360 (43%), Gaps = 25/360 (6%) Query: 4 IGIGETEYYRHGASPDPEFKLALKAILAACEDA-GLDPREIDGF------SSYSDDRSEA 56 +G G T + R AS L ++A A +D LD +++D F ++ Sbjct: 1 MGAGITNFGRREASWK---DLVVEAGKALFDDVPNLDKKDVDSFFIGAAQPERWTYQTHV 57 Query: 57 SRLAAALGTHRLRSATMQWGGGGGGCSAAVANAAASIVAGLADC-VVVFRSLAQGQYGRF 115 + LAA L + R + A+ A ++ +GL+D VVV ++ Sbjct: 58 APLAAELLGIKPRRVVARTESACASGQIAIRYAWLAVASGLSDVAVVVGVEKMNTKFMNL 117 Query: 116 GQAAGIHTVSGERSYLMPYGVLAPPQRFAMRVQRYMHEHGVRQEALRAIALASYHHAQAN 175 Q + ++ G R + G+ APP FAM QR+MH +G ++ + + + +A AN Sbjct: 118 SQTSMMNV--GNREFDTAMGLTAPPY-FAMVAQRHMHLYGTTEDQMALVREKAGEYASAN 174 Query: 176 PRAVMRGKPLDVERYDASRWIVEPFHLYDCCMENDGAAALVLVSAERASDFRHKPAYLLG 235 P A + K + E SR + P L DC DGAAAL++ + E+A F P ++LG Sbjct: 175 PYAQFQ-KKISKEDVLNSRMVAPPLKLLDCSGITDGAAALLITTEEKARKFTDTPVWILG 233 Query: 236 AAFGSGHRAAATAHN--APLYATANFGTVASDLYRMAGVGPSDVGVVQAYENFTGGVVMA 293 R A + N + + +A D+Y + + P D+ V + ++ FT +M Sbjct: 234 GI----QRTMANSINEMGEMSDWLSLRYLAKDVYDLFNITPDDIDVAEVHDCFTISEIME 289 Query: 294 LAEHGFFRPEKANDFLTFDNLIAPSGRLPLNTSGGNLAECY---MHGFELVLEAVRQVRG 350 E GF + + F+ + G++ +N SGG LA + G E V Q RG Sbjct: 290 YEELGFCKKGEGGKFIE-EGQSYIGGKVAVNPSGGLLANGHPLGATGVRQAWEMVMQFRG 348 >MTH793 [I] COG0183 Acetyl-CoA acetyltransferase Mth Methanothermobacter thermautotrophicus Length = 383 Score = 97.1 bits (240), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 98/363 (26%), Positives = 171/363 (47%), Gaps = 28/363 (7%) Query: 1 VAVIGIGETEYYRHGASPDPEFK-LALKAILAACEDAGLDPREIDGF-------SSYSDD 52 VAVIG+ +T++ G D F+ + +A L A EDAG++ ++D + Sbjct: 4 VAVIGVSQTKF---GELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQ 60 Query: 53 RSEASRLAAALGTHRLRSATMQWGGGGGGCSAAVANAAASIVAGLADCVVVFRSLAQGQY 112 +S +A G + S ++ GG A+ + ++ +G D +V + + Sbjct: 61 EHISSLIADHAGLTPIPSTRVEAACASGGL--ALRSGIMAVASGYHD--IVIAAGVEKMT 116 Query: 113 GRFGQAAGIHTVSGERSYLMPYGVLAPPQRFAMRVQRYMHEHGVRQEALRAIALASYHHA 172 I T S ++ + GV P +AM +R+M+E+G +E L +++ ++ +A Sbjct: 117 DVVDPTPAIATAS-DQEWEAQQGVTFP-SLYAMMARRHMYEYGTTREQLAMVSVINHENA 174 Query: 173 QANPRAVMRGKPLDVERYDASRWIVEPFHLYDCCMENDGAAALVLVSAERASDFRHKPAY 232 NPRA K + VE+ S + +P L DC +DGAAA++L A+ A ++ P Y Sbjct: 175 SNNPRAQFPMK-VTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVY 233 Query: 233 LLGAAFGSGHRAAATAHNAP-LYATANFGTVASDLYRMAGVGPSDVGVVQAYENFTGGVV 291 + +A SG A + + AT N A + ++MA + P D+ +V+ ++ F+ + Sbjct: 234 VKASAQASGTIALHDRRDITRIDATVN---AARNAFKMAKLTPGDIDLVEVHDCFSINGI 290 Query: 292 MALAEHGFFRPEKANDFLTF-DNLIAPSGRLPLNTSGGNLAECY---MHGFELVLEAVRQ 347 +A+ + GF EK F D + G +P+N SGG A + G E V Q Sbjct: 291 LAVEDLGFV--EKGEGGRAFEDGMTRIDGDIPVNPSGGLKARGHPLGATGIAQAAEVVWQ 348 Query: 348 VRG 350 +RG Sbjct: 349 LRG 351