BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0129.0006.p (386 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH2373 [C] COG1013 Pyruvate Bha Bacillus halodurans 189 1e-47 MA3076 [C] COG1013 Pyruvate Mac Methanosarcina acetivorans str.C2A 177 3e-44 SA1132 [C] COG1013 Pyruvate Sau Staphylococcus aureus N315 170 6e-42 CAC2458 [C] COG1013 Pyruvate Cac Clostridium acetobutylicum 166 9e-41 AF0750 [C] COG1013 Pyruvate Afu Archaeoglobus fulgidus 157 5e-38 >BH2373 [C] COG1013 Pyruvate Bha Bacillus halodurans Length = 288 Score = 189 bits (479), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 118/321 (36%), Positives = 172/321 (53%), Gaps = 55/321 (17%) Query: 57 THRDYEGKIS-TLCAGCGHDSITASIIEACYELSIEPHRVAKISGIGCSSKTPDYFLGNS 115 T +D+ K+ C GCG S+ A+I A + +EP ++A ISGIGCS + Y N+ Sbjct: 3 TFKDFRNKVKPNWCPGCGDFSVQAAIQRAAANVGLEPDQLAVISGIGCSGRISGYI--NA 60 Query: 116 HGFNSVHGRMPSVLTGANLANRDLIYLGVSGDGDSASIGFGQFAHSIRRAVNMTYIVENN 175 +GF+ VHGR+ + G +ANRD+ + GDGD +IG G H+IRR +N+TYIV +N Sbjct: 61 YGFHGVHGRVLPIAQGVKMANRDVTVIASGGDGDGFAIGMGHTVHAIRRNINITYIVMDN 120 Query: 176 GVYGLTKGQFSATADRGSKSKKGVT-NTDNAIDLVAIALQLGATFVARSFSGDKTQLVPL 234 +YGLTKGQ S +D G K+K + + ++A++++ +AL GATFVA+SFS D +L L Sbjct: 121 QIYGLTKGQTSPRSDVGFKTKSTPSGSVESALNVMEMALTAGATFVAQSFSSDLKELTAL 180 Query: 235 IAAAIRHKGASFIDVISPCIAFNNHAGSTKSFDYVREHNDAVNRLDVLVGRDPISVDYAP 294 I I H G S I+V SPC+ FN ++D+ +E+ + +L L G Sbjct: 181 IEKGINHNGFSLINVFSPCVTFN----KVNTYDWFKEN---LTKLSDLEG---------- 223 Query: 295 GSVQVVEQHDGSRLALRKLDADYDPHDRLGAMTFLQKHAAKGQIVTGLLYVD---PEAED 351 YDP +R+ AM L +H +VTGL+Y + P +D Sbjct: 224 ----------------------YDPQNRMVAMQTLMEHNG---LVTGLIYQNDKQPSYQD 258 Query: 352 LHTHLDTVETPLN----TLDE 368 L D E PL T+DE Sbjct: 259 LIAGYD--EKPLADQDLTIDE 277 >MA3076 [C] COG1013 Pyruvate Mac Methanosarcina acetivorans str.C2A Length = 283 Score = 177 bits (450), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 109/331 (32%), Positives = 161/331 (48%), Gaps = 54/331 (16%) Query: 57 THRDYEGKISTLCAGCGHDSITASIIEACYELSIEPHRVAKISGIGCSSKTPDYFLGNSH 116 T DY+G++ C GCG+ I +++ +A EL IEP V +SGIG S K P Y H Sbjct: 3 TSEDYKGQVPAWCPGCGNFQILSAVKQALVELGIEPWEVLAVSGIGQSGKLPHYM--KCH 60 Query: 117 GFNSVHGRMPSVLTGANLANRDLIYLGVSGDGDSASIGFGQFAHSIRRAVNMTYIVENNG 176 FN +HGR V T A LAN L + V+GDGD G F H+IRR N+T IV +N Sbjct: 61 TFNGLHGRTLPVATAAKLANHSLHVIAVAGDGDCYGEGGNHFLHAIRRNPNITLIVHDNQ 120 Query: 177 VYGLTKGQFSATADRGSKSKKGVTNTD-NAIDLVAIALQLGATFVARSFSGDKTQLVPLI 235 +YGLTKGQ S T +G+++K + ++ +A+A+ +FVAR F+GD L L+ Sbjct: 121 IYGLTKGQASPTTAKGTRTKVQPSGVPAEPMNPLALAISQDCSFVARGFAGDPEYLKELM 180 Query: 236 AAAIRHKGASFIDVISPCIAFNNHAGSTKSFDYVREHNDAVNRLDVLVGRDPISVDYAPG 295 AAI HKG S +D++ PC+ FN +F + RE Sbjct: 181 KAAITHKGFSLLDILQPCVTFNK----VNTFKWYRER----------------------- 213 Query: 296 SVQVVEQHDGSRLALRKLDADYDPHDRLGAMTFLQKHAAKGQIVTGLLYVDPEAEDLHTH 355 + KL+A+YDP+DR+ A + + K I G+ Y + Sbjct: 214 --------------VYKLEAEYDPYDRMKAFERVLEWGEK--IPNGIFYKKDK------- 250 Query: 356 LDTVETPLNTLDEQALCPGSAVLDKINASLR 386 DT+E T+ E+ L ++ + + + Sbjct: 251 -DTLEEMFPTIREEPLVRQKFSIEDVKSEIE 280 >SA1132 [C] COG1013 Pyruvate Sau Staphylococcus aureus N315 Length = 288 Score = 170 bits (430), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 107/316 (33%), Positives = 162/316 (51%), Gaps = 51/316 (16%) Query: 57 THRDYEGKIS-TLCAGCGHDSITASIIEACYELSIEPHRVAKISGIGCSSKTPDYFLGNS 115 T +D+ + C GCG S+ A+I +A + +EP VA I+GIGCS + Y NS Sbjct: 3 TFKDFRNNVKPNWCPGCGDFSVQAAIQKAAANIGLEPEEVAIITGIGCSGRLSGYI--NS 60 Query: 116 HGFNSVHGRMPSVLTGANLANRDLIYLGVSGDGDSASIGFGQFAHSIRRAVNMTYIVENN 175 +G +S+HGR + G +AN+DL + GDGD +IG G H++RR +NMTYIV +N Sbjct: 61 YGVHSIHGRALPLAQGVKMANKDLTVIASGGDGDGYAIGMGHTIHALRRNMNMTYIVMDN 120 Query: 176 GVYGLTKGQFSATADRGSKSK---KGVTNTDNAIDLVAIALQLGATFVARSFSGDKTQLV 232 +YGLTKGQ S ++ G +K KG N + + + +AL GATFVA+ FS D L Sbjct: 121 QIYGLTKGQTSPSSAVGFVTKTTPKG--NIEKNVAPLELALSSGATFVAQGFSSDIKGLT 178 Query: 233 PLIAAAIRHKGASFIDVISPCIAFNNHAGSTKSFDYVREHNDAVNRLDVLVGRDPISVDY 292 LI AI H G SF++V SPC+ +N ++D+ +EH +V+ ++ Sbjct: 179 KLIEDAINHDGFSFVNVFSPCVTYN----KINTYDWFKEHLTSVDDIE------------ 222 Query: 293 APGSVQVVEQHDGSRLALRKLDADYDPHDRLGAMTFLQKHAAKGQIVTGLLYVDPEAEDL 352 +YD D+ A + +H + +VTG++Y D E Sbjct: 223 -----------------------NYDSTDKQLATKTVIEHES---LVTGIVYQDKETPSY 256 Query: 353 HTHLDTV-ETPLNTLD 367 + + + +TPL D Sbjct: 257 ESQIKELDDTPLAKRD 272 >CAC2458 [C] COG1013 Pyruvate Cac Clostridium acetobutylicum Length = 284 Score = 166 bits (420), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 105/322 (32%), Positives = 163/322 (50%), Gaps = 52/322 (16%) Query: 66 STLCAGCGHDSITASIIEACYELSIEPHRVAKISGIGCSSKTPDYFLGNSHGFNSVHGRM 125 + C GCG+ +I +S+ E+ EL + PH+V + GIG ++KTP Y N++GF +HGR Sbjct: 11 TAWCQGCGNFNILSSLKESLTELKLNPHQVLIVGGIGQAAKTPQYI--NTNGFCGLHGRA 68 Query: 126 PSVLTGANLANRDLIYLGVSGDGDSASIGFGQFAHSIRRAVNMTYIVENNGVYGLTKGQF 185 GA +AN+DL + +GDGD+ G F H+IRR V++T V +N +YGLTKGQ Sbjct: 69 LPPAVGAKIANKDLTVIIDTGDGDAYGEGGNHFIHNIRRNVDITEFVHDNQIYGLTKGQA 128 Query: 186 SATADRGSKSKKGVTNTDNA-IDLVAIALQLGATFVARSFSGDKTQLVPLIAAAIRHKGA 244 S T D G ++ ++N ++ V +A+ LGA FVAR+FSGDK L ++ AI +KG Sbjct: 129 SPTTDIGHVTEVQPYGSNNVPLNPVLLAITLGAGFVARAFSGDKNHLKEIMKQAINYKGY 188 Query: 245 SFIDVISPCIAFNNHAGSTKSFDYVREHNDAVNRLDVLVGRDPISVDYAPGSVQVVEQHD 304 S +D++ PC++FN +N + R Sbjct: 189 SLVDILQPCVSFN-----------------KINTFKWYMDR------------------- 212 Query: 305 GSRLALRKLDADYDPHDRLGAMTFLQKHAAKGQIVTGLLYVDPEAEDLHTHLDTVETPLN 364 + KLD +YDP +++ AM + K I G+LY D ++ +L+ ++ Sbjct: 213 -----VYKLDNNYDPSNKIKAMEKAMEWGDK--IPIGILYKDENKKEFSENLEFLKK--- 262 Query: 365 TLDEQALCPGSAVLDKINASLR 386 E+ L +DKI L Sbjct: 263 ---EKPLVYSEIKIDKIKNFLE 281 >AF0750 [C] COG1013 Pyruvate Afu Archaeoglobus fulgidus Length = 245 Score = 157 bits (396), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 83/214 (38%), Positives = 125/214 (58%), Gaps = 3/214 (1%) Query: 67 TLCAGCGHDSITASIIEACYELSIEPHRVAKISGIGCSSKTPDYFLGNSHGFNSVHGRMP 126 T C GCG+ +I + A + E +A SGIGC K DY + GF+ +HGR+P Sbjct: 5 TWCPGCGNFAILKAFERASRRVIEEGFDIAVSSGIGCHGKISDYL--SLPGFHVIHGRVP 62 Query: 127 SVLTGANLANRDLIYLGVSGDGDSASIGFGQFAHSIRRAVNMTYIVENNGVYGLTKGQFS 186 LTG LAN +L+ +G SGDGD + G H+ RR ++T I+ NNGV+GLT GQ + Sbjct: 63 PFLTGLKLANPNLVVVGFSGDGDGLNEGVEHLVHAARRNTDITIILHNNGVFGLTTGQVT 122 Query: 187 ATADRGSKSKKGVT-NTDNAIDLVAIALQLGATFVARSFSGDKTQLVPLIAAAIRHKGAS 245 AT+ RG KS+ N + ++ + L GATFVAR F+G++ +L + A++HKG S Sbjct: 123 ATSPRGRKSRSTPRGNPEYPLNPCHLMLVSGATFVARVFAGEQERLSEVFYNAMKHKGFS 182 Query: 246 FIDVISPCIAFNNHAGSTKSFDYVREHNDAVNRL 279 F++V+ PC++FNN K ++ +D + + Sbjct: 183 FVEVMQPCVSFNNFWEMRKEIYWIERSSDLLEAM 216