BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0118.0040.p (331 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC1957 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetr... 365 e-101 BMEI0894 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene te... 365 e-100 YPO3484 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tet... 361 2e-99 SMc03968 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene te... 356 4e-98 AGl2217 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tet... 352 8e-97 >CC1957 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Ccr Caulobacter vibrioides Length = 337 Score = 365 bits (938), Expect = e-101, Method: Compositional matrix adjust. Identities = 182/320 (56%), Positives = 229/320 (71%) Query: 4 LSILDLVRVTEETDARGALYNARDVAVHAEALGYRRIWVAEHHNMAGIASAATSVVIGHI 63 +S+LDL V + + AL N+ D+A HAE LG+ R W+AEHHNM GIASAAT+VVIG I Sbjct: 15 ISVLDLAPVPQGSSVGQALRNSIDLAQHAETLGFHRYWLAEHHNMPGIASAATAVVIGQI 74 Query: 64 AAGTKTIRVGAGGIMLPNHAPYVIAEQFGTLARLFPDRIDLGLGRAPGTDQLTLRALRRT 123 AA T TIRVG+GG+MLPNHAP ++AEQFGTL L+P RIDLGLGRAPGTDQ T+RALRR Sbjct: 75 AAATTTIRVGSGGVMLPNHAPLMVAEQFGTLNALYPGRIDLGLGRAPGTDQATMRALRRY 134 Query: 124 PESAENFPQDVLEVQAFLAAAGPNQRIQAVPAAGTDVPLWILGSSNFCAMLAGELGLPYA 183 + ++F QDV+E+Q + A +Q ++AVP G DVP+WILGSS + A LA LGLPYA Sbjct: 135 AGAVDSFAQDVVELQHWFKPASTDQSVRAVPGEGQDVPIWILGSSTWGAQLAAALGLPYA 194 Query: 184 FASHFAPELLIQALQIYRARFKPSEQLAHPYTMVGVNIIAADTDEEARRLATTQQMSFTN 243 FA+HFAP+ LI+AL +YR FKPSE L PY MV + + AADTDEEA+RL+T+ Q F Sbjct: 195 FAAHFAPDALIEALTLYRRHFKPSESLDRPYAMVCIGVCAADTDEEAKRLSTSTQQQFLA 254 Query: 244 IFRGARGLSQPPIDDIESYWSPAEKVQAMRMLARSIIGSPATVRAGIDALVAETGADELM 303 + RG GL PP+DDI + SP E L + IGSP TVR ID ++ TGADELM Sbjct: 255 LRRGRPGLLPPPVDDIREHASPGELAGLDHTLQYAAIGSPETVRRKIDRVLELTGADELM 314 Query: 304 IVSDVYDHQKRLRSFELIAK 323 + ++DH R RS+E++A Sbjct: 315 AAAQIHDHAARRRSYEILAS 334 >BMEI0894 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Bme Brucella melitensis Length = 327 Score = 365 bits (936), Expect = e-100, Method: Compositional matrix adjust. Identities = 182/322 (56%), Positives = 230/322 (71%), Gaps = 1/322 (0%) Query: 4 LSILDLVRVTEETDARGALYNARDVAVHAEALGYRRIWVAEHHNMAGIASAATSVVIGHI 63 LS+LDL V+E +DA +L N ++A HAE LG+ R W+AEHHNM GI SAATSVVIG++ Sbjct: 4 LSVLDLSPVSEGSDAAHSLRNTLELAQHAERLGFHRYWLAEHHNMPGITSAATSVVIGYV 63 Query: 64 AAGTKTIRVGAGGIMLPNHAPYVIAEQFGTLARLFPDRIDLGLGRAPGTDQLTLRALRRT 123 A GT TIRVGAGG+MLPNH+P VIAEQFGTLA LFP RIDLGLGRAPGTD +T ALRR Sbjct: 64 ANGTSTIRVGAGGVMLPNHSPLVIAEQFGTLASLFPGRIDLGLGRAPGTDPVTAHALRRN 123 Query: 124 PESAEN-FPQDVLEVQAFLAAAGPNQRIQAVPAAGTDVPLWILGSSNFCAMLAGELGLPY 182 +S N FPQDV+E+ + A P QR++AVP G +VP+WILGSS F A LA LGLPY Sbjct: 124 LDSDANAFPQDVVELLNYFKPAEPGQRVRAVPGEGLNVPVWILGSSPFGAQLAAMLGLPY 183 Query: 183 AFASHFAPELLIQALQIYRARFKPSEQLAHPYTMVGVNIIAADTDEEARRLATTQQMSFT 242 AFASHFAP + +A+ +YR RF+PSE + PY M+G+N+IAADTDEEA L T+Q +F Sbjct: 184 AFASHFAPAEMERAIALYRERFEPSEYMQKPYVMLGLNVIAADTDEEANYLFTSQLQAFI 243 Query: 243 NIFRGARGLSQPPIDDIESYWSPAEKVQAMRMLARSIIGSPATVRAGIDALVAETGADEL 302 N+ G G P++ PA + +ML+ ++G P TV GI A TGADEL Sbjct: 244 NLRSGRPGKLPAPVEGYMERLDPAAQALVRQMLSCRVVGGPETVAKGIKAFAENTGADEL 303 Query: 303 MIVSDVYDHQKRLRSFELIAKA 324 MI ++DH+KRLRS+E+++ + Sbjct: 304 MITGMIHDHKKRLRSYEIVSNS 325 >YPO3484 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Ype Yersinia pestis Length = 351 Score = 361 bits (926), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 177/321 (55%), Positives = 229/321 (71%), Gaps = 1/321 (0%) Query: 4 LSILDLVRVTEETDARGALYNARDVAVHAEALGYRRIWVAEHHNMAGIASAATSVVIGHI 63 LS+LDL + + AR A + + D+A HAE GY+R W+AEHHNM GIASAATSV+IG+I Sbjct: 20 LSVLDLSPIAQGKTARDAFHASLDLAQHAEKWGYQRYWLAEHHNMTGIASAATSVLIGYI 79 Query: 64 AAGTKTIRVGAGGIMLPNHAPYVIAEQFGTLARLFPDRIDLGLGRAPGTDQLTLRALRR- 122 A+GT IRVGAGG+MLPNH+P VIAEQFGTLA L+PDRIDLGLGRAPG+DQ T+ ALRR Sbjct: 80 ASGTNKIRVGAGGVMLPNHSPLVIAEQFGTLASLYPDRIDLGLGRAPGSDQRTMMALRRH 139 Query: 123 TPESAENFPQDVLEVQAFLAAAGPNQRIQAVPAAGTDVPLWILGSSNFCAMLAGELGLPY 182 +NFP DV E+Q + A P Q +QAVP G VPLW+LGSS + A LA +GLP+ Sbjct: 140 LSGEVDNFPADVRELQNYFAEVQPGQAVQAVPGQGLHVPLWLLGSSLYSAQLAAAMGLPF 199 Query: 183 AFASHFAPELLIQALQIYRARFKPSEQLAHPYTMVGVNIIAADTDEEARRLATTQQMSFT 242 AFASHFAP++L+QAL +YR F PS Q PY +V VN++AAD++ +AR L T+ Q F Sbjct: 200 AFASHFAPDMLLQALSLYRENFTPSAQWPKPYAIVCVNVVAADSERDARFLFTSMQQQFV 259 Query: 243 NIFRGARGLSQPPIDDIESYWSPAEKVQAMRMLARSIIGSPATVRAGIDALVAETGADEL 302 ++ RG G PP++++ + SPAE+ + L SI+G + VR G+ +L+ ET ADEL Sbjct: 260 SLRRGTPGQLPPPVENMAAICSPAEQFGVDQALRLSIVGDKSKVRHGLQSLLRETQADEL 319 Query: 303 MIVSDVYDHQKRLRSFELIAK 323 MI ++DHQ RL SFE +A Sbjct: 320 MINGQIFDHQARLYSFETVAS 340 >SMc03968 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Sme Sinorhizobium meliloti Length = 329 Score = 356 bits (913), Expect = 4e-98, Method: Compositional matrix adjust. Identities = 181/325 (55%), Positives = 233/325 (71%), Gaps = 4/325 (1%) Query: 4 LSILDLVRVTEETDARGALYNARDVAVHAEALGYRRIWVAEHHNMAGIASAATSVVIGHI 63 SILDL +TE +L N++ +A+ AE GY+R W+AEHH M GIASAATS+VI H+ Sbjct: 4 FSILDLSPITEGGSIAESLENSQRLAIAAEENGYQRFWLAEHHGMKGIASAATSLVISHV 63 Query: 64 AAGTKTIRVGAGGIMLPNHAPYVIAEQFGTLARLFPDRIDLGLGRAPGTDQLTLRALRRT 123 A+ T+TIRVG+GGIMLPNH+P VIAEQFGTLA L+P RIDLGLGRAPGTD T +ALRR Sbjct: 64 ASATRTIRVGSGGIMLPNHSPLVIAEQFGTLAALYPGRIDLGLGRAPGTDMRTAQALRRN 123 Query: 124 PE-SAENFPQDVLEVQAFLAAAGPNQRIQAVPAAGTDVPLWILGSSNFCAMLAGELGLPY 182 E SA NFP DV+E+QA L A +Q+I AVP A ++VP+W+LGSS+F A LAG LGLP+ Sbjct: 124 MEASANNFPNDVVELQALLGPATEDQKIIAVPGADSNVPIWLLGSSHFSAHLAGMLGLPF 183 Query: 183 AFASHFAPELLIQALQIYRARFKPSEQLAHPYTMVGVNIIAADTDEEARRLATTQQMSFT 242 AFASHFAP++L+ AL+IYR RF PS QL P+ MVGV +AADTDEEA L T+ Q SF Sbjct: 184 AFASHFAPDMLLSALEIYRERFTPSPQLDKPHVMVGVMGVAADTDEEANHLFTSMQQSFV 243 Query: 243 NIFRGARGLSQPPIDDIESYWSPAEKVQAMRMLARSIIGSPATVRAGIDALVAETGADEL 302 + R ARG PP+ ++ WS EK+ ++ +++G P T+R I+A V T ADEL Sbjct: 244 ALRRNARGRFPPPVKSMDGLWSQDEKIFVDHAMSYAVVGGPETIRRKIEAFVDLTRADEL 303 Query: 303 MIVSDVYDHQKRLRSFELIAKAGGI 327 ++ ++D + RLRS +L GG+ Sbjct: 304 IVSMPIFDMEARLRSVKLF---GGV 325 >AGl2217 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 333 Score = 352 bits (902), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 173/320 (54%), Positives = 222/320 (69%), Gaps = 1/320 (0%) Query: 4 LSILDLVRVTEETDARGALYNARDVAVHAEALGYRRIWVAEHHNMAGIASAATSVVIGHI 63 SILDL + E AL N+R +A+ AE GY R+W+AEHH M GIASAATS+VI H+ Sbjct: 4 FSILDLSPIGEGESVSAALENSRRMAIKAEEHGYNRLWLAEHHGMPGIASAATSLVIAHV 63 Query: 64 AAGTKTIRVGAGGIMLPNHAPYVIAEQFGTLARLFPDRIDLGLGRAPGTDQLTLRALRRT 123 A TK IRVG+GGIMLPNH+P VIAEQFGTLA L P R+DLGLGRAPGTD T RALRR Sbjct: 64 GAATKHIRVGSGGIMLPNHSPLVIAEQFGTLAALLPGRVDLGLGRAPGTDMRTARALRRN 123 Query: 124 PES-AENFPQDVLEVQAFLAAAGPNQRIQAVPAAGTDVPLWILGSSNFCAMLAGELGLPY 182 ++ AENFP D++E+Q +L P+Q I AVP ++VPLW+LGSS + A LA LGLPY Sbjct: 124 LDAGAENFPHDIVELQRYLGPPQPDQAILAVPGMNSNVPLWLLGSSTYSAHLAAALGLPY 183 Query: 183 AFASHFAPELLIQALQIYRARFKPSEQLAHPYTMVGVNIIAADTDEEARRLATTQQMSFT 242 +FASHFAP++L++A+ IYR RF+PSE L PY MVGV + ADTDEEA+ L T+ Q F Sbjct: 184 SFASHFAPDMLMEAIHIYRERFQPSEVLDKPYVMVGVMGVGADTDEEAQHLFTSSQQQFV 243 Query: 243 NIFRGARGLSQPPIDDIESYWSPAEKVQAMRMLARSIIGSPATVRAGIDALVAETGADEL 302 N+ R R P+ ++ YW+ E+ L + +GSP T+ +D +AET ADEL Sbjct: 244 NLRRNVRTQFPKPVHSMDDYWNEMERFSVEHTLRFAAVGSPETIERHLDGFLAETQADEL 303 Query: 303 MIVSDVYDHQKRLRSFELIA 322 ++ ++D +KRLRS E+ A Sbjct: 304 IVSMPIHDIEKRLRSVEIFA 323