BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0116.0052.p (267 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SPy1502 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenas... 201 2e-51 L76582 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase... 199 6e-51 BH2784 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase... 192 5e-49 lin1397 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenas... 191 2e-48 BS_folD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenas... 189 5e-48 >SPy1502 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Spy Streptococcus pyogenes M1 GAS Length = 284 Score = 201 bits (510), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 100/209 (47%), Positives = 142/209 (67%), Gaps = 4/209 (1%) Query: 5 ILDGHAHAQIVIDKIAGELDRLPR----APGLAVVLVGCDPASQIYVQSKVRMAERLGLR 60 ++DG A AQ + ++A +++ L + PGLAV+LVG DPASQ+YV++K R A +G + Sbjct: 4 LIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFK 63 Query: 61 GEVARLPDDASEADLLARVETLNARDDIDGILVQLPLPAHIDALRVMAAVDPAKDVDGLH 120 E RL + + +L+A +E NA + I GILVQLPLP HI+ +++ A+DP KDVDG H Sbjct: 64 SETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFH 123 Query: 121 ALNAGRLFHGDDALVPCTPLGCLRLIKSTLPDLTGAHAVVIGSSNIVGKPMAALLLQEHA 180 +N G L+ G +VPCTP G + L++ +L G HAV+IG SNIVGKPMA LLL ++A Sbjct: 124 PMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNA 183 Query: 181 TVTQTHIHTRGISRICREADILVSAVGKA 209 TVT TH TR + +CR AD+L+ A+G+ Sbjct: 184 TVTLTHSRTRQLEEVCRCADVLIVAIGQG 212 >L76582 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Lla Lactococcus lactis Length = 294 Score = 199 bits (506), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 100/210 (47%), Positives = 137/210 (65%), Gaps = 3/210 (1%) Query: 2 TANILDGHAHAQIVIDKIAGELDRLPRA---PGLAVVLVGCDPASQIYVQSKVRMAERLG 58 + N++DG A A + ++ ++D+L A PGLAV+LVG DPASQIYV++K R A +G Sbjct: 10 SMNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIG 69 Query: 59 LRGEVARLPDDASEADLLARVETLNARDDIDGILVQLPLPAHIDALRVMAAVDPAKDVDG 118 L V RLP+ SE +LL +E N + GILVQLPLP HI +V+ A+DP KDVDG Sbjct: 70 LNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDG 129 Query: 119 LHALNAGRLFHGDDALVPCTPLGCLRLIKSTLPDLTGAHAVVIGSSNIVGKPMAALLLQE 178 H +N GRL+ G+ ++P TP G + + + +L+G AVVIG SNIVGKPMA LL+ Sbjct: 130 FHPMNMGRLWSGNPLMIPSTPAGIMEMFREYDVELSGKRAVVIGRSNIVGKPMAQLLMMA 189 Query: 179 HATVTQTHIHTRGISRICREADILVSAVGK 208 ATVT H T + + +EAD+LV A+G+ Sbjct: 190 DATVTIAHSKTENLRELTKEADVLVVAIGR 219 >BH2784 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Bha Bacillus halodurans Length = 279 Score = 192 bits (489), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 97/212 (45%), Positives = 136/212 (64%), Gaps = 3/212 (1%) Query: 1 MTANILDGHAHAQIVIDKIAGELDRLPR---APGLAVVLVGCDPASQIYVQSKVRMAERL 57 M+A +LDG A A D++ E+ +L PGLAV+LVG DPAS +YV+SK + E++ Sbjct: 1 MSAVLLDGKALAAKKRDELKSEVTKLKERGITPGLAVILVGNDPASTVYVRSKQKACEQI 60 Query: 58 GLRGEVARLPDDASEADLLARVETLNARDDIDGILVQLPLPAHIDALRVMAAVDPAKDVD 117 G+ + LP SE +LL ++ LN I GILVQLPLP I V+ + PAKDVD Sbjct: 61 GIYSVLKELPASTSEEELLTEIDRLNNDPTIHGILVQLPLPEQISEQAVIERISPAKDVD 120 Query: 118 GLHALNAGRLFHGDDALVPCTPLGCLRLIKSTLPDLTGAHAVVIGSSNIVGKPMAALLLQ 177 G H ++ GR+ G+D +PCTP G L +++ ++ G H VV+G SNIVGKP+ L+L Sbjct: 121 GFHPISVGRMMIGEDTFLPCTPFGVLVMLQEANVEIAGKHVVVVGRSNIVGKPVGQLMLN 180 Query: 178 EHATVTQTHIHTRGISRICREADILVSAVGKA 209 EHATVT H T+ ++ I ++ADIL+ AVG+A Sbjct: 181 EHATVTYCHSRTKNLTEITKQADILIVAVGRA 212 >lin1397 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Lin Listeria innocua Length = 284 Score = 191 bits (484), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 102/210 (48%), Positives = 134/210 (63%), Gaps = 3/210 (1%) Query: 3 ANILDGHAHAQIVIDKIAGELDRL---PRAPGLAVVLVGCDPASQIYVQSKVRMAERLGL 59 I+DG A+ + +K+ E+ L + PGLAVVLVG + AS+ YV++K + E G+ Sbjct: 2 GEIIDGKKLAKEIQEKVTSEVAELVKQGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGM 61 Query: 60 RGEVARLPDDASEADLLARVETLNARDDIDGILVQLPLPAHIDALRVMAAVDPAKDVDGL 119 + + LP+ +E LL VE LN + I GILVQLPLP HI +V+ A+ KDVDG Sbjct: 62 KSVLIELPETVTEEKLLKVVEELNEDNTIHGILVQLPLPKHISEEKVIDAISFDKDVDGF 121 Query: 120 HALNAGRLFHGDDALVPCTPLGCLRLIKSTLPDLTGAHAVVIGSSNIVGKPMAALLLQEH 179 H +N G LF G D+ VPCTP G + LIKST + G AVVIG SNIVGKP+A LLL E+ Sbjct: 122 HPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAVVIGRSNIVGKPVAQLLLNEN 181 Query: 180 ATVTQTHIHTRGISRICREADILVSAVGKA 209 ATVT H T+ + ++ +EADILV A G A Sbjct: 182 ATVTIAHSRTKDLPQVAKEADILVVATGLA 211 >BS_folD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Bsu Bacillus subtilis Length = 283 Score = 189 bits (480), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 97/214 (45%), Positives = 136/214 (63%), Gaps = 3/214 (1%) Query: 1 MTANILDGHAHAQIVIDKIAGELDRLPR---APGLAVVLVGCDPASQIYVQSKVRMAERL 57 MTA I+DG A+ +++A E++ L + PGLAV+L+G DPAS YV+ K + AE + Sbjct: 1 MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDPASHSYVRGKKKAAETM 60 Query: 58 GLRGEVARLPDDASEADLLARVETLNARDDIDGILVQLPLPAHIDALRVMAAVDPAKDVD 117 G+ ++ + +EA+LL+ ++ N + GILVQLPLP HI V+ + P KDVD Sbjct: 61 GMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPDHISEKAVIERISPDKDVD 120 Query: 118 GLHALNAGRLFHGDDALVPCTPLGCLRLIKSTLPDLTGAHAVVIGSSNIVGKPMAALLLQ 177 G H LN G++ G+D +PCTP G + L+K T DL+G VV+G SNIVGKP+ LLL Sbjct: 121 GFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKEVVVVGRSNIVGKPVGQLLLN 180 Query: 178 EHATVTQTHIHTRGISRICREADILVSAVGKAGL 211 E+ATVT H T I+ ++ADILV AVG+A Sbjct: 181 ENATVTYCHSRTENITEHTKKADILVVAVGRANF 214