BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0115.0136.p (459 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC0265 [I] COG0183 Acetyl-CoA acetyltransferase Ccr Caulobacter ... 502 e-142 PA1736 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas ... 285 1e-76 MT0882 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacteriu... 269 1e-71 Rv0859 [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacteriu... 266 6e-71 ML2162 [I] COG0183 Acetyl-CoA acetyltransferase Mle Mycobacteriu... 266 6e-71 >CC0265 [I] COG0183 Acetyl-CoA acetyltransferase Ccr Caulobacter vibrioides Length = 412 Score = 502 bits (1293), Expect = e-142, Method: Compositional matrix adjust. Identities = 256/365 (70%), Positives = 291/365 (79%), Gaps = 6/365 (1%) Query: 1 MSEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLGALKERNKLDTSTVDDIIWSTST 60 M+EAYIIDA RTPRGIGK GKGAL+ HPQHLAATVL AL ERN L+T+ VDDIIW TS+ Sbjct: 1 MAEAYIIDACRTPRGIGKVGKGALADFHPQHLAATVLKALAERNGLNTAEVDDIIWGTSS 60 Query: 61 QEGKQGGDLGRMSALAAGYDINASGTTLDRFCGGGITSVNLAAASVMSGMEDCVIAGGTE 120 Q G Q GDLGRM+AL AGYD+ ASG TLDRFCG GIT+VNLAAAS+MSGMED VIAGGTE Sbjct: 61 QRGSQAGDLGRMAALDAGYDVRASGVTLDRFCGSGITTVNLAAASIMSGMEDLVIAGGTE 120 Query: 121 MMSYQQTLAAERSKAGQPARMMGSGNPALDEIHPQSHQGVCGDAIATREGISREACDALA 180 MMSY A S M+ SGN L HPQSHQGVC DAIAT EGI+R DALA Sbjct: 121 MMSYTSATANVTSPP-----MLDSGNLRLRARHPQSHQGVCADAIATLEGITRADVDALA 175 Query: 181 LTSQQRAKRAIDEGRFAKSVIPVLNDDGSVALNREEFPRPETTAEGLASLKPSFEQLADF 240 L SQ+RA AI G FAKS+IPVL DDGSVAL+ EEFPRP+TTAEGLASLK SF LA+ Sbjct: 176 LESQRRADLAIQGGHFAKSLIPVLRDDGSVALDHEEFPRPQTTAEGLASLKASFAALAEI 235 Query: 241 DLGN-GTTFKKQIQRRYPDLEWKGVHHAGNSSGVVDGAAAVLITSKAYAEKHGLKPRGRI 299 + G T+ I++ YPDL+ + +HHAGNSSGVVDGAAAVL+ S AYA++HGLKPR ++ Sbjct: 236 PVDEAGNTYGGLIRQVYPDLKIQHMHHAGNSSGVVDGAAAVLLASPAYAQRHGLKPRAKV 295 Query: 300 VAYANQGDDPTLMLNAPVPAAKKVLAKAGLTKNDIDVWEINEAFAVVAEKFIRDLELDRE 359 +A AN GD PTLMLNAPVPAA+K LAKAGLT +DID+WEINEAFAVVAEKFIRDL+LDR+ Sbjct: 296 IAMANVGDSPTLMLNAPVPAARKALAKAGLTVDDIDLWEINEAFAVVAEKFIRDLKLDRD 355 Query: 360 KVNXD 364 KVN + Sbjct: 356 KVNVN 360 >PA1736 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas aeruginosa Length = 401 Score = 285 bits (730), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 170/374 (45%), Positives = 224/374 (59%), Gaps = 35/374 (9%) Query: 1 MSEAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLGALKERNKLDTSTVDDIIWSTST 60 M++A+I DAVRTPRG GK GAL + P +L A +L A++ RN LDT+ VDDI+ T Sbjct: 1 MTDAFIYDAVRTPRGKGKK-DGALHSVKPVNLMAGLLRAVQRRNDLDTAQVDDIVLGCVT 59 Query: 61 QEGKQGGDLGRMSALAAGYDINASGTTLDRFCGGGITSVNLAAASVMSGMEDCVIAGGTE 120 G QG D+ + +AL A +D +G ++RFC G+ +VNL A V SG ED V+ GG E Sbjct: 60 PVGDQGADIAKTAALVADWDEQVAGVQINRFCASGLEAVNLGAMKVRSGFEDLVLVGGVE 119 Query: 121 MMSYQQTLAAERSKAGQPARMMGS--GNPALDEIHPQSH-------QGVCGDAIATREGI 171 MS MGS G ALD P+++ QG+ D IAT EG Sbjct: 120 SMSRVP---------------MGSDGGAWALD---PETNLHTSFVPQGIGADLIATLEGF 161 Query: 172 SREACDALALTSQQRAKRAIDEGRFAKSVIPVLNDDGSVALNREEFPRPETTAEGLASLK 231 SR DA AL SQQ+A +A EG F KS++PV + +G V L+ +EF R ++T EGLA+LK Sbjct: 162 SRADVDAFALRSQQKAAKARAEGLFGKSLVPVADQNGIVLLDHDEFIRADSTLEGLAALK 221 Query: 232 PSFEQLADFDLGNGTTFKKQIQRRYPDLE-WKGVHHAGNSSGVVDGAAAVLITSKAYAEK 290 PSFE + F R+Y +E + VH GNSSG+VDGA+A+LI S+A + Sbjct: 222 PSFEMMGQMG------FDATALRKYSQVERIEHVHTPGNSSGIVDGASAMLIGSEAKGRE 275 Query: 291 HGLKPRGRIVAYANQGDDPTLMLNAPVPAAKKVLAKAGLTKNDIDVWEINEAFAVVAEKF 350 GLK R RIVA A DPT+ML P PA +K LAKAGL DID++E+NEAFA V KF Sbjct: 276 LGLKARARIVATAVTSTDPTIMLTGPAPATRKALAKAGLKVEDIDLFEVNEAFASVVMKF 335 Query: 351 IRDLELDREKVNXD 364 ++D+ + KVN + Sbjct: 336 MKDMGVAESKVNVN 349 >MT0882 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacterium tuberculosis CDC1551 Length = 403 Score = 269 bits (687), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 161/363 (44%), Positives = 215/363 (59%), Gaps = 16/363 (4%) Query: 3 EAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLGALKERN-KLDTSTVDDIIWSTSTQ 61 EA+I +A+RTPRG K G+L + P L ++ L++R+ LD + + D+I + Sbjct: 4 EAFIYEAIRTPRG--KQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSP 61 Query: 62 EGKQGGDLGRMSALAAGYDINASGTTLDRFCGGGITSVNLAAASVMSGMEDCVIAGGTEM 121 G QGGD+ R + LA+G + + G L+RFC G+ +VN AA V SG +D V+AGG E Sbjct: 62 VGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVES 121 Query: 122 MSYQQTLAAERSKAGQPARMMGSGNPALDEIHPQSHQGVCGDAIATREGISREACDALAL 181 MS R G MG +PA + QG+ D IAT EG SRE DA AL Sbjct: 122 MS--------RVPMGSDGGAMGL-DPATNYDVMFVPQGIGADLIATIEGFSREDVDAYAL 172 Query: 182 TSQQRAKRAIDEGRFAKSVIPVLNDDGSVALNREEFPRPETTAEGLASLKPSFEQLADFD 241 SQQ+A A G FAKSV+PV + +G + L+ +E RP+TT EGLA LKP+FE LA Sbjct: 173 RSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAAL- 231 Query: 242 LGNGTTFKKQIQRRYPDLEWKGVHHAGNSSGVVDGAAAVLITSKAYAEKHGLKPRGRIVA 301 G +Q+ + + VH GNSSG+VDGAA V+I S A + GL PR RIVA Sbjct: 232 ---GGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVA 288 Query: 302 YANQGDDPTLMLNAPVPAAKKVLAKAGLTKNDIDVWEINEAFAVVAEKFIRDLELDREKV 361 A G DP +ML P PA +KVL +AGLT +DID++E+NEAFA V KF +DL + EK+ Sbjct: 289 TATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKL 348 Query: 362 NXD 364 N + Sbjct: 349 NVN 351 >Rv0859 [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacterium tuberculosis H37Rv Length = 403 Score = 266 bits (681), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 160/363 (44%), Positives = 214/363 (58%), Gaps = 16/363 (4%) Query: 3 EAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLGALKERN-KLDTSTVDDIIWSTSTQ 61 EA+I +A+RTPRG K G+L + P L ++ L++R+ LD + + D+I + Sbjct: 4 EAFIYEAIRTPRG--KQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSP 61 Query: 62 EGKQGGDLGRMSALAAGYDINASGTTLDRFCGGGITSVNLAAASVMSGMEDCVIAGGTEM 121 G QGGD+ R + LA+G + + G L+RFC G+ +VN AA V SG +D V+AGG E Sbjct: 62 VGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVES 121 Query: 122 MSYQQTLAAERSKAGQPARMMGSGNPALDEIHPQSHQGVCGDAIATREGISREACDALAL 181 MS R G MG +PA + Q + D IAT EG SRE DA AL Sbjct: 122 MS--------RVPMGSDGGAMGL-DPATNYDVMFVPQSIGADLIATIEGFSREDVDAYAL 172 Query: 182 TSQQRAKRAIDEGRFAKSVIPVLNDDGSVALNREEFPRPETTAEGLASLKPSFEQLADFD 241 SQQ+A A G FAKSV+PV + +G + L+ +E RP+TT EGLA LKP+FE LA Sbjct: 173 RSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAAL- 231 Query: 242 LGNGTTFKKQIQRRYPDLEWKGVHHAGNSSGVVDGAAAVLITSKAYAEKHGLKPRGRIVA 301 G +Q+ + + VH GNSSG+VDGAA V+I S A + GL PR RIVA Sbjct: 232 ---GGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVA 288 Query: 302 YANQGDDPTLMLNAPVPAAKKVLAKAGLTKNDIDVWEINEAFAVVAEKFIRDLELDREKV 361 A G DP +ML P PA +KVL +AGLT +DID++E+NEAFA V KF +DL + EK+ Sbjct: 289 TATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKL 348 Query: 362 NXD 364 N + Sbjct: 349 NVN 351 >ML2162 [I] COG0183 Acetyl-CoA acetyltransferase Mle Mycobacterium leprae Length = 403 Score = 266 bits (681), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 159/363 (43%), Positives = 215/363 (59%), Gaps = 16/363 (4%) Query: 3 EAYIIDAVRTPRGIGKPGKGALSHLHPQHLAATVLGALKERN-KLDTSTVDDIIWSTSTQ 61 EA+I +A+RTPRG K G+L + P L ++ L++RN LD + + D+I + Sbjct: 4 EAFIYEAIRTPRG--KQKNGSLHEVKPVSLVVGLVEELRKRNPDLDENLISDVILGCVSP 61 Query: 62 EGKQGGDLGRMSALAAGYDINASGTTLDRFCGGGITSVNLAAASVMSGMEDCVIAGGTEM 121 G QGGD+ R + LAAG + A G L+RFC G+ +VN AA V SG +D V+AGG E Sbjct: 62 VGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVES 121 Query: 122 MSYQQTLAAERSKAGQPARMMGSGNPALDEIHPQSHQGVCGDAIATREGISREACDALAL 181 MS R G MG +PA + QG+ D IAT EG SR+ D AL Sbjct: 122 MS--------RVPMGSDGGAMGL-DPATNYDVMFVPQGIGADLIATIEGFSRDDVDVYAL 172 Query: 182 TSQQRAKRAIDEGRFAKSVIPVLNDDGSVALNREEFPRPETTAEGLASLKPSFEQLADFD 241 SQ++A A G FAKSV+PV + +G + L+ +E RP+T+ EGLA LKP+FE LA Sbjct: 173 RSQEKAAAAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTSKEGLAKLKPAFEGLAAM- 231 Query: 242 LGNGTTFKKQIQRRYPDLEWKGVHHAGNSSGVVDGAAAVLITSKAYAEKHGLKPRGRIVA 301 G +Q+ + + VH GNSSG+VDGAA V+I S+A + GL PR R+VA Sbjct: 232 ---GGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRARMVA 288 Query: 302 YANQGDDPTLMLNAPVPAAKKVLAKAGLTKNDIDVWEINEAFAVVAEKFIRDLELDREKV 361 A G DP +ML P PA +KVL +AGLT +DID++E+NEAFA V KF +DL + EK+ Sbjct: 289 TATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKL 348 Query: 362 NXD 364 N + Sbjct: 349 NVN 351