BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0107.0004.p (868 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv3820c [Q] COG1020 Non-ribosomal peptide synthetase modules and... 124 7e-28 MT3928 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 124 7e-28 MT3932 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 108 5e-23 Rv3824c [Q] COG1020 Non-ribosomal peptide synthetase modules and... 107 1e-22 Rv1182 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 107 1e-22 >Rv3820c [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Mtu Mycobacterium tuberculosis H37Rv Length = 468 Score = 124 bits (312), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 120/455 (26%), Positives = 187/455 (41%), Gaps = 30/455 (6%) Query: 415 LMDIKEFGDLDRQPGRLMVWRINVTEPISWRADPRR---PSYVQEEHLRSADDGRPGWLG 471 + I D PG ++ W + T R P PSY Q +HLR D L Sbjct: 1 MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQQAQHLRRYRDHVARGLD 60 Query: 472 AA------FELPGELNAAALTKAILGWVDRHEVLRSRLAKDGSA--MRRATIDPGAAALE 523 + ++LPG N A+ AI + RH+ S D + +R DP + Sbjct: 61 MSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDTYHSWFEFDNAEHIVRHTIADPA----D 116 Query: 524 QTVVSDCADSGETAQLLEKLFDAETNPLRWPAYVFVTISRPTSTSLLLASDHSVSDAYSM 583 VV + +A+L + A PL+W ++F I + + H D + Sbjct: 117 IEVVQAEHQNMTSAELRHHI--ATPQPLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIV 174 Query: 584 ALVPYEIHELYTAAIRRVEP-QLAAVHSYLDHAEAERERLTDLTDDHPAICHWRELIAAN 642 ++ EIH +Y+A + P +L Y DH + LT D + W E A N Sbjct: 175 GVLFIEIHMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANN 234 Query: 643 GGQLPDFPLSFDTPEKSLQRSGKMW---LLDAAGACEFDRGCRSQGGNAATGIFACLALA 699 G LP FPL + S+ +GK+ L+D F+ C + G + G+FAC ALA Sbjct: 235 DGTLPHFPLPLG--DLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAALA 292 Query: 700 GKTLANQRQFHAVAPFHTRYDLRSMRSVGWYVGMSPVSFRVADTLPE-ILNAARFELKRA 758 + L N F V TR +R+ GW+ G+ P++ VA L + A+ Sbjct: 293 ERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDSAARVAQISFDSG 352 Query: 759 KKTAQVPFSKAMELL--GTTLRD----RFMVSYMDNRTVPGSDRWPHWRTRFLISRSSDA 812 K A VPF + +EL T LR F++S++D P S + + Sbjct: 353 KDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIAPLSTVANSDLNFRIYDEGRVS 412 Query: 813 CETYLWISRWQDGISVNFRHPGTATARSAMDNYLA 847 + +W++R+Q +V P A ++ NY+A Sbjct: 413 HQVSMWVNRYQHQTTVTVLFPDNPIASESVANYIA 447 >MT3928 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins MtC Mycobacterium tuberculosis CDC1551 Length = 468 Score = 124 bits (312), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 120/455 (26%), Positives = 187/455 (41%), Gaps = 30/455 (6%) Query: 415 LMDIKEFGDLDRQPGRLMVWRINVTEPISWRADPRR---PSYVQEEHLRSADDGRPGWLG 471 + I D PG ++ W + T R P PSY Q +HLR D L Sbjct: 1 MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQQAQHLRRYRDHVARGLD 60 Query: 472 AA------FELPGELNAAALTKAILGWVDRHEVLRSRLAKDGSA--MRRATIDPGAAALE 523 + ++LPG N A+ AI + RH+ S D + +R DP + Sbjct: 61 MSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDTYHSWFEFDNAEHIVRHTIADPA----D 116 Query: 524 QTVVSDCADSGETAQLLEKLFDAETNPLRWPAYVFVTISRPTSTSLLLASDHSVSDAYSM 583 VV + +A+L + A PL+W ++F I + + H D + Sbjct: 117 IEVVQAEHQNMTSAELRHHI--ATPQPLQWDCFLFGIIQSDDHFTFYASIAHLCVDPMIV 174 Query: 584 ALVPYEIHELYTAAIRRVEP-QLAAVHSYLDHAEAERERLTDLTDDHPAICHWRELIAAN 642 ++ EIH +Y+A + P +L Y DH + LT D + W E A N Sbjct: 175 GVLFIEIHMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALTLDSARVRRWVEFAANN 234 Query: 643 GGQLPDFPLSFDTPEKSLQRSGKMW---LLDAAGACEFDRGCRSQGGNAATGIFACLALA 699 G LP FPL + S+ +GK+ L+D F+ C + G + G+FAC ALA Sbjct: 235 DGTLPHFPLPLG--DLSVPHTGKLLTETLMDEQQGERFEAACVAAGARFSGGVFACAALA 292 Query: 700 GKTLANQRQFHAVAPFHTRYDLRSMRSVGWYVGMSPVSFRVADTLPE-ILNAARFELKRA 758 + L N F V TR +R+ GW+ G+ P++ VA L + A+ Sbjct: 293 ERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVASGLFDSAARVAQISFDSG 352 Query: 759 KKTAQVPFSKAMELL--GTTLRD----RFMVSYMDNRTVPGSDRWPHWRTRFLISRSSDA 812 K A VPF + +EL T LR F++S++D P S + + Sbjct: 353 KDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIAPLSTVANSDLNFRIYDEGRVS 412 Query: 813 CETYLWISRWQDGISVNFRHPGTATARSAMDNYLA 847 + +W++R+Q +V P A ++ NY+A Sbjct: 413 HQVSMWVNRYQHQTTVTVLFPDNPIASESVANYIA 447 >MT3932 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins MtC Mycobacterium tuberculosis CDC1551 Length = 511 Score = 108 bits (270), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 105/400 (26%), Positives = 162/400 (40%), Gaps = 35/400 (8%) Query: 416 MDIKEFGDLDRQPGRLMVWRINVTEPISWRADPRR---PSYVQEEHLRSADD------GR 466 +++ D D PG L+ W A P PSYVQ +RS + Sbjct: 6 VELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDH 65 Query: 467 PGWLGAAFELPGELNAAALTKAILGWVDRHEVLRS--RLAKDGSAMRRATIDPGAAALEQ 524 L A+ E+ G + A+T I + RH+ RS L +R + DP Sbjct: 66 SRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVP 125 Query: 525 TVVSDCADSGE-TAQLLEKLFDAETNPLRWPAYVFVTISRPTSTSLLLASDHSVSDAYSM 583 T GE T+ L + A + L W + F I R S + + DH +D + Sbjct: 126 TT------HGEMTSADLRQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFV 179 Query: 584 ALVPYEIHELYTAAIRRVEP-QLAAVHSYLDHAEAERERLTDLTDDHPAICHWRELIAAN 642 + E +YTA I P L+ SY+D + E + LT D P + W + N Sbjct: 180 GVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFAEIN 239 Query: 643 GGQLPDFPLSFDTPEKSLQRSGK---MWLLDAAGACEFDRGCRSQGGNAATGIFACLALA 699 G P+FPL P S++ G M L+D F+ C + GI AC+A+A Sbjct: 240 NGTFPEFPLPLGDP--SVRCGGDLLSMMLMDEQQTQRFESACMAANARFIGGILACIAIA 297 Query: 700 GKTLANQRQFHAVAPFHTRYDLRS---MRSVGWYVGMSPVSFRVAD-TLPEILNAARFEL 755 L + + P D+R+ + + GW+ G PV+ VA + EI A+ Sbjct: 298 IHELTGADTYFGITP----KDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQTSF 353 Query: 756 KRAKKTAQVPFSKAMELLGTTLRDR---FMVSYMDNRTVP 792 A+VPF + +EL + R + +V++ D + P Sbjct: 354 DTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGP 393 >Rv3824c [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Mtu Mycobacterium tuberculosis H37Rv Length = 511 Score = 107 bits (267), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 104/400 (26%), Positives = 162/400 (40%), Gaps = 35/400 (8%) Query: 416 MDIKEFGDLDRQPGRLMVWRINVTEPISWRADPRR---PSYVQEEHLRSADD------GR 466 +++ D D PG L+ W A P PSYVQ +RS + Sbjct: 6 VELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDH 65 Query: 467 PGWLGAAFELPGELNAAALTKAILGWVDRHEVLRS--RLAKDGSAMRRATIDPGAAALEQ 524 L A+ E+ G + A+T I + RH+ RS L +R + DP Sbjct: 66 SRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVP 125 Query: 525 TVVSDCADSGE-TAQLLEKLFDAETNPLRWPAYVFVTISRPTSTSLLLASDHSVSDAYSM 583 T GE T+ L + A + L W + F I R S + + DH +D + Sbjct: 126 TT------HGEMTSADLRQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFV 179 Query: 584 ALVPYEIHELYTAAIRRVEP-QLAAVHSYLDHAEAERERLTDLTDDHPAICHWRELIAAN 642 + E +YTA I P L+ SY+D + E + LT D P + W + N Sbjct: 180 GVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFAEIN 239 Query: 643 GGQLPDFPLSFDTPEKSLQRSGK---MWLLDAAGACEFDRGCRSQGGNAATGIFACLALA 699 G P+FPL P S++ G M L+D F+ C + G+ AC+A+A Sbjct: 240 NGTFPEFPLPLGDP--SVRCGGDLLSMMLMDEQQTQRFESACMAANARFIGGMLACIAIA 297 Query: 700 GKTLANQRQFHAVAPFHTRYDLRS---MRSVGWYVGMSPVSFRVAD-TLPEILNAARFEL 755 L + + P D+R+ + + GW+ G PV+ VA + EI A+ Sbjct: 298 IHELTGADTYFGITP----KDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQTSF 353 Query: 756 KRAKKTAQVPFSKAMELLGTTLRDR---FMVSYMDNRTVP 792 A+VPF + +EL + R + +V++ D + P Sbjct: 354 DTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGP 393 >Rv1182 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Mtu Mycobacterium tuberculosis H37Rv Length = 472 Score = 107 bits (267), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 103/418 (24%), Positives = 173/418 (41%), Gaps = 24/418 (5%) Query: 452 SYVQEEHLRSADDGRPGWLG------AAFELPGELNAAALTKAILGWVDRHEVLRS--RL 503 SY+Q +H+R + + L + + PG+ + A I + RH+ RS + Sbjct: 46 SYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQY 105 Query: 504 AKDGSAMRRATIDPGAAALEQTVVSDCADSGE-TAQLLEKLFDAETNPLRWPAYVFVTIS 562 +G +RR DP A +E V GE T + ++ +PL+W + F + Sbjct: 106 NGNGQIIRRTIQDP--ADIEFVPVH----HGELTLPQIREIVQNTPDPLQWGCFRFGIVQ 159 Query: 563 RPTSTSLLLASDHSVSDAYSMALVPYEIHELYTAAIRRVEP-QLAAVHSYLDHAEAERER 621 + + DH DA + + E H +Y A + P +L SY D + Sbjct: 160 GCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYDDFCRRQHTF 219 Query: 622 LTDLTDDHPAICHWRELIAANGGQLPDFPLSFDTPEK-SLQRSGKMWLLDAAGACEFDRG 680 + LT + P + W + G PDFPL P K S + +LD +F+ Sbjct: 220 SSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESV 279 Query: 681 CRSQGGNAATGIFACLALAGKTLANQRQFHAVAPFHTRYDLRSMRSVGWYVGMSPVSFRV 740 C + G G+ AC LA L ++ + P TR + GW+ G+ P++ + Sbjct: 280 CTAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPI 339 Query: 741 ADT-LPEILNAARFELKRAKKTAQVPFSKAMELLGTTL--RDRF-MVSYMDNRTVPGSDR 796 A + + AA+ K A+VP+ + +EL T R F +V+++D P S Sbjct: 340 AGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVL 399 Query: 797 WPHWRTRFLISRSSDACETY---LWISRWQDGISVNFRHPGTATARSAMDNYLAEVAA 851 T I SD +Y +++ R + G +V P AR ++ YLA + + Sbjct: 400 LTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKS 457