BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0106.0048.p (529 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2815 [GEPR] COG0477 Permeases of the major facilitator superf... 318 2e-86 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 314 3e-85 emrB [GEPR] COG0477 Permeases of the major facilitator superfami... 313 6e-85 ECs3548 [GEPR] COG0477 Permeases of the major facilitator superf... 313 6e-85 ZemrB [GEPR] COG0477 Permeases of the major facilitator superfam... 309 9e-84 >STM2815 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 512 Score = 318 bits (815), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 178/489 (36%), Positives = 279/489 (57%), Gaps = 28/489 (5%) Query: 22 LIAIVVALASFMEVLDTTIANVALPYIAGGMGVSEDESSWVVTTYLVSNAIILTASGFLA 81 ++ I ++LA+FM+VLD+TIANVA+P IAG +G S + +WV+T++ V+NAI + +G+LA Sbjct: 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLA 73 Query: 82 RTLGRKTFFLICLGIFTVSSILCGFAPNLNALLLFRILQGLGGGGMVPVAQSILADAFPP 141 + G F+ F +S CG + +LN L+ FR++QG+ G ++P++QS+L + +PP Sbjct: 74 KRFGEVKLFMWSTVAFAAASWACGVSSSLNMLIFFRVVQGVVAGPLIPLSQSLLLNNYPP 133 Query: 142 AKRGQAFAVFGIAVVVAPVVGPTLGGWLSDNLSWHWCFLINAPVGVFAIALIAAVLQEPA 201 AKR A A++ + V+VAP+ GP LGG++SDN W W F IN P+G IA VL Sbjct: 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIG------IAVVLMTLH 187 Query: 202 TAKARGAQPQGNRFDFIGFALVATFLGALEVVLDRGLEDDWFASPFIITFAVICATAFVL 261 T + R + R D +G AL+ +G+L+++LDRG E DWF+S II V+ A Sbjct: 188 TLRGRETHTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVIAISF 247 Query: 262 MIPWEMTRRNPMIDLRMVATRQFG-ACFLV----MLATGAILLATTQFLPQLVQQDFGYT 316 +I WE+T +P++DL + +R F C + ML GAI+L LPQL+Q+ +GYT Sbjct: 248 LIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVL-----LPQLLQEVYGYT 302 Query: 317 ATWAGLVLSPGGVVTMMMMFAVGRLAARVQPKYLIVAGALVIAASMYSMTNVYA-DLGFW 375 ATWAGL +P G++ +++ +GR A ++ + L+ ++ A Y + + F Sbjct: 303 ATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAWTFEPGMDFG 362 Query: 376 FMARSRMLIG--VGLPLVPIMAASYDGIPPDKTDQASALINAARNTGGS-GVSIVSNVLT 432 A + + G V +P+ + G+PP++ AS+L N R GS G SI + + T Sbjct: 363 ASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWT 422 Query: 433 HRQQFHQSRLVEQVTPSSPQYQDTLHQITDFFVAQGSSLAQAHQQAIQWIGQQVQTQASF 492 R+ H ++L E VT +P Q ++ L HQQA WI QQ+ Q Sbjct: 423 DRESLHHAQLTESVTAYNPNAQTMYDKL--------EGLGMTHQQASGWIAQQITNQGLI 474 Query: 493 LSYMDAFWV 501 +S + FW+ Sbjct: 475 ISANEIFWM 483 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 314 bits (804), Expect = 3e-85, Method: Compositional matrix adjust. Identities = 178/499 (35%), Positives = 284/499 (56%), Gaps = 33/499 (6%) Query: 23 IAIVVALASFMEVLDTTIANVALPYIAGGMGVSEDESSWVVTTYLVSNAIILTASGFLAR 82 + + ++LA+FM+VLD+TIANVA+P IAG +G S + +WV+T++ V+NAI + +G+LA+ Sbjct: 14 MTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAK 73 Query: 83 TLGRKTFFLICLGIFTVSSILCGFAPNLNALLLFRILQGLGGGGMVPVAQSILADAFPPA 142 +G FL G+F ++S LCG + +L L+ FR++QGL G ++P++QS+L + +PPA Sbjct: 74 RVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPA 133 Query: 143 KRGQAFAVFGIAVVVAPVVGPTLGGWLSDNLSWHWCFLINAPVGVFAIALIAAVLQEPAT 202 KR A A++ + +VVAP+ GP LGG++SDN W W F IN P+G + VL +T Sbjct: 134 KRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG------LVVVLLAGST 187 Query: 203 AKARGAQPQGNRFDFIGFALVATFLGALEVVLDRGLEDDWFASPFIITFAVICATAFVLM 262 K R + + D IG L+ +GAL+++LD+G E DWF S II V+ A + Sbjct: 188 LKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFL 247 Query: 263 IPWEMTRRNPMIDLRMVATRQFG-ACFLV----MLATGAILLATTQFLPQLVQQDFGYTA 317 I WE+T +P+IDL + +R F C + ML GAI+L LPQL+Q+ +GYTA Sbjct: 248 IVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVL-----LPQLLQEVYGYTA 302 Query: 318 TWAGLVLSPGGVVTMMMMFAVGRLAARVQPKYLIVAGALVIAASMYSMTNVYA-DLGFWF 376 TWAGL +P G++ +++ +GR A R+ + L+ ++ A Y + + F Sbjct: 303 TWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEPGMDFGA 362 Query: 377 MARSRMLIGVGLP--LVPIMAASYDGIPPDKTDQASALINAARNTGGS-GVSIVSNVLTH 433 A + G + +P+ + G+PP++ AS+L N R GS G SI + + T Sbjct: 363 SAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQ 422 Query: 434 RQQFHQSRLVEQVTPSSPQYQDTLHQITDFFVAQGSSLAQAHQQAIQWIGQQVQTQASFL 493 R+ H ++L E V P +P ++ L + QQA ++ +++ Q + Sbjct: 423 RESLHHAQLTEFVNPYNPNATQAYQEL--------EKLGMSQQQASAYLAREITNQGLII 474 Query: 494 SYMDAFWV-----LMLIAL 507 S + FW+ LML+AL Sbjct: 475 SANEIFWLSAGVFLMLLAL 493 >emrB [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 512 Score = 313 bits (802), Expect = 6e-85, Method: Compositional matrix adjust. Identities = 180/489 (36%), Positives = 282/489 (57%), Gaps = 28/489 (5%) Query: 22 LIAIVVALASFMEVLDTTIANVALPYIAGGMGVSEDESSWVVTTYLVSNAIILTASGFLA 81 ++ I ++LA+FM+VLD+TIANVA+P IAG +G S + +WV+T++ V+NAI + +G+LA Sbjct: 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLA 73 Query: 82 RTLGRKTFFLICLGIFTVSSILCGFAPNLNALLLFRILQGLGGGGMVPVAQSILADAFPP 141 + +G FL F ++S CG + +LN L+ FR++QG+ G ++P++QS+L + +PP Sbjct: 74 KRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPP 133 Query: 142 AKRGQAFAVFGIAVVVAPVVGPTLGGWLSDNLSWHWCFLINAPVGVFAIALIAAVLQEPA 201 AKR A A++ + V+VAP+ GP LGG++SDN W W F IN P+GV A VL Sbjct: 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGV------AVVLMTLQ 187 Query: 202 TAKARGAQPQGNRFDFIGFALVATFLGALEVVLDRGLEDDWFASPFIITFAVICATAFVL 261 T + R + + R D +G AL+ +G+L+++LDRG E DWF+S II V+ A Sbjct: 188 TLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICF 247 Query: 262 MIPWEMTRRNPMIDLRMVATRQFG-ACFLV----MLATGAILLATTQFLPQLVQQDFGYT 316 +I WE+T NP++DL + +R F C + ML GAI+L LPQL+Q+ +GYT Sbjct: 248 LIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVL-----LPQLLQEVYGYT 302 Query: 317 ATWAGLVLSPGGVVTMMMMFAVGRLAARVQPKYLIVAGALVIAASMYSMTNVYA-DLGFW 375 ATWAGL +P G++ +++ +GR A ++ + L+ ++ A Y + + F Sbjct: 303 ATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFG 362 Query: 376 FMARSRMLIG--VGLPLVPIMAASYDGIPPDKTDQASALINAARNTGGS-GVSIVSNVLT 432 A + + G V +P+ + G+PP++ AS+L N R GS G SI + + T Sbjct: 363 ASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWT 422 Query: 433 HRQQFHQSRLVEQVTPSSPQYQDTLHQITDFFVAQGSSLAQAHQQAIQWIGQQVQTQASF 492 +R+ H ++L E V P +P Q Q+ L QQA WI QQ+ Q Sbjct: 423 NRESMHHAQLTESVNPFNPNAQAMYSQL--------EGLGMTQQQASGWIAQQITNQGLI 474 Query: 493 LSYMDAFWV 501 +S + FW+ Sbjct: 475 ISANEIFWM 483 >ECs3548 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 512 Score = 313 bits (802), Expect = 6e-85, Method: Compositional matrix adjust. Identities = 180/489 (36%), Positives = 282/489 (57%), Gaps = 28/489 (5%) Query: 22 LIAIVVALASFMEVLDTTIANVALPYIAGGMGVSEDESSWVVTTYLVSNAIILTASGFLA 81 ++ I ++LA+FM+VLD+TIANVA+P IAG +G S + +WV+T++ V+NAI + +G+LA Sbjct: 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLA 73 Query: 82 RTLGRKTFFLICLGIFTVSSILCGFAPNLNALLLFRILQGLGGGGMVPVAQSILADAFPP 141 + +G FL F ++S CG + +LN L+ FR++QG+ G ++P++QS+L + +PP Sbjct: 74 KRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPP 133 Query: 142 AKRGQAFAVFGIAVVVAPVVGPTLGGWLSDNLSWHWCFLINAPVGVFAIALIAAVLQEPA 201 AKR A A++ + V+VAP+ GP LGG++SDN W W F IN P+GV A VL Sbjct: 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGV------AVVLMTLQ 187 Query: 202 TAKARGAQPQGNRFDFIGFALVATFLGALEVVLDRGLEDDWFASPFIITFAVICATAFVL 261 T + R + + R D +G AL+ +G+L+++LDRG E DWF+S II V+ A Sbjct: 188 TLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWFSSQEIIILTVVAVVAICF 247 Query: 262 MIPWEMTRRNPMIDLRMVATRQFG-ACFLV----MLATGAILLATTQFLPQLVQQDFGYT 316 +I WE+T NP++DL + +R F C + ML GAI+L LPQL+Q+ +GYT Sbjct: 248 LIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVL-----LPQLLQEVYGYT 302 Query: 317 ATWAGLVLSPGGVVTMMMMFAVGRLAARVQPKYLIVAGALVIAASMYSMTNVYA-DLGFW 375 ATWAGL +P G++ +++ +GR A ++ + L+ ++ A Y + + F Sbjct: 303 ATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFG 362 Query: 376 FMARSRMLIG--VGLPLVPIMAASYDGIPPDKTDQASALINAARNTGGS-GVSIVSNVLT 432 A + + G V +P+ + G+PP++ AS+L N R GS G SI + + T Sbjct: 363 ASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWT 422 Query: 433 HRQQFHQSRLVEQVTPSSPQYQDTLHQITDFFVAQGSSLAQAHQQAIQWIGQQVQTQASF 492 +R+ H ++L E V P +P Q Q+ L QQA WI QQ+ Q Sbjct: 423 NRESMHHAQLTESVNPFNPNAQAMYSQL--------EGLGMTQQQASGWIAQQITNQGLI 474 Query: 493 LSYMDAFWV 501 +S + FW+ Sbjct: 475 ISANEIFWM 483 >ZemrB [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 512 Score = 309 bits (792), Expect = 9e-84, Method: Compositional matrix adjust. Identities = 179/489 (36%), Positives = 281/489 (57%), Gaps = 28/489 (5%) Query: 22 LIAIVVALASFMEVLDTTIANVALPYIAGGMGVSEDESSWVVTTYLVSNAIILTASGFLA 81 ++ I ++LA+FM+VLD+TIANVA+P IAG +G S + +WV+T++ V+NAI + +G+LA Sbjct: 14 IMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPLTGWLA 73 Query: 82 RTLGRKTFFLICLGIFTVSSILCGFAPNLNALLLFRILQGLGGGGMVPVAQSILADAFPP 141 + +G FL F ++S CG + +LN L+ FR++QG+ G ++P++QS+L + +PP Sbjct: 74 KRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLLNNYPP 133 Query: 142 AKRGQAFAVFGIAVVVAPVVGPTLGGWLSDNLSWHWCFLINAPVGVFAIALIAAVLQEPA 201 AKR A A++ + V+VAP+ GP LGG++SDN W W F IN P+GV A VL Sbjct: 134 AKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGV------AVVLMTLQ 187 Query: 202 TAKARGAQPQGNRFDFIGFALVATFLGALEVVLDRGLEDDWFASPFIITFAVICATAFVL 261 T + R + + R D +G AL+ +G+L+++LD G E DWF+S II V+ A Sbjct: 188 TLRGRETRTERRRIDAVGLALLVIGIGSLQIMLDXGKELDWFSSQEIIILTVVAVVAICF 247 Query: 262 MIPWEMTRRNPMIDLRMVATRQFG-ACFLV----MLATGAILLATTQFLPQLVQQDFGYT 316 +I WE+T NP++DL + +R F C + ML GAI+L LPQL+Q+ +GYT Sbjct: 248 LIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVL-----LPQLLQEVYGYT 302 Query: 317 ATWAGLVLSPGGVVTMMMMFAVGRLAARVQPKYLIVAGALVIAASMYSMTNVYA-DLGFW 375 ATWAGL +P G++ +++ +GR A ++ + L+ ++ A Y + + F Sbjct: 303 ATWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFXFIMYAVCFYWRAYTFEPGMDFG 362 Query: 376 FMARSRMLIG--VGLPLVPIMAASYDGIPPDKTDQASALINAARNTGGS-GVSIVSNVLT 432 A + + G V +P+ + G+PP++ AS+L N R GS G SI + + T Sbjct: 363 ASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTTMWT 422 Query: 433 HRQQFHQSRLVEQVTPSSPQYQDTLHQITDFFVAQGSSLAQAHQQAIQWIGQQVQTQASF 492 +R+ H ++L E V P +P Q Q+ L QQA WI QQ+ Q Sbjct: 423 NRESMHHAQLTESVNPFNPNAQAMYSQL--------EGLGMTQQQASGWIAQQITNQGLI 474 Query: 493 LSYMDAFWV 501 +S + FW+ Sbjct: 475 ISANEIFWM 483