BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0106.0012.p (554 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0547 [GEPR] COG0477 Permeases of the major facilitator superf... 662 0.0 CC0980 [GEPR] COG0477 Permeases of the major facilitator superfa... 607 e-173 PA3709 [GEPR] COG0477 Permeases of the major facilitator superfa... 584 e-166 SMc04407 [GEPR] COG0477 Permeases of the major facilitator super... 553 e-157 BMEII0406 [GEPR] COG0477 Permeases of the major facilitator supe... 543 e-154 >RSc0547 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 567 Score = 662 bits (1708), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/562 (61%), Positives = 417/562 (74%), Gaps = 30/562 (5%) Query: 10 RPAGMTKDERFVILASSLGTVFEWYDFYLYGSLAGIIGAQFFSDYPPATRDIFALLAFAA 69 +P+ MT++E+ VI ASSLGTVFEWYDFYLYGSLA II QFFS P IFALLAFAA Sbjct: 16 QPSPMTREEKKVIFASSLGTVFEWYDFYLYGSLAAIIAKQFFSGLDPTAAFIFALLAFAA 75 Query: 70 GFLVRPFGAIVFGRVGDIVGRKYTFLVTILIMGLSTFIVGLLPNAKTIGLAAPIILISLR 129 GFLVRPFGA+VFGR+GD++GRKYTFL+TILIMG STFIVGLLP+ TIG AAP+ILI LR Sbjct: 76 GFLVRPFGALVFGRLGDMIGRKYTFLITILIMGTSTFIVGLLPSYTTIGAAAPVILIMLR 135 Query: 130 LLQGLALGGEYGGAATYVAEHAPNGRRGYYTSFIQTTATLGLFLSLLVILFTRSITGEKD 189 LLQGLALGGEYGGAATYVAEHAP+GRRG YTS+IQTTATLGLFLSL+VIL R +TG Sbjct: 136 LLQGLALGGEYGGAATYVAEHAPHGRRGNYTSWIQTTATLGLFLSLIVILVVRELTG-AS 194 Query: 190 FADWGWRIPFLVSVLLLGISVWIRLRLNESPVFQRMKDEGKSSKAPLTEAFANWGNAKIV 249 F DWGWRIPFLVS++LL SV+IRL ++ESP FQ+MK EGK+SKAPLTE+F W N KIV Sbjct: 195 FEDWGWRIPFLVSIVLLATSVYIRLSMSESPAFQKMKAEGKTSKAPLTESFGQWRNLKIV 254 Query: 250 LLALLGGTMGQGVVWYTGQFYALFFLQSILKVDGYTANLLIAWSLLFGTGFFIVFGALSD 309 +LAL+G T GQ VVWYTGQFYALFFL +LKVD +TAN+LIA +L GT FF+ FG+LSD Sbjct: 255 ILALVGLTAGQAVVWYTGQFYALFFLTQVLKVDAFTANVLIAVALAIGTPFFVFFGSLSD 314 Query: 310 RIGRKPIILAGCAIAALTFIPIFKMISSNANPALERAIESTKVEVVADPAGCGDLFNPVG 369 RIGRK II+AGC +A LT+ P+FK ++ ANPALERA ++ ++ + ADP C +P+ Sbjct: 315 RIGRKGIIMAGCLLAVLTYFPLFKALTHYANPALERAQQTAQITIKADPKECSFQGSPIA 374 Query: 370 TRV-FTAPCDTARAFLAQSSVKYSTTYGAAGSGVKVVVNGKDVPYANAK----------- 417 V F + CD A+ LAQSS Y + AG+ V + G+++ NA Sbjct: 375 REVDFRSSCDIAKRTLAQSSASYESEDAPAGTIASVTIAGREIASLNASRTADGQNFDAD 434 Query: 418 ------DGNAAITTAVAAAGYPKAGDAGIVKMSHPFDIFRPQVAAVIGLLFILVIFVTMV 471 D +++ A+ AA YP D + V+ +L ILVI+VTMV Sbjct: 435 SKKKITDFKKSVSDALKAANYPSKADPA-----------QMNTVMVLVILVILVIYVTMV 483 Query: 472 YGPIAAMLVELFPTKIRYTSMSLPYHIGNGWFGGLLPATAFAIVASTGDIYAGLWYPIIF 531 YGPIAAMLVELFPT+IRYTSMSLPYHIGNGWFGGLLP +FA+VA G+IY GLWYPI Sbjct: 484 YGPIAAMLVELFPTRIRYTSMSLPYHIGNGWFGGLLPTISFALVAQHGNIYYGLWYPIWI 543 Query: 532 AAITAVVGLIFLPETKDVDISK 553 AAIT V+G +F+ ETKDVDI + Sbjct: 544 AAITFVIGALFVRETKDVDIYR 565 >CC0980 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 567 Score = 607 bits (1565), Expect = e-173, Method: Compositional matrix adjust. Identities = 341/543 (62%), Positives = 410/543 (75%), Gaps = 23/543 (4%) Query: 18 ERFVILASSLGTVFEWYDFYLYGSLAGIIGAQFFSDYPPATRDIFALLAFAAGFLVRPFG 77 + V+ ASSLGTVFEWYDFYLYGSLA II + FFS T I ALLAFAAGF +RP G Sbjct: 31 DTMVVGASSLGTVFEWYDFYLYGSLAPIITSHFFSGVNETTGFILALLAFAAGFAIRPLG 90 Query: 78 AIVFGRVGDIVGRKYTFLVTILIMGLSTFIVGLLPNAKTIGLAAPIILISLRLLQGLALG 137 A++FGR+GD+ GRK TFL+T+L+MG+STF+VGLLP+ IG+AAPI L+ +RL+QGLALG Sbjct: 91 ALIFGRLGDLWGRKNTFLITMLLMGVSTFVVGLLPSYAQIGVAAPIALVLMRLVQGLALG 150 Query: 138 GEYGGAATYVAEHAPNGRRGYYTSFIQTTATLGLFLSLLVILFTRSITGEKDFADWGWRI 197 GEYGGAATYVAEHAP G+RG+YTS+IQTTAT+GLFLSL VIL R GE+ F WGWRI Sbjct: 151 GEYGGAATYVAEHAPPGKRGFYTSWIQTTATIGLFLSLAVILVARIQLGEEAFKAWGWRI 210 Query: 198 PFLVSVLLLGISVWIRLRLNESPVFQRMKDEGKSSKAPLTEAFANWGNAKIVLLALLGGT 257 PFLVS+LLLG+S+WIRL+L+ESP F+RM EGK SK PLTEAF NW N KIVLLAL+G T Sbjct: 211 PFLVSLLLLGVSLWIRLKLHESPTFERMIAEGKGSKKPLTEAFGNWPNLKIVLLALVGLT 270 Query: 258 MGQGVVWYTGQFYALFFLQSILKVDGYTANLLIAWSLLFGTGFFIVFGALSDRIGRKPII 317 MGQ VVWYTGQFYALFFL+ LK+DG AN L+A +LL GT FF++ G LSD+IGRKPII Sbjct: 271 MGQAVVWYTGQFYALFFLEKTLKLDGALANTLVAVALLIGTPFFVICGWLSDKIGRKPII 330 Query: 318 LAGCAIAALTFIPIFKMISSNANPALERAIESTKVEVVADPAGCGDLFNPVGTRVFTAPC 377 + GC +AALT+ PIFK I++ ANPAL +A + V V AD A C F+ +G F PC Sbjct: 331 ILGCLLAALTYFPIFKAITTYANPALAKAEATAPVVVTADTATCAFQFDLIGKAKFNTPC 390 Query: 378 DTARAFLAQSSVKYSTTYGAAG--SGVK---VVVNGKDVP------YANAKDG-NAAITT 425 D A+A+LA++ V YS AG + VK V + G D +A+A+ A + Sbjct: 391 DVAKAYLAKAGVSYSVQAAPAGTPTAVKVGDVTLEGLDSKGATGQAFADARKAWEADLGA 450 Query: 426 AVAAAGYPKAGDAGIVKMSHPFDIFRPQVAAVIGLLFILVIFVTMVYGPIAAMLVELFPT 485 + AAGYP DA +V +P AVIGLL +LVI+VTMVYGPIAAMLVELFPT Sbjct: 451 QLKAAGYPAKADAALVN--------KP---AVIGLLALLVIYVTMVYGPIAAMLVELFPT 499 Query: 486 KIRYTSMSLPYHIGNGWFGGLLPATAFAIVASTGDIYAGLWYPIIFAAITAVVGLIFLPE 545 +IRYT+MSLPYHIGNGWFGG LP TAFAIVA+TGDIY+GLWYP+I AAITAVVG +FL + Sbjct: 500 RIRYTAMSLPYHIGNGWFGGFLPTTAFAIVAATGDIYSGLWYPVIIAAITAVVGGLFLKD 559 Query: 546 TKD 548 T+ Sbjct: 560 TRH 562 >PA3709 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 539 Score = 584 bits (1506), Expect = e-166, Method: Compositional matrix adjust. Identities = 313/543 (57%), Positives = 394/543 (72%), Gaps = 16/543 (2%) Query: 11 PAGMTKDERFVILASSLGTVFEWYDFYLYGSLAGIIGAQFFSDYPPATRDIFALLAFAAG 70 PA ++ER VI ASSLGTVFEWYDF+LYG+LA +I QFF+ T IFAL+AFAAG Sbjct: 13 PATTPQEERKVIFASSLGTVFEWYDFFLYGALAAVISKQFFAGVNDTTAFIFALMAFAAG 72 Query: 71 FLVRPFGAIVFGRVGDIVGRKYTFLVTILIMGLSTFIVGLLPNAKTIGLAAPIILISLRL 130 FLVRPFGA+VFGR+GD++GRKYTFLVTIL+MGLSTF VGLLP +IG+AAPIIL++LR+ Sbjct: 73 FLVRPFGALVFGRLGDMIGRKYTFLVTILLMGLSTFAVGLLPTYASIGVAAPIILVTLRM 132 Query: 131 LQGLALGGEYGGAATYVAEHAPNGRRGYYTSFIQTTATLGLFLSLLVILFTRSITGEKDF 190 LQGLALGGEYGGAA YVAEHAP +RG YTS+IQ+TATLGL LSLLVIL R +TG+ +F Sbjct: 133 LQGLALGGEYGGAAIYVAEHAPANKRGSYTSWIQSTATLGLLLSLLVILACRQLTGD-EF 191 Query: 191 ADWGWRIPFLVSVLLLGISVWIRLRLNESPVFQRMKDEGKSSKAPLTEAFANWGNAKIVL 250 WGWR+PFL+S++LLGIS WIRL + ESP F +MK EGK SKAPL E+F WGN K+VL Sbjct: 192 ETWGWRLPFLLSIVLLGISTWIRLSMRESPAFLKMKAEGKVSKAPLRESFTQWGNLKVVL 251 Query: 251 LALLGGTMGQGVVWYTGQFYALFFLQSILKVDGYTANLLIAWSLLFGTGFFIVFGALSDR 310 AL GQ V +YT QFY LFFL +LKVDG TAN L+ +L+ G FFIV G LSDR Sbjct: 252 TALFSINAGQAVTFYTAQFYVLFFLTQVLKVDGGTANGLLIVALVLGAPFFIVAGWLSDR 311 Query: 311 IGRKPIILAGCAIAALTFIPIFKMISSNANPALERAIESTKVEVVADPAGCGDLFNPVGT 370 IGRKP++LAG +A L + P+FK ++ ANPA+++A + + VVADPA C F+PVG Sbjct: 312 IGRKPVLLAGLLLATLFYFPLFKGLTHYANPAIDQASRQSPISVVADPATCTFQFDPVGK 371 Query: 371 RVFTAPCDTARAFLAQSSVKYSTTYGAAGSGVKVVVNGKDVPYANAKDGNAAITTAVAAA 430 F +PCD + FL ++ + YST AGS V+V + ++ +A+ A+ AV A Sbjct: 372 ATFDSPCDKVKTFLVKAGLPYSTVAAPAGSDVRVRIGETEIAGFDAE----AMAAAVKTA 427 Query: 431 GYPKAGDAGIVKMSHPFDIFRPQVAAVIGLLFILVIFVTMVYGPIAAMLVELFPTKIRYT 490 GYP+ D V +P V A+I F LV+ T+ YGP+AA++VELFPT+IRY+ Sbjct: 428 GYPQQADGSQVN--------KPMVIAII---FALVLISTLCYGPLAALMVELFPTRIRYS 476 Query: 491 SMSLPYHIGNGWFGGLLPATAFAIVASTGDIYAGLWYPIIFAAITAVVGLIFLPETKDVD 550 S+SLPYHIGNGWFGG LP +FA+V TGDI+ GLWYP++ + V L+FL ET+ D Sbjct: 477 SLSLPYHIGNGWFGGFLPTVSFALVVYTGDIFYGLWYPVLITGGSLVCALLFLRETRHTD 536 Query: 551 ISK 553 I + Sbjct: 537 IHR 539 >SMc04407 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 629 Score = 553 bits (1426), Expect = e-157, Method: Compositional matrix adjust. Identities = 285/444 (64%), Positives = 338/444 (76%), Gaps = 13/444 (2%) Query: 2 STMTATSARPAGMTKDERFVILASSLGTVFEWYDFYLYGSLAGIIGAQFFSDYPPATRDI 61 + +TA + MT +E+ VI ASSLGTVFEWYDFYLYGSLA IGA FFS YP TR+I Sbjct: 3 NVVTAGGTKAGPMTGEEKKVIFASSLGTVFEWYDFYLYGSLAVYIGATFFSQYPETTRNI 62 Query: 62 FALLAFAAGFLVRPFGAIVFGRVGDIVGRKYTFLVTILIMGLSTFIVGLLPNAKTIGLAA 121 FALLAFAAGFLVRPFGA+VFGR+GD+VGRKYTFLVTILIMG+STF+VG+LP A +IG+AA Sbjct: 63 FALLAFAAGFLVRPFGALVFGRLGDLVGRKYTFLVTILIMGVSTFLVGVLPGAASIGIAA 122 Query: 122 PIILISLRLLQGLALGGEYGGAATYVAEHAPNGRRGYYTSFIQTTATLGLFLSLLVILFT 181 PIILI+LRLLQGLALGGEYGGAATYVAEHAP+GRRGY+TS+IQTTATLGLFLSL+VIL Sbjct: 123 PIILIALRLLQGLALGGEYGGAATYVAEHAPHGRRGYFTSWIQTTATLGLFLSLVVILLV 182 Query: 182 RSITGEKDFADWGWRIPFLVSVLLLGISVWIRLRLNESPVFQRMKDEGKSSKAPLTEAFA 241 + + G++ FA+WGWRIPFL+S +LLG+SVWIRL++NESP F++MK+EGK SKAPLTEAF Sbjct: 183 QYMLGKEAFAEWGWRIPFLLSFVLLGVSVWIRLKMNESPAFKKMKEEGKGSKAPLTEAFG 242 Query: 242 NWGNAKIVLLALLGGTMGQGVVWYTGQFYALFFLQSILKVDGYTANLLIAWSLLFGTGFF 301 W NAKI +LAL G +GQ VVWY+GQFYALFFLQSILKVDG +ANL++A SLL GTGFF Sbjct: 243 QWRNAKIAVLALFGAVVGQAVVWYSGQFYALFFLQSILKVDGQSANLMVAASLLLGTGFF 302 Query: 302 IVFGALSDRIGRKPIILAGCAIAALTFIPIFKMISSNANPALERAIESTKVEVVADPAGC 361 + FG LSD+IGRKPII+AG +A LT+ P+FK ++ NPAL A +S + V A P C Sbjct: 303 VFFGWLSDKIGRKPIIMAGLLLAMLTYFPLFKALTWAGNPALAEAQQSVRATVTAAPGDC 362 Query: 362 GDLFNPVGTRVFTAPCDTARAFLAQSSVKYSTTYGAAGSGVKVVVNGKDVPYANAKDGNA 421 FNP GT FT CD A AFL ++SV Y VV A K G Sbjct: 363 KFQFNPTGTAKFTTSCDIATAFLTKNSVPYD-----------VVTTAAAGTPATVKIGET 411 Query: 422 AITT--AVAAAGYPKAGDAGIVKM 443 IT+ A+AA KA +A K Sbjct: 412 TITSYDAIAAGDRAKAEEAAFGKQ 435 Score = 162 bits (409), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 77/105 (73%), Positives = 88/105 (83%) Query: 448 DIFRPQVAAVIGLLFILVIFVTMVYGPIAAMLVELFPTKIRYTSMSLPYHIGNGWFGGLL 507 D R +I +L +LVI+VTMVYGPIAA+LVELFPT+IRYT MSLPYHIGNGWFGGLL Sbjct: 522 DPARVNWTVIIAVLTVLVIYVTMVYGPIAALLVELFPTRIRYTGMSLPYHIGNGWFGGLL 581 Query: 508 PATAFAIVASTGDIYAGLWYPIIFAAITAVVGLIFLPETKDVDIS 552 PATAFA+ A+ GDIY GLWYPI+FA IT V+GL+FLPETKD DI Sbjct: 582 PATAFAMSAAKGDIYYGLWYPIVFAGITLVIGLLFLPETKDRDIH 626 >BMEII0406 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 632 Score = 543 bits (1399), Expect = e-154, Method: Compositional matrix adjust. Identities = 263/385 (68%), Positives = 321/385 (83%) Query: 14 MTKDERFVILASSLGTVFEWYDFYLYGSLAGIIGAQFFSDYPPATRDIFALLAFAAGFLV 73 MT +ER VI ASSLGTVFEWYDFYLYG+LA IGA FF++YP ATR+IF LLAFAAGF+V Sbjct: 14 MTGEERKVIFASSLGTVFEWYDFYLYGTLASFIGAAFFNEYPEATRNIFVLLAFAAGFVV 73 Query: 74 RPFGAIVFGRVGDIVGRKYTFLVTILIMGLSTFIVGLLPNAKTIGLAAPIILISLRLLQG 133 RPFGA+VFGR+GD+VGRKYTFLVTI+IMG STF+VGLLP + ++G+ APIILI+LR+LQG Sbjct: 74 RPFGALVFGRIGDLVGRKYTFLVTIVIMGGSTFLVGLLPGSASLGIFAPIILIALRMLQG 133 Query: 134 LALGGEYGGAATYVAEHAPNGRRGYYTSFIQTTATLGLFLSLLVILFTRSITGEKDFADW 193 LALGGEYGGAATYVAEHAPN RRG++TS+IQTTATLGLFLSLLVIL +++ + FA W Sbjct: 134 LALGGEYGGAATYVAEHAPNNRRGFFTSWIQTTATLGLFLSLLVILGAQTLLSKDAFAAW 193 Query: 194 GWRIPFLVSVLLLGISVWIRLRLNESPVFQRMKDEGKSSKAPLTEAFANWGNAKIVLLAL 253 GWRIPFLVSVLLLGISVWIR++++ESP F+RMK+EGK+SKAPL+EAF W NAKI L+AL Sbjct: 194 GWRIPFLVSVLLLGISVWIRMQMSESPAFKRMKEEGKTSKAPLSEAFGQWKNAKIALIAL 253 Query: 254 LGGTMGQGVVWYTGQFYALFFLQSILKVDGYTANLLIAWSLLFGTGFFIVFGALSDRIGR 313 G T GQ VVWY GQFYALFFLQ++LKV+ +AN+++A +LL GTGFF++FG LSD+IGR Sbjct: 254 FGLTAGQAVVWYCGQFYALFFLQNVLKVENQSANIMVAIALLIGTGFFVIFGWLSDKIGR 313 Query: 314 KPIILAGCAIAALTFIPIFKMISSNANPALERAIESTKVEVVADPAGCGDLFNPVGTRVF 373 KPII+AG +AA+T+ P+FK +++ ANPAL +A ++ K V+A P C FN GT F Sbjct: 314 KPIIMAGLILAAVTYFPLFKALTNAANPALAQAEQTVKATVMAAPGDCNFQFNATGTSKF 373 Query: 374 TAPCDTARAFLAQSSVKYSTTYGAA 398 T CD A +FLA+SSV Y T AA Sbjct: 374 TTSCDVATSFLAKSSVPYETVQTAA 398 Score = 149 bits (377), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 69/96 (71%), Positives = 84/96 (87%) Query: 458 IGLLFILVIFVTMVYGPIAAMLVELFPTKIRYTSMSLPYHIGNGWFGGLLPATAFAIVAS 517 I +L ILVI+VTMVYGPIAA+LVE+FPT+IRYT MSLPYHIGNGWFGGLLPA FA+ A+ Sbjct: 535 IAILTILVIYVTMVYGPIAAILVEMFPTRIRYTGMSLPYHIGNGWFGGLLPAGVFALSAA 594 Query: 518 TGDIYAGLWYPIIFAAITAVVGLIFLPETKDVDISK 553 GDIY GLWYPII A++T V+G++F+ ETK VD++K Sbjct: 595 KGDIYYGLWYPIIIASVTFVIGMLFVKETKGVDLNK 630