BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0105.0005.p (600 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VC0300 [T] COG2905 Predicted signal-transduction protein contain... 355 2e-97 PA3233 Non COG 355 2e-97 aq_2107 [T] COG2905 Predicted signal-transduction protein contai... 312 2e-84 VC1291 [T] COG2905 Predicted signal-transduction protein contain... 189 1e-47 Cgl1258 [T] COG2905 Predicted signal-transduction protein contai... 183 1e-45 >VC0300 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains Vch Vibrio cholerae Length = 607 Score = 355 bits (910), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 201/611 (32%), Positives = 326/611 (53%), Gaps = 20/611 (3%) Query: 1 MPKAFDAANPPFDRLTPHEMETLRAALDIVYFRPGEPVIDQGSPSQALFVVIKGTIEE-- 58 MP F+ +PPF+RLT + LR+ALD+ YFR + +ID P L ++IKGT+EE Sbjct: 1 MPDKFNMQSPPFNRLTAEQQHQLRSALDVAYFRQRDVLIDAQHPVTHLHILIKGTVEERS 60 Query: 59 SDGAGLLALLGPKDSFDSRALVHGKSGHAFRARDETLCYSVPRSTVLDLIQNNPRFASFF 118 DG + A D FD RA+ S H + A ++TL Y +P+S L L + N FA++F Sbjct: 61 PDGKEVFAHYANDDLFDVRAMFEELSKHQYMALEDTLSYLLPKSIFLQLYEQNGEFAAYF 120 Query: 119 YHDIARKLDEFVRDHDEQRH-GSMMRARISELFLHPAAFVEADDSVETAGRKMEEINSNA 177 +++A++ E + +Q++ + ++ HP + + + + ++++E +A Sbjct: 121 DNNLAKR-QELIEAAAQQKNIAEFILTKVDRSIYHPPFILSPEQPIHSVTQQLKERGIDA 179 Query: 178 LFVR-----------DGQRTGIITGMNLSKAVVLRRQSIQTSVRNLAHFDLVTLRPDDLV 226 V I+T N+ AV+L + + T V +A F ++ + D + Sbjct: 180 ALVELHPSDPRLAHNHAHPYAIVTRTNMLHAVMLEGRPLDTPVGEIATFPVLHVDEGDFL 239 Query: 227 SSALVLMTKLNKRRVVIRDDERFVGILEDIDVLGYLAGSAQVIAGRIERAANQDDLAAAA 286 +A+V+MT+ +RV++ + VG+L I +L + + V+ I RAA+ D+LA AA Sbjct: 240 FNAMVMMTRQRIKRVMVCLGNQAVGLLSLIQILSAFSTHSHVLTLAIARAASIDELALAA 299 Query: 287 RQTAAQVRTLRRQGIGVELIGEIVSDLNQRLFSRLFDLLAPADIRADGCLMVMGSEGRGE 346 + V +L +G+ + E+++ +N+++ + F+L+ P + CL+V+GSEGRGE Sbjct: 300 NKQRELVESLMSRGVRTRFVMELIAAVNEQIIEKAFELVVPPALHDQCCLVVLGSEGRGE 359 Query: 347 QTARTDQDNGLILSRAIEQAELDKFRTSFSGALLDFGFPPCPGHVMVNNPAWSKPLPDYI 406 Q +TDQDN LI+ +E + + + LL G+P CPG VMVNNP W + D+ Sbjct: 360 QILKTDQDNALIIQDGLEWHQCQPIMETLTHTLLQLGYPLCPGKVMVNNPKWVRSQSDWK 419 Query: 407 ADIRRWLALPDDSAHLNVAILFDARCVAGDATLLTEVKTRLIEMVGGEQAFLAHFARAID 466 + W+ +++AI DA VAG+ LL VK L ++ G++ LA F R Sbjct: 420 RTLTDWVKAARPEQVMDIAIFADAHAVAGNRALLAPVKAHLQHLMAGQELILAEFTRPAL 479 Query: 467 LFATPIGLFKNLITSAGNGDAIDLKKGGLFPIVHGVRSLALEHGLIETATDKRINRLRDM 526 F+ P+ LF N+ +S ID+K+GG+FPIVHGVR+L+LEH + T RI L Sbjct: 480 NFSVPLTLFGNVKSSK---QGIDIKQGGIFPIVHGVRALSLEHAIDANNTFDRIEALVKK 536 Query: 527 GVLHAEFARELHQAFNFMLMLRLDGQLAESAGATGTLVRPSSLSSMERDLLRDAFYVVKK 586 VL E L +AF L LRL QL + L ERDLLR + +VVKK Sbjct: 537 RVLEQETGDNLSEAFKLFLKLRLAQQLGNQHSTNQLDFK--QLDRTERDLLRHSLHVVKK 594 Query: 587 FREFIRHHFNL 597 F++++ +H+ + Sbjct: 595 FKQWLGYHYQI 605 >PA3233 Non COG Length = 599 Score = 355 bits (910), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 230/601 (38%), Positives = 324/601 (53%), Gaps = 9/601 (1%) Query: 1 MPKAFDAANPPFDRLTPHEMETLRAALDIVYFRPGEPVIDQGSPSQALFVVIKGTIEE-S 59 MP +F+ A+PPFD+L PH+ ETL+ AL + Y+ PGE +++ GS LFV++KG +EE Sbjct: 1 MPDSFNFASPPFDQLRPHQRETLKQALSVGYYAPGETLLEAGSAVPGLFVLLKGVVEERG 60 Query: 60 DGAGLLALLGPKDSFDSRALVHGKSGHAFRARDETLCYSVPRSTVLDLIQNNPRFASFFY 119 D + A D FD R L G S H + A +E++ Y +P S L NP FA FF Sbjct: 61 DDGRVFAQYAADDLFDVRGLFSGSSKHRYLAIEESIVYELPASCFHQLCGENPGFARFFQ 120 Query: 120 HDIARKLDEFVRDHDEQRHGSMMRARISELFLHPAAFVEADDSVETAGRKMEEINSNALF 179 D+A K + D Q + RI+ L PA VEA S+ A R ++AL Sbjct: 121 ADLAAKRQ--LAQRDGQNLAEFILTRIAREHLLPALEVEASLSLGDAARLQLSHGADALL 178 Query: 180 VR---DGQRTGIITGMNLSKAVVLRRQSIQTSVRNLAHFDLVTLRPDDLVSSALVLMTKL 236 VR DG GI+T +L A +S ++ LAH L ++ D + A++LMT+ Sbjct: 179 VRLERDGPELGIVTRTDLMSAHFRDGRSELEAIGPLAHGPLASVELGDFLFDAMILMTRQ 238 Query: 237 NKRRVVIRDDERFVGILEDIDVLGYLAGSAQVIAGRIERAANQDDLAAAARQTAAQVRTL 296 RV + +D + +G+L VL + + V+A RI RA + DL A + TL Sbjct: 239 RIERVAVTEDGQVIGLLHLTQVLSLFSTHSHVLALRIARADDLGDLRRCAETLDTLIATL 298 Query: 297 RRQGIGVELIGEIVSDLNQRLFSRLFDLLAPADIRADGCLMVMGSEGRGEQTARTDQDNG 356 GI + I ++VS LN++L RLF+LL P +R CL+VMGSEGRGEQ +TDQDN Sbjct: 299 AGNGIRLRFIMQLVSALNEQLLERLFELLLPPTLRGRCCLLVMGSEGRGEQLLKTDQDNA 358 Query: 357 LILSRAIEQAELDKFRTSFSGALLDFGFPPCPGHVMVNNPAWSKPLPDYIADIRRWLALP 416 L+L+ + Q + FS ALL+FG+PPCPG VM + P W KPL + A++R L Sbjct: 359 LVLADDLPQEQALAMMQRFSAALLEFGYPPCPGGVMASRPEWCKPLAAWQAELRGTLLEG 418 Query: 417 DDSAHLNVAILFDARCVAGDATLLTEVKTRLIEMVGGEQAFLAHFARAIDLFATPIGLFK 476 L ++IL DA VAG+ L ++ +L G + +LA A A F TP+ Sbjct: 419 KPEQLLRLSILADAWPVAGNLQLFEPLRWQLRGFADGGERWLADIAAAALQFDTPLTFLG 478 Query: 477 NLITSAGNGDAIDLKKGGLFPIVHGVRSLALEHGLIETATDKRINRLRDMGVLHAEFARE 536 L T +DLK+GG+FPIVHG+R+LAL GL T RI L+ VL A A + Sbjct: 479 QLKTQDAR---LDLKRGGIFPIVHGIRTLALREGLETRGTLARIEALKRHKVLEARLADD 535 Query: 537 LHQAFNFMLMLRLDGQLAESAGATGTLVRPSSLSSMERDLLRDAFYVVKKFREFIRHHFN 596 L ++F L LRL QLA + S +S +RD+LR +VVKKF++ + F+ Sbjct: 536 LSESFELFLQLRLTRQLAGQRDGRQQGLDVSGMSRHDRDMLRYGLHVVKKFKQSVARQFH 595 Query: 597 L 597 L Sbjct: 596 L 596 >aq_2107 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains Aae Aquifex aeolicus Length = 619 Score = 312 bits (799), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 188/615 (30%), Positives = 309/615 (50%), Gaps = 29/615 (4%) Query: 3 KAFDAANPPFDRLTPHEMETLRAALDIVYFRPGEPVIDQG-SPSQALFVVIKGTIE-ESD 60 K F + PF L P +E L + + Y+ G + + P + L+V+ KG + SD Sbjct: 6 KEFLQTHYPFSSLPPSSLENLSKVIKVKYYPKGSEIFKKDEKPLEYLYVIRKGNVSLRSD 65 Query: 61 GAGLLALLGPKDSFDSRALV-HGKSGHAFRARDETLCYSVPRSTVLDLIQNNPRFASFFY 119 G + L DSF +L+ A + + Y +P+ L++ P F ++F Sbjct: 66 GVEI-DFLSEGDSFGFISLITDSPPSSTAVAETDVILYLIPKEVFKQLMEKYPEFRNYFT 124 Query: 120 HDIARKLD---EFVRDHD-EQRHGSMMRARISELFLHPAAFVEADDSVETAGRKMEEINS 175 +A+++ E V+++ + + ++ +L L F+ +SV A +KM E NS Sbjct: 125 TSLAKRIAHTAERVKENGGAKTFEKFLTVQVKDLKLRKVPFILPSESVYEAVKKMVEDNS 184 Query: 176 NALFVRDGQRTGIITGMNLSKAVVLRR-QSIQTSVRNLAHFDLVTLRPDDLVSSALVLMT 234 + V+ GIIT ++ K V+ R + V+ + L+++ P D + L+ M+ Sbjct: 185 SCAIVKSEDEEGIITERDVLKKVIYRDLNPKEVKVKEVMTSPLISVEPTDFLFDVLLTMS 244 Query: 235 KLNKRRVVIRDDERFVGILEDIDVLGYLAGSAQVIAGRIERAANQDDLAAAARQTAAQVR 294 K N RRVV+++D +G+LED D++ + VI +E+A + ++L+ Sbjct: 245 KNNIRRVVVKEDGNILGVLEDKDIIALETQNLIVIVKEVEKAKSVEELSYLYSLVDDMAV 304 Query: 295 TLRRQGIGVELIGEIVSDLNQRLFSRLFDL------LAPADIRADGCLMVMGSEGRGEQT 348 L +G+ E+I ++S++N + S+ L L P MV+GSEGR EQT Sbjct: 305 NLFNEGVKPEVISRLISEINDKFISKAIQLAIKELGLEPI---VSFSFMVLGSEGRKEQT 361 Query: 349 ARTDQDNGLILSRAIEQAELD------KFRTSFSGALLDFGFPPCPGHVMVNNPAWSKPL 402 +TDQDN LI ++D KF S LL GFPPCP +VMV NP W+K Sbjct: 362 LKTDQDNALIYDDTYPSLDVDLEDYFKKFGEKISEILLKIGFPPCPSNVMVRNPEWNKGK 421 Query: 403 PDYIADIRRWLALPDDSAHLNVAILFDARCVAGDATLLTEVKTRLIEMVGGEQAFLAHFA 462 +++ + +W + PD L + I D R V GD TL E++ ++ E+ + +A+ Sbjct: 422 TEWLKTLEKWFSKPDPENTLKLGIFLDFRNVFGDKTLEEELRKKVFELAKENELLIAYMF 481 Query: 463 RAIDLFATPIGLFKNLITSAGNGDAIDLKKGGLFPIVHGVRSLALEHGLIETATDKRINR 522 + F P+GLF L + ID+KKGG+FPI G+R+LA+++ + ET T R+ + Sbjct: 482 KDTVRFKPPLGLFGRLKVEK---EGIDIKKGGIFPITSGIRTLAIKNEIAETNTLDRMKK 538 Query: 523 LRDMGVLHAEFARELHQAFNFMLMLRLDGQLA--ESAGATGTLVRPSSLSSMERDLLRDA 580 L + GVL+ E L +AFN++ +RL Q+ + V P LS +E DLL+DA Sbjct: 539 LYEKGVLYKELYENLKEAFNYLQYIRLKSQIEKLKEGKQPDNYVNPERLSKLELDLLKDA 598 Query: 581 FYVVKKFREFIRHHF 595 F VV +F+EFI + Sbjct: 599 FKVVAQFQEFIETKY 613 >VC1291 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains Vch Vibrio cholerae Length = 637 Score = 189 bits (481), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 152/617 (24%), Positives = 278/617 (45%), Gaps = 27/617 (4%) Query: 3 KAFDAANPPFDRLTPHEMETLRAALDIVYFRPGEPVIDQGSPSQALFVVIKGTIEESDGA 62 + F +PPFD L + + ++I YFR P+I L++V G +E Sbjct: 17 QQFLQQHPPFDALPNERLPEIAQQIEIAYFRKDTPIIGYKQAISDLYLVRSGAVEVYRRH 76 Query: 63 G-LLALLGPKDSFDSRALV-HGKSGHAFRARDETLCYSVPRSTVLDLIQNNPRFASFFYH 120 G L L F L+ + A A ++TL Y +P + L Q FA F Sbjct: 77 GELYNRLTEGSLFGQMGLLTRNQVSFAVTAIEDTLLYCLPEALFHRLHQEFDSFADFVEV 136 Query: 121 DIARKLDEFVRDHDEQRHGSMMRARISELFLHPAAFVEADDSVETAGRKMEEINSNALFV 180 + A +L + V EQ ++ +++ +L A ++ S++ A ++M + N +AL + Sbjct: 137 EQAVRLRQTVAKQKEQ--NDLITSKVKQLLTRSAPTIDKQASIQQAAQRMADENVSALLI 194 Query: 181 RDGQ-----------RTGIITGMNLSKAVVLRRQSIQTSVRNLAHFDLVTLRPDDLVSSA 229 D Q GI+T +L + V+ + + +V + ++++L + V A Sbjct: 195 LDNQILLDTEDDSTPMVGIVTERDLCRRVLAQGMDVTQTVSQVMTHEVISLDHNAYVYEA 254 Query: 230 LVLMTKLNKRRVVIRDDERFVGILEDIDVLGYLAGSAQVIAGRIERAANQDDLAAAARQT 289 ++ M + N + + + + +GI++ D++ + + ++ ++ RI + DDLA A + Sbjct: 255 MLAMLRNNVHHLPVLRERQPIGIIDMTDIVRHESQNSLLLVSRIYQQTCIDDLAQLANEV 314 Query: 290 AAQVRTLRRQGIGVELIGEIVSDLNQRLFSRLFDLLAPADIRA---DGCLMVMGSEGRGE 346 A L + +IG +S + + R+ +L+ A++ A C + GS GR E Sbjct: 315 KASFVRLVNEDANSHMIGTAMSTIGRAFTQRIIELVE-AELGAAPLPYCFVAFGSMGRDE 373 Query: 347 QTARTDQDNGLILSRAIEQAELDKFRTSFSGAL---LD-FGFPPCPGHVMVNNPAWSKPL 402 Q TDQDN LIL + + + F+ + LD G+P C G +M +NP W Sbjct: 374 QLIVTDQDNALILDDRYDVQQHGAYFAQFAELVCRGLDRCGYPLCDGEIMASNPKWRMTR 433 Query: 403 PDYIADIRRWLALPDDSAHLNVAILFDARCVAGDATLLTEVKTRLIEMVGGEQAFLAHFA 462 ++ W+ P+ A LN +I FD V G ++ ++ Q FLA A Sbjct: 434 KEWETCFADWIDNPNPQALLNASIFFDLDGVYGRTKWAEQLSGFIVRRARRNQRFLACLA 493 Query: 463 RAIDLFATPIGLFKNLITSAG--NGDAIDLKKGGLFPIVHGVRSLALEHGLIETATDKRI 520 R P+G FKN + + ++I+LK+ G P+ +R AL G + +R+ Sbjct: 494 RNALNRTPPLGFFKNFVMEKDGRHNNSINLKRRGTAPLADLIRVHALAAGSRAKNSFERL 553 Query: 521 NRLRDMGVLHAEFARELHQAFNFMLMLRLDGQL--AESAGATGTLVRPSSLSSMERDLLR 578 + + + G+L ++L A F+ M+R+ Q E + P LS ER L+ Sbjct: 554 DDVIEAGLLPQGKGKDLRDALEFIAMVRIRHQAIDVEQEREADNSIEPEHLSDFERRNLK 613 Query: 579 DAFYVVKKFREFIRHHF 595 DAF ++ + ++++ + Sbjct: 614 DAFQILSNGQNYLKYRY 630 >Cgl1258 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains Cgl Corynebacterium glutamicum Length = 622 Score = 183 bits (464), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 155/602 (25%), Positives = 264/602 (43%), Gaps = 24/602 (3%) Query: 5 FDAANPPFDRLTPHEMETLRAALDIVYFRPGEPVIDQGSPSQALFVVIKGTIEESDGAGL 64 F A PF +L E++ L + + YFR GE +I G P+ + V+ G I+ D G+ Sbjct: 15 FLAGFEPFAQLPAEELDQLPGKMSLRYFRRGEEIIPIGVPNHYMGVIRSGAIDVLDQEGV 74 Query: 65 LALLGPKDSFDSRALVHGKSGHAFRAR------DETLCYSVPRSTVLDLIQNNPRFASFF 118 L L +D+ R+ + G +R +++L + R +L + NP + + Sbjct: 75 L--LDRRDA--GRSFGYSTMGPERNSRYRMVAVEDSLVLRLGRDDFDELAKRNPDL-NRY 129 Query: 119 YHDIARKLDEFVRDHDEQRHGSMMRARISELFLHPAAFVEADDSVETAGRKMEEINSNAL 178 Y ++++ ++ ++R ++ E + D ++ A KM+E ++L Sbjct: 130 YSSWSKRIRAAADQLRQESSSKVLRTKLGEFKIANPISCSPDTTIMDAAIKMDEFGVSSL 189 Query: 179 FVR-DGQRTGIITGMNLSKAVVLRRQSIQTSVRNLAHFDLVTLRPDDLVSSALVLMTKLN 237 V+ DG+ GIIT ++ VV + IQ V + D L A++LM++L Sbjct: 190 LVQIDGELKGIITDRDMRSRVVAKDLDIQLPVSEVMTVDPRCATSQGLAFEAMLLMSELR 249 Query: 238 KRRVVIRDDERFVGILEDIDVLGYLAGSAQVIAGRIERAANQDDLAAAARQTAAQVRTLR 297 + I DD + GI+ D++ L + + R ++LA + A Sbjct: 250 IHHLPIVDDGQISGIVTAADIMRLLRHDPIYLTADLSRKNTVEELANTFQSAAEVASRFI 309 Query: 298 RQGIGVELIGEIVSDLNQRLFSRLFDLLAPADIRADG---CLMVMGSEGRGEQTARTDQD 354 +G E + +++ L RL +LA A C +V+GS+GR E +DQD Sbjct: 310 DRGASAEEVSSLLTVAADSLARRLL-VLAERKFGAPPVPYCFVVVGSQGRKEMGLASDQD 368 Query: 355 NGLILSRAIEQAELDKFRTSFS----GALLDFGFPPCPGHVMVNNPAWSKPLPDYIADIR 410 N L+L + E ++ + S L G CPG +M +NP W K +I+ Sbjct: 369 NALVLDNSYNDREHGQYFAALSEFVCQGLDRAGQVLCPGDMMASNPEWRKTADQWISTFH 428 Query: 411 RWLALPDDSAHLNVAILFDARCVAGDATLLTEVKTRLIEMVGGEQAFLAHFARAIDLFAT 470 W+ P+ A L+ FD R + GD + +V + M G + AH A Sbjct: 429 SWITAPEPDALLHAQTFFDFRGIYGDTEMAKDVHQNAVNMARGARRMHAHLASLAARRDP 488 Query: 471 PIGLFKNLIT--SAGNGDAIDLKKGGLFPIVHGVRSLALEHGLIETATDKRINRLRDMGV 528 P+G F+ L+ S G +D+KKGG IV R AL G T +R+ G Sbjct: 489 PLGFFRGLVVERSGEYGATMDIKKGGTAGIVQMARLYALATGSDAIGTRERLIAASGHGQ 548 Query: 529 LHAEFARELHQAFNFMLMLRLDGQ--LAESAGATGTLVRPSSLSSMERDLLRDAFYVVKK 586 + + A++L AF+F+ + Q L + + P +L M+R+ LRDAF ++K Sbjct: 549 VSRKGAQDLLDAFDFLAAMAFQHQARLIKVGEKPNYHIDPKTLGKMDREHLRDAFSIIKD 608 Query: 587 FR 588 + Sbjct: 609 MQ 610