BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0104.0050.p (288 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII0533 [V] COG1566 Multidrug resistance efflux pump Bme Bruce... 301 1e-81 AGpA806 [V] COG1566 Multidrug resistance efflux pump Atu Agrobac... 278 1e-74 PA3892 [V] COG1566 Multidrug resistance efflux pump Pae Pseudomo... 241 1e-63 PA3304 [V] COG1566 Multidrug resistance efflux pump Pae Pseudomo... 214 1e-55 ydhJ [V] COG1566 Multidrug resistance efflux pump Eco Escherichi... 205 7e-53 >BMEII0533 [V] COG1566 Multidrug resistance efflux pump Bme Brucella melitensis Length = 285 Score = 301 bits (770), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 158/288 (54%), Positives = 204/288 (70%), Gaps = 3/288 (1%) Query: 1 MKGNFAWLGRVALTAIAVIAALAVARALWVYYMEAPWTRDGRVRADIVQVAPDVSGFVTD 60 MK A GRV LT + V+ A + LW YYM APWTRDG++RAD+V++APDVSG V++ Sbjct: 1 MKKLLAHSGRVFLTLVMVVMAGLLGWHLWDYYMNAPWTRDGKIRADVVRIAPDVSGLVSE 60 Query: 61 VLVKDNQPVHRGDILFRIDRARFALALKQADAAVAGHRATLDQADADLKRYSSLTTDAVS 120 VLV DNQ VH+GD++FRID+AR+ LAL+ A+A +A LD A+ DL RY L V+ Sbjct: 61 VLVHDNQTVHKGDVIFRIDQARYKLALQTAEAKADSSKAALDMANRDLVRYRQLNDTTVT 120 Query: 121 QQKQEQVLATQLQAKAAYDQAVADRAVAQLNLDRSEVHASVNGTITNMDLRPGAYVTAGK 180 +QK EQV QA+AA+ QA DR +A LN++R A VNG ITN L+PG YV+AG Sbjct: 121 RQKLEQVETAAQQAEAAHRQAELDRDLAALNMERK---APVNGVITNFSLQPGDYVSAGS 177 Query: 181 GVMALVDTDTLHVEGYFEETKLARIRVGDKAQIRLMGEPVRLTGHVESIAAGIEDRDRAA 240 V ALVDTD+ +V GYFEE KL RI +GD + +MG V+L G VE IA GIEDR+R+ Sbjct: 178 AVTALVDTDSYYVSGYFEENKLERIHIGDPVVVDVMGSKVQLKGKVEGIAGGIEDRERSD 237 Query: 241 GASLLANVNPTFSWVRLAQRIPVRIALDHLPDRIALVAGRSATVEIMD 288 SLLANV+PTF+WVRLAQR+PVR+ L+ +P I LVAGR+ +V ++D Sbjct: 238 SQSLLANVSPTFNWVRLAQRVPVRVKLEDVPQGIHLVAGRTVSVSVVD 285 >AGpA806 [V] COG1566 Multidrug resistance efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 392 Score = 278 bits (710), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 142/279 (50%), Positives = 190/279 (68%), Gaps = 1/279 (0%) Query: 9 GRVALTAIAVIAALAVARALWVYYMEAPWTRDGRVRADIVQVAPDVSGFVTDVLVKDNQP 68 GRV LT A + LW +++ PWTRD VRADIV++APD+SG VT+VLV DN Sbjct: 110 GRVLLTLSMSSCAAVMGWHLWSFHIGTPWTRDAHVRADIVRLAPDISGPVTEVLVSDNAL 169 Query: 69 VHRGDILFRIDRARFALALKQADAAVAGHRATLDQADADLKRYSSLTTDAVSQQKQEQVL 128 V + LFRI++ RF LAL++A+A V G +A D A D +RY L + + ++ Q Sbjct: 170 VEKDAPLFRIEKDRFELALREAEAQVTGAKAGTDAAKVDFERYQRLASKEAASVRERQHA 229 Query: 129 ATQL-QAKAAYDQAVADRAVAQLNLDRSEVHASVNGTITNMDLRPGAYVTAGKGVMALVD 187 TQ+ QA+AAY A+ R +A+LNL+R+ V A +G ITN LR G YV AG V LV+ Sbjct: 230 ETQMYQAEAAYQSALVARDLAKLNLERTTVRAPASGAITNFSLRKGNYVLAGNAVGVLVE 289 Query: 188 TDTLHVEGYFEETKLARIRVGDKAQIRLMGEPVRLTGHVESIAAGIEDRDRAAGASLLAN 247 ++++V GYFEETKL RI +GD+ +I +MGEP GHV +AAGIEDR+R+ A LA+ Sbjct: 290 KESVYVAGYFEETKLPRIHIGDRVKIDIMGEPESAIGHVAGVAAGIEDRERSDTAGSLAS 349 Query: 248 VNPTFSWVRLAQRIPVRIALDHLPDRIALVAGRSATVEI 286 V PTFSWVRLAQRIPVRI +DH+P+ + L+AGR+AT+ I Sbjct: 350 VAPTFSWVRLAQRIPVRIEIDHVPNNVRLIAGRTATIAI 388 >PA3892 [V] COG1566 Multidrug resistance efflux pump Pae Pseudomonas aeruginosa Length = 302 Score = 241 bits (615), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 128/265 (48%), Positives = 176/265 (66%), Gaps = 3/265 (1%) Query: 21 ALAVARALWVYYMEAPWTRDGRVRADIVQVAPDVSGFVTDVLVKDNQPVHRGDILFRIDR 80 A+ + R LWV YM+ PWTRDGRVRAD++ VA DVSG V DV V+DNQ V +GD+L +ID Sbjct: 19 AVFIGRTLWVNYMDTPWTRDGRVRADVINVAADVSGIVVDVPVRDNQLVKKGDLLMQIDP 78 Query: 81 ARFALALKQADAAVAGHRATLDQADADLKRYSSLTTDAVSQQKQEQVLATQLQAKAAYDQ 140 + +A+KQA++ VA +ATL+ + +R + + VS++ ++ T A A Y+Q Sbjct: 79 DHYRIAVKQAESLVASRKATLEMRQLNARRRAEMDEMVVSRESRDDAHNTAAAAMADYEQ 138 Query: 141 AVADRAVAQLNLDRSEVHASVNGTITNMDLRPGAYVTAGKGVMALVDTDTLHVEGYFEET 200 A A A+LNL+R+ V A V+G +TN+++ G Y G+ MA++D ++ V GYFEET Sbjct: 139 AKAQLDAARLNLERTRVVAQVDGYVTNLNVHRGDYARVGEAKMAVIDKNSYWVYGYFEET 198 Query: 201 KLARIRVGDKAQIRLM-GEPVRLTGHVESIAAGIEDRDRAAGASLLANVNPTFSWVRLAQ 259 KL IR GD ++LM GE L GHVESIA GI DRD L A+VNPTF+WVRLAQ Sbjct: 199 KLPYIREGDPVDMQLMSGE--HLKGHVESIARGIYDRDNPESRELTADVNPTFNWVRLAQ 256 Query: 260 RIPVRIALDHLPDRIALVAGRSATV 284 R+PVR+ +D +PD + L AG + TV Sbjct: 257 RVPVRVHIDEVPDGVLLSAGITCTV 281 >PA3304 [V] COG1566 Multidrug resistance efflux pump Pae Pseudomonas aeruginosa Length = 285 Score = 214 bits (546), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 134/260 (51%), Positives = 174/260 (66%), Gaps = 2/260 (0%) Query: 28 LWVYYMEAPWTRDGRVRADIVQVAPDVSGFVTDVLVKDNQPVHRGDILFRIDRARFALAL 87 LW YYM +PWTRD RVRAD+V VAPDVSG+VTD+ VKDNQ V GD+L RID+ R+ L Sbjct: 24 LWRYYMLSPWTRDARVRADVVVVAPDVSGWVTDLEVKDNQVVKVGDVLMRIDQERYQANL 83 Query: 88 KQADA-AVAGHRATLDQADADLKRYSSLTTDAVSQQKQEQVLATQLQAKAAYDQAVADRA 146 +QA A A H+ L + + +R S L A+S + +E A++ Y +A+A Sbjct: 84 EQARAVAETRHQQYLLRQNEAARR-SRLGIGAISAEDKENAQINAAIARSEYQEALAQVK 142 Query: 147 VAQLNLDRSEVHASVNGTITNMDLRPGAYVTAGKGVMALVDTDTLHVEGYFEETKLARIR 206 +A+LNL RSE+ A+ NG +TN+ L G Y TAG+ VMALVD + +V YFEETKL IR Sbjct: 143 IAELNLKRSELRAARNGQVTNLRLAQGNYATAGQAVMALVDQQSFYVVAYFEETKLPGIR 202 Query: 207 VGDKAQIRLMGEPVRLTGHVESIAAGIEDRDRAAGASLLANVNPTFSWVRLAQRIPVRIA 266 VG +AQ+RLM + G VESI++GI DR+ LLANV PTF+WVRLAQRIPVRI Sbjct: 203 VGMRAQVRLMSGDQPIDGTVESISSGITDRNSTPDGQLLANVEPTFNWVRLAQRIPVRIR 262 Query: 267 LDHLPDRIALVAGRSATVEI 286 LD +P + L AG +A+V + Sbjct: 263 LDQVPADVHLSAGMTASVTV 282 >ydhJ [V] COG1566 Multidrug resistance efflux pump Eco Escherichia coli K12 Length = 299 Score = 205 bits (522), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 110/271 (40%), Positives = 164/271 (60%), Gaps = 1/271 (0%) Query: 16 IAVIAALAVARALWVYYMEAPWTRDGRVRADIVQVAPDVSGFVTDVLVKDNQPVHRGDIL 75 +AV+A LA LW YYM++PWTRDG++RA+ V + P VSG + ++ +KDNQ V+ GD+L Sbjct: 28 VAVVAVLA-GWWLWNYYMQSPWTRDGKIRAEQVSITPQVSGRIVELNIKDNQLVNAGDLL 86 Query: 76 FRIDRARFALALKQADAAVAGHRATLDQADADLKRYSSLTTDAVSQQKQEQVLATQLQAK 135 ID+ F +A A A +A ++ L +A+ + R L+ + +S ++ + + Sbjct: 87 LTIDKTPFQIAELNAQAQLAKAQSDLAKANNEANRRRHLSQNFISAEELDTANLNVKAMQ 146 Query: 136 AAYDQAVADRAVAQLNLDRSEVHASVNGTITNMDLRPGAYVTAGKGVMALVDTDTLHVEG 195 A+ D A A AQ L ++E+ A V+G +TN+ R G Y GK + ALVD+ + +V G Sbjct: 147 ASVDAAQATLKQAQWQLAQTEIRAPVSGWVTNLTTRIGDYADTGKPLFALVDSHSFYVIG 206 Query: 196 YFEETKLARIRVGDKAQIRLMGEPVRLTGHVESIAAGIEDRDRAAGASLLANVNPTFSWV 255 YFEETKL IR G AQI L + L GHV SI I D+ + +SL+ +V P WV Sbjct: 207 YFEETKLRHIREGAPAQITLYSDNKTLQGHVSSIGRAIYDQSVESDSSLIPDVKPNVPWV 266 Query: 256 RLAQRIPVRIALDHLPDRIALVAGRSATVEI 286 RLAQR+PVR ALD +P + LV+G + ++ + Sbjct: 267 RLAQRVPVRFALDKVPGDVTLVSGTTCSIAV 297