BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0098.0016.p (444 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc3790 [GEPR] COG0477 Permeases of the major facilitator superf... 292 1e-78 Rv1200 [GEPR] COG0477 Permeases of the major facilitator superfa... 280 6e-75 MT1238 [GEPR] COG0477 Permeases of the major facilitator superfa... 280 6e-75 shiA [GEPR] COG0477 Permeases of the major facilitator superfami... 278 2e-74 ECs2778 [GEPR] COG0477 Permeases of the major facilitator superf... 276 9e-74 >AGc3790 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 434 Score = 292 bits (747), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 172/428 (40%), Positives = 261/428 (60%), Gaps = 5/428 (1%) Query: 6 SARSRGAELSDEERKVLTATLVGTTIEWYDFFVYAQAAGLVFGALFFAPMNANNPLLAQI 65 +A + A ++ +VLTA+LVGTTIE++DF+VYA AA LVF ALFF ++P A + Sbjct: 11 TAGNSNAVKTNSPARVLTASLVGTTIEFFDFYVYATAAVLVFPALFFP---NSDPTTALL 67 Query: 66 VSFATLGLSFLFRPLGAIVCGHLGDRFGRKNMLVVTLLLMGAATALVGLLPTYAQIGAWA 125 SFAT ++F RPLGA+V GH GDR GRK LV LL MG +T ++GLLPTY G A Sbjct: 68 ASFATFSIAFFARPLGAVVFGHYGDRVGRKATLVAALLTMGVSTVVIGLLPTYETAGVLA 127 Query: 126 PALLILLRILQGFSAGGEWGGAALMSVESAPVDKRSFFGSFPQIGTPLGMILATGVLWVL 185 P LL L R QGF GGEWGGA L++ E+AP KRS++G FPQ+G P+G+ L++GV W+L Sbjct: 128 PLLLALCRFGQGFGLGGEWGGAVLLATENAPPGKRSWYGMFPQLGAPVGLFLSSGVFWIL 187 Query: 186 TATFGKQAMIEWGWRIPFLLSIVLIVVGIVIRRTVEESPVFQAMQRRHKESSAPLRDLMR 245 ++A++ WGWRIPF+ SI+LI VG+ +R ++ E+P FQ + + + P+ +L R Sbjct: 188 LHFMSQEALLSWGWRIPFVASIILIAVGMWVRLSITETPDFQKAIEKEERVAVPIAELFR 247 Query: 246 NHSKEILRTALIFMANNAAGYILIAFIISYGANTLKMPSEQLLLIGTLAAVSWFIFTLLG 305 +H + ++ + +A YI A+++SY LK+P L + L ++ + IF + Sbjct: 248 SHKRSLVLGTFVALATFVLFYIGTAYLLSYNVKVLKIPFLDALEVQILGSIVFGIFIPVA 307 Query: 306 GILGDKIGRVRCFQIGYSLMVLWAVPMWFLIDSKNPLLFLASAVGLTIALGLSYGPQAAL 365 G L +K GR + L+ L++ + L+ +F+ +A+ + + +G++YG Sbjct: 308 GKLAEKFGRREVLIVTTILIGLFSFLLPSLMTGGEGSIFVFAALAMML-MGMTYGLIGTA 366 Query: 366 YAELFPAKVRYSGVSIGYALGAIFGGAFAPMIAQWIIGTYGQSWRVGVYIAVLSLISLIT 425 A FP +VRY+G SI + + IFG + AP IA W+ YG + VG Y+ + +LI+L Sbjct: 367 LAAPFPTRVRYTGSSITFNMAGIFGASLAPYIATWLQVNYGMGY-VGYYLCISALITLAC 425 Query: 426 VSTIRDPQ 433 + R + Sbjct: 426 IFLSRKDE 433 >Rv1200 [GEPR] COG0477 Permeases of the major facilitator superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 425 Score = 280 bits (715), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 162/421 (38%), Positives = 241/421 (57%), Gaps = 12/421 (2%) Query: 19 RKVLTATLVGTTIEWYDFFVYAQAAGLVFGALFFAPMNANNPLLAQIVSFATLGLSFLFR 78 ++V A LVG+ IE+YDF +Y AA LVF +FF ++ P +A + S T ++FL R Sbjct: 2 KRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLD---PTVAAVASMGTFAVAFLSR 58 Query: 79 PLGAIVCGHLGDRFGRKNMLVVTLLLMGAATALVGLLPTYAQIGAWAPALLILLRILQGF 138 P GA V G+ GDR GRK LV TLL+MG AT VGL+PT IGA AP +L +R+LQGF Sbjct: 59 PFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGAAAPLILTTMRLLQGF 118 Query: 139 SAGGEWGGAALMSVESAPVDKRSFFGSFPQIGTPLGMILATGVLWVLTATFGKQA--MIE 196 + GGEW G+AL+S E AP KR ++G F +G + ++L + + T G+ + ++ Sbjct: 119 AVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQ 178 Query: 197 WGWRIPFLLSIVLIVVGIVIRRTVEESPVFQAMQRRHKE----SSAPLRDLMRNHSKEIL 252 WGWRIPFL+S LI V + +R ++E+PVF + K + P+ ++R +EI+ Sbjct: 179 WGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTRLGPAETPIAQVLRRQRREIV 238 Query: 253 RTALIFMANNAAGYILIAFIISYGANTLKMPSEQLLLIGTLAAVSWFIFTLLGGILGDKI 312 A + Y+ ++ SY L +L L + +FT L L D++ Sbjct: 239 LAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFDSVLGGLLCIVFTALSSALCDQL 298 Query: 313 GRVRCFQIGYSLMVLWAVPMWFLIDSKNPLLFLASAVGLTIALGLSYGPQAALYAELFPA 372 GR R G+++ + W++ + LIDS +P LF + VG+ G +GP A+ ELF Sbjct: 299 GRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFGPTASFIPELFAT 358 Query: 373 KVRYSGVSIGYALGAIFGGAFAPMIAQWIIGTYGQSWRVGVYIAVLSLISLITVSTIRDP 432 RY+G ++ L + GGA P+IA ++ TYG SW +GV +A+L+LISL V T R P Sbjct: 359 SYRYTGSALAANLAGVAGGALPPVIAGALVATYG-SWAIGVMLAILALISL--VCTYRLP 415 Query: 433 Q 433 + Sbjct: 416 E 416 >MT1238 [GEPR] COG0477 Permeases of the major facilitator superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 425 Score = 280 bits (715), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 162/421 (38%), Positives = 241/421 (57%), Gaps = 12/421 (2%) Query: 19 RKVLTATLVGTTIEWYDFFVYAQAAGLVFGALFFAPMNANNPLLAQIVSFATLGLSFLFR 78 ++V A LVG+ IE+YDF +Y AA LVF +FF ++ P +A + S T ++FL R Sbjct: 2 KRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLD---PTVAAVASMGTFAVAFLSR 58 Query: 79 PLGAIVCGHLGDRFGRKNMLVVTLLLMGAATALVGLLPTYAQIGAWAPALLILLRILQGF 138 P GA V G+ GDR GRK LV TLL+MG AT VGL+PT IGA AP +L +R+LQGF Sbjct: 59 PFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGAAAPLILTTMRLLQGF 118 Query: 139 SAGGEWGGAALMSVESAPVDKRSFFGSFPQIGTPLGMILATGVLWVLTATFGKQA--MIE 196 + GGEW G+AL+S E AP KR ++G F +G + ++L + + T G+ + ++ Sbjct: 119 AVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQ 178 Query: 197 WGWRIPFLLSIVLIVVGIVIRRTVEESPVFQAMQRRHKE----SSAPLRDLMRNHSKEIL 252 WGWRIPFL+S LI V + +R ++E+PVF + K + P+ ++R +EI+ Sbjct: 179 WGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTRLGPAETPIAQVLRRQRREIV 238 Query: 253 RTALIFMANNAAGYILIAFIISYGANTLKMPSEQLLLIGTLAAVSWFIFTLLGGILGDKI 312 A + Y+ ++ SY L +L L + +FT L L D++ Sbjct: 239 LAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFDSVLGGLLCIVFTALSSALCDQL 298 Query: 313 GRVRCFQIGYSLMVLWAVPMWFLIDSKNPLLFLASAVGLTIALGLSYGPQAALYAELFPA 372 GR R G+++ + W++ + LIDS +P LF + VG+ G +GP A+ ELF Sbjct: 299 GRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFGPTASFIPELFAT 358 Query: 373 KVRYSGVSIGYALGAIFGGAFAPMIAQWIIGTYGQSWRVGVYIAVLSLISLITVSTIRDP 432 RY+G ++ L + GGA P+IA ++ TYG SW +GV +A+L+LISL V T R P Sbjct: 359 SYRYTGSALAANLAGVAGGALPPVIAGALVATYG-SWAIGVMLAILALISL--VCTYRLP 415 Query: 433 Q 433 + Sbjct: 416 E 416 >shiA [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 438 Score = 278 bits (711), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 158/439 (35%), Positives = 252/439 (57%), Gaps = 12/439 (2%) Query: 2 SIELSARSRGAELS-DEERKVLTATLVGTTIEWYDFFVYAQAAGLVFGALFFAPMNANNP 60 S +S R LS R+ + G ++WYDF +Y A LVF FF ++ P Sbjct: 3 STLISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVS---P 59 Query: 61 LLAQIVSFATLGLSFLFRPLGAIVCGHLGDRFGRKNMLVVTLLLMGAATALVGLLPTYAQ 120 + + +FAT G+ FLFRPLG ++ GH GDR GRK ML++T+ +MG ATAL+G+LP+++ Sbjct: 60 AMGTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFST 119 Query: 121 IGAWAPALLILLRILQGFSAGGEWGGAALMSVESAPVDKRSFFGSFPQIGTPLGMILATG 180 IG WAP LL+ LR +QGF+ GGEWGGAAL+SVESAP +K++F+ S Q+G +G++L+TG Sbjct: 120 IGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTG 179 Query: 181 VLWVLTATFGKQAMIEWGWRIPFLLSIVLIVVGIVIRRTVEESPVFQAMQRRHKESSA-- 238 ++ +++ + + WGWRIPFL SIVL++ + +R +EES F+ Q++H +++A Sbjct: 180 LVSLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFE--QQQHYQAAAKK 237 Query: 239 --PLRDLMRNHSKEILRTALIFMANNAAGYILIAFIISYGANTLKMPSEQLLLIGTLAAV 296 P+ + + H L+ + + YI+ AF ++Y + +P E L IG L Sbjct: 238 RIPVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGG 297 Query: 297 SWFIFTLLGGILGDKIGRVRCFQIGYSLMVLWAVPMWFLIDSKNPLLFLASAVGL-TIAL 355 + L D+ GR R + G + L A P + +++++ + ++ L IA Sbjct: 298 LSCLTIPCFAWLADRFGRRRVYITGTLIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAH 357 Query: 356 GLSYGPQAALYAELFPAKVRYSGVSIGYALGAIFGGAFAPMIAQWIIGTYGQSWR-VGVY 414 + Q ++ E+F A RYSG +GY + ++ GG F P IA +I + +W V +Y Sbjct: 358 DMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFAGNWHSVAIY 417 Query: 415 IAVLSLISLITVSTIRDPQ 433 + LIS +T ++D Q Sbjct: 418 LLAGCLISAMTALLMKDSQ 436 >ECs2778 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 438 Score = 276 bits (705), Expect = 9e-74, Method: Compositional matrix adjust. Identities = 157/437 (35%), Positives = 250/437 (57%), Gaps = 12/437 (2%) Query: 3 IELSARSRGAELSDEERKVLTATLVGTTIEWYDFFVYAQAAGLVFGALFFAPMNANNPLL 62 I R LS R L + G ++WYDF +Y A LVF FF ++ P + Sbjct: 6 ISTRPDERTVSLSRARRAAL-GSFAGAVVDWYDFLLYGITAALVFNREFFPQVS---PAM 61 Query: 63 AQIVSFATLGLSFLFRPLGAIVCGHLGDRFGRKNMLVVTLLLMGAATALVGLLPTYAQIG 122 + +FAT G+ FLFRPLG ++ GH GDR GRK ML++T+ +MG ATAL+G+LP+++ IG Sbjct: 62 GTLAAFATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIG 121 Query: 123 AWAPALLILLRILQGFSAGGEWGGAALMSVESAPVDKRSFFGSFPQIGTPLGMILATGVL 182 WAP LL+ LR +QGF+ GGEWGGAAL+SVESAP +K++F+ S Q+G +G++L+TG++ Sbjct: 122 WWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLV 181 Query: 183 WVLTATFGKQAMIEWGWRIPFLLSIVLIVVGIVIRRTVEESPVFQAMQRRHKESSA---- 238 +++ + + WGWRIPFL SIVL++ + +R +EES F+ Q+++ +++A Sbjct: 182 SLISMMTTDEQFLSWGWRIPFLFSIVLVLGALWVRNGMEESAEFE--QQQYNQAAAKKRI 239 Query: 239 PLRDLMRNHSKEILRTALIFMANNAAGYILIAFIISYGANTLKMPSEQLLLIGTLAAVSW 298 P+ + + H L+ + + YI+ AF ++Y + +P E L IG L Sbjct: 240 PVIEALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLS 299 Query: 299 FIFTLLGGILGDKIGRVRCFQIGYSLMVLWAVPMWFLIDSKNPLLFLASAVGL-TIALGL 357 + L D+ GR R + G + L A P + +++++ + ++ L IA + Sbjct: 300 CLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDM 359 Query: 358 SYGPQAALYAELFPAKVRYSGVSIGYALGAIFGGAFAPMIAQWIIGTYGQSWR-VGVYIA 416 Q ++ E+F A RYSG +GY + ++ GG F P IA +I + +W V +Y+ Sbjct: 360 VVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALITYFAGNWHSVAIYLL 419 Query: 417 VLSLISLITVSTIRDPQ 433 LIS +T ++D Q Sbjct: 420 AGCLISAMTALLMKDNQ 436