BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0084.0024.p (1060 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMc01095 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1514 0.0 RSp1113 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1488 0.0 AGc4508 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1476 0.0 PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1333 0.0 STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1241 0.0 >SMc01095 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1061 Score = 1514 bits (3919), Expect = 0.0, Method: Compositional matrix adjust. Identities = 785/1049 (74%), Positives = 916/1049 (87%) Query: 1 MNLSKFFIDRPIFAGVLSILIFLAGLISLLAMPISEYPDVVPPSVVVRATYPGANPKVIA 60 MN S+FF+DRP+FAGVLS++IF+AGLI + +PISEYP+VVPP +VVRA YPGANP VIA Sbjct: 1 MNFSRFFVDRPVFAGVLSVIIFVAGLIGMTGLPISEYPEVVPPQIVVRAQYPGANPAVIA 60 Query: 61 ETVATPIEEQINGVEGMLYMSSQATTDGAMTLTVTFRLGTDPDKATQLVQNRVQQAEPRL 120 ETVATP+EEQINGVEGMLYM SQAT DG MTLTVTF LGTDPD+A QLVQNRV Q EPRL Sbjct: 61 ETVATPLEEQINGVEGMLYMQSQATADGLMTLTVTFELGTDPDQAQQLVQNRVSQGEPRL 120 Query: 121 PAVVRQLGIITKKSSPDLTMVVHLLSPNNRYDMTYLRNYAVLNVKDRLARIDGVGDVQLY 180 P VR+LG+ T KSSPDLT+VVHL+SPN +YD+ YLRNY VLNVKDRLAR+DGVG VQ++ Sbjct: 121 PEEVRRLGVTTVKSSPDLTLVVHLISPNGQYDINYLRNYGVLNVKDRLARVDGVGQVQIF 180 Query: 181 GAGDYSMRVWVDPQKAAEHSLTASDVVRAIQAQNVEAAAGVVGSSPSVKGIDLQLSVNAE 240 G GDYSMRVW+DP+KAAE L ASD+ A++ QNV+AAAGV+G+SPSV G+DLQLSVNA+ Sbjct: 181 GGGDYSMRVWIDPEKAAERGLAASDIANAVRGQNVQAAAGVIGASPSVPGLDLQLSVNAQ 240 Query: 241 GRLSTEEQFGDIVVKTGSAGEVVRLRDVARVELGASEYGLRSLLDNKQAVAIPIFQAPGS 300 GRL T E F DIVVK+G +GE+ RL DVARVE+GA++Y LRSLLDNK AV + +FQAPGS Sbjct: 241 GRLKTPEDFADIVVKSGESGEITRLGDVARVEMGAADYSLRSLLDNKAAVGMGVFQAPGS 300 Query: 301 NALEISDHVRATMAEIKKNMPEGVSYQIVYDPTQFVRSSIEAVIHTLLEAVALVVLVVIL 360 NA++IS++V MAE+K+ MP+GV Y+IVYD TQFVR+SIE+VIHTLLEA+ALVV+VVI+ Sbjct: 301 NAIQISENVHKVMAELKQTMPDGVDYEIVYDTTQFVRASIESVIHTLLEAIALVVVVVIV 360 Query: 361 FLQTWRASIIPLIAVPVSIVGTFAVMHVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL+AVPVSIVGTFAVM+VFGFSINALSLFGLVLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLVAVPVSIVGTFAVMYVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIESGLSPRDATNQAMREVSGPIIAIALVLIAVFVPLAFISGLTGQFYKQFALTIAIST 480 RNI GLSP AT +AM+EVSGPIIAIALVL+AVFVPLAFI+GLTGQFY+QFALTIAIST Sbjct: 421 RNISQGLSPVQATYRAMQEVSGPIIAIALVLVAVFVPLAFITGLTGQFYRQFALTIAIST 480 Query: 481 VISAINSLTLSPALSALLLKGHHEPKDWLTRIMERSLGWFFRGFNKVFTKSSENYGRTVT 540 VISA+NSLTLSPAL+ALLLK HH PKD LTR+M+ GWFFRGFN+ F SSE YGR V Sbjct: 481 VISALNSLTLSPALAALLLKDHHAPKDRLTRVMDGLFGWFFRGFNRFFGASSEAYGRGVG 540 Query: 541 KVIYGKAVVIGLYVLLIGLTGVLFKQVPSGFVPGQDKQYLVGFARLPDGATLDRTEEVIR 600 ++ K++V+G+YV+L+G+T VLF+ VP GFVP QDKQYL+GFA+LPD ATLDR+E+VIR Sbjct: 541 GILTRKSLVMGVYVVLLGVTFVLFRAVPGGFVPAQDKQYLIGFAQLPDAATLDRSEDVIR 600 Query: 601 KMSDIALTQPGVESSVAFPGLSISGFTNSSNAGIVFSTLKPFDERKDPSLSGPAIAAALN 660 +MS+IAL PGVE ++AFPGLSI+GFTNSSN+GIVF +LKPF+ER P LSG AIA LN Sbjct: 601 RMSEIALKHPGVEHAIAFPGLSINGFTNSSNSGIVFVSLKPFEERTTPELSGGAIAMQLN 660 Query: 661 KKYAGIQDAFIAMFPPPPVNGLGTIGGFKLQIEDRAGLGYEALNDATKAFMAAMQKAPEI 720 +++ IQDAFIAMFPPPPV GLGT GGFKLQIEDR GLGY L+DATKA +A APE+ Sbjct: 661 QEFGAIQDAFIAMFPPPPVQGLGTTGGFKLQIEDRNGLGYRTLDDATKAVLAKAMAAPEL 720 Query: 721 AGVFSSFQVNVPQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYYVNDFNKFGRTYSVYV 780 AG++SSFQ+NVPQL+AD+DRTKA QLGV VT+VF TLQIYLGS YVNDFN FGRTYSV + Sbjct: 721 AGLYSSFQINVPQLYADLDRTKARQLGVAVTDVFETLQIYLGSLYVNDFNAFGRTYSVRI 780 Query: 781 QADAPFRARADDIRQLKVRSSSGDMVPLSALLKVRQSAGPERAIRYNGFLSSDINAAAAP 840 QADA +R+ ADDI +LKVRS +G+M+PLSALL V Q+ G ERAIRYNGFL++DIN AP Sbjct: 781 QADASYRSHADDIGKLKVRSQTGEMIPLSALLNVEQTVGAERAIRYNGFLAADINGGPAP 840 Query: 841 GFSSGQAQEAATRIAAETLPPGFAFEWTDLTYQEFIAGNSGIWVFPLAILLVFLVLAALY 900 GFSSGQAQ A RIAAETLPPG ++EWTDLTYQ+ +AGNSGI VFPLA+LLV+LVLAA Y Sbjct: 841 GFSSGQAQAAIERIAAETLPPGISYEWTDLTYQQILAGNSGILVFPLALLLVYLVLAAQY 900 Query: 901 ESLALPLSIIMIVPMGLLAAMFGVWLSKGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL 960 ESL LP++II+IVPMG++AA+ GVWL+ GDNNVFTQIGLIVLVGLSAKNAILIVEFAREL Sbjct: 901 ESLLLPIAIILIVPMGIMAALTGVWLTGGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL 960 Query: 961 EFAGRSPIRAAIEASRLRLRPILMTSMAFIMGVLPLVLSTGAGSEMRRAMGVAVFSGMIG 1020 E +G + + AAIEASRLRLRPILMTSMAFIMGV+PLV STGAG+EMR AMGVAVF+GMIG Sbjct: 961 ELSGSNAVSAAIEASRLRLRPILMTSMAFIMGVVPLVTSTGAGAEMRSAMGVAVFAGMIG 1020 Query: 1021 VTVFGLFLTPVFYVLLRSLTGMKPLTQHG 1049 VT FG+F+TPVFYVL+R L+G KPL G Sbjct: 1021 VTAFGIFMTPVFYVLIRKLSGEKPLKHTG 1049 >RSp1113 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1069 Score = 1488 bits (3851), Expect = 0.0, Method: Compositional matrix adjust. Identities = 784/1043 (75%), Positives = 909/1043 (87%) Query: 1 MNLSKFFIDRPIFAGVLSILIFLAGLISLLAMPISEYPDVVPPSVVVRATYPGANPKVIA 60 MN SKFF+DRPIFAGVLS LI L G+IS+ +PISEYP+VVPPSVVVRA +PGANPKVIA Sbjct: 1 MNFSKFFVDRPIFAGVLSTLILLIGIISIWRLPISEYPEVVPPSVVVRAQFPGANPKVIA 60 Query: 61 ETVATPIEEQINGVEGMLYMSSQATTDGAMTLTVTFRLGTDPDKATQLVQNRVQQAEPRL 120 ETVA+P+EEQINGVE MLYM SQA +DG +T+TVTF+LGTDPDKA QLVQNRV QA PRL Sbjct: 61 ETVASPLEEQINGVENMLYMQSQANSDGNLTVTVTFKLGTDPDKAQQLVQNRVSQAMPRL 120 Query: 121 PAVVRQLGIITKKSSPDLTMVVHLLSPNNRYDMTYLRNYAVLNVKDRLARIDGVGDVQLY 180 P VV++LG+ T KSSPDLTMVVHLLSPN+RYDMTYLRNYAVLNVKDRLARI+GVG VQL+ Sbjct: 121 PDVVQRLGVTTIKSSPDLTMVVHLLSPNDRYDMTYLRNYAVLNVKDRLARINGVGQVQLF 180 Query: 181 GAGDYSMRVWVDPQKAAEHSLTASDVVRAIQAQNVEAAAGVVGSSPSVKGIDLQLSVNAE 240 G+GDYSMRVW+DP K AE LTA++VVRAI+ QNV+ AAGV+G SPS+ G DLQLSVNA+ Sbjct: 181 GSGDYSMRVWLDPNKVAERGLTANEVVRAIRDQNVQVAAGVIGGSPSLPGTDLQLSVNAQ 240 Query: 241 GRLSTEEQFGDIVVKTGSAGEVVRLRDVARVELGASEYGLRSLLDNKQAVAIPIFQAPGS 300 GRL TE++FGDI++K+ G V LRDVAR+EL ASEYGLRSLLDNKQAVAIPIFQAPGS Sbjct: 241 GRLKTEQEFGDIILKSSPNGAVTTLRDVARIELAASEYGLRSLLDNKQAVAIPIFQAPGS 300 Query: 301 NALEISDHVRATMAEIKKNMPEGVSYQIVYDPTQFVRSSIEAVIHTLLEAVALVVLVVIL 360 NAL+ISD VR TMAE+K++ PEGV Y+IVYDPTQFVRSSIEAV HTLLEAVALVVLVVIL Sbjct: 301 NALQISDDVRKTMAELKEDFPEGVDYRIVYDPTQFVRSSIEAVTHTLLEAVALVVLVVIL 360 Query: 361 FLQTWRASIIPLIAVPVSIVGTFAVMHVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 FLQTWRAS+IPL+AVPVSI+GTF +M +FGFSINALSLFGLVLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASVIPLLAVPVSIIGTFGLMLMFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIESGLSPRDATNQAMREVSGPIIAIALVLIAVFVPLAFISGLTGQFYKQFALTIAIST 480 RNI GLSPR+AT +AMREVSGPIIAIAL LIAVFVPLAF++GLTGQFYKQFALTI+IST Sbjct: 421 RNIADGLSPREATYKAMREVSGPIIAIALTLIAVFVPLAFMTGLTGQFYKQFALTISIST 480 Query: 481 VISAINSLTLSPALSALLLKGHHEPKDWLTRIMERSLGWFFRGFNKVFTKSSENYGRTVT 540 VISA NSLTLSPAL+ALLLK H PKD L R+MER LGW FR FN+VF +SE+YGR+ + Sbjct: 481 VISAFNSLTLSPALAALLLKSHDAPKDLLARVMERGLGWIFRPFNRVFGAASESYGRSTS 540 Query: 541 KVIYGKAVVIGLYVLLIGLTGVLFKQVPSGFVPGQDKQYLVGFARLPDGATLDRTEEVIR 600 +VI KAV++G+Y+ LIGLT +LF +VP GFVP QDKQYLV FA+LPDGA+LDRTE+VIR Sbjct: 541 RVIGRKAVMLGIYLALIGLTALLFNRVPGGFVPMQDKQYLVSFAQLPDGASLDRTEDVIR 600 Query: 601 KMSDIALTQPGVESSVAFPGLSISGFTNSSNAGIVFSTLKPFDERKDPSLSGPAIAAALN 660 +MSDIAL PGVES+VAFPGLSI+GFTNS +AGIVF TLKPFD+RK P+LSG AIA LN Sbjct: 601 RMSDIALKHPGVESAVAFPGLSINGFTNSPSAGIVFVTLKPFDQRKTPNLSGGAIAGQLN 660 Query: 661 KKYAGIQDAFIAMFPPPPVNGLGTIGGFKLQIEDRAGLGYEALNDATKAFMAAMQKAPEI 720 ++Y I+DAFIA+FPPPPV GLGT+GGFK+Q+EDR +GYE L A++AFM ++ PE+ Sbjct: 661 QQYGAIKDAFIAVFPPPPVQGLGTVGGFKMQLEDRGSVGYEQLFAASQAFMQKARQTPEL 720 Query: 721 AGVFSSFQVNVPQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYYVNDFNKFGRTYSVYV 780 FSS+Q+NVPQL AD+DR KA QLGVPVT+VF+T+QIYLGS YVNDFN+FGRTY V V Sbjct: 721 GPSFSSYQINVPQLNADLDRVKAKQLGVPVTDVFDTMQIYLGSLYVNDFNRFGRTYQVKV 780 Query: 781 QADAPFRARADDIRQLKVRSSSGDMVPLSALLKVRQSAGPERAIRYNGFLSSDINAAAAP 840 QADAPFRA A+DI QLK R++ GDMVPLS+LL+V Q GP+ +RYNG+ ++DIN AP Sbjct: 781 QADAPFRAHAEDILQLKTRNTDGDMVPLSSLLRVSQGFGPDMVVRYNGYTAADINGGPAP 840 Query: 841 GFSSGQAQEAATRIAAETLPPGFAFEWTDLTYQEFIAGNSGIWVFPLAILLVFLVLAALY 900 G+SSGQAQ AA RIA E LP G FEWTDLTYQ+ +AGNS +W+FPL +LLVFLVLAA Y Sbjct: 841 GYSSGQAQAAAERIAREVLPKGVRFEWTDLTYQQILAGNSAVWIFPLCVLLVFLVLAAQY 900 Query: 901 ESLALPLSIIMIVPMGLLAAMFGVWLSKGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL 960 ESL LPL++I+IVPM L AAM GVW+S GDNN+FTQIGL+VLVGL+ KNAILIVEFAREL Sbjct: 901 ESLTLPLAVILIVPMSLFAAMLGVWISHGDNNIFTQIGLVVLVGLACKNAILIVEFAREL 960 Query: 961 EFAGRSPIRAAIEASRLRLRPILMTSMAFIMGVLPLVLSTGAGSEMRRAMGVAVFSGMIG 1020 E GRS + AAIEA RLRLRPILMTS+AFIMGV+PLV+STGAG+EMR AMGVAVF+GM+G Sbjct: 961 ELQGRSIVEAAIEACRLRLRPILMTSIAFIMGVVPLVMSTGAGAEMRHAMGVAVFAGMLG 1020 Query: 1021 VTVFGLFLTPVFYVLLRSLTGMK 1043 VT+FGLFLTPVFYV+LR+L + Sbjct: 1021 VTLFGLFLTPVFYVVLRTLASRR 1043 >AGc4508 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1064 Score = 1476 bits (3822), Expect = 0.0, Method: Compositional matrix adjust. Identities = 775/1050 (73%), Positives = 911/1050 (86%) Query: 1 MNLSKFFIDRPIFAGVLSILIFLAGLISLLAMPISEYPDVVPPSVVVRATYPGANPKVIA 60 MN+S+FF+DRP+FAGVLSILI +AGL+ + A+PISEYP+VVPPSVVVRATYPGANP VIA Sbjct: 1 MNISRFFVDRPVFAGVLSILIVVAGLLGMRALPISEYPEVVPPSVVVRATYPGANPTVIA 60 Query: 61 ETVATPIEEQINGVEGMLYMSSQATTDGAMTLTVTFRLGTDPDKATQLVQNRVQQAEPRL 120 ETVATP+EEQINGVE MLYM SQAT+DG +TLTVTF+LGTDPDKA QLVQNRV QAEPRL Sbjct: 61 ETVATPLEEQINGVEDMLYMGSQATSDGVLTLTVTFKLGTDPDKAQQLVQNRVSQAEPRL 120 Query: 121 PAVVRQLGIITKKSSPDLTMVVHLLSPNNRYDMTYLRNYAVLNVKDRLARIDGVGDVQLY 180 PA VR LGI T KSSPD MVV+L+S + YD+TYLRNYA LNVKDRLARI+GVG VQ++ Sbjct: 121 PAEVRALGITTVKSSPDFIMVVNLVSKTDAYDITYLRNYATLNVKDRLARIEGVGQVQVF 180 Query: 181 GAGDYSMRVWVDPQKAAEHSLTASDVVRAIQAQNVEAAAGVVGSSPSVKGIDLQLSVNAE 240 GAGDYSMRVW+DPQK AEH L A+DV AI+ QNV+AAAGV+G+SPS G+DLQL+VNA+ Sbjct: 181 GAGDYSMRVWLDPQKVAEHDLAAADVSDAIRQQNVQAAAGVIGASPSPNGVDLQLNVNAQ 240 Query: 241 GRLSTEEQFGDIVVKTGSAGEVVRLRDVARVELGASEYGLRSLLDNKQAVAIPIFQAPGS 300 GRL+T E+FG+I+VK+G+ GE+ RLRDVAR+ELGA++Y LRSLLD + AVA+ + QAPGS Sbjct: 241 GRLTTPEEFGNIIVKSGANGEITRLRDVARIELGAADYTLRSLLDGEPAVAVAVLQAPGS 300 Query: 301 NALEISDHVRATMAEIKKNMPEGVSYQIVYDPTQFVRSSIEAVIHTLLEAVALVVLVVIL 360 NA+EI+D+VRATM ++ MP+GV Y+IVYD T+FVRSSIE V+ TLLEAV LVVLVVIL Sbjct: 301 NAIEIADNVRATMDNLQLAMPDGVKYEIVYDTTKFVRSSIEKVVDTLLEAVGLVVLVVIL 360 Query: 361 FLQTWRASIIPLIAVPVSIVGTFAVMHVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPLIAVPVSI+GTFAVM+ FGFSINAL+LFGLVLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLIAVPVSIIGTFAVMYAFGFSINALTLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIESGLSPRDATNQAMREVSGPIIAIALVLIAVFVPLAFISGLTGQFYKQFALTIAIST 480 RNIE+GLSPRDAT +AMREVSGPIIAIALVL+AVFVPLAFISGL+GQFY+QFALTIAIST Sbjct: 421 RNIENGLSPRDATYKAMREVSGPIIAIALVLVAVFVPLAFISGLSGQFYRQFALTIAIST 480 Query: 481 VISAINSLTLSPALSALLLKGHHEPKDWLTRIMERSLGWFFRGFNKVFTKSSENYGRTVT 540 VISAINSLTLSPAL+ALLLK H PKDWLTR M++ LGWFFRGFN+ F +S YG+TV Sbjct: 481 VISAINSLTLSPALAALLLKEHGAPKDWLTRFMDKILGWFFRGFNRAFGAASNGYGKTVG 540 Query: 541 KVIYGKAVVIGLYVLLIGLTGVLFKQVPSGFVPGQDKQYLVGFARLPDGATLDRTEEVIR 600 ++ K++V+ +Y+ L+ T +F VPSGFVP QDKQYL+GFA+LPDGATLDRTE VI+ Sbjct: 541 GLVTRKSLVMIVYMALVAATYGMFTTVPSGFVPAQDKQYLIGFAQLPDGATLDRTESVIK 600 Query: 601 KMSDIALTQPGVESSVAFPGLSISGFTNSSNAGIVFSTLKPFDERKDPSLSGPAIAAALN 660 +MS IA+ PGV ++AFPGLSI+GFT SN+GIVF+ L F++RK P LSG AIA LN Sbjct: 601 RMSAIAMETPGVSHAIAFPGLSINGFTIGSNSGIVFAVLDDFEKRKTPELSGGAIAMQLN 660 Query: 661 KKYAGIQDAFIAMFPPPPVNGLGTIGGFKLQIEDRAGLGYEALNDATKAFMAAMQKAPEI 720 +K+AGIQDAFIAMFPPPPVNGLG GGFKLQIEDRAG GY+ L++A KA +A + PE+ Sbjct: 661 QKFAGIQDAFIAMFPPPPVNGLGQTGGFKLQIEDRAGYGYQTLDEAAKAVIAKAYQTPEL 720 Query: 721 AGVFSSFQVNVPQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYYVNDFNKFGRTYSVYV 780 AG+FSSFQ+NVPQLFAD+DR KA QLGV V++VF TLQIYLGS YVNDFN FGRTYSV V Sbjct: 721 AGIFSSFQINVPQLFADLDRAKAEQLGVSVSDVFQTLQIYLGSLYVNDFNAFGRTYSVRV 780 Query: 781 QADAPFRARADDIRQLKVRSSSGDMVPLSALLKVRQSAGPERAIRYNGFLSSDINAAAAP 840 QAD+ FRA A+DI +LKVRS++G M+PLS LLKV + GPER RYNGFL++DIN AP Sbjct: 781 QADSQFRAHAEDIGRLKVRSATGQMIPLSTLLKVDATTGPERTNRYNGFLAADINGGPAP 840 Query: 841 GFSSGQAQEAATRIAAETLPPGFAFEWTDLTYQEFIAGNSGIWVFPLAILLVFLVLAALY 900 GFSSGQAQ A +I AE LP G +EWTDLTYQ+ +AGNS I VFPLA+LLV+LVLAA Y Sbjct: 841 GFSSGQAQAAMEKILAENLPAGIDYEWTDLTYQQILAGNSSIVVFPLALLLVYLVLAAQY 900 Query: 901 ESLALPLSIIMIVPMGLLAAMFGVWLSKGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL 960 ESL LP++II+IVP+G+LAA+ GVWL+ GDNN+FTQIGL+VLVGLSAKNAILIVEFAREL Sbjct: 901 ESLTLPIAIILIVPLGVLAALTGVWLTGGDNNIFTQIGLVVLVGLSAKNAILIVEFAREL 960 Query: 961 EFAGRSPIRAAIEASRLRLRPILMTSMAFIMGVLPLVLSTGAGSEMRRAMGVAVFSGMIG 1020 EF GR+P++AA+EASRLRLRPILMTS+AFIMGV+PLV+STGAG+EMR AMGVAVFSGMIG Sbjct: 961 EFEGRTPLQAAVEASRLRLRPILMTSLAFIMGVVPLVVSTGAGAEMRAAMGVAVFSGMIG 1020 Query: 1021 VTVFGLFLTPVFYVLLRSLTGMKPLTQHGE 1050 VT FG+F+TPVFYVL+R L G +PL QH + Sbjct: 1021 VTFFGIFMTPVFYVLVRKLAGNRPLIQHKQ 1050 >PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1062 Score = 1333 bits (3450), Expect = 0.0, Method: Compositional matrix adjust. Identities = 691/1040 (66%), Positives = 841/1040 (80%), Gaps = 3/1040 (0%) Query: 1 MNLSKFFIDRPIFAGVLSILIFLAGLISLLAMPISEYPDVVPPSVVVRATYPGANPKVIA 60 MN S+FFI RPIFA VLS+LI + G ISL +PISEYP+VVPP+VVVRA +PGANPKVI Sbjct: 1 MNFSQFFIQRPIFAAVLSLLILIGGAISLFQLPISEYPEVVPPTVVVRANFPGANPKVIG 60 Query: 61 ETVATPIEEQINGVEGMLYMSSQATTDGAMTLTVTFRLGTDPDKATQLVQNRVQQAEPRL 120 ETVA+P+E+ I GVE MLYMSSQ+T+DG +TLT+TF LGTD D A VQNRV + EP+L Sbjct: 61 ETVASPLEQAITGVENMLYMSSQSTSDGKLTLTITFALGTDLDNAQVQVQNRVTRTEPKL 120 Query: 121 PAVVRQLGIITKKSSPDLTMVVHLLSPNNRYDMTYLRNYAVLNVKDRLARIDGVGDVQLY 180 P V +LGI K+SPDLTMVVHL SP+NRYDM YL NYAVLNVKD LAR+DGVGDVQL+ Sbjct: 121 PEEVTRLGITVDKASPDLTMVVHLTSPDNRYDMLYLSNYAVLNVKDELARLDGVGDVQLF 180 Query: 181 GAGDYSMRVWVDPQKAAEHSLTASDVVRAIQAQNVEAAAGVVGSSPSVKGIDLQLSVNAE 240 G GDYS+RVW+DP K A +LTA+DVV AI+ QN + AAG +G+ P+ QLS+N + Sbjct: 181 GLGDYSLRVWLDPNKVASRNLTATDVVNAIREQNRQVAAGTLGAPPAPSDTSFQLSINTQ 240 Query: 241 GRLSTEEQFGDIVVKTGSAGEVVRLRDVARVELGASEYGLRSLLDNKQAVAIPIFQAPGS 300 GRL TEE+F +I+++ G+ GE+ RLRD+ARVELG+++Y LRSLL+NK AVAIPIFQ PGS Sbjct: 241 GRLVTEEEFENIIIRAGANGEITRLRDIARVELGSNQYALRSLLNNKPAVAIPIFQRPGS 300 Query: 301 NALEISDHVRATMAEIKKNMPEGVSYQIVYDPTQFVRSSIEAVIHTLLEAVALVVLVVIL 360 NA+EIS+ VR MAE+K + P+G+ Y IVYDPT FVR SIEAV+HTL EA+ LVVLVVIL Sbjct: 301 NAIEISNLVREKMAELKHSFPQGMDYSIVYDPTIFVRGSIEAVVHTLFEALVLVVLVVIL 360 Query: 361 FLQTWRASIIPLIAVPVSIVGTFAVMHVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL AVPVS++GTFAVMH+ GFS+NALSLFGLVLAIGIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLAAVPVSLIGTFAVMHMLGFSLNALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 421 RNIESGLSPRDATNQAMREVSGPIIAIALVLIAVFVPLAFISGLTGQFYKQFALTIAIST 480 RNI GL P +AT +AMREV+GPIIA ALVL AVF+P AFISGLTGQFY+QFALTIAIST Sbjct: 421 RNIGLGLKPVEATKRAMREVTGPIIATALVLCAVFIPTAFISGLTGQFYRQFALTIAIST 480 Query: 481 VISAINSLTLSPALSALLLKGHHEPKDWLTRIMERSLG-WFFRGFNKVFTKSSENYGRTV 539 VISA NSLTLSPAL+A+LLKGHHEPKD + +++ LG W FR FN+ F ++S Y TV Sbjct: 481 VISAFNSLTLSPALAAVLLKGHHEPKDRFSVFLDKLLGSWLFRPFNRFFDRASHGYVGTV 540 Query: 540 TKVIYGKAVVIGLYVLLIGLTGVLFKQVPSGFVPGQDKQYLVGFARLPDGATLDRTEEVI 599 +V+ G ++ + +Y L+ LT F P+GFVP QDKQYLV FA+LPD A+LDRTE VI Sbjct: 541 NRVLRGSSIALLVYGGLMVLTYFGFSSTPTGFVPQQDKQYLVAFAQLPDAASLDRTEAVI 600 Query: 600 RKMSDIALTQPGVESSVAFPGLSISGFTNSSNAGIVFSTLKPFDERKDPSLSGPAIAAAL 659 ++MS+IAL QPGV SVAFPGLSI+GFTNS N+GIVF+ LKPFDERKDPS S AIAAAL Sbjct: 601 KQMSEIALAQPGVADSVAFPGLSINGFTNSPNSGIVFTPLKPFDERKDPSQSAGAIAAAL 660 Query: 660 NKKYAGIQDAFIAMFPPPPVNGLGTIGGFKLQIEDRAGLGYEALNDATKAFMAAMQKAPE 719 N KYA IQDA+IA+FPPPPV GLGTIGGF+LQIEDR GYE L T+ + + PE Sbjct: 661 NAKYADIQDAYIAIFPPPPVQGLGTIGGFRLQIEDRGNQGYEELFKQTQNIITKARALPE 720 Query: 720 I--AGVFSSFQVNVPQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYYVNDFNKFGRTYS 777 + + VFSS+QVNVPQ+ ADIDR KA GV ++++F+TLQ+YLGS Y NDFN+FGRTY Sbjct: 721 LEPSSVFSSYQVNVPQIDADIDREKAKTHGVAISDIFDTLQVYLGSLYANDFNRFGRTYQ 780 Query: 778 VYVQADAPFRARADDIRQLKVRSSSGDMVPLSALLKVRQSAGPERAIRYNGFLSSDINAA 837 V VQA+ FR + I QLKVR++ G+MVPL++ +KV ++GP+R + YNGF+++++N A Sbjct: 781 VNVQAEQQFRLEPEQIGQLKVRNNLGEMVPLASFIKVSDTSGPDRVMHYNGFITAELNGA 840 Query: 838 AAPGFSSGQAQEAATRIAAETLPPGFAFEWTDLTYQEFIAGNSGIWVFPLAILLVFLVLA 897 A G+SSGQAQ A ++ E LP G +EWT+LTYQ+ +AGN+ ++VFPL +LL FLVLA Sbjct: 841 PAAGYSSGQAQAAIEKLLKEELPNGMTYEWTELTYQQILAGNTALFVFPLCVLLAFLVLA 900 Query: 898 ALYESLALPLSIIMIVPMGLLAAMFGVWLSKGDNNVFTQIGLIVLVGLSAKNAILIVEFA 957 A YES +LPL++I+IVPM LL+A+ GV L+ DNN+FTQIGLIVLVGL+ KNAILIVEFA Sbjct: 901 AQYESWSLPLAVILIVPMTLLSAITGVILAGSDNNIFTQIGLIVLVGLACKNAILIVEFA 960 Query: 958 RELEFAGRSPIRAAIEASRLRLRPILMTSMAFIMGVLPLVLSTGAGSEMRRAMGVAVFSG 1017 ++ + G + A +EA RLRLRPILMTS+AFIMGV+PLV+STGAG+EMR AMGVAVFSG Sbjct: 961 KDKQEEGMDRVAAVLEACRLRLRPILMTSIAFIMGVVPLVISTGAGAEMRHAMGVAVFSG 1020 Query: 1018 MIGVTVFGLFLTPVFYVLLR 1037 MIGVT FGL LTPVFYVL+R Sbjct: 1021 MIGVTFFGLLLTPVFYVLIR 1040 >STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1055 Score = 1241 bits (3211), Expect = 0.0, Method: Compositional matrix adjust. Identities = 627/1041 (60%), Positives = 800/1041 (76%), Gaps = 3/1041 (0%) Query: 1 MNLSKFFIDRPIFAGVLSILIFLAGLISLLAMPISEYPDVVPPSVVVRATYPGANPKVIA 60 M + FFI RPIFA VLS+L+ LAG I+ L +P+SEYP V PP+V V A+YPGANP+VIA Sbjct: 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIA 60 Query: 61 ETVATPIEEQINGVEGMLYMSSQATTDGAMTLTVTFRLGTDPDKATQLVQNRVQQAEPRL 120 +TVA P+E+ INGV+GMLYM++Q DG M +++ F GTDPD A VQNRV +A PRL Sbjct: 61 DTVAAPLEQVINGVDGMLYMNTQMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRL 120 Query: 121 PAVVRQLGIITKKSSPDLTMVVHLLSPNNRYDMTYLRNYAVLNVKDRLARIDGVGDVQLY 180 P V+++G++T+K+SPD+ MVVHL+SP RYD YL N+A+ V+D LAR+ GVGDV ++ Sbjct: 121 PEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVRDELARLPGVGDVLVW 180 Query: 181 GAGDYSMRVWVDPQKAAEHSLTASDVVRAIQAQNVEAAAGVVGSSPSVKGIDLQLSVNAE 240 GAG+Y+MRVW+DP K A LTASD+V A++ QNV+ AAG VG P Q++VN Sbjct: 181 GAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASAA-FQMTVNTL 239 Query: 241 GRLSTEEQFGDIVVKTGSAGEVVRLRDVARVELGASEYGLRSLLDNKQAVAIPIFQAPGS 300 GRL++EEQFG+IVVK G+ GEV RLRDVARV LGA Y LRSLL+ + A A+ I Q+PG+ Sbjct: 240 GRLTSEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGA 299 Query: 301 NALEISDHVRATMAEIKKNMPEGVSYQIVYDPTQFVRSSIEAVIHTLLEAVALVVLVVIL 360 NA+++S+ +R M E+++N P+ + Y+I YDPT FVR+S+++V TLLEA+ LVVLVV++ Sbjct: 300 NAIDVSNAIRGKMDELQQNFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVM 359 Query: 361 FLQTWRASIIPLIAVPVSIVGTFAVMHVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE 420 FLQTWRASIIPL+AVPVS+VGTFA+MH+FGFS+N LSLFGLVL+IGIVVDDAIVVVENVE Sbjct: 360 FLQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVE 419 Query: 421 RNIESGLSPRDATNQAMREVSGPIIAIALVLIAVFVPLAFISGLTGQFYKQFALTIAIST 480 R+I G SP +A +AM EV+GPI++I VL AVF+P AF++GL G+FY+QFALTIAIST Sbjct: 420 RHISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAIST 479 Query: 481 VISAINSLTLSPALSALLLKGHHE--PKDWLTRIMERSLGWFFRGFNKVFTKSSENYGRT 538 ++SAINSLTLSPAL+A+LL+ HH+ DWLTR+M G FF FN+ F +S Y Sbjct: 480 ILSAINSLTLSPALAAILLRPHHDTAKADWLTRLMGTVTGGFFHRFNRFFDSASNRYVSA 539 Query: 539 VTKVIYGKAVVIGLYVLLIGLTGVLFKQVPSGFVPGQDKQYLVGFARLPDGATLDRTEEV 598 V + + G +V+ LY +GLT + F QVP+GFVP QDK YLVG A+LP GA+LDRTE V Sbjct: 540 VRRAVRGSVIVMVLYAGFVGLTWLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEAV 599 Query: 599 IRKMSDIALTQPGVESSVAFPGLSISGFTNSSNAGIVFSTLKPFDERKDPSLSGPAIAAA 658 +++MS IAL +PGVES V FPGLS++G N N+ ++F+ LKPFDER+DPSLS AIA Sbjct: 600 VKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAMLKPFDEREDPSLSANAIAGK 659 Query: 659 LNKKYAGIQDAFIAMFPPPPVNGLGTIGGFKLQIEDRAGLGYEALNDATKAFMAAMQKAP 718 L K++ I D FI +FPPPPV GLG GGFKLQIEDRA LG+EA+ M+ + P Sbjct: 660 LMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQTP 719 Query: 719 EIAGVFSSFQVNVPQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYYVNDFNKFGRTYSV 778 E+A + +SFQ N PQL DIDR KA +GV +T++F TLQI LGS YVNDFN+FGR + V Sbjct: 720 ELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRAWRV 779 Query: 779 YVQADAPFRARADDIRQLKVRSSSGDMVPLSALLKVRQSAGPERAIRYNGFLSSDINAAA 838 QADAPFR + +DI LKVR++ G+M+PLSA + + + +GP+R I YNGF S DI+ Sbjct: 780 MAQADAPFRMQQEDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGGP 839 Query: 839 APGFSSGQAQEAATRIAAETLPPGFAFEWTDLTYQEFIAGNSGIWVFPLAILLVFLVLAA 898 APGFSSGQA +A +I ETLP G FEWTDL YQE AGNS + +F LA+LL FL+LAA Sbjct: 840 APGFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSALAIFALAVLLAFLILAA 899 Query: 899 LYESLALPLSIIMIVPMGLLAAMFGVWLSKGDNNVFTQIGLIVLVGLSAKNAILIVEFAR 958 Y S +LP ++++I PM LL+A+ GVW+S GDNN+FTQIG +VLVGL+AKNAILIVEFAR Sbjct: 900 QYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFAR 959 Query: 959 ELEFAGRSPIRAAIEASRLRLRPILMTSMAFIMGVLPLVLSTGAGSEMRRAMGVAVFSGM 1018 E G P+ A +EASRLRLRPILMTS AFI GV+PLVL+TGAG+EMR AMG+AVF+GM Sbjct: 960 AKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAGM 1019 Query: 1019 IGVTVFGLFLTPVFYVLLRSL 1039 +GVT+FGL LTPVFYV++R + Sbjct: 1020 LGVTLFGLLLTPVFYVVVRRM 1040