BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0082.0050.p         (253 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MA1946 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    69   7e-12
MJ0301 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    65   2e-10
PAB0518 [R] COG1237 Metal-dependent hydrolases of the beta-lacta...    63   5e-10
PH1382 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    59   8e-09

>MA1946 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Mac Methanosarcina acetivorans str.C2A
          Length = 320

 Score = 69.3 bits (168), Expect = 7e-12,   Method: Compositional matrix adjust.
 Identities = 62/205 (30%), Positives = 89/205 (43%), Gaps = 15/205 (7%)

Query: 43  DKLSIRVLVDSSFDLFFKPKQAGGVTIASPPRSADYQKSLHNEWGLSLWLESEAKGAQRT 102
           D+L I VL+D+  D+F          +   P+   + + L  E G S  ++  A   + T
Sbjct: 10  DRLEITVLMDNYTDIFL----IESTDVCRRPQIPFFPQMLFAEHGFSCLIKVWAGNEEHT 65

Query: 103 LMLDYGYTPEVLLNNMALVGVDPAKLDALIVSHGHYDHFGGLNGFLDKFRDKLPADVKLY 162
           +++D   TP  L NN  L+  D  +++A+ +SHGH DHF GL   L KF  K        
Sbjct: 66  VLMDAAVTPANLFNNAELLKADLGRIEAVALSHGHPDHFLGLVDLL-KFVSKEQGKEVPL 124

Query: 163 AGGEDNFCHRVSATPTKGQFSDFGTLDRRQLAAQRVTTVLCETPTVIA-GHAFTTGKITR 221
               D F  R    P  G      +LD   L       +  E  + IA G   TTG+   
Sbjct: 125 VLHPDAFLERRFNIPVIGHPVILPSLDEGDLKGAGADIIKSEKASPIANGLIHTTGE--- 181

Query: 222 RSIERVLPQTDNFIKARPEAKAVVD 246
             +ER +P    F K  P A+A VD
Sbjct: 182 --VERKIP----FEKGFPWAEAKVD 200


>MJ0301 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Mja Methanococcus jannaschii
          Length = 294

 Score = 64.7 bits (156), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 27/81 (33%), Positives = 47/81 (58%)

Query: 76  ADYQKSLHNEWGLSLWLESEAKGAQRTLMLDYGYTPEVLLNNMALVGVDPAKLDALIVSH 135
           A Y     ++ GLS  +E E+ G ++ ++ D     E +L NM L+ ++P  +D +I+SH
Sbjct: 21  AGYNSPFWSQHGLSFLIEVESNGIKKRILFDTATYAEPILFNMKLLNINPKSIDMIILSH 80

Query: 136 GHYDHFGGLNGFLDKFRDKLP 156
            H+DH GGL G + +   ++P
Sbjct: 81  NHFDHTGGLFGIMKEINKEIP 101


>PAB0518 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Pab Pyrococcus abyssi
          Length = 272

 Score = 63.2 bits (152), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 48/154 (31%), Positives = 73/154 (47%), Gaps = 13/154 (8%)

Query: 76  ADYQKSLHNEWGLSLWLESEAKGAQRTLMLDYGYTPEVLLNNMALVGVDPAKLDALIVSH 135
           A Y+K L    G S  +ES        +++D G   +VLLNNM  +G+D   +D L ++H
Sbjct: 16  AGYRKGLIGYHGFSALVESNG----YKVLVDTGTDGKVLLNNMHELGIDANDIDVLFITH 71

Query: 136 GHYDHFGGLNGFLDKFRDKLPADVKLYAGGEDNFCHRVSATPTKGQFSDFGT-LDRRQLA 194
           GHYDH GGL  FL +  +  P +V  + G    F  R++  P K    D G    R++L 
Sbjct: 72  GHYDHTGGLKEFLKERSE--PIEVYAHPG---IFDERIALKPRK---RDIGIPFQRKELE 123

Query: 195 AQRVTTVLCETPTVIAGHAFTTGKITRRSIERVL 228
                  L   P        ++G+I R + +R +
Sbjct: 124 ELGARFNLSPEPLEFLPGFISSGEIKRVTWDRAV 157


>PH1382 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Pho Pyrococcus horikoshii
          Length = 274

 Score = 59.3 bits (142), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 47/153 (30%), Positives = 75/153 (49%), Gaps = 11/153 (7%)

Query: 76  ADYQKSLHNEWGLSLWLESEAKGAQRTLMLDYGYTPEVLLNNMALVGVDPAKLDALIVSH 135
           A Y+K L    G S  +E  A G +  +++D G   +VLLNNM+ +G+ P  +DAL ++H
Sbjct: 18  AGYRKGLIGYHGFSALVE--ANGYR--VLVDTGTDGKVLLNNMSELGISPDDIDALFITH 73

Query: 136 GHYDHFGGLNGFLDKFRDKLPADVKLYAGGEDNFCHRVSATPTKGQFSDFGTLDRRQLAA 195
           GHYDH GGL   L    + L  D+  + G    F  R++  P K +        R +L  
Sbjct: 74  GHYDHTGGLRELLSARTEAL--DIYAHPG---IFKRRLALKPKKREIGI--PFTREELEE 126

Query: 196 QRVTTVLCETPTVIAGHAFTTGKITRRSIERVL 228
                +L +    I     ++G+I R + +R +
Sbjct: 127 LGGKFILSDKSKEILPGFISSGEIERITWDRAV 159