BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0076.0004.p (523 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr8233 [GEPR] COG0477 Permeases of the major facilitator superf... 439 e-123 BMEI0927 [GEPR] COG0477 Permeases of the major facilitator super... 430 e-120 YPO3268 [GEPR] COG0477 Permeases of the major facilitator superf... 248 2e-65 emrB [GEPR] COG0477 Permeases of the major facilitator superfami... 244 4e-64 ECs3548 [GEPR] COG0477 Permeases of the major facilitator superf... 244 4e-64 >mlr8233 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 511 Score = 439 bits (1128), Expect = e-123, Method: Compositional matrix adjust. Identities = 223/492 (45%), Positives = 322/492 (65%), Gaps = 12/492 (2%) Query: 13 RRNMVTICAMTATIMQALDTTIANVALPYMQGSLSASQDQINWVLTSYIVAAAIMTAPVG 72 R ++T+ M AT+MQALDTTIANVALP M G L AS D INWVLTSYIVAAAIMT G Sbjct: 12 HRGLITVALMLATVMQALDTTIANVALPTMTGDLGASPDNINWVLTSYIVAAAIMTPVTG 71 Query: 73 WIANRYGRKRIFIICSAGFTVASVFCGLAQDITQMVLFRLLQGVFGAALVPLSQAVMLDS 132 W+A+R+GRK +F+ GFT+ S+ CGLA + +VLFRL+QGVFGAA+VPLSQ +LD Sbjct: 72 WLADRFGRKELFLTAVVGFTIFSMLCGLAWSLETIVLFRLMQGVFGAAIVPLSQTFLLDI 131 Query: 133 YALHERAKAMSIWGMGVMMGPIMGPSLGAWLTETYSWHWVFFVNLPFGAITVLGLAIFMD 192 +AM+IWG G+M+GPI+GP+LG WLTE ++W WVFF+NLP G + LG+A ++ Sbjct: 132 NPKERHGQAMAIWGAGIMLGPILGPTLGGWLTENFNWRWVFFINLPVGIVAFLGMAAYLP 191 Query: 193 ETKQDLNLRFDWFGFTALAVAIGSLQLALGRGEQLGWLDPIRSSGVTLKAFDDVAAVGAY 252 + + FD+FGF +++ +G+LQL L RG ++ W S V + +A G + Sbjct: 192 AVARRVR-SFDFFGFAMISLGVGALQLMLDRGGEVDWF-----SSVEIWIELGLAITGFW 245 Query: 253 FFFAHSLTTSRPFIQFALFKDKNFLGGCVFMTVMGLVLYSTMALSSPYLQNVIGYPIITA 312 F H++T PFI +F D+NF+ G F+ VMG+++ ++M+L P L + GYP IT Sbjct: 246 VFIIHTMTADHPFIDPKIFLDQNFVTGLAFIFVMGVLILASMSLLPPMLSTIFGYPTITI 305 Query: 313 GLLLASRGVGTFVAMMLVGRMMRYIEARTLIISGLALTAASLFQMTGWTDMTQASEIIVV 372 G+++ RG+GT ++M++VGR+M I+AR L++ G LTA SL+ M +T II Sbjct: 306 GMVIGPRGIGTMISMLVVGRIMGKIDARILVVIGFLLTAHSLYTMASFTPQMDNWLIISS 365 Query: 373 SVIQGFGFGLVFVPLSTVSFLTLPNHLRTDGTSMLTLLRNVASSVGISIVIAQLTEGSRR 432 VIQG G G+VFVPLSTV+F TL RTD T++ +L+RN+ SS+G+S+V L ++ Sbjct: 366 GVIQGLGMGMVFVPLSTVAFATLDARYRTDATALFSLVRNLGSSIGVSVVTVLLVRNTQI 425 Query: 433 IYAKLSEQINPFNHALQM--PDVSGMINLNTDAGRAMADKMVAAQSQIIAFSHDYQLVML 490 +A+LS INPFN L P +G +M D+MV Q+ +I++ +D++++M+ Sbjct: 426 NHAELSAFINPFNPNLWAVSPAAAG----GDPMALSMVDRMVNLQAMMISYVNDFKILMV 481 Query: 491 FILVSIPLAMMI 502 L +IP ++ Sbjct: 482 MTLAAIPFVFLL 493 >BMEI0927 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 472 Score = 430 bits (1106), Expect = e-120, Method: Compositional matrix adjust. Identities = 221/473 (46%), Positives = 325/473 (68%), Gaps = 8/473 (1%) Query: 42 MQGSLSASQDQINWVLTSYIVAAAIMTAPVGWIANRYGRKRIFIICSAGFTVASVFCGLA 101 MQGSL+ + Q+NWVLTSYIVAAAI+T GW+ R+GR+ +FIIC AGF +AS+ CG A Sbjct: 1 MQGSLATTSSQVNWVLTSYIVAAAILTPATGWLEERFGRRPLFIICVAGFVIASMLCGTA 60 Query: 102 QDITQMVLFRLLQGVFGAALVPLSQAVMLDSYALHERAKAMSIWGMGVMMGPIMGPSLGA 161 I QMV++R+LQG FGA +VPL+QAV+LDSY+ R +AM+++G+GVM+GPI+GP+LG Sbjct: 61 TSIEQMVIYRMLQGAFGAPVVPLAQAVLLDSYSARMRGQAMAVFGLGVMLGPILGPTLGG 120 Query: 162 WLTETYSWHWVFFVNLPFGAITVLGLAIFMDETKQDLNLRFDWFGFTALAVAIGSLQLAL 221 WLT+ Y W WVF+VN+P G +T+L F++ K R DW GF L +AI +LQL L Sbjct: 121 WLTQYYDWRWVFYVNVPLGVMTLLLAFGFLEGKKGSSLARLDWLGFATLGLAIAALQLFL 180 Query: 222 GRGEQLGWLDPIRSSGVTLKAFDDVAAVGAYFFFAHSLTTSRPFIQFALFKDKNFLGGCV 281 RGEQL W D +K + +G Y F H++T +PF+ LF D+NF+ G V Sbjct: 181 DRGEQLNWFDSTE-----IKTEFILTILGLYLFIVHTVTARKPFLDKRLFADRNFVMGQV 235 Query: 282 FMTVMGLVLYSTMALSSPYLQNVIGYPIITAGLLLASRGVGTFVAMMLVGRMMRYIEART 341 + V+G VL +T++L +PYL+ ++GY ++ AGL+LA RGVGT VAM+LVGR+ ++ + Sbjct: 236 LIFVIGAVLLATLSLLAPYLERLMGYSVLMAGLVLAPRGVGTMVAMVLVGRLTSVVDIKY 295 Query: 342 LIISGLALTAASLFQMTGWTDMTQASEIIVVSVIQGFGFGLVFVPLSTVSFLTLPNHLRT 401 L+++GLALTA +L QM+ +T S II +IQGFG G VFVPLST++F+TLP L T Sbjct: 296 LLLTGLALTAVALHQMSMFTPDVSQSTIIWSGIIQGFGLGFVFVPLSTITFVTLPADLHT 355 Query: 402 DGTSMLTLLRNVASSVGISIVIAQLTEGSRRIYAKLSEQINPFNHALQMPDVSGMINLNT 461 GT +L+RNV SSVGIS+ L++ + ++A L+ I+P++ A Q S ++L+T Sbjct: 356 QGTGFFSLMRNVGSSVGISVTTFLLSQNAAIVHAGLTNDISPYSRATQ--HFSSAVHLDT 413 Query: 462 DAGRAMADKMVAAQSQIIAFSHDYQLVMLFILVSIPLAMMIGSTKAALRTQSA 514 AG+AM ++++ Q++ IA++ +++L+M ++++PL + TK +T SA Sbjct: 414 LAGKAMLNELITVQAETIAYADNFRLMMYITILTMPLVFFLRHTKPQ-KTSSA 465 >YPO3268 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 511 Score = 248 bits (633), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 151/479 (31%), Positives = 247/479 (51%), Gaps = 18/479 (3%) Query: 17 VTICAMTATIMQALDTTIANVALPYMQGSLSASQDQINWVLTSYIVAAAIMTAPVGWIAN 76 +T+ AT MQ LD+TIANVA+P + G L +S Q WV+TS+ VA AI GW+A Sbjct: 14 MTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAK 73 Query: 77 RYGRKRIFIICSAGFTVASVFCGLAQDITQMVLFRLLQGVFGAALVPLSQAVMLDSYALH 136 R G R+F+ + F +AS CG++ + ++ FR++QG+ L+PLSQ+++L++Y Sbjct: 74 RVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPA 133 Query: 137 ERAKAMSIWGMGVMMGPIMGPSLGAWLTETYSWHWVFFVNLPFGAITVL--GLAIFMDET 194 +R+ A+++W M +++ PI GP LG ++++ Y W W+FF+N+P G + VL G + ET Sbjct: 134 KRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRET 193 Query: 195 KQDLNLRFDWFGFTALAVAIGSLQLALGRGEQLGWLDPIRSSGVTLKAFDDVAAVGAYFF 254 K ++ D G L V IG+LQ+ L +G++L W + +T+ VA V F Sbjct: 194 KTEIR-PIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTV-----VAVVAITFL 247 Query: 255 FAHSLTTSRPFIQFALFKDKNFLGGCVFMTVMGLVLYSTMALSSPYLQNVIGYPIITAGL 314 LT P I +LFK +NF GC+ +++ ++ + + L LQ V GY AGL Sbjct: 248 IVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGL 307 Query: 315 LLASRGVGTFVAMMLVGRMMRYIEARTLIISGLALTAASLFQMTGWTDMTQASEIIV--- 371 A G+ + L+GR I+ R L+ + A + W T + Sbjct: 308 ASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFY----WRAYTFEPGMDFGAS 363 Query: 372 --VSVIQGFGFGLVFVPLSTVSFLTLPNHLRTDGTSMLTLLRNVASSVGISIVIAQLTEG 429 QGF F+PL+T++ LP +S+ +R +A S+G SI T+ Sbjct: 364 AWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQR 423 Query: 430 SRRIYAKLSEQINPFN-HALQMPDVSGMINLNTDAGRAMADKMVAAQSQIIAFSHDYQL 487 +A+L+E +NP+N +A Q + ++ A + + Q II+ + + L Sbjct: 424 ESLHHAQLTEFVNPYNPNATQAYQELEKLGMSQQQASAYLAREITNQGLIISANEIFWL 482 >emrB [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 512 Score = 244 bits (623), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 144/445 (32%), Positives = 230/445 (51%), Gaps = 15/445 (3%) Query: 11 GMRRNMVTICAMTATIMQALDTTIANVALPYMQGSLSASQDQINWVLTSYIVAAAIMTAP 70 G + ++TI AT MQ LD+TIANVA+P + G+L +S Q WV+TS+ VA AI Sbjct: 9 GAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPL 68 Query: 71 VGWIANRYGRKRIFIICSAGFTVASVFCGLAQDITQMVLFRLLQGVFGAALVPLSQAVML 130 GW+A R G ++F+ + F +AS CG++ + ++ FR++QG+ L+PLSQ+++L Sbjct: 69 TGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLL 128 Query: 131 DSYALHERAKAMSIWGMGVMMGPIMGPSLGAWLTETYSWHWVFFVNLPFG-AITVLGLAI 189 ++Y +R+ A+++W M V++ PI GP LG ++++ Y W W+FF+N+P G A+ ++ L Sbjct: 129 NNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQT 188 Query: 190 FMDETKQDLNLRFDWFGFTALAVAIGSLQLALGRGEQLGWLDPIRSSGVTLKAFDDVAAV 249 + R D G L + IGSLQ+ L RG++L W S + VA V Sbjct: 189 LRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWF-----SSQEIIILTVVAVV 243 Query: 250 GAYFFFAHSLTTSRPFIQFALFKDKNFLGGCVFMTVMGLVLYSTMALSSPYLQNVIGYPI 309 F LT P + +LFK +NF GC+ +++ ++ + + L LQ V GY Sbjct: 244 AICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTA 303 Query: 310 ITAGLLLASRGVGTFVAMMLVGRMMRYIEARTLIISGLALTAASLFQMTGWTDMTQASEI 369 AGL A G+ + ++GR ++ R L+ + A + W T + Sbjct: 304 TWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFY----WRAYTFEPGM 359 Query: 370 IV-----VSVIQGFGFGLVFVPLSTVSFLTLPNHLRTDGTSMLTLLRNVASSVGISIVIA 424 IQGF F+PL+T++ LP +S+ R +A S+G SI Sbjct: 360 DFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT 419 Query: 425 QLTEGSRRIYAKLSEQINPFNHALQ 449 T +A+L+E +NPFN Q Sbjct: 420 MWTNRESMHHAQLTESVNPFNPNAQ 444 >ECs3548 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 512 Score = 244 bits (623), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 144/445 (32%), Positives = 230/445 (51%), Gaps = 15/445 (3%) Query: 11 GMRRNMVTICAMTATIMQALDTTIANVALPYMQGSLSASQDQINWVLTSYIVAAAIMTAP 70 G + ++TI AT MQ LD+TIANVA+P + G+L +S Q WV+TS+ VA AI Sbjct: 9 GAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITSFGVANAISIPL 68 Query: 71 VGWIANRYGRKRIFIICSAGFTVASVFCGLAQDITQMVLFRLLQGVFGAALVPLSQAVML 130 GW+A R G ++F+ + F +AS CG++ + ++ FR++QG+ L+PLSQ+++L Sbjct: 69 TGWLAKRVGEVKLFLWSTIAFAIASWACGVSSSLNMLIFFRVIQGIVAGPLIPLSQSLLL 128 Query: 131 DSYALHERAKAMSIWGMGVMMGPIMGPSLGAWLTETYSWHWVFFVNLPFG-AITVLGLAI 189 ++Y +R+ A+++W M V++ PI GP LG ++++ Y W W+FF+N+P G A+ ++ L Sbjct: 129 NNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPIGVAVVLMTLQT 188 Query: 190 FMDETKQDLNLRFDWFGFTALAVAIGSLQLALGRGEQLGWLDPIRSSGVTLKAFDDVAAV 249 + R D G L + IGSLQ+ L RG++L W S + VA V Sbjct: 189 LRGRETRTERRRIDAVGLALLVIGIGSLQIMLDRGKELDWF-----SSQEIIILTVVAVV 243 Query: 250 GAYFFFAHSLTTSRPFIQFALFKDKNFLGGCVFMTVMGLVLYSTMALSSPYLQNVIGYPI 309 F LT P + +LFK +NF GC+ +++ ++ + + L LQ V GY Sbjct: 244 AICFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTA 303 Query: 310 ITAGLLLASRGVGTFVAMMLVGRMMRYIEARTLIISGLALTAASLFQMTGWTDMTQASEI 369 AGL A G+ + ++GR ++ R L+ + A + W T + Sbjct: 304 TWAGLASAPVGIIPVILSPIIGRFAHKLDMRRLVTFSFIMYAVCFY----WRAYTFEPGM 359 Query: 370 IV-----VSVIQGFGFGLVFVPLSTVSFLTLPNHLRTDGTSMLTLLRNVASSVGISIVIA 424 IQGF F+PL+T++ LP +S+ R +A S+G SI Sbjct: 360 DFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERLAAASSLSNFTRTLAGSIGTSITTT 419 Query: 425 QLTEGSRRIYAKLSEQINPFNHALQ 449 T +A+L+E +NPFN Q Sbjct: 420 MWTNRESMHHAQLTESVNPFNPNAQ 444