BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0073.0021.p         (271 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

AGl2211 [R] COG2220 Predicted Zn-dependent hydrolases of the bet...   256   5e-68
SMc03970 [R] COG2220 Predicted Zn-dependent hydrolases of the be...   248   8e-66
TM0207 [R] COG2220 Predicted Zn-dependent hydrolases of the beta...    62   2e-09

>AGl2211 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase
           fold Atu Agrobacterium tumefaciens strain C58 (Cereon)
          Length = 280

 Score =  256 bits (653), Expect = 5e-68,   Method: Compositional matrix adjust.
 Identities = 138/283 (48%), Positives = 185/283 (65%), Gaps = 16/283 (5%)

Query: 1   MLR-LLAALVLLGTFTSHAFAQDAQR---SECLAMA-NAPLRAFP------VNYRRVAAK 49
           MLR L+ A+  L      AF+Q A R   S+C A+A N P   F       V   +  AK
Sbjct: 2   MLRVLMLAMTGLIACAGAAFSQTASRPPVSQCQAIAQNIPGVMFASFNTPGVQLAQATAK 61

Query: 50  ADEVAITYAGHSTYYIDTPGGIRIATDYNGVYRTGRLPDVATMNRAHATHYTLFPDPKIP 109
            +EV I++ GHSTY I++P G+ IATDYNGVYR   +P V TMNRAH+TH+TL PDP I 
Sbjct: 62  -EEVKISFIGHSTYLIESPDGVTIATDYNGVYRPPVMPTVVTMNRAHSTHFTLNPDPAIQ 120

Query: 110 HVLHGWGEN-GQAAHYAERIGDVYIRNVTTDISRYWGEDAGGEMIKDGNSIFIFEVAGLC 168
           +VLHGW +  G+ A +   +GDVYIRNV TDI   WG+    +  ++GNSIFIFEVAGLC
Sbjct: 121 YVLHGWSDTPGEKAEHRVLVGDVYIRNVATDIRNRWGDYESFQ--ENGNSIFIFEVAGLC 178

Query: 169 IGHLGHLHVKLDDSHFAAIGRLDIVMVPIDGTYTMSLDGISEITRRLRAAVVLPMHRFAT 228
           IGHLGHLH +L D+H+A IGRLD++MVP+DG  TM  D +S + +RLR+A++LPMHR   
Sbjct: 179 IGHLGHLHHELTDTHYAEIGRLDVLMVPVDGGLTMGADSMSRVVKRLRSALILPMHRTGP 238

Query: 229 PLDEFMRLIGQQFEIDRRGGERTLRISRDTLPATPTVIILDGV 271
           PL++F+ + G  F I     +  +R+S   LP  P +++  G+
Sbjct: 239 PLEQFLTMFGGSFRI-AYATDPVIRVSMRNLPRQPQILVPKGM 280


>SMc03970 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase
           fold Sme Sinorhizobium meliloti
          Length = 277

 Score =  248 bits (634), Expect = 8e-66,   Method: Compositional matrix adjust.
 Identities = 123/226 (54%), Positives = 163/226 (72%), Gaps = 10/226 (4%)

Query: 47  AAKADEVAITYAGHSTYYIDTPGGIRIATDYNGVYRTGRLPDVATMNRAHATHYTLFPDP 106
           +A   EV IT+ GHST+ I+TPGG+ IATDYNG +RT   P V TMNRAH++HYTL PDP
Sbjct: 61  SADTSEVTITFLGHSTFLIETPGGVSIATDYNGWFRTPSPPTVVTMNRAHSSHYTLAPDP 120

Query: 107 KIPHVLHGWGENGQAAHYAERIGDVYIRNVTTDISRYWGEDAGGE-MIKDGNSIFIFEVA 165
            I HVLHGWG+NG+ A +   +GD YIRNVTTDI       +G E M +DGNSIFIFE+A
Sbjct: 121 AIAHVLHGWGDNGEPADHDLVVGDAYIRNVTTDIR------SGFEGMERDGNSIFIFEIA 174

Query: 166 GLCIGHLGHLHVKLDDSHFAAIGRLDIVMVPIDGTYTMSLDGISEITRRLRAAVVLPMHR 225
           GLCIGHLGHLH +LD+SH+  IGRLD++MVP+DG  TM  + +S +  RLR+A++LPMHR
Sbjct: 175 GLCIGHLGHLHHELDESHYRQIGRLDVLMVPVDGGLTMGAESMSRVVSRLRSALILPMHR 234

Query: 226 FATPLDEFMRLIGQQFEIDRRGGERTLRISRDTLPATPTVIILDGV 271
             T  ++F+ + G  F+  R   E ++++S  +LP+ P + +L GV
Sbjct: 235 PMT--NDFLAMFGDDFD-KRFATEPSVKVSLRSLPSRPLIYVLQGV 277


>TM0207 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase
           fold Tma Thermotoga maritima
          Length = 208

 Score = 61.6 bits (148), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 35/111 (31%), Positives = 59/111 (53%), Gaps = 13/111 (11%)

Query: 157 NSIFIFEVAGLCIGHLGHLHVKLDDSHFAAIGRLDIVMVPIDGTYTMSLDGISEITRRLR 216
           N +F+FE  G+ + HLG L   L  +    IG +D+++VP+ GTYT+      E+   L 
Sbjct: 94  NIVFVFEGEGIKVCHLGDLGHVLTPAQVEEIGEIDVLLVPVGGTYTIGPKEAKEVADLLN 153

Query: 217 AAVVLPMH------RFA-TPLDEFMRL------IGQQFEIDRRGGERTLRI 254
           A V++PMH      +F   P+D+F++L      +G   E+  +  ER + +
Sbjct: 154 AKVIIPMHYKTKYLKFNLLPVDDFLKLFDSYERVGNILELFEKPKERKVVV 204