BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0072.0126.p (556 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEI1143 [R] COG0595 Predicted hydrolase of the metallo-beta-lac... 600 e-171 SMc01929 [R] COG0595 Predicted hydrolase of the metallo-beta-lac... 593 e-169 AGc2368 [R] COG0595 Predicted hydrolase of the metallo-beta-lact... 585 e-167 mll1350 [R] COG0595 Predicted hydrolase of the metallo-beta-lact... 584 e-166 CC1934 [R] COG0595 Predicted hydrolase of the metallo-beta-lacta... 488 e-137 >BMEI1143 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Bme Brucella melitensis Length = 558 Score = 600 bits (1548), Expect = e-171, Method: Compositional matrix adjust. Identities = 284/555 (51%), Positives = 399/555 (71%), Gaps = 3/555 (0%) Query: 1 MARPD--ELTFAPLGGVGEIGMNLSIYGLGNRHQRSFLAVDLGVSFGDEEHLPGIDLIMP 58 MAR + E F PLGGVGEIGMNL++YG G R +L VD+GVSF E PG DLI+P Sbjct: 1 MARSNTTEFVFLPLGGVGEIGMNLAMYGFGPADNREWLVVDMGVSFAGPEQ-PGADLILP 59 Query: 59 DVRFLEKERNNLVGLVLTHAHEDHFGAIIDLWPKLGCKIYATQFSAALFEAKCAAERNPP 118 D+R+LE E++NL G+V+THAHEDHFGA++DLWP+L +YAT F A L EAK +E + P Sbjct: 60 DIRYLEAEKHNLRGIVITHAHEDHFGALLDLWPRLKVPVYATPFIAGLLEAKRQSEDSAP 119 Query: 119 KIPVTVIPSGGRVDIGPFNVEFIPVAHSIPESHALAIKTDVGTVLHTGDWKIDPTPIIGQ 178 +IP+T+ +G ++GPF +E + V HSIPE +LAI T +GTV+HTGDWK+DP P +G Sbjct: 120 EIPITIYKAGETFEVGPFKIEAVAVTHSIPEPVSLAITTPLGTVVHTGDWKMDPEPSLGP 179 Query: 179 PTDERRLRELGDEGVLALVGDSTNAVRDGRSPSETEVAATIKKLVKAAKGRVAVTTFASN 238 DE R R +G+ GVLAL+ DSTNA+R+G SPSE +V ++++L++ A+GRVA+TTF+SN Sbjct: 180 VIDEARFRAIGEAGVLALICDSTNALREGESPSERQVGESLRELIQNARGRVAITTFSSN 239 Query: 239 VARVRAVADAANAADREVVVVGRAMERVVQVARECGYLDGSHKFRSADYYGHFPADKVLA 298 V R+R++ +AA A R+V+VVGR+M+R + VA E GY++G ++ S + YG+ P + V+ Sbjct: 240 VGRIRSITEAARDAGRQVLVVGRSMKRAISVATELGYMEGLPEYLSEEDYGYIPRENVVM 299 Query: 299 LCTGXPGEPRAALARIANDDHPQVTLNKGDTVIFSSRTIPGNEKAVGSIINNLVMQGVEI 358 + TG GEPRAALA++A D+ + L GDTVI+SSR IPGNEKA+ I N L+ +G++I Sbjct: 300 ILTGSQGEPRAALAKLARDEMRSLALTAGDTVIYSSRAIPGNEKAILDIKNRLIDRGIKI 359 Query: 359 ITDREHLVHVSGHPRRDELRDMISWVRPQLLIPVHGEALHLAEHAKLARAAGVPKVLTCR 418 I D + LVHVSGHPRR ELR M SWVRPQ+L+PVHGEA HL L G+ ++ R Sbjct: 360 IGDEDALVHVSGHPRRSELRRMYSWVRPQILVPVHGEAAHLVAQGSLGAMEGIEQIAQVR 419 Query: 419 NGDLVKLGPGEPGIIGEVPAGRLYKDGTILEDAKSRAVVERRRMGFAGCAFVAIAMTEQG 478 +GD+++L PG+ II E P GRLYKDG ++ D + +VERR++ + G V++ + + Sbjct: 420 DGDMLRLAPGKAEIIDEAPVGRLYKDGKLIGDEEEIGMVERRKLAYVGHVAVSVLLDREH 479 Query: 479 ELVDDPEVDLVGMPENNAAGELLDDIVFDVVVSTIEGLPKPRRRDPDALGESVRRAVRAA 538 +++D+P++ G+PE + GEL++DI+ D + I+ +P+ RR+D + + ESVRRAVRAA Sbjct: 480 KMLDEPDLVAFGLPEEDRQGELMEDILLDAAIEAIDSIPRVRRKDIETVRESVRRAVRAA 539 Query: 539 LNEQWGKKPICVVHV 553 NE WGKKP+ V V Sbjct: 540 ANEAWGKKPVVTVFV 554 >SMc01929 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Sme Sinorhizobium meliloti Length = 564 Score = 593 bits (1530), Expect = e-169, Method: Compositional matrix adjust. Identities = 285/556 (51%), Positives = 402/556 (72%), Gaps = 1/556 (0%) Query: 1 MARPDELTFAPLGGVGEIGMNLSIYGLGNRHQRSFLAVDLGVSFGDEEHLPGIDLIMPDV 60 MA+ +EL F PLGGVGEIGMNL +YG G R ++ VD GV+F E LPG+DL++PD+ Sbjct: 10 MAQDEELVFLPLGGVGEIGMNLGLYGYGRPGHRQWIMVDCGVTFPGPE-LPGVDLVLPDI 68 Query: 61 RFLEKERNNLVGLVLTHAHEDHFGAIIDLWPKLGCKIYATQFSAALFEAKCAAERNPPKI 120 FL ++R NL +++THAHEDH+GA+ DLWP L +YA+ F+A + EAK A E++ +I Sbjct: 69 AFLAEQRRNLKAIIITHAHEDHYGALNDLWPGLNVPVYASPFTAGMLEAKRAFEKSRSEI 128 Query: 121 PVTVIPSGGRVDIGPFNVEFIPVAHSIPESHALAIKTDVGTVLHTGDWKIDPTPIIGQPT 180 P+T+ G R+++GPF+VE + V HSIPE AL I+T +GTV+HTGDWKID P +G T Sbjct: 129 PITIFKQGDRINVGPFSVEAVGVNHSIPEPMALVIRTQLGTVVHTGDWKIDLEPSLGPLT 188 Query: 181 DERRLRELGDEGVLALVGDSTNAVRDGRSPSETEVAATIKKLVKAAKGRVAVTTFASNVA 240 DE R R++G+EGVLALV DSTNA+R+G SPSE +V+ ++ K++ A+GRV +TTF+SNV Sbjct: 189 DESRFRQIGEEGVLALVCDSTNALREGVSPSERQVSESLAKIIADAEGRVGITTFSSNVG 248 Query: 241 RVRAVADAANAADREVVVVGRAMERVVQVARECGYLDGSHKFRSADYYGHFPADKVLALC 300 R+R+VA+AA AA REV+++G +M+RVV VAR+ G ++G F + D +G+ P DKV+ + Sbjct: 249 RIRSVAEAAEAAGREVLLLGSSMKRVVDVARDVGLMEGVKPFLAEDEFGYIPRDKVVVIL 308 Query: 301 TGXPGEPRAALARIANDDHPQVTLNKGDTVIFSSRTIPGNEKAVGSIINNLVMQGVEIIT 360 TG GEPRAALA+IA D+ V + GDT++FSSRTIPGNEKA+ I N L+ QG+ IIT Sbjct: 309 TGSQGEPRAALAKIARDEMRNVAFSAGDTIVFSSRTIPGNEKAINDIKNGLIEQGIHIIT 368 Query: 361 DREHLVHVSGHPRRDELRDMISWVRPQLLIPVHGEALHLAEHAKLARAAGVPKVLTCRNG 420 D E LVHVSGHPRR EL+ M WV+PQ+L+PVHGEA HL HA+L +G+P V RNG Sbjct: 369 DSEALVHVSGHPRRTELQQMYQWVKPQILVPVHGEAAHLTAHAELGLQSGIPSVPRLRNG 428 Query: 421 DLVKLGPGEPGIIGEVPAGRLYKDGTILEDAKSRAVVERRRMGFAGCAFVAIAMTEQGEL 480 ++++L PG +I E P GR+YKDGT++ D + + ERR++ FAG V++ + + + Sbjct: 429 EMLRLAPGPAEVIDEAPHGRIYKDGTLIGDFEEMGIGERRKLSFAGHVSVSVVLDSRYDF 488 Query: 481 VDDPEVDLVGMPENNAAGELLDDIVFDVVVSTIEGLPKPRRRDPDALGESVRRAVRAALN 540 + DP+V +G+PE + GE ++D ++D V+ +E +P+ +R+D L E+VRRAVR+ N Sbjct: 489 LGDPDVVPIGLPEFDDEGEAMEDTLYDAVLGAVESIPRAKRKDLAMLQEAVRRAVRSTTN 548 Query: 541 EQWGKKPICVVHVLTV 556 + WGKKP+ V + V Sbjct: 549 QVWGKKPVVTVFITKV 564 >AGc2368 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 579 Score = 585 bits (1508), Expect = e-167, Method: Compositional matrix adjust. Identities = 278/556 (50%), Positives = 396/556 (71%), Gaps = 1/556 (0%) Query: 1 MARPDELTFAPLGGVGEIGMNLSIYGLGNRHQRSFLAVDLGVSFGDEEHLPGIDLIMPDV 60 MA+ DEL F PLGGVGEIGMNL++YG G +R ++ VD GV+F + LPG+DL++PD+ Sbjct: 25 MAKQDELVFVPLGGVGEIGMNLALYGYGPESKRQWIMVDCGVTFAGPD-LPGVDLVLPDI 83 Query: 61 RFLEKERNNLVGLVLTHAHEDHFGAIIDLWPKLGCKIYATQFSAALFEAKCAAERNPPKI 120 ++ +++ NL G+++THAHEDH+GA+ DLWP L +YA+ F+A + EAK A E +I Sbjct: 84 SYIAEQKKNLKGIIITHAHEDHYGAMNDLWPGLNVPVYASPFTAGMLEAKRAYEGTRAEI 143 Query: 121 PVTVIPSGGRVDIGPFNVEFIPVAHSIPESHALAIKTDVGTVLHTGDWKIDPTPIIGQPT 180 PVT+ +G R+++GPF +E + V HSIPE +L I+T +G V+HTGDWKID P +G T Sbjct: 144 PVTIFKAGDRINVGPFEIEAVGVNHSIPEPMSLIIRTPLGNVIHTGDWKIDEAPSLGPLT 203 Query: 181 DERRLRELGDEGVLALVGDSTNAVRDGRSPSETEVAATIKKLVKAAKGRVAVTTFASNVA 240 DE R R +G+EGVLAL+ DSTNA+RDG SPSE EV+ +++++++A+GRVAVTTF+SNV Sbjct: 204 DEARFRAIGEEGVLALMCDSTNALRDGVSPSEHEVSEGLRQIIESAEGRVAVTTFSSNVG 263 Query: 241 RVRAVADAANAADREVVVVGRAMERVVQVARECGYLDGSHKFRSADYYGHFPADKVLALC 300 R+R++A AA AA REV+++G +++RVV V+++ G ++G F + D YG+ P D+V+ + Sbjct: 264 RIRSIAQAAEAAGREVLLLGSSLKRVVNVSQDLGIMEGIKPFLAEDEYGYIPRDRVVVIL 323 Query: 301 TGXPGEPRAALARIANDDHPQVTLNKGDTVIFSSRTIPGNEKAVGSIINNLVMQGVEIIT 360 TG GEPRAALA+++ D+ V L GDTV+FSSR IPGNEKA+ I N L+ QGV I+T Sbjct: 324 TGSQGEPRAALAKLSRDEMRNVALASGDTVVFSSRAIPGNEKAIIEIKNGLIEQGVHIVT 383 Query: 361 DREHLVHVSGHPRRDELRDMISWVRPQLLIPVHGEALHLAEHAKLARAAGVPKVLTCRNG 420 D E LVHVSGHPRR+EL M W +PQ+L+PVHGEA HL +LA AG+ +V RNG Sbjct: 384 DNEALVHVSGHPRRNELLRMYEWTKPQILVPVHGEAAHLVAQKELAEQAGISQVPKVRNG 443 Query: 421 DLVKLGPGEPGIIGEVPAGRLYKDGTILEDAKSRAVVERRRMGFAGCAFVAIAMTEQGEL 480 ++++L PG +I +VP GR++KDG ++ D + RR++ FAG V + + + + Sbjct: 444 NVLRLAPGPAEVINDVPHGRVFKDGNLVGDMDEMGISNRRKLSFAGHVAVNVVLDSRYDF 503 Query: 481 VDDPEVDLVGMPENNAAGELLDDIVFDVVVSTIEGLPKPRRRDPDALGESVRRAVRAALN 540 + DP+V G+PE + E ++D ++D V+ +E +P+ RR+D L ESVRRAVRAA N Sbjct: 504 LGDPDVVPFGLPEFDDEDEAMEDTLYDAVLGAVESIPRARRKDLALLRESVRRAVRAAAN 563 Query: 541 EQWGKKPICVVHVLTV 556 + WGKKPI V V V Sbjct: 564 QSWGKKPIVTVFVTKV 579 >mll1350 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Mlo Mesorhizobium loti Length = 556 Score = 584 bits (1505), Expect = e-166, Method: Compositional matrix adjust. Identities = 279/548 (50%), Positives = 387/548 (70%), Gaps = 1/548 (0%) Query: 6 ELTFAPLGGVGEIGMNLSIYGLGNRHQRSFLAVDLGVSFGDEEHLPGIDLIMPDVRFLEK 65 EL F PLGGVGEIGMN ++YG G R ++ +D+GV+F D H PG+DLI+PD RF+E+ Sbjct: 8 ELVFVPLGGVGEIGMNFALYGYGPPSAREWIVIDVGVTFPDAAH-PGVDLILPDTRFIEE 66 Query: 66 ERNNLVGLVLTHAHEDHFGAIIDLWPKLGCKIYATQFSAALFEAKCAAERNPPKIPVTVI 125 NL G+++THAHEDH+GA++D WPKL ++ T FSA L EAK E+ PKIP+T+ Sbjct: 67 NLANLRGIIITHAHEDHYGALLDTWPKLKAPVWMTPFSAGLLEAKRQGEQGAPKIPLTIY 126 Query: 126 PSGGRVDIGPFNVEFIPVAHSIPESHALAIKTDVGTVLHTGDWKIDPTPIIGQPTDERRL 185 +G + +GPF +E IPVAHSIPE +LAI T GTV+HTGDWKIDP P IG TDE R Sbjct: 127 RAGEKFTVGPFEIEAIPVAHSIPEPMSLAITTPAGTVIHTGDWKIDPEPTIGPKTDEARF 186 Query: 186 RELGDEGVLALVGDSTNAVRDGRSPSETEVAATIKKLVKAAKGRVAVTTFASNVARVRAV 245 R GD+GVLAL+ DSTNA+R+G SPSE V +K ++++A GRVAVTTF+SNV R+ ++ Sbjct: 187 RAYGDKGVLALICDSTNALREGESPSEVAVGEGLKGVIQSAVGRVAVTTFSSNVGRIVSI 246 Query: 246 ADAANAADREVVVVGRAMERVVQVARECGYLDGSHKFRSADYYGHFPADKVLALCTGXPG 305 A AA A R+ +V+GR+++RV+ VA E GY+DG +F + + +G P + ++ +CTG G Sbjct: 247 AKAARDAGRQCLVLGRSLKRVIDVADELGYMDGLPEFIAEEDFGFIPRENLVIICTGSQG 306 Query: 306 EPRAALARIANDDHPQVTLNKGDTVIFSSRTIPGNEKAVGSIINNLVMQGVEIITDREHL 365 EP AALA+++ D+ V+L GDTV+FSSRTIPGNEKA+ I N L+ G++II D + L Sbjct: 307 EPLAALAKLSRDEMKSVSLTAGDTVVFSSRTIPGNEKAILEIKNRLIDLGIKIIEDGDAL 366 Query: 366 VHVSGHPRRDELRDMISWVRPQLLIPVHGEALHLAEHAKLARAAGVPKVLTCRNGDLVKL 425 VHVSGHPRR ELR M WVRPQ+ +PVHGEA HL L +G+ +V R+GD+++L Sbjct: 367 VHVSGHPRRSELRKMYEWVRPQIGVPVHGEAAHLVAQGSLMSTSGIGQVAQVRDGDMLRL 426 Query: 426 GPGEPGIIGEVPAGRLYKDGTILEDAKSRAVVERRRMGFAGCAFVAIAMTEQGELVDDPE 485 PG II +VP GR+YKDG ++ ++ + +RR++ FAG V + + ++ EL DP+ Sbjct: 427 APGPATIIDQVPFGRIYKDGNLIGTDQAMGIRDRRKLSFAGHVAVNVVLDDKYELAGDPD 486 Query: 486 VDLVGMPENNAAGELLDDIVFDVVVSTIEGLPKPRRRDPDALGESVRRAVRAALNEQWGK 545 + +G+ E +A+GE L+D++ D V ++ +P+ RR+D D + E+VRRAVR A NE WGK Sbjct: 487 LVAIGVAEADASGETLEDLMIDAAVGAVDSIPRQRRKDLDLVQEAVRRAVRGAANEAWGK 546 Query: 546 KPICVVHV 553 KP+ V V Sbjct: 547 KPLVTVFV 554 >CC1934 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily Ccr Caulobacter vibrioides Length = 559 Score = 488 bits (1255), Expect = e-137, Method: Compositional matrix adjust. Identities = 255/559 (45%), Positives = 353/559 (63%), Gaps = 7/559 (1%) Query: 2 ARPDELTFAPLGGVGEIGMNLSIYGLGNRHQRSFLAVDLGVSFGDEEHLPGIDLIMPDVR 61 ++ DE F PLGG EIGMN ++YG G H R ++ VDLGV+FGD+ PG+++I+PD Sbjct: 4 SKNDEFVFLPLGGSNEIGMNFNLYGFGPAHDRKWIVVDLGVTFGDQT-TPGVEIILPDPS 62 Query: 62 FLEKERNNLVGLVLTHAHEDHFGAIIDLWPKLGCKIYATQFSAALFEAKCAAERNPPKIP 121 ++E ++++G+VLTHAHEDH GA+ LWP+L ++AT F+A L K ++ Sbjct: 63 YIEPYADDILGIVLTHAHEDHLGAVHWLWPRLKAPVFATPFTAFLLREKLRDADLLGEVE 122 Query: 122 VTVIPSGGRVDIGPFNVEFIPVAHSIPESHALAIKTDVGTVLHTGDWKIDPTPIIGQPTD 181 +T +P GG +GPF +E I + HSIPE + LAIKT +GTVLHTGDWKIDP P +G PTD Sbjct: 123 ITEVPLGGSFKLGPFELELITLTHSIPEPNGLAIKTPLGTVLHTGDWKIDPDPQLGAPTD 182 Query: 182 ERRLRELGDEGVLALVGDSTNAVRDGRSPSETEVAATIKKLVKAAKGRVAVTTFASNVAR 241 E +R LGDEGVLA+V DSTN ++G + SE +V + L+K+ G++AV FASNVAR Sbjct: 183 EAAIRRLGDEGVLAMVCDSTNVFQEGSAGSEADVRTALGDLIKSLNGKIAVACFASNVAR 242 Query: 242 VRAVADAANAADREVVVVGRAMERVVQVARECGYLDGSHKFRSADYYGHFPADKVLALCT 301 + V AA A R+V + GR+M R+ AR G L+G F + D H P ++VL LCT Sbjct: 243 MDTVIRAAQACGRKVSLAGRSMHRMAAAARSVGLLEGLEPFINDDQAKHLPENEVLYLCT 302 Query: 302 GXPGEPRAALARIANDDHPQVTLNKGDTVIFSSRTIPGNEKAVGSIINNLVMQGVEIITD 361 G GE RAAL+RIA+ HP V + GD VIFSSR IPGNE + ++ N L +GV + T+ Sbjct: 303 GSQGEARAALSRIADGSHPHVKMGSGDHVIFSSRVIPGNEIPIRNLQNKLADRGVRLHTE 362 Query: 362 REHL-VHVSGHPRRDELRDMISWVRPQLLIPVHGEALHLAEHAKLARAAGVPKVLTCRNG 420 R+ +HVSGHP RDELR M +WVRP + +P HGE HL EHA LA+ VP ++ RNG Sbjct: 363 RDTPGIHVSGHPCRDELRQMYAWVRPHIAVPTHGERRHLIEHAALAKDLQVPHAVSPRNG 422 Query: 421 DLVKLGPGEPGIIGEVPAGRLYKDGTILEDAKSRAVVERRRMGFAGCAFVAIAMTEQGEL 480 D+V L PG+PGII EVPAGRLY DG ++ A+ ERR F G V+I + + ++ Sbjct: 423 DMVLLAPGQPGIIDEVPAGRLYVDGGVVTPENGEALRERRHAAFNGVLAVSIVLDGRNKI 482 Query: 481 VDDPEVDLVGMPENNAAGELLDDIVFDVV---VSTIEGLPKPRRRDPDALGESVRRAVRA 537 V P++ +G+ ++ LDD + D+ S + L R + + ++ RAV+ Sbjct: 483 VSGPQIRGIGLTGDDEY--TLDDALDDLCEEAESAYKKLDGDAREIDETIESAISRAVKK 540 Query: 538 ALNEQWGKKPICVVHVLTV 556 A W +KP+ VL + Sbjct: 541 AAFRIWERKPVVETTVLRI 559