BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0072.0025.p (355 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO3862 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Ype Yersinia ... 466 e-131 CC3629 Non COG 459 e-129 STM2097 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Sty Salmonell... 458 e-129 NMB0079 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Nme Neisseria... 457 e-128 NMB0063 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Nme Neisseria... 457 e-128 >YPO3862 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Ype Yersinia pestis Length = 355 Score = 466 bits (1200), Expect = e-131, Method: Compositional matrix adjust. Identities = 225/351 (64%), Positives = 269/351 (76%), Gaps = 4/351 (1%) Query: 8 IFVTGGAGFIGSAVVRHLLRDTHARVVNIDKLTYAANLASLPRAAESLNYTFEKACICEA 67 I VTGGAGFIGSAVVRH++ T VV +DKLTYA NL SL A S Y FE+ IC++ Sbjct: 4 ILVTGGAGFIGSAVVRHIIDGTSDSVVVVDKLTYAGNLESLSVVAGSERYAFEQVDICDS 63 Query: 68 QNLRRLFEKYQPDAVMNLAAESHVDRSIDGPGEFIQTNIVGTFTILQETLRHWRTLSPEK 127 L R+F +YQP+ VM+LAAESHVDRSIDGP FI+TN+VGT+T+L+ +W+ LS E Sbjct: 64 SELDRVFAQYQPNVVMHLAAESHVDRSIDGPAAFIETNVVGTYTLLEAARHYWQQLSVEA 123 Query: 128 RDRFRFLHISTDEVFGSL-GDEGLFTETTAYAPNSPYSASKASSDHLVRAWRETYELPTL 186 + FRF HISTDEV+G L G + LFTETT YAP+SPYSASKASSDHLVRAW TY LPTL Sbjct: 124 KQAFRFHHISTDEVYGDLHGTDDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTL 183 Query: 187 VTNCSNNYGPYHFPEKLIPHMIIKGLAGEPLPVYGDGKNIRDWLFVEDHAKALTLVLERG 246 VTNCSNNYGPYHFPEKLIP +I+ LAG+PLPVYG+G +RDWL+VEDHA+AL V+ G Sbjct: 184 VTNCSNNYGPYHFPEKLIPLVILNALAGKPLPVYGNGAQVRDWLYVEDHARALYQVVTEG 243 Query: 247 EVGETYNVGGRNERTNLHVVESICDLLDEVV---PAAAGPRRQLINFVADRPGHDRRYAI 303 VGETYN+GG NER N+ VVE+IC LLDE+V PA R LI +V DRPGHD RYAI Sbjct: 244 VVGETYNIGGHNERKNIEVVETICALLDELVPAKPAGIAHYRDLITYVKDRPGHDMRYAI 303 Query: 304 DATKLETELGWRAEENFETGIAKTVRWYVDEQPWWRSILEGGYKVERVGLN 354 DA K+E ELGWR +E FE+GI KTV WY++ + WWR + +G Y ER+GL+ Sbjct: 304 DAGKIERELGWRPQETFESGIRKTVLWYLNNESWWRRVQDGSYAGERLGLS 354 >CC3629 Non COG Length = 356 Score = 459 bits (1182), Expect = e-129, Method: Compositional matrix adjust. Identities = 218/348 (62%), Positives = 264/348 (75%), Gaps = 1/348 (0%) Query: 8 IFVTGGAGFIGSAVVRHLLRDTHARVVNIDKLTYAANLASLPRAAESLNYTFEKACICEA 67 + VTGG+GFIGSAV RHL + ++N DKLTYAA+ ASL +Y F + + +A Sbjct: 8 VMVTGGSGFIGSAVCRHLAGQNNVAILNYDKLTYAASQASLAMLEGKADYQFVQGDVADA 67 Query: 68 QNLRRLFEKYQPDAVMNLAAESHVDRSIDGPGEFIQTNIVGTFTILQETLRHWRTLSPEK 127 + + ++PD VM+LAAESHVDRSI GPG+FIQTNIVGT+ +LQ L HWR L E Sbjct: 68 ARVCATIKAFRPDVVMHLAAESHVDRSITGPGDFIQTNIVGTYVMLQAALEHWRGLEGEA 127 Query: 128 RDRFRFLHISTDEVFGSLGDEGLFTETTAYAPNSPYSASKASSDHLVRAWRETYELPTLV 187 + RFRF HISTDEVFGSLG EGLF+ETT Y P SPYSASKASSDHL RAW+ TY LP +V Sbjct: 128 KGRFRFHHISTDEVFGSLGAEGLFSETTPYDPRSPYSASKASSDHLARAWQHTYGLPVVV 187 Query: 188 TNCSNNYGPYHFPEKLIPHMIIKGLAGEPLPVYGDGKNIRDWLFVEDHAKALTLVLERGE 247 +NCSNNYGPYHFPEKLIP + + L G+PLPVYG G N+RDWL VEDHA+AL L+ +G Sbjct: 188 SNCSNNYGPYHFPEKLIPLVTLNALEGKPLPVYGKGDNVRDWLHVEDHARALHLIATKGV 247 Query: 248 VGETYNVGGRNERTNLHVVESICDLLDEVVPAAAGPRRQLINFVADRPGHDRRYAIDATK 307 GE+YNVGGRNERTNL VVE+ICD+LDE+ P RR LI FVADRPGHD RYAIDATK Sbjct: 248 PGESYNVGGRNERTNLQVVEAICDILDELRPIPGQSRRDLITFVADRPGHDARYAIDATK 307 Query: 308 LETELGWRAEENFETGIAKTVRWYVDEQPWWRSILEGGYKVERVGLNQ 355 LETELGW A+E F+TG+ KT++WY+D + WW + E Y +R+GL++ Sbjct: 308 LETELGWTAQETFDTGLRKTIQWYLDNEAWWAPLRE-RYAGQRLGLSK 354 >STM2097 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Sty Salmonella typhimurium LT2 Length = 361 Score = 458 bits (1179), Expect = e-129, Method: Compositional matrix adjust. Identities = 221/349 (63%), Positives = 266/349 (76%), Gaps = 10/349 (2%) Query: 8 IFVTGGAGFIGSAVVRHLLRDTHARVVNIDKLTYAANLASLPRAAESLNYTFEKACICEA 67 I +TGGAGFIGSAVVRH++++T VVNIDKLTYA NL SL +ES Y FE A IC++ Sbjct: 3 ILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADICDS 62 Query: 68 QNLRRLFEKYQPDAVMNLAAESHVDRSIDGPGEFIQTNIVGTFTILQETLRHWRTLSPEK 127 + R+FE+YQPDAVM+LAAESHVDRSI GP FI+TNIVGT+ +L+ ++W L +K Sbjct: 63 AEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALGEDK 122 Query: 128 RDRFRFLHISTDEVFGSLG--DE-------GLFTETTAYAPNSPYSASKASSDHLVRAWR 178 ++ FRF HISTDEV+G L DE LFTETTAYAP+SPYSASKASSDHLVRAWR Sbjct: 123 KNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWR 182 Query: 179 ETYELPTLVTNCSNNYGPYHFPEKLIPHMIIKGLAGEPLPVYGDGKNIRDWLFVEDHAKA 238 TY LPT+VTNCSNNYGPYHFPEKLIP +I+ L G+PLP+YG G IRDWL+VEDHA+A Sbjct: 183 RTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARA 242 Query: 239 LTLVLERGEVGETYNVGGRNERTNLHVVESICDLLDEVVPAAAGPRRQLINFVADRPGHD 298 L +V+ G+ GETYN+GG NE+ NL VV +ICDLLDE+VP A R Q I +VADRPGHD Sbjct: 243 LHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQ-ITYVADRPGHD 301 Query: 299 RRYAIDATKLETELGWRAEENFETGIAKTVRWYVDEQPWWRSILEGGYK 347 RRYAIDA K+ ELGW+ E FE+GI KTV WY+ W ++ G Y+ Sbjct: 302 RRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQWVNNVKSGAYQ 350 >NMB0079 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Nme Neisseria meningitidis MC58 Length = 355 Score = 457 bits (1176), Expect = e-128, Method: Compositional matrix adjust. Identities = 218/349 (62%), Positives = 266/349 (76%), Gaps = 4/349 (1%) Query: 8 IFVTGGAGFIGSAVVRHLLRDTHARVVNIDKLTYAANLASLPRAAESLNYTFEKACICEA 67 I VTGGAGFIGSAVVRH++R+T VVN+DKLTYA NL SL A++ Y FE+ IC+ Sbjct: 4 ILVTGGAGFIGSAVVRHIIRNTRDAVVNVDKLTYAGNLESLTEVADNPRYAFEQVDICDR 63 Query: 68 QNLRRLFEKYQPDAVMNLAAESHVDRSIDGPGEFIQTNIVGTFTILQETLRHWRTLSPEK 127 L R+F +Y+PDAVM+LAAESHVDRSI GEFIQTNIVGTF +L+ +W+ + E+ Sbjct: 64 AELDRVFAQYRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPSEQ 123 Query: 128 RDRFRFLHISTDEVFGSLG-DEGLFTETTAYAPNSPYSASKASSDHLVRAWRETYELPTL 186 + FRF HISTDEV+G LG + LFTET YAP+SPYSASKASSDHLVRAW TY LPT+ Sbjct: 124 HEAFRFHHISTDEVYGDLGGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGLPTI 183 Query: 187 VTNCSNNYGPYHFPEKLIPHMIIKGLAGEPLPVYGDGKNIRDWLFVEDHAKALTLVLERG 246 VTNCSNNYGPYHFPEKLIP MI+ L G+PLPVYGDG IRDWLFVEDHA+AL V+ G Sbjct: 184 VTNCSNNYGPYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVVTEG 243 Query: 247 EVGETYNVGGRNERTNLHVVESICDLLDEVV---PAAAGPRRQLINFVADRPGHDRRYAI 303 VGETYN+GG NE+ N+ VV++IC LL+E+ PA LI FV DRPGHD RYA+ Sbjct: 244 VVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDVRYAV 303 Query: 304 DATKLETELGWRAEENFETGIAKTVRWYVDEQPWWRSILEGGYKVERVG 352 DA K+ +LGW E FE+G+ KTV+WY+D + WW+++L G Y++ER+G Sbjct: 304 DAAKIRRDLGWLPLETFESGLRKTVQWYLDNKTWWQNVLNGSYRLERLG 352 >NMB0063 [M] COG1088 dTDP-D-glucose 4,6-dehydratase Nme Neisseria meningitidis MC58 Length = 355 Score = 457 bits (1176), Expect = e-128, Method: Compositional matrix adjust. Identities = 218/349 (62%), Positives = 266/349 (76%), Gaps = 4/349 (1%) Query: 8 IFVTGGAGFIGSAVVRHLLRDTHARVVNIDKLTYAANLASLPRAAESLNYTFEKACICEA 67 I VTGGAGFIGSAVVRH++R+T VVN+DKLTYA NL SL A++ Y FE+ IC+ Sbjct: 4 ILVTGGAGFIGSAVVRHIIRNTRDAVVNVDKLTYAGNLESLTEVADNPRYAFEQVDICDR 63 Query: 68 QNLRRLFEKYQPDAVMNLAAESHVDRSIDGPGEFIQTNIVGTFTILQETLRHWRTLSPEK 127 L R+F +Y+PDAVM+LAAESHVDRSI GEFIQTNIVGTF +L+ +W+ + E+ Sbjct: 64 AELDRVFAQYRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPSEQ 123 Query: 128 RDRFRFLHISTDEVFGSLG-DEGLFTETTAYAPNSPYSASKASSDHLVRAWRETYELPTL 186 + FRF HISTDEV+G LG + LFTET YAP+SPYSASKASSDHLVRAW TY LPT+ Sbjct: 124 HEAFRFHHISTDEVYGDLGGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGLPTI 183 Query: 187 VTNCSNNYGPYHFPEKLIPHMIIKGLAGEPLPVYGDGKNIRDWLFVEDHAKALTLVLERG 246 VTNCSNNYGPYHFPEKLIP MI+ L G+PLPVYGDG IRDWLFVEDHA+AL V+ G Sbjct: 184 VTNCSNNYGPYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVVTEG 243 Query: 247 EVGETYNVGGRNERTNLHVVESICDLLDEVV---PAAAGPRRQLINFVADRPGHDRRYAI 303 VGETYN+GG NE+ N+ VV++IC LL+E+ PA LI FV DRPGHD RYA+ Sbjct: 244 VVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDVRYAV 303 Query: 304 DATKLETELGWRAEENFETGIAKTVRWYVDEQPWWRSILEGGYKVERVG 352 DA K+ +LGW E FE+G+ KTV+WY+D + WW+++L G Y++ER+G Sbjct: 304 DAAKIRRDLGWLPLETFESGLRKTVQWYLDNKTWWQNVLNGSYRLERLG 352