BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0070.0038.p (307 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1607 [GER] COG0697 Permeases of the drug/metabolite transport... 105 9e-23 SMb20885 [GER] COG0697 Permeases of the drug/metabolite transpor... 88 2e-17 BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transport... 85 2e-16 AF0266 [GER] COG0697 Permeases of the drug/metabolite transporte... 84 5e-16 PA4783 [GER] COG0697 Permeases of the drug/metabolite transporte... 79 1e-14 >RSc1607 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 307 Score = 105 bits (263), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 96/287 (33%), Positives = 139/287 (48%), Gaps = 16/287 (5%) Query: 23 LFCLLWSYAFVAGKIGVTDCPPLILLAARFSLAGVLILAISWLRR---------DQWDLS 73 LF L+WS FV K G+ P+ L RF V +L + W+ R D + Sbjct: 24 LFVLIWSTGFVVAKFGMPYAEPITFLFLRFVGVLVCLLPLVWVARVPLPRRAGADADAVD 83 Query: 74 WRDAAVFAVLGVANNALYLGLGYTGLKT-VSAGLGALIVSANPVFTAMLAALFLGESMTL 132 WR AV GV YLG + +K + AG+ ALIV P+ TA+ ++ GE ++ Sbjct: 84 WRTIGHLAVAGVLMQWGYLGGVWEAIKLGMPAGMSALIVGMQPILTALYVSM-RGERVSP 142 Query: 133 RKVIGLVLGIVGVALIVWHRMSVGSDSPHGILFTLASLASIVAGTVLFKLLAPKGSLWIG 192 R+ +GL+ GI GV L+V +++ + + + F + +L SI AGT+ K P L +G Sbjct: 143 RQWLGLLFGIAGVGLVVANKLHLAGVNVTTLGFCVGALLSITAGTLYQKRFCPVFDLRMG 202 Query: 193 NGIQNIAGGLAVMP--FAFTLSSVSDIVPSIRLAGAFTFLVLGGSILAYLLWFHLLKVCG 250 IQ A L +P FAF +V P I GA + VL SI A L F L++ Sbjct: 203 ACIQFGASALLCLPFMFAFETRAVQWTGPMI---GALVWSVLALSIGAISLLFMLIRQGA 259 Query: 251 ATAASAYHFLMPPLGMLFAYLVLGEHVEFRDLLGIVPVALGIYLVTR 297 AT ++ +L PP A+ + GE LG+V A G+ LV R Sbjct: 260 ATKVTSLLYLTPPTTAAMAWALFGERFPPLAALGMVIAACGVALVIR 306 >SMb20885 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 306 Score = 88.2 bits (217), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 137/285 (48%), Gaps = 7/285 (2%) Query: 22 ALFCLLWSYAFVAGKIGVTDCPPLILLAARFSLAGVLILAISWLRRDQWDLSWRDAAVFA 81 A+F LLWS +V K PLI LA R+S A +L + L +W S Sbjct: 8 AIFVLLWSTGWVVAKYAAIFADPLIFLALRYSFAILLFIGFCLLSGARWPRSATAIGHAV 67 Query: 82 VLGVANNALYLGLGYTGL-KTVSAGLGALIVSANPVFTAMLAALFLGESMTLRKVIGLVL 140 V G+ + LYLG + + + V A + +I P+ TA +A +GE + ++ +GL+L Sbjct: 68 VSGIFLHGLYLGAVWWAIGQGVPAAISGIIAGLQPLMTAAVAPWLIGEKLAGQQKLGLIL 127 Query: 141 GIVGVALIVWHRM-SVGSDSPHGILFTLA----SLASIVAGTVLFKLLAPKGSLWIGNGI 195 G G+AL V +M ++ + + L LA +A++ GT+ K G + + Sbjct: 128 GFCGIALAVAPKMLTIDATATPIHLLPLAVNVLGMAAVTYGTLYQKRYLQTGDIRSIAAL 187 Query: 196 QNIAGGLAVMPFAFTLSSVSDIVPSIRLAGAFTFLVLGGSILAYLLWFHLLKVCGATAAS 255 Q + L +P A L + + +I L A + VLG S+ A L +L++ + A+ Sbjct: 188 QYVGALLVTIPLALMLEDL-RVTWNIELVAALAWSVLGLSMGAIALLLYLIRRGQVSRAA 246 Query: 256 AYHFLMPPLGMLFAYLVLGEHVEFRDLLGIVPVALGIYLVTRPAA 300 + +L+PPL A L GE + + ++G V G+YL R AA Sbjct: 247 SLIYLVPPLAAGEAALFFGEALTWPMIIGTVIAVTGVYLTNRKAA 291 >BS_yoaV [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 292 Score = 85.1 bits (209), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 1/272 (0%) Query: 26 LLWSYAFVAGKIGVTDCPPLILLAARFSLAGVLILAISWLRRDQWDLSWRDAAVFAVLGV 85 L+W Y +VA K+G+ D PPL+ R + V + I +++R + + + ++ + Sbjct: 13 LIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAVPLFLILFIQRKKLSIQKEHLKSYIIMSL 72 Query: 86 ANNALYLGLGYTGLKTVSAGLGALIVSANPVFTAMLAALFLGESMTLRKVIGLVLGIVGV 145 Y+G+ G++ V +G +++V P+F +++ L E M + K +GLV G+ G+ Sbjct: 73 LMGLGYMGILTYGMQFVDSGKTSVLVYTMPIFVTVISHFSLNEKMNVYKTMGLVCGLFGL 132 Query: 146 ALIVWHRM-SVGSDSPHGILFTLASLASIVAGTVLFKLLAPKGSLWIGNGIQNIAGGLAV 204 I M ++ + G L L + S V KL + N + G + + Sbjct: 133 LFIFGKEMLNIDQSALFGELCVLVAALSWGIANVFSKLQFKHIDIIHMNAWHLMMGAVML 192 Query: 205 MPFAFTLSSVSDIVPSIRLAGAFTFLVLGGSILAYLLWFHLLKVCGATAASAYHFLMPPL 264 + F+F +V + + + F L + +++WF +L A+ AS +P L Sbjct: 193 LVFSFIFEAVPSAEWTYQAVWSLLFNGLLSTGFTFVVWFWVLNQIQASKASMALMFVPVL 252 Query: 265 GMLFAYLVLGEHVEFRDLLGIVPVALGIYLVT 296 + F +L L E + +LG + + GI++ T Sbjct: 253 ALFFGWLQLHEQITINIILGALLICCGIFMNT 284 >AF0266 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Afu Archaeoglobus fulgidus Length = 276 Score = 83.6 bits (205), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 77/282 (27%), Positives = 138/282 (48%), Gaps = 15/282 (5%) Query: 19 LLIALFCLLWSYAFVAGKIGVTDCPPLILLAARFSLAGVLILAISWLRRDQWDLSWRD-A 77 +++AL W AF A K V P+ + + RF++A L I L + + W+D Sbjct: 5 IVLALTVTFWGLAFTAIKYSVRFLSPIAIASLRFAIANTLFAVIIILGKR---IKWKDLP 61 Query: 78 AVFA--VLGVANNALYLGLGYTGLKTVSAGLGALIVSANPVFTAMLAALFLGESMTLRKV 135 VFA + GV+ ++L LG +S+G+ ++++S P+F +L+A+FL E +T KV Sbjct: 62 KVFALGIFGVSVYHVFLNLGEV---YISSGVASVVISLAPIFVLILSAIFLRERITYSKV 118 Query: 136 IGLVLGIVGVALIVWHRMSVGSDSPHGILFTLASLASIVAGTVLFKLLAPKGSLWIGNGI 195 +G+++ +GV +I + + +GI + S + T K L K + Sbjct: 119 VGIIIAFLGVVVISEPSYA----NIYGIALVMVSTVAAAIYTTFGKSLLSKYNPITLTSN 174 Query: 196 QNIAGGLAVMPFAFTLSSVSDIVPSIRLAGAFTFLVLGGSILAYLLWFHLLKVCGATAAS 255 + G + + P F S+ + + L G+ FL + + YL W++ L+ A+ AS Sbjct: 175 AMVLGSIPLYP--FLPDSIRSLGGDLNLIGSIVFLGIFSTFFGYLGWYYFLEKEEASRAS 232 Query: 256 AYHFLMPPLGMLFAYLVLGEHVEFRDLLGIVPVALGIYLVTR 297 + +P + +L ++L E + R + G V LGIY+V R Sbjct: 233 VFLLAIPVVSLLAGNILLAEPLTLRTVAGSGLVLLGIYIVVR 274 >PA4783 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 79.3 bits (194), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 89/305 (29%), Positives = 152/305 (49%), Gaps = 28/305 (9%) Query: 15 NTLPLLI--ALFCL--LWSYAFVAGKIGVTDCPPLILLAARFSLAGVLILAISWLRRDQW 70 LPLL+ A F L +W ++A + GV PP+++ RF +AG L+ A WLR Sbjct: 4 RRLPLLLFGAFFALYFIWGSTYLAIRFGVESWPPMLMAGVRFVIAGGLMFA--WLRWRGA 61 Query: 71 DL-SWRDAAVFAVLGVANNALYLGLGYTGLKT-----VSAGLGALIVSANPVFTAMLAAL 124 L +WR+ V+G+ L L G G+ VS+G+ AL V+ P+FT + + L Sbjct: 62 PLPTWREWRGAGVVGI----LLLSCGNGGVTVAEHWGVSSGVAALAVATVPLFTLLFSQL 117 Query: 125 FLGESMTLRKVIGLVLGIVGVALIVWHRMSVGSD---SPHGILFTLASLASIVAGTVLFK 181 F G+ T + G+VLG+ G+ L +++GS+ SP G L + AS G+V + Sbjct: 118 F-GQRNTTLEWGGIVLGLFGIVL-----LNLGSNLQASPAGAGLILFAAASWAFGSVWSR 171 Query: 182 LLA-PKGSLWIGNGIQNIAGGLAVMPFAFTLSSVSDIVPSIRLAGAFTFLVLGGSILAYL 240 L+ P G + + + + GG ++ + + PS A +L+L GSI+A+ Sbjct: 172 RLSLPAGPM--ASAAEMLVGGAVLLVGSLASGERLEHWPSTSGWLALVYLILFGSIIAFS 229 Query: 241 LWFHLLKVCGATAASAYHFLMPPLGMLFAYLVLGEHVEFRDLLGIVPVALGIYLVTRPAA 300 + +LL+ AA++Y ++ P + +L L GE + + L ++ + + L+ P Sbjct: 230 AYQYLLRNVRPAAATSYAYVNPAVAVLLGTLFAGERIGGIEGLAMLVIISAVVLIGLPQW 289 Query: 301 PTSRS 305 SR+ Sbjct: 290 RASRA 294