BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0068.0018.p (456 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VCA0683 [T] COG3851 Signal transduction histidine kinase, glucos... 106 1e-22 Z0462 [T] COG3851 Signal transduction histidine kinase, glucose-... 104 4e-22 ECs0417 [T] COG3851 Signal transduction histidine kinase, glucos... 104 4e-22 STM3789 [T] COG3851 Signal transduction histidine kinase, glucos... 91 4e-18 uhpB [T] COG3851 Signal transduction histidine kinase, glucose-6... 91 6e-18 >VCA0683 [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific Vch Vibrio cholerae Length = 527 Score = 106 bits (264), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/243 (31%), Positives = 123/243 (50%), Gaps = 15/243 (6%) Query: 213 RSMELAMIGRAVSDLGDRLALAEEERTVLTRRLLEIRNDERRTLARELHDEFGQNLTAIL 272 R +LA++ + + RLA E+ L R+L+ + R+++ARELHDE GQN+TAI Sbjct: 283 RQHQLALL---LQKMNTRLAKELREKQDLARQLVSVEEQIRKSVARELHDEIGQNITAI- 338 Query: 273 AFANTIEASAGDKYAAGTEIAQDARMISQATRRIMACLRDTLNRLRHPPAEELGLEASLV 332 I++ ++ A+ + Q A + RI R L +LR +ELGLE ++ Sbjct: 339 ----QIQSMLAERLASNDQAKQAASSVQSLAMRIHQSTRQLLKQLRPHILDELGLEHAIR 394 Query: 333 DLVDSWRSRTVQPMIQLDLQGDLADISGTVAATAYRVAQECLTNALRHSSAREIVLRIER 392 LV R ++L++ + + T T YR+ QE L N +H+ A + I Sbjct: 395 QLVQEMRFAEQGMTVRLNMGVNPQKLDDTTRVTLYRIVQELLNNICKHAKATRV--HISL 452 Query: 393 RTGSENALLVRVEDDGGGDAAKVAQSAGFGLTGVSERVTALGGSLSIARAS--RGLSVAA 450 GSE +++ V+DDG G + G GL G+SERV+ALGG L + ++ G + Sbjct: 453 FPGSE--MVLEVKDDGIGLPTD-WRVRGHGLKGLSERVSALGGQLKMTSSTFQTGTRIIV 509 Query: 451 TIP 453 +P Sbjct: 510 NLP 512 >Z0462 [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific EcZ Escherichia coli O157:H7 EDL933 Length = 513 Score = 104 bits (259), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 72/210 (34%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 244 RLLEIRNDERRTLARELHDEFGQNLTAILAFANTIEASAGDKYAAGTEIAQDARMISQAT 303 +L+ D R+ LARELHDE GQN+TAI I++ + +I A I++ Sbjct: 307 KLIHTEEDTRKNLARELHDEIGQNITAI-----QIQSQLVKRARDPAQIQSAASQINELA 361 Query: 304 RRIMACLRDTLNRLRHPPAEELGLEASLVDLVDSWRSRTVQPMIQLDLQGDLADISGTVA 363 RRI R L +LR P +EL +L+ L++ + Q Q + + TV Sbjct: 362 RRIHLSTRQLLRQLRPPALDELTFREALLHLINEFAFSERGIHCQFAYQLNSTPENETVR 421 Query: 364 ATAYRVAQECLTNALRHSSAREIVLRIERRTGSENALLVRVEDDGGGDAAKVAQSAGFGL 423 T YR+ QE L N +H+ A E+ + I R+ G L + V D+G G A+ + AGFG+ Sbjct: 422 FTLYRLLQELLNNICKHAEASEVTI-ILRQQGE--VLHLEVSDNGVGIAS--GKMAGFGI 476 Query: 424 TGVSERVTALGGSLSIARASRGLSVAATIP 453 G+ ERV+ALGG L++ + G V +P Sbjct: 477 QGMRERVSALGGDLTLEK-QHGTRVIVNLP 505 >ECs0417 [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific Ecs Escherichia coli O157:H7 Length = 513 Score = 104 bits (259), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 72/210 (34%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 244 RLLEIRNDERRTLARELHDEFGQNLTAILAFANTIEASAGDKYAAGTEIAQDARMISQAT 303 +L+ D R+ LARELHDE GQN+TAI I++ + +I A I++ Sbjct: 307 KLIHTEEDTRKNLARELHDEIGQNITAI-----QIQSQLVKRARDPAQIQSAASQINELA 361 Query: 304 RRIMACLRDTLNRLRHPPAEELGLEASLVDLVDSWRSRTVQPMIQLDLQGDLADISGTVA 363 RRI R L +LR P +EL +L+ L++ + Q Q + + TV Sbjct: 362 RRIHLSTRQLLRQLRPPALDELTFREALLHLINEFAFSERGIHCQFAYQLNSTPENETVR 421 Query: 364 ATAYRVAQECLTNALRHSSAREIVLRIERRTGSENALLVRVEDDGGGDAAKVAQSAGFGL 423 T YR+ QE L N +H+ A E+ + I R+ G L + V D+G G A+ + AGFG+ Sbjct: 422 FTLYRLLQELLNNICKHAEASEVTI-ILRQQGE--VLHLEVSDNGVGIAS--GKMAGFGI 476 Query: 424 TGVSERVTALGGSLSIARASRGLSVAATIP 453 G+ ERV+ALGG L++ + G V +P Sbjct: 477 QGMRERVSALGGDLTLEK-QHGTRVIVNLP 505 >STM3789 [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific Sty Salmonella typhimurium LT2 Length = 500 Score = 91.3 bits (225), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 71/213 (33%), Positives = 114/213 (53%), Gaps = 9/213 (4%) Query: 241 LTRRLLEIRNDERRTLARELHDEFGQNLTAILAFANTIEASAGDKYAAGTEIAQDARMIS 300 L RLLE RR +ARELHD+ GQ +TAI A ++ A D + Q ++I Sbjct: 293 LAERLLETEESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNGG----VKQSGQLIE 348 Query: 301 QATRRIMACLRDTLNRLRHPPAEELGLEASLVDLVDSWRSRTVQPMIQLDLQGDLADISG 360 Q + + +R L RLR ++L L ++ L+ + + LD + D +S Sbjct: 349 QLSLGVYDAVRRLLGRLRPRQLDDLTLAQAIRSLLREMELESRGIVSHLDWRIDETALSE 408 Query: 361 TVAATAYRVAQECLTNALRHSSAREIVLRIERRTGSENALLVRVEDDGGGDAAKVAQSAG 420 + T +RV QE L N ++H++A + L+ ++ + L++ +EDDG G Q G Sbjct: 409 SQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQ---DERLMLVIEDDGSGLPPGSHQQ-G 464 Query: 421 FGLTGVSERVTALGGSLSIARASRGLSVAATIP 453 FGLTG+ ERV+ALGG+L+I+ + G V+ ++P Sbjct: 465 FGLTGMRERVSALGGTLTIS-CTHGTRVSVSLP 496 >uhpB [T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific Eco Escherichia coli K12 Length = 501 Score = 90.9 bits (224), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 9/213 (4%) Query: 241 LTRRLLEIRNDERRTLARELHDEFGQNLTAILAFANTIEASAGDKYAAGTEIAQDARMIS 300 L RLLE RR +ARELHD+ GQ +TAI A ++ A D + Q ++I Sbjct: 294 LAERLLETEESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADN----ASVKQSGQLIE 349 Query: 301 QATRRIMACLRDTLNRLRHPPAEELGLEASLVDLVDSWRSRTVQPMIQLDLQGDLADISG 360 Q + + +R L RLR ++L LE ++ L+ + L+ + D + +S Sbjct: 350 QLSLGVYDAVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSE 409 Query: 361 TVAATAYRVAQECLTNALRHSSAREIVLRIERRTGSENALLVRVEDDGGGDAAKVAQSAG 420 T +RV QE L N ++H+ A + L+ ++ + L++ +EDDG G Q G Sbjct: 410 NQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQ---DERLMLVIEDDGSGLPPGSGQQ-G 465 Query: 421 FGLTGVSERVTALGGSLSIARASRGLSVAATIP 453 FGLTG+ ERVTALGG+L I+ G V+ ++P Sbjct: 466 FGLTGMRERVTALGGTLHIS-CLHGTRVSVSLP 497