BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0066.0030.p (379 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1016 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas ... 270 4e-72 Rv3540c [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacteri... 177 3e-44 MT3644 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacteriu... 177 3e-44 MTH793 [I] COG0183 Acetyl-CoA acetyltransferase Mth Methanotherm... 169 1e-41 AF0018 [I] COG0183 Acetyl-CoA acetyltransferase Afu Archaeoglobu... 152 2e-36 >PA1016 [I] COG0183 Acetyl-CoA acetyltransferase Pae Pseudomonas aeruginosa Length = 383 Score = 270 bits (690), Expect = 4e-72, Method: Compositional matrix adjust. Identities = 155/378 (41%), Positives = 214/378 (56%), Gaps = 11/378 (2%) Query: 3 RNQVAVVGAAETTELGVIPNMSQIQLHADAALNAIADAGLKLSDIDGFATAVET----PQ 58 R + A+VG + +G P S I+L A+L AIADAGLKLSDID A + Sbjct: 6 RGKTAIVGIG-SAGVGEAPGYSAIELLGQASLKAIADAGLKLSDIDAIFAATSSHAFPTL 64 Query: 59 QMAHYLGITPTWVDGTSVGGCSFMLHVRHAAAAIEAGLCKTVLITHAESGKSMIGKQPRF 118 +A YLGI P +VDGT++GG SF LH+ A A+EAGLC LI + + ++ G+ Sbjct: 65 SVAEYLGIRPKFVDGTNIGGSSFELHLLQATLALEAGLCDAALICYGSNQRTAGGRLVSM 124 Query: 119 TPADSLNGQFEAPFGVYGPPSMFPIPVLRFMKTHGITHEQLAMVAVVQREWAAKNPRATM 178 + E P+ P + + + R M +G T EQLA VAV R+WA NP A Sbjct: 125 SEPQ----WHETPYKPRHPITAYALAASRHMHQYGTTREQLAEVAVSARQWANLNPEAFA 180 Query: 179 KDPITVADVLNSRMIAYPFRLLQCCLVTDGGGALILTSADRAKDFPNKPVYILGTGESVE 238 + P++V DVL +RM++ P CCLVTDGGGA ++ A+RA+D PN PVY LG + Sbjct: 181 RGPLSVDDVLAARMVSDPLSAADCCLVTDGGGACVVVRAERARDLPNAPVYFLGAAGAQW 240 Query: 239 TPMVSQMKTFDSSRAFKVAGPLAFKEAGITHKDVDHLMIYDAFAHLPLYGLGDLGFMPYE 298 + M + A + A P A + AG+ H D+D +M+YDAF L L DLGF Sbjct: 241 HRSIVSMPDLTVTAASESA-PRAMQMAGVRHADIDLVMLYDAFTINTLLFLEDLGFCAKG 299 Query: 299 ETGRFIADGNTRPGGKLPLNTNGGGLSYMHSGMYGMYALQESVRQMRGIA-PAQVPNAKI 357 E G F+ G PGG+L +NTNGGGLS +H GMYGM+ + E+V Q+R A Q+ A + Sbjct: 300 EGGPFVQGGRIAPGGELAVNTNGGGLSCVHPGMYGMFLIIEAVTQLRRQAGERQLAKADV 359 Query: 358 SVCHGVGGMFAASGTIIF 375 ++ HG GG ++ T + Sbjct: 360 ALLHGNGGTLSSQVTALL 377 >Rv3540c [I] COG0183 Acetyl-CoA acetyltransferase Mtu Mycobacterium tuberculosis H37Rv Length = 386 Score = 177 bits (449), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 130/365 (35%), Positives = 181/365 (49%), Gaps = 22/365 (6%) Query: 1 MRRNQVAVVGAAETTELGVIPNMSQIQLHADAALNAIADAGLKLSDIDG---FATAVETP 57 M Q A+VG T+ S+++L A+A L+A+ADAGL +D+DG F T Sbjct: 1 MLSGQAAIVGIG-ATDFSKNSGRSELRLAAEAVLDALADAGLSPTDVDGLTTFTMDTNTE 59 Query: 58 QQMAHYLGITP-TWVDGTSVGGCSFMLHVRHAAAAIEAGLCKTVLITHA---ESGKSMIG 113 +A GI T+ GG + V+HAA A+ G+ V+ A SG Sbjct: 60 IAVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQ 119 Query: 114 KQPRFTP-ADS--LNGQFEAPFGVYGPPSMFPIPVLRFMKTHGITHEQLAMVAVVQREWA 170 Q R T ADS ++ F P G+ P + + R+M G T V+V R+ A Sbjct: 120 VQTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGATSRDFGAVSVADRKHA 179 Query: 171 AKNPRATM-KDPITVADVLNSRMIAYPFRLLQCCLVTDGGGALILTSADRAKDFPNKPVY 229 A NP+A PIT+ D NSR IA P RLL CC TDG A+++TSA RA+D +PV Sbjct: 180 ANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAIVVTSAARARDLKQRPVV 239 Query: 230 ILGTGESV---ETPMVSQMK-TFDSSRAFKVAGPLAFKEAGITHKDVDHLMIYDAFAHLP 285 I + + MVS + D + G + ++G+T DV ++YD F Sbjct: 240 IEAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFT 299 Query: 286 LYGLGDLGFMPYEETGRFIADGNTRPGGKLPLNTNGG--GLSYMHSGMYGMYALQESVRQ 343 L L +LGF E FIADG GG+LP+NT+GG G +Y+H GM + E VRQ Sbjct: 300 LIQLEELGFCGKGEAKDFIADGAIEVGGRLPINTHGGQLGEAYIH----GMNGIAEGVRQ 355 Query: 344 MRGIA 348 +RG + Sbjct: 356 LRGTS 360 >MT3644 [I] COG0183 Acetyl-CoA acetyltransferase MtC Mycobacterium tuberculosis CDC1551 Length = 386 Score = 177 bits (449), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 130/365 (35%), Positives = 181/365 (49%), Gaps = 22/365 (6%) Query: 1 MRRNQVAVVGAAETTELGVIPNMSQIQLHADAALNAIADAGLKLSDIDG---FATAVETP 57 M Q A+VG T+ S+++L A+A L+A+ADAGL +D+DG F T Sbjct: 1 MLSGQAAIVGIG-ATDFSKNSGRSELRLAAEAVLDALADAGLSPTDVDGLTTFTMDTNTE 59 Query: 58 QQMAHYLGITP-TWVDGTSVGGCSFMLHVRHAAAAIEAGLCKTVLITHA---ESGKSMIG 113 +A GI T+ GG + V+HAA A+ G+ V+ A SG Sbjct: 60 IAVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQ 119 Query: 114 KQPRFTP-ADS--LNGQFEAPFGVYGPPSMFPIPVLRFMKTHGITHEQLAMVAVVQREWA 170 Q R T ADS ++ F P G+ P + + R+M G T V+V R+ A Sbjct: 120 VQTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGATSRDFGAVSVADRKHA 179 Query: 171 AKNPRATM-KDPITVADVLNSRMIAYPFRLLQCCLVTDGGGALILTSADRAKDFPNKPVY 229 A NP+A PIT+ D NSR IA P RLL CC TDG A+++TSA RA+D +PV Sbjct: 180 ANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAIVVTSAARARDLKQRPVV 239 Query: 230 ILGTGESV---ETPMVSQMK-TFDSSRAFKVAGPLAFKEAGITHKDVDHLMIYDAFAHLP 285 I + + MVS + D + G + ++G+T DV ++YD F Sbjct: 240 IEAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFT 299 Query: 286 LYGLGDLGFMPYEETGRFIADGNTRPGGKLPLNTNGG--GLSYMHSGMYGMYALQESVRQ 343 L L +LGF E FIADG GG+LP+NT+GG G +Y+H GM + E VRQ Sbjct: 300 LIQLEELGFCGKGEAKDFIADGAIEVGGRLPINTHGGQLGEAYIH----GMNGIAEGVRQ 355 Query: 344 MRGIA 348 +RG + Sbjct: 356 LRGTS 360 >MTH793 [I] COG0183 Acetyl-CoA acetyltransferase Mth Methanothermobacter thermautotrophicus Length = 383 Score = 169 bits (428), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 122/384 (31%), Positives = 190/384 (49%), Gaps = 16/384 (4%) Query: 5 QVAVVGAAETTELGVIPNMSQIQLHADAALNAIADAGLKLSDIDG----------FATAV 54 VAV+G ++T + G + ++S + +A L AI DAG++ +D+D F Sbjct: 3 DVAVIGVSQT-KFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQE 61 Query: 55 ETPQQMAHYLGITPTWVDGTSVGGCSFMLHVRHAAAAIEAGLCKTVLITHAESGKSMIGK 114 +A + G+TP S L +R A+ +G V+ E ++ Sbjct: 62 HISSLIADHAGLTPIPSTRVEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVDP 121 Query: 115 QPRFTPADSLNGQFEAPFGVYGPPSMFPIPVLRFMKTHGITHEQLAMVAVVQREWAAKNP 174 P A + ++EA GV PS++ + R M +G T EQLAMV+V+ E A+ NP Sbjct: 122 TPAIATAS--DQEWEAQQGVT-FPSLYAMMARRHMYEYGTTREQLAMVSVINHENASNNP 178 Query: 175 RATMKDPITVADVLNSRMIAYPFRLLQCCLVTDGGGALILTSADRAKDFPNKPVYILGTG 234 RA +TV V+NS M+A P RLL C ++DG A+IL AD A+++ + PVY+ + Sbjct: 179 RAQFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASA 238 Query: 235 ESVETPMVSQMKTFDSSRAFKVAGPLAFKEAGITHKDVDHLMIYDAFAHLPLYGLGDLGF 294 ++ T + + A A AFK A +T D+D + ++D F+ + + DLGF Sbjct: 239 QASGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGF 298 Query: 295 MPYEETGRFIADGNTRPGGKLPLNTNGGGLSYMHS-GMYGMYALQESVRQMRGIA-PAQV 352 + E GR DG TR G +P+N +GG + H G G+ E V Q+RG A QV Sbjct: 299 VEKGEGGRAFEDGMTRIDGDIPVNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQV 358 Query: 353 PNAKISVCHGVGGMFAASGTIIFT 376 A+I + H +GG + IF+ Sbjct: 359 EGAEIGMTHNIGGTGGTAAVHIFS 382 >AF0018 [I] COG0183 Acetyl-CoA acetyltransferase Afu Archaeoglobus fulgidus Length = 391 Score = 152 bits (383), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 99/339 (29%), Positives = 162/339 (47%), Gaps = 15/339 (4%) Query: 42 LKLSDIDGFATAVETPQQM----------AHYLGITPTWVDGTSVGGC-SFMLHVRHAAA 90 L D+D F P++ A LGI P V + C S + +R+A Sbjct: 33 LDKKDVDSFFIGAAQPERWTYQTHVAPLAAELLGIKPRRVVARTESACASGQIAIRYAWL 92 Query: 91 AIEAGLCKTVLITHAESGKSMIGKQPRFTPADSLNGQFEAPFGVYGPPSMFPIPVLRFMK 150 A+ +GL ++ E + + + + N +F+ G+ PP F + R M Sbjct: 93 AVASGLSDVAVVVGVEKMNTKFMNLSQTSMMNVGNREFDTAMGLTAPP-YFAMVAQRHMH 151 Query: 151 THGITHEQLAMVAVVQREWAAKNPRATMKDPITVADVLNSRMIAYPFRLLQCCLVTDGGG 210 +G T +Q+A+V E+A+ NP A + I+ DVLNSRM+A P +LL C +TDG Sbjct: 152 LYGTTEDQMALVREKAGEYASANPYAQFQKKISKEDVLNSRMVAPPLKLLDCSGITDGAA 211 Query: 211 ALILTSADRAKDFPNKPVYILGTGESVETPMVSQMKTFDSSRAFKVAGPLAFKEAGITHK 270 AL++T+ ++A+ F + PV+ILG + +++M + + + IT Sbjct: 212 ALLITTEEKARKFTDTPVWILGGIQRTMANSINEMGEMSDWLSLRYLAKDVYDLFNITPD 271 Query: 271 DVDHLMIYDAFAHLPLYGLGDLGFMPYEETGRFIADGNTRPGGKLPLNTNGGGLSYMHS- 329 D+D ++D F + +LGF E G+FI +G + GGK+ +N +GG L+ H Sbjct: 272 DIDVAEVHDCFTISEIMEYEELGFCKKGEGGKFIEEGQSYIGGKVAVNPSGGLLANGHPL 331 Query: 330 GMYGMYALQESVRQMRGIAPAQ--VPNAKISVCHGVGGM 366 G G+ E V Q RG P + V A++ + H + GM Sbjct: 332 GATGVRQAWEMVMQFRGEVPDKRYVSGAELGLAHNLSGM 370